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The map label for this gene is zwf2 [H]

Identifier: 116695442

GI number: 116695442

Start: 1686376

End: 1687872

Strand: Direct

Name: zwf2 [H]

Synonym: H16_B1501

Alternate gene names: 116695442

Gene position: 1686376-1687872 (Clockwise)

Preceding gene: 116695441

Following gene: 116695443

Centisome position: 57.9

GC content: 68.34

Gene sequence:

>1497_bases
ATGATGGCTAGCCCCCCTGCCGGCGCTCCGGCACCTGAACCTGCTCCAGAGTTCGATTTCGTACTGTTCGGCGCCACCGG
CGACCTGGCGCGGCGCAAGCTGCTGCCGGCACTGTTCGATGCCCACGCCGCCGGTTCGCTGCATCCGCGCGGGCGCATCC
TGGCACTGGGCAGCCAGCCGCTGTCGCATGACGCCTACCTGGCGATGCTAAACGACGAAGTGCTGCCAGCGCTGGCCGGC
AACGCCGCGGCCGCAGCGTGGCAGGGCTTTCTCGACCGCATCGTGTACCTGCAGGTCGATGCCAACGCCGATGCCGGCTT
CGGCGCGCTGGCCGAGCTGGTCAATGCGCGCGCGGCGCCAGTGGTGGTGTTCTACCTGGCCACGGCCCCGCACCTGTTCG
TCACCATCTGCGAGCAACTGGCGCGCGTGGGCCTGACCGGCCCGCGCAGCCGCATCGTGCTGGAAAAACCGCTCGGGCAC
GACCTGGCCTCGTCCGAGGCCATCAACGCGGAAGTGGCGCGGCACTTTGCCGAGGACCAGATCTACCGGATCGACCACTA
CCTGGGCAAGGAGTCGGTGCAGAACCTGATGGCGGTGCGCTTTGGCAACGTGCTGTTCGAGCCGCTGTGGCGGCGCGAAT
GGGTGCGCCAGGTGCAGATCACCATCGCCGAAGAGCTGGGCGTGGAGCGCCGCGGCAACTTCTATGACGGCATCGGCGCG
CTGCGCGACATGGTGCAGAACCACCTGCTGCAGCTGCTGTGCATGGTGGCGATGGAGCCGCCCACGAGCCTGTCGGAAGA
CGCCATCCGCGATGAGAAGCTCAAGATCCTGAAGGCGCTGCGGCCGATCCGGCCGGAAGACGTGGCCGAAAAGGTGGTGC
GTGGCCAGTACTCCCGTGGCGCCGCGGGCGGCGACCCGGTGCCCGGCTATGCCAGTGAACCCGGCATCGCGCCCGACAGC
CGCACCGAGACCTTCGTCGCTATCCGCGCCGAGATCGCCAACTGGCGCTGGGCCGGGGTGCCGTTCTACCTGCGTACCGG
CAAGCGCATGCAGTCGCGCGTGGCGGAGATCGTAATCCATTTCCATGACGTGCCCTACCCGCTGTTCCCGCACCCGCTGG
GAATCATGTCCGGCAACCGGCTGGTGATCACGCTGCAGCCCGAGGAGAGCATCCGGCTGTATTTCCTGACCAAGCAGCCG
GGCGACACGCAGGCGCTGATTCCCGCGTCCCTCGACCTGCAGCTGAACACTGCCGCCCCACGTGTACGGCGCGTGGGCGC
GTACGAGCGCCTGCTGCTCGACGTGATCCGCGGCCGGCTGGGCCTGTTCGTGCGGCGCGATGAGCAGGTACAGGCGTGGC
GCTGGGTCGCGCCCATCCTGAAGACGTGGGAGAACTCGCCCACGCCGCCCAAGCCTTACACCGCCGGCACCTGGGGCCCG
GCAGCCTCCAGTGCCCTGCTGTCGCGAGACGGCATGGCCTGGCATGAAGAGATGTAG

Upstream 100 bases:

>100_bases
GCTGGTGACGCGTGCCAATGTAGGCCAGTACAAGGGCTGGGCCGCGCCGCGGTAAGCGGCACGGCCGGTCCTTCCACCCT
CTTTTCCATTTGCTGATTCC

Downstream 100 bases:

