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The map label for this gene is tdo2 [H]

Identifier: 116695361

GI number: 116695361

Start: 1586804

End: 1587700

Strand: Direct

Name: tdo2 [H]

Synonym: H16_B1418

Alternate gene names: 116695361

Gene position: 1586804-1587700 (Clockwise)

Preceding gene: 116695360

Following gene: 116695368

Centisome position: 54.48

GC content: 66.44

Gene sequence:

>897_bases
GTGAACGATACCGTCAAGCCCGCATCCCCGTCGCCGGCCGGGCATACGCCATACAGTGACTGGTTACAAACAGACGTGCT
CCACTCGCTGCAGCACCCGGTCAGCGATCATCCCGGCGAGCACGCCTGGATCGTATCGGCGCAGGTGTCCGAGCTCTACT
GGATGCTGATCATCAAGGAAATACAGGCCGCGCAGGCGCAATTGCGTGCCGATGACCTGACCGGGGCCTGCCGGACGCTG
CGGCGCGTCGTCGCCCACCACGAGCCGCTCAATGCCACATGGCGCTCTATCGCGTGGATGACGCCGGTCGACCTGCTGGC
CATCCTGTCCTGCGTTGGCCCAAAGTTCGGCAAGGACACCGCCCTCCAGGGCTGGACGTACCGGCAGATGGTCTACCTGC
TCGGCATCAAGCAAGGGGAGCACCTGCAGCACTTCCTGCCGCAACCCCGGCGCTGGGAACAACTCAGCAAGGCGCTGGCG
GAGCCGAGCCTGTATGACGAGGTGCTCGCCCACCTGGGCCGCAAGGGCTTCGCCGTGCCGGCGGTGGTACTCGAACGCGA
TTTCAGTGTGCCCTACACGCCGGACCAGGCGGTAGAGAATGTCTGGCGCGAGGTCTACGCCGACCCGGACGAGCACCGTG
AACTGCAGCAGCTCGGCGAGACGCTGGCCGATATCGCGGAGGGGTTCTCCGCTTGGAAGCACCTGCACCTGATGGCAACG
CGCCGGACGTTCGGCGCCCGGCCGGCCTACTTCGGCACCGAGGGCATTGCGTGGCTCCTGCCGACCATGAACGAGATCCC
GTTCCCGGAACTCTGGTCTGCGCGCGGCTTCATCGGCGATCCGCCCGCGGTGTGTCCGCACGCCCGCGGACAGAGAAACG
CCCAGGCTGCGGAGTGA

Upstream 100 bases:

>100_bases
TGTTGGAGAGCCTGTGGTAATGACCGCCCAGCCATCCGATGCTGCGCATCGTCGCCGTTCCACAAAACTTGCCTGACCCC
ACCACCACGAGGAGACCAAA

Downstream 100 bases:

>100_bases
CGCGCTCAAGACGGTCATGGAAGCGGTCTGCGGTCACAAGATCGCGGCGCTCGAGTCCATGATCGTCAAGCAAGCTGCGT
GGAGACTGCGCCAGCCTGAG

Product: tryptophan 2,3-dioxygenase

Products: NA

Alternate protein names: TDO; Tryptamin 2,3-dioxygenase; Tryptophan oxygenase; TO; TRPO; Tryptophan pyrrolase; Tryptophanase [H]

Number of amino acids: Translated: 298; Mature: 298

Protein sequence:

>298_residues
MNDTVKPASPSPAGHTPYSDWLQTDVLHSLQHPVSDHPGEHAWIVSAQVSELYWMLIIKEIQAAQAQLRADDLTGACRTL
RRVVAHHEPLNATWRSIAWMTPVDLLAILSCVGPKFGKDTALQGWTYRQMVYLLGIKQGEHLQHFLPQPRRWEQLSKALA
EPSLYDEVLAHLGRKGFAVPAVVLERDFSVPYTPDQAVENVWREVYADPDEHRELQQLGETLADIAEGFSAWKHLHLMAT
RRTFGARPAYFGTEGIAWLLPTMNEIPFPELWSARGFIGDPPAVCPHARGQRNAQAAE

