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The map label for this gene is mmgC [H]

Identifier: 116695314

GI number: 116695314

Start: 1533479

End: 1534636

Strand: Direct

Name: mmgC [H]

Synonym: H16_B1371

Alternate gene names: 116695314

Gene position: 1533479-1534636 (Clockwise)

Preceding gene: 116695313

Following gene: 116695315

Centisome position: 52.65

GC content: 66.15

Gene sequence:

>1158_bases
ATGATCCGCGATAACGACATCCTCGAAGCCCTGCTCGACAGCGTGCGCCGCTTTGTGCGCGAGCGCCTGGTGCCCGCCGA
GGCGCTGGTCGCCGAGACCGACGAAATCCCGCAGGATATCGTGCAGGACATGCGCGAGATGGGCCTGTTCGGCATGACCA
TCCCCGAGGGCTTTGGCGGCCTGGAGCTGACCATGGAGGAGGAAGTGCGCGTGGTCATGGAGCTGTGCCAGACCTCGCCG
GCCTTCCGCTCGCTGCTGGGCACCACCGTGGGCATCGGCTCGCAGGGCATCCTGATGGATGGCACGCCGGAGCAGCAGGC
CGCGTGGCTGCCCCGCCTGGCCACCGGCGAGATCCTGGCCTCCTTTGCCCTGACCGAACCGGATGCCGGCTCGGACGCCG
GTTCGCTGCGCACCACCGCGGTCAGGAATGGCGACCACTACGTGGTCAACGGCACCAAGCGCTTTATCACCAACGCGCCG
CAGGCCGGCATGTTCACGCTGATGGCGCGTACCAACCCTGAAATCAAGGGCTCGGCCGGCGTCTCGGCATTTATCGTCGA
TGCCAGGACGCCCGGCATCAGCTTCGGCAAGCGCGACGTGAAGATGGGGCAGAAAGGCGCGCATACCTGCGACGTGATCT
TCGACAACGTGCGCGTACCGGCCGAGAACCTGATCGGCCTGAAGGAAGGCCAGGGCTTCAAGACGGCGATGAAGGTGCTC
GACAAGGGCCGGCTGCACATTGCGGCGGTCAGCGTCGGGGTGGCCAGGCGCGTGCTGCGCGACGCGCTGAACTACGCACT
GGAGCGCCAGCAGTTCGGCCAGCCGATCTGCGAGTTCCAGCTGATCCAGGCCATGCTGGCCGACAGCCAGGCCGAGCTTT
ATGCCGCCGAATGCATGGTGATCGACGCCGCGCGCCGCCGCGACGAAGGCAGGAACGTCTCCACCGAAGCCTCGTGCTGC
AAGATGTTCGCCACCGAGATGGTGGGCCGCGTGGCGGACCGCGCGGTACAGATTCTCGGCGGTTCCGGCTATATTTCCGA
GTTCGGCATCGAGCGCTTCTACCGCGATGTGCGCCTGTTCCGCCTGTATGAGGGCACCACGCAGATCCAGCAGGTCATCA
TCGCGCGCAACATGATCCGTGAGGCCCGCGGCGCGTAA

Upstream 100 bases:

>100_bases
CGAGCGCACGCAGTGGGCCAGCGTGCTCAAGGGCGTGACGCTGGACTGATGGTCCCGCCCCCTCGAACCGACACCGACCC
GACACCCAGGAAGAACCGAC

Downstream 100 bases:

>100_bases
GCACCGCGCCCCGCGCCAATACACCTGAACCATGCCCGCGCGCAACGCTGCCCGTCCCCAGGACGGGCAGCCTGCCTTGA
GACCGCCTGACCTGACATGA

Product: Acyl-CoA dehydrogenase, short-chain specific

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MIRDNDILEALLDSVRRFVRERLVPAEALVAETDEIPQDIVQDMREMGLFGMTIPEGFGGLELTMEEEVRVVMELCQTSP
AFRSLLGTTVGIGSQGILMDGTPEQQAAWLPRLATGEILASFALTEPDAGSDAGSLRTTAVRNGDHYVVNGTKRFITNAP
QAGMFTLMARTNPEIKGSAGVSAFIVDARTPGISFGKRDVKMGQKGAHTCDVIFDNVRVPAENLIGLKEGQGFKTAMKVL
DKGRLHIAAVSVGVARRVLRDALNYALERQQFGQPICEFQLIQAMLADSQAELYAAECMVIDAARRRDEGRNVSTEASCC
KMFATEMVGRVADRAVQILGGSGYISEFGIERFYRDVRLFRLYEGTTQIQQVIIARNMIREARGA

Sequences:

>Translated_385_residues
MIRDNDILEALLDSVRRFVRERLVPAEALVAETDEIPQDIVQDMREMGLFGMTIPEGFGGLELTMEEEVRVVMELCQTSP
AFRSLLGTTVGIGSQGILMDGTPEQQAAWLPRLATGEILASFALTEPDAGSDAGSLRTTAVRNGDHYVVNGTKRFITNAP
QAGMFTLMARTNPEIKGSAGVSAFIVDARTPGISFGKRDVKMGQKGAHTCDVIFDNVRVPAENLIGLKEGQGFKTAMKVL
DKGRLHIAAVSVGVARRVLRDALNYALERQQFGQPICEFQLIQAMLADSQAELYAAECMVIDAARRRDEGRNVSTEASCC
KMFATEMVGRVADRAVQILGGSGYISEFGIERFYRDVRLFRLYEGTTQIQQVIIARNMIREARGA
>Mature_385_residues
MIRDNDILEALLDSVRRFVRERLVPAEALVAETDEIPQDIVQDMREMGLFGMTIPEGFGGLELTMEEEVRVVMELCQTSP
AFRSLLGTTVGIGSQGILMDGTPEQQAAWLPRLATGEILASFALTEPDAGSDAGSLRTTAVRNGDHYVVNGTKRFITNAP
QAGMFTLMARTNPEIKGSAGVSAFIVDARTPGISFGKRDVKMGQKGAHTCDVIFDNVRVPAENLIGLKEGQGFKTAMKVL
DKGRLHIAAVSVGVARRVLRDALNYALERQQFGQPICEFQLIQAMLADSQAELYAAECMVIDAARRRDEGRNVSTEASCC
KMFATEMVGRVADRAVQILGGSGYISEFGIERFYRDVRLFRLYEGTTQIQQVIIARNMIREARGA

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI187960098, Length=368, Percent_Identity=36.9565217391304, Blast_Score=256, Evalue=2e-68,
Organism=Homo sapiens, GI4557231, Length=368, Percent_Identity=36.9565217391304, Blast_Score=256, Evalue=2e-68,
Organism=Homo sapiens, GI4557233, Length=373, Percent_Identity=36.9973190348526, Blast_Score=254, Evalue=1e-67,
Organism=Homo sapiens, GI76496475, Length=379, Percent_Identity=37.9947229551451, Blast_Score=247, Evalue=1e-65,
Organism=Homo sapiens, GI4557235, Length=377, Percent_Identity=38.1962864721485, Blast_Score=246, Evalue=2e-65,
Organism=Homo sapiens, GI4501859, Length=369, Percent_Identity=34.1463414634146, Blast_Score=242, Evalue=4e-64,
Organism=Homo sapiens, GI21361497, Length=384, Percent_Identity=35.4166666666667, Blast_Score=238, Evalue=8e-63,
Organism=Homo sapiens, GI226958412, Length=369, Percent_Identity=32.2493224932249, Blast_Score=225, Evalue=4e-59,
Organism=Homo sapiens, GI226958414, Length=364, Percent_Identity=33.2417582417582, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI7656849, Length=372, Percent_Identity=34.4086021505376, Blast_Score=214, Evalue=8e-56,
Organism=Homo sapiens, GI4501857, Length=387, Percent_Identity=30.4909560723514, Blast_Score=189, Evalue=4e-48,
Organism=Homo sapiens, GI4503943, Length=366, Percent_Identity=30.327868852459, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI7669494, Length=354, Percent_Identity=29.9435028248588, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI48976061, Length=390, Percent_Identity=28.974358974359, Blast_Score=135, Evalue=6e-32,
Organism=Homo sapiens, GI211971008, Length=390, Percent_Identity=28.974358974359, Blast_Score=135, Evalue=7e-32,
Organism=Homo sapiens, GI38505218, Length=403, Percent_Identity=27.5434243176179, Blast_Score=132, Evalue=5e-31,
Organism=Escherichia coli, GI1786223, Length=382, Percent_Identity=31.9371727748691, Blast_Score=179, Evalue=4e-46,
Organism=Escherichia coli, GI87081958, Length=377, Percent_Identity=31.0344827586207, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI87081702, Length=385, Percent_Identity=27.7922077922078, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI87082384, Length=278, Percent_Identity=26.6187050359712, Blast_Score=81, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17569725, Length=370, Percent_Identity=37.8378378378378, Blast_Score=258, Evalue=3e-69,
Organism=Caenorhabditis elegans, GI17534899, Length=368, Percent_Identity=36.9565217391304, Blast_Score=252, Evalue=3e-67,
Organism=Caenorhabditis elegans, GI17570075, Length=368, Percent_Identity=35.3260869565217, Blast_Score=246, Evalue=1e-65,
Organism=Caenorhabditis elegans, GI17508101, Length=367, Percent_Identity=35.149863760218, Blast_Score=240, Evalue=1e-63,
Organism=Caenorhabditis elegans, GI17506239, Length=386, Percent_Identity=35.2331606217617, Blast_Score=239, Evalue=1e-63,
Organism=Caenorhabditis elegans, GI71985184, Length=352, Percent_Identity=38.6363636363636, Blast_Score=239, Evalue=1e-63,
Organism=Caenorhabditis elegans, GI17538396, Length=379, Percent_Identity=31.9261213720317, Blast_Score=213, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI17533517, Length=379, Percent_Identity=31.3984168865435, Blast_Score=205, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI71985192, Length=299, Percent_Identity=38.1270903010033, Blast_Score=193, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI71990804, Length=293, Percent_Identity=34.8122866894198, Blast_Score=182, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17534353, Length=372, Percent_Identity=29.0322580645161, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI32563615, Length=232, Percent_Identity=37.0689655172414, Blast_Score=162, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI71982178, Length=278, Percent_Identity=32.0143884892086, Blast_Score=142, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17505929, Length=370, Percent_Identity=28.3783783783784, Blast_Score=140, Evalue=8e-34,
Organism=Caenorhabditis elegans, GI17551932, Length=374, Percent_Identity=27.0053475935829, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17531909, Length=248, Percent_Identity=33.4677419354839, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17562446, Length=289, Percent_Identity=31.8339100346021, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17531913, Length=178, Percent_Identity=30.8988764044944, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI86563383, Length=274, Percent_Identity=27.3722627737226, Blast_Score=81, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI86563381, Length=274, Percent_Identity=27.3722627737226, Blast_Score=81, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17540912, Length=379, Percent_Identity=22.1635883905013, Blast_Score=65, Evalue=9e-11,
Organism=Drosophila melanogaster, GI24660351, Length=376, Percent_Identity=38.563829787234, Blast_Score=272, Evalue=2e-73,
Organism=Drosophila melanogaster, GI24666513, Length=367, Percent_Identity=38.6920980926431, Blast_Score=248, Evalue=3e-66,
Organism=Drosophila melanogaster, GI281363737, Length=388, Percent_Identity=37.8865979381443, Blast_Score=246, Evalue=3e-65,
Organism=Drosophila melanogaster, GI21356377, Length=371, Percent_Identity=36.1185983827493, Blast_Score=241, Evalue=5e-64,
Organism=Drosophila melanogaster, GI24646207, Length=372, Percent_Identity=33.6021505376344, Blast_Score=217, Evalue=9e-57,
Organism=Drosophila melanogaster, GI21355753, Length=374, Percent_Identity=32.620320855615, Blast_Score=205, Evalue=4e-53,
Organism=Drosophila melanogaster, GI19920834, Length=371, Percent_Identity=27.4932614555256, Blast_Score=142, Evalue=6e-34,
Organism=Drosophila melanogaster, GI24652780, Length=345, Percent_Identity=23.4782608695652, Blast_Score=94, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 42206; Mature: 42206