>100_bases
CCCACGTATTGCGGAGTATCTGACATGACCACTTCCCTGCCCGCCTGGCAAGCCCTGCGCGCGCACGCCGACACCCTGCG
CGGCACCCATATGCGCGACT

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 498; Mature: 498

Protein sequence:

>498_residues
MMASPPAGAPAPEPAPEFDFVLFGATGDLARRKLLPALFDAHAAGSLHPRGRILALGSQPLSHDAYLAMLNDEVLPALAG
NAAAAAWQGFLDRIVYLQVDANADAGFGALAELVNARAAPVVVFYLATAPHLFVTICEQLARVGLTGPRSRIVLEKPLGH
DLASSEAINAEVARHFAEDQIYRIDHYLGKESVQNLMAVRFGNVLFEPLWRREWVRQVQITIAEELGVERRGNFYDGIGA
LRDMVQNHLLQLLCMVAMEPPTSLSEDAIRDEKLKILKALRPIRPEDVAEKVVRGQYSRGAAGGDPVPGYASEPGIAPDS
RTETFVAIRAEIANWRWAGVPFYLRTGKRMQSRVAEIVIHFHDVPYPLFPHPLGIMSGNRLVITLQPEESIRLYFLTKQP
GDTQALIPASLDLQLNTAAPRVRRVGAYERLLLDVIRGRLGLFVRRDEQVQAWRWVAPILKTWENSPTPPKPYTAGTWGP
AASSALLSRDGMAWHEEM

Sequences:

>Translated_498_residues
MMASPPAGAPAPEPAPEFDFVLFGATGDLARRKLLPALFDAHAAGSLHPRGRILALGSQPLSHDAYLAMLNDEVLPALAG
NAAAAAWQGFLDRIVYLQVDANADAGFGALAELVNARAAPVVVFYLATAPHLFVTICEQLARVGLTGPRSRIVLEKPLGH
DLASSEAINAEVARHFAEDQIYRIDHYLGKESVQNLMAVRFGNVLFEPLWRREWVRQVQITIAEELGVERRGNFYDGIGA
LRDMVQNHLLQLLCMVAMEPPTSLSEDAIRDEKLKILKALRPIRPEDVAEKVVRGQYSRGAAGGDPVPGYASEPGIAPDS
RTETFVAIRAEIANWRWAGVPFYLRTGKRMQSRVAEIVIHFHDVPYPLFPHPLGIMSGNRLVITLQPEESIRLYFLTKQP
GDTQALIPASLDLQLNTAAPRVRRVGAYERLLLDVIRGRLGLFVRRDEQVQAWRWVAPILKTWENSPTPPKPYTAGTWGP
AASSALLSRDGMAWHEEM
>Mature_498_residues
MMASPPAGAPAPEPAPEFDFVLFGATGDLARRKLLPALFDAHAAGSLHPRGRILALGSQPLSHDAYLAMLNDEVLPALAG
NAAAAAWQGFLDRIVYLQVDANADAGFGALAELVNARAAPVVVFYLATAPHLFVTICEQLARVGLTGPRSRIVLEKPLGH
DLASSEAINAEVARHFAEDQIYRIDHYLGKESVQNLMAVRFGNVLFEPLWRREWVRQVQITIAEELGVERRGNFYDGIGA
LRDMVQNHLLQLLCMVAMEPPTSLSEDAIRDEKLKILKALRPIRPEDVAEKVVRGQYSRGAAGGDPVPGYASEPGIAPDS
RTETFVAIRAEIANWRWAGVPFYLRTGKRMQSRVAEIVIHFHDVPYPLFPHPLGIMSGNRLVITLQPEESIRLYFLTKQP
GDTQALIPASLDLQLNTAAPRVRRVGAYERLLLDVIRGRLGLFVRRDEQVQAWRWVAPILKTWENSPTPPKPYTAGTWGP
AASSALLSRDGMAWHEEM