Sequences:

>Translated_298_residues
MNDTVKPASPSPAGHTPYSDWLQTDVLHSLQHPVSDHPGEHAWIVSAQVSELYWMLIIKEIQAAQAQLRADDLTGACRTL
RRVVAHHEPLNATWRSIAWMTPVDLLAILSCVGPKFGKDTALQGWTYRQMVYLLGIKQGEHLQHFLPQPRRWEQLSKALA
EPSLYDEVLAHLGRKGFAVPAVVLERDFSVPYTPDQAVENVWREVYADPDEHRELQQLGETLADIAEGFSAWKHLHLMAT
RRTFGARPAYFGTEGIAWLLPTMNEIPFPELWSARGFIGDPPAVCPHARGQRNAQAAE
>Mature_298_residues
MNDTVKPASPSPAGHTPYSDWLQTDVLHSLQHPVSDHPGEHAWIVSAQVSELYWMLIIKEIQAAQAQLRADDLTGACRTL
RRVVAHHEPLNATWRSIAWMTPVDLLAILSCVGPKFGKDTALQGWTYRQMVYLLGIKQGEHLQHFLPQPRRWEQLSKALA
EPSLYDEVLAHLGRKGFAVPAVVLERDFSVPYTPDQAVENVWREVYADPDEHRELQQLGETLADIAEGFSAWKHLHLMAT
RRTFGARPAYFGTEGIAWLLPTMNEIPFPELWSARGFIGDPPAVCPHARGQRNAQAAE

Specific function: Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring [H]

COG id: COG3483

COG function: function code E; Tryptophan 2,3-dioxygenase (vermilion)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tryptophan 2,3-dioxygenase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017485
- InterPro:   IPR004981 [H]

Pfam domain/function: PF03301 Trp_dioxygenase [H]

EC number: =1.13.11.11 [H]

Molecular weight: Translated: 33527; Mature: 33527

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDTVKPASPSPAGHTPYSDWLQTDVLHSLQHPVSDHPGEHAWIVSAQVSELYWMLIIKE
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEEHHHHHHHHHHHHHH
IQAAQAQLRADDLTGACRTLRRVVAHHEPLNATWRSIAWMTPVDLLAILSCVGPKFGKDT
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHCCCCCCCC
ALQGWTYRQMVYLLGIKQGEHLQHFLPQPRRWEQLSKALAEPSLYDEVLAHLGRKGFAVP
CCCCCHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCH
AVVLERDFSVPYTPDQAVENVWREVYADPDEHRELQQLGETLADIAEGFSAWKHLHLMAT
HHHHHCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRTFGARPAYFGTEGIAWLLPTMNEIPFPELWSARGFIGDPPAVCPHARGQRNAQAAE
HHHHCCCCCCCCCCCHHHHCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNDTVKPASPSPAGHTPYSDWLQTDVLHSLQHPVSDHPGEHAWIVSAQVSELYWMLIIKE
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEEHHHHHHHHHHHHHH
IQAAQAQLRADDLTGACRTLRRVVAHHEPLNATWRSIAWMTPVDLLAILSCVGPKFGKDT
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHCCCCCCCC
ALQGWTYRQMVYLLGIKQGEHLQHFLPQPRRWEQLSKALAEPSLYDEVLAHLGRKGFAVP
CCCCCHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCH
AVVLERDFSVPYTPDQAVENVWREVYADPDEHRELQQLGETLADIAEGFSAWKHLHLMAT
HHHHHCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRTFGARPAYFGTEGIAWLLPTMNEIPFPELWSARGFIGDPPAVCPHARGQRNAQAAE
HHHHCCCCCCCCCCCHHHHCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA