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The map label for this gene is adhP [H]

Identifier: 116695375

GI number: 116695375

Start: 1604142

End: 1605155

Strand: Direct

Name: adhP [H]

Synonym: H16_B1433

Alternate gene names: 116695375

Gene position: 1604142-1605155 (Clockwise)

Preceding gene: 116695374

Following gene: 116695376

Centisome position: 55.08

GC content: 67.06

Gene sequence:

>1014_bases
ATGCCCCACCAAACCATGCGTGCAATGGTCTTCGAGGGCGCAGGCCTGCCGCTGCGCCTCCACCACTTGCCGGTTGCCGA
ACCGGGGCCCGGCGAACTTCGCATTGCCGTGGGAGCTTGCGGGGTGTGCCGGACCGACCTGCATATCGCCGACGGCGACC
TGCGCCATCCCAAGCCGGTGCTCATCCCGGGACATGAAATCGTCGGACAGGTGGATTCGTGCGGCGCCGGTGTCACCGTC
TTCAAGCCGGGGGACCGCGTCGGTGTGCCCTGGCTCGGACATAGCTGTGGCCATTGTCGCTACTGCCTGCGTCATCACGA
GAATCTTTGCGACGCACCGCTGTTCACTGGCTATACCCGCGATGGCGGCTATGCGGAGTACGTTGTTGCCGACAGCGGCT
ATTGCTTCCGGATTCCGCCCGGCTACGATGACGAACACGCCGCGCCACTACTCTGCGCGGGCCTGATCGGCTACCGGACG
CTGCGCATGGCGGGCGCAGCCAGCCATGCGCAGCGCGTCGGCATCTACGGCTTCGGCGCCGCCGCCCACCTGGTGACGCA
GATCGCGGTGGCGCAAGGCCGCGAAGTCTACGCCTTCACCCGCACGGGCGACGCAGGCGCCCAGCAACTCGCCTACCAAT
CCGGTGCGTGCTGGGCCGGCTCGAGCGAGCTCGAGTCGCCCGTGCCGCTGGACGCCGCGCTGATTTTCGCCCCGGTGGGC
GCGCTGGTGCCCAAGGCGCTGCGCGCCGTGGACAAGGGTGGCATCGTGGTCTGTGGCGGAATTCATATGAGCGATATCCC
AAGCATGCCTTACCAGCTGCTTTGGGAAGAAAGGCGCCTGTGTTCCGTAGCCAACCTCACGCGTGCCGACGGCATCGCGC
TGATGGATATCGCCGCCCGGACGCCGCTGCATACGCACACCACCGCGTATCCGCTGGAGCAGGCCAACGAAGCACTGGCC
GACCTGCGCGAGGGCCGGCTTACCGGCGCCGCCGTCCTGAAAGTCCGTCAATAG

Upstream 100 bases:

>100_bases
GTCCGGCGCCTGCTGATGGGCAGCGTGTCGGAAGGCGTGCTTGCCAAGACCAGCAAGCCCGTGCTCCTGGTCCGCAGCGA
AGTCGAAGGTTAGGCGCGCC

Downstream 100 bases:

>100_bases
ATCCCTGGCAGATAGATCGATGAGCCGTTACCAGACACGTTTTCAGGCGCGTGAGCATGCGGGCTCGGAGCTCGCCTGGG
CGTTGCGCGCGTATCGGGGA

Product: alcohol dehydrogenase, Zn-dependent

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 337; Mature: 336

Protein sequence:

>337_residues
MPHQTMRAMVFEGAGLPLRLHHLPVAEPGPGELRIAVGACGVCRTDLHIADGDLRHPKPVLIPGHEIVGQVDSCGAGVTV
FKPGDRVGVPWLGHSCGHCRYCLRHHENLCDAPLFTGYTRDGGYAEYVVADSGYCFRIPPGYDDEHAAPLLCAGLIGYRT
LRMAGAASHAQRVGIYGFGAAAHLVTQIAVAQGREVYAFTRTGDAGAQQLAYQSGACWAGSSELESPVPLDAALIFAPVG
ALVPKALRAVDKGGIVVCGGIHMSDIPSMPYQLLWEERRLCSVANLTRADGIALMDIAARTPLHTHTTAYPLEQANEALA
DLREGRLTGAAVLKVRQ

Sequences:

>Translated_337_residues
MPHQTMRAMVFEGAGLPLRLHHLPVAEPGPGELRIAVGACGVCRTDLHIADGDLRHPKPVLIPGHEIVGQVDSCGAGVTV
FKPGDRVGVPWLGHSCGHCRYCLRHHENLCDAPLFTGYTRDGGYAEYVVADSGYCFRIPPGYDDEHAAPLLCAGLIGYRT
LRMAGAASHAQRVGIYGFGAAAHLVTQIAVAQGREVYAFTRTGDAGAQQLAYQSGACWAGSSELESPVPLDAALIFAPVG
ALVPKALRAVDKGGIVVCGGIHMSDIPSMPYQLLWEERRLCSVANLTRADGIALMDIAARTPLHTHTTAYPLEQANEALA
DLREGRLTGAAVLKVRQ
>Mature_336_residues
PHQTMRAMVFEGAGLPLRLHHLPVAEPGPGELRIAVGACGVCRTDLHIADGDLRHPKPVLIPGHEIVGQVDSCGAGVTVF
KPGDRVGVPWLGHSCGHCRYCLRHHENLCDAPLFTGYTRDGGYAEYVVADSGYCFRIPPGYDDEHAAPLLCAGLIGYRTL
RMAGAASHAQRVGIYGFGAAAHLVTQIAVAQGREVYAFTRTGDAGAQQLAYQSGACWAGSSELESPVPLDAALIFAPVGA
LVPKALRAVDKGGIVVCGGIHMSDIPSMPYQLLWEERRLCSVANLTRADGIALMDIAARTPLHTHTTAYPLEQANEALAD
LREGRLTGAAVLKVRQ

Specific function: Preferred Specificity Is Towards 1-Propanol. [C]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=184, Percent_Identity=29.8913043478261, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI34577061, Length=194, Percent_Identity=29.3814432989691, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI262073058, Length=193, Percent_Identity=28.4974093264249, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI71743840, Length=193, Percent_Identity=28.4974093264249, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI4501929, Length=194, Percent_Identity=28.8659793814433, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI156627571, Length=347, Percent_Identity=25.6484149855908, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI71565152, Length=104, Percent_Identity=38.4615384615385, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI71565154, Length=105, Percent_Identity=41.9047619047619, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI87081918, Length=326, Percent_Identity=32.2085889570552, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI87082401, Length=327, Percent_Identity=29.0519877675841, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI1786518, Length=200, Percent_Identity=37, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1790045, Length=147, Percent_Identity=36.734693877551, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1787863, Length=221, Percent_Identity=28.9592760180996, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1788407, Length=199, Percent_Identity=32.6633165829146, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI87082125, Length=200, Percent_Identity=29, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1786552, Length=363, Percent_Identity=25.8953168044077, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1788073, Length=133, Percent_Identity=33.0827067669173, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71988145, Length=333, Percent_Identity=28.2282282282282, Blast_Score=117, Evalue=7e-27,
Organism=Caenorhabditis elegans, GI17562584, Length=339, Percent_Identity=26.5486725663717, Blast_Score=104, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI17562582, Length=165, Percent_Identity=33.3333333333333, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17562878, Length=192, Percent_Identity=29.6875, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI25146526, Length=210, Percent_Identity=31.9047619047619, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17562876, Length=206, Percent_Identity=29.6116504854369, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71997431, Length=212, Percent_Identity=31.6037735849057, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6323961, Length=162, Percent_Identity=40.1234567901235, Blast_Score=117, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6323729, Length=210, Percent_Identity=36.1904761904762, Blast_Score=117, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6324486, Length=254, Percent_Identity=33.4645669291339, Blast_Score=113, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6319621, Length=359, Percent_Identity=28.6908077994429, Blast_Score=111, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6319949, Length=182, Percent_Identity=35.7142857142857, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6323980, Length=179, Percent_Identity=36.8715083798883, Blast_Score=84, Evalue=5e-17,
Organism=Drosophila melanogaster, GI17737897, Length=153, Percent_Identity=33.3333333333333, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI17137530, Length=138, Percent_Identity=32.6086956521739, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17737895, Length=113, Percent_Identity=38.9380530973451, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR014187
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 35838; Mature: 35706

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
3.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPHQTMRAMVFEGAGLPLRLHHLPVAEPGPGELRIAVGACGVCRTDLHIADGDLRHPKPV
CCCHHHHHHHCCCCCCCEEEEECCCCCCCCCCEEEEEECCCEEECCCEECCCCCCCCCCE
LIPGHEIVGQVDSCGAGVTVFKPGDRVGVPWLGHSCGHCRYCLRHHENLCDAPLFTGYTR
EECCHHHHCCCCCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCC
DGGYAEYVVADSGYCFRIPPGYDDEHAAPLLCAGLIGYRTLRMAGAASHAQRVGIYGFGA
CCCEEEEEEECCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHEECEEECCH
AAHLVTQIAVAQGREVYAFTRTGDAGAQQLAYQSGACWAGSSELESPVPLDAALIFAPVG
HHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHH
ALVPKALRAVDKGGIVVCGGIHMSDIPSMPYQLLWEERRLCSVANLTRADGIALMDIAAR
HHHHHHHHHHCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEHHHC
TPLHTHTTAYPLEQANEALADLREGRLTGAAVLKVRQ
CCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECC
>Mature Secondary Structure 
PHQTMRAMVFEGAGLPLRLHHLPVAEPGPGELRIAVGACGVCRTDLHIADGDLRHPKPV
CCHHHHHHHCCCCCCCEEEEECCCCCCCCCCEEEEEECCCEEECCCEECCCCCCCCCCE
LIPGHEIVGQVDSCGAGVTVFKPGDRVGVPWLGHSCGHCRYCLRHHENLCDAPLFTGYTR
EECCHHHHCCCCCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCC
DGGYAEYVVADSGYCFRIPPGYDDEHAAPLLCAGLIGYRTLRMAGAASHAQRVGIYGFGA
CCCEEEEEEECCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHEECEEECCH
AAHLVTQIAVAQGREVYAFTRTGDAGAQQLAYQSGACWAGSSELESPVPLDAALIFAPVG
HHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHH
ALVPKALRAVDKGGIVVCGGIHMSDIPSMPYQLLWEERRLCSVANLTRADGIALMDIAAR
HHHHHHHHHHCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEHHHC
TPLHTHTTAYPLEQANEALADLREGRLTGAAVLKVRQ
CCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]