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI108773793, Length=481, Percent_Identity=36.5904365904366, Blast_Score=300, Evalue=3e-81,
Organism=Homo sapiens, GI109389365, Length=481, Percent_Identity=36.5904365904366, Blast_Score=299, Evalue=4e-81,
Organism=Homo sapiens, GI52145310, Length=371, Percent_Identity=31.8059299191375, Blast_Score=152, Evalue=6e-37,
Organism=Escherichia coli, GI1788158, Length=486, Percent_Identity=45.4732510288066, Blast_Score=447, Evalue=1e-127,
Organism=Caenorhabditis elegans, GI17538218, Length=485, Percent_Identity=35.0515463917526, Blast_Score=297, Evalue=9e-81,
Organism=Saccharomyces cerevisiae, GI6324088, Length=482, Percent_Identity=36.3070539419087, Blast_Score=291, Evalue=2e-79,
Organism=Drosophila melanogaster, GI24643350, Length=482, Percent_Identity=36.3070539419087, Blast_Score=294, Evalue=1e-79,
Organism=Drosophila melanogaster, GI24643352, Length=482, Percent_Identity=36.3070539419087, Blast_Score=293, Evalue=1e-79,
Organism=Drosophila melanogaster, GI221513548, Length=503, Percent_Identity=29.2246520874751, Blast_Score=206, Evalue=4e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 54961; Mature: 54961

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMASPPAGAPAPEPAPEFDFVLFGATGDLARRKLLPALFDAHAAGSLHPRGRILALGSQP
CCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCC
LSHDAYLAMLNDEVLPALAGNAAAAAWQGFLDRIVYLQVDANADAGFGALAELVNARAAP
CCCCCEEEEECCCHHHHHCCCHHHHHHHHHHHEEEEEEEECCCCCCHHHHHHHHCCCCCC
VVVFYLATAPHLFVTICEQLARVGLTGPRSRIVLEKPLGHDLASSEAINAEVARHFAEDQ
EEEEEHHCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHH
IYRIDHYLGKESVQNLMAVRFGNVLFEPLWRREWVRQVQITIAEELGVERRGNFYDGIGA
HHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
LRDMVQNHLLQLLCMVAMEPPTSLSEDAIRDEKLKILKALRPIRPEDVAEKVVRGQYSRG
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCC
AAGGDPVPGYASEPGIAPDSRTETFVAIRAEIANWRWAGVPFYLRTGKRMQSRVAEIVIH
CCCCCCCCCCCCCCCCCCCCCCCEEEEEEEHHCCCEECCCCCEECCCHHHHHHHHHHHHH
FHDVPYPLFPHPLGIMSGNRLVITLQPEESIRLYFLTKQPGDTQALIPASLDLQLNTAAP
HCCCCCCCCCCCCCEECCCEEEEEECCCCCEEEEEEECCCCCCCEEECEEEEEEECCCCC
RVRRVGAYERLLLDVIRGRLGLFVRRDEQVQAWRWVAPILKTWENSPTPPKPYTAGTWGP
HHHHHHHHHHHHHHHHHHHHCEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
AASSALLSRDGMAWHEEM
HHHHHHHHCCCCCHHCCC
>Mature Secondary Structure
MMASPPAGAPAPEPAPEFDFVLFGATGDLARRKLLPALFDAHAAGSLHPRGRILALGSQP
CCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCC
LSHDAYLAMLNDEVLPALAGNAAAAAWQGFLDRIVYLQVDANADAGFGALAELVNARAAP
CCCCCEEEEECCCHHHHHCCCHHHHHHHHHHHEEEEEEEECCCCCCHHHHHHHHCCCCCC
VVVFYLATAPHLFVTICEQLARVGLTGPRSRIVLEKPLGHDLASSEAINAEVARHFAEDQ
EEEEEHHCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHH
IYRIDHYLGKESVQNLMAVRFGNVLFEPLWRREWVRQVQITIAEELGVERRGNFYDGIGA
HHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
LRDMVQNHLLQLLCMVAMEPPTSLSEDAIRDEKLKILKALRPIRPEDVAEKVVRGQYSRG
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCC
AAGGDPVPGYASEPGIAPDSRTETFVAIRAEIANWRWAGVPFYLRTGKRMQSRVAEIVIH
CCCCCCCCCCCCCCCCCCCCCCCEEEEEEEHHCCCEECCCCCEECCCHHHHHHHHHHHHH
FHDVPYPLFPHPLGIMSGNRLVITLQPEESIRLYFLTKQPGDTQALIPASLDLQLNTAAP
HCCCCCCCCCCCCCEECCCEEEEEECCCCCEEEEEEECCCCCCCEEECEEEEEEECCCCC
RVRRVGAYERLLLDVIRGRLGLFVRRDEQVQAWRWVAPILKTWENSPTPPKPYTAGTWGP
HHHHHHHHHHHHHHHHHHHHCEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
AASSALLSRDGMAWHEEM
HHHHHHHHCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10400573; 11481430 [H]