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRDNDILEALLDSVRRFVRERLVPAEALVAETDEIPQDIVQDMREMGLFGMTIPEGFGG
CCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHCCCEECCCCCCCCC
LELTMEEEVRVVMELCQTSPAFRSLLGTTVGIGSQGILMDGTPEQQAAWLPRLATGEILA
CEEEHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCEEECCCCCHHHHHCCCHHHHHHHH
SFALTEPDAGSDAGSLRTTAVRNGDHYVVNGTKRFITNAPQAGMFTLMARTNPEIKGSAG
HHHCCCCCCCCCCCCCEEEEEECCCEEEECCHHHHHCCCCCCCEEEEEECCCCCCCCCCC
VSAFIVDARTPGISFGKRDVKMGQKGAHTCDVIFDNVRVPAENLIGLKEGQGFKTAMKVL
CEEEEEECCCCCCCCCCHHHHCCCCCCCCHHHEECCCCCCHHHCCCCCCCCCHHHHHHHH
DKGRLHIAAVSVGVARRVLRDALNYALERQQFGQPICEFQLIQAMLADSQAELYAAECMV
HCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHH
IDAARRRDEGRNVSTEASCCKMFATEMVGRVADRAVQILGGSGYISEFGIERFYRDVRLF
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
RLYEGTTQIQQVIIARNMIREARGA
HHHCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIRDNDILEALLDSVRRFVRERLVPAEALVAETDEIPQDIVQDMREMGLFGMTIPEGFGG
CCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHCCCEECCCCCCCCC
LELTMEEEVRVVMELCQTSPAFRSLLGTTVGIGSQGILMDGTPEQQAAWLPRLATGEILA
CEEEHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCEEECCCCCHHHHHCCCHHHHHHHH
SFALTEPDAGSDAGSLRTTAVRNGDHYVVNGTKRFITNAPQAGMFTLMARTNPEIKGSAG
HHHCCCCCCCCCCCCCEEEEEECCCEEEECCHHHHHCCCCCCCEEEEEECCCCCCCCCCC
VSAFIVDARTPGISFGKRDVKMGQKGAHTCDVIFDNVRVPAENLIGLKEGQGFKTAMKVL
CEEEEEECCCCCCCCCCHHHHCCCCCCCCHHHEECCCCCCHHHCCCCCCCCCHHHHHHHH
DKGRLHIAAVSVGVARRVLRDALNYALERQQFGQPICEFQLIQAMLADSQAELYAAECMV
HCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHH
IDAARRRDEGRNVSTEASCCKMFATEMVGRVADRAVQILGGSGYISEFGIERFYRDVRLF
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
RLYEGTTQIQQVIIARNMIREARGA
HHHCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]