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The map label for this gene is acrA9 [H]

Identifier: 116695058

GI number: 116695058

Start: 1260737

End: 1261978

Strand: Direct

Name: acrA9 [H]

Synonym: H16_B1113

Alternate gene names: 116695058

Gene position: 1260737-1261978 (Clockwise)

Preceding gene: 116695057

Following gene: 116695059

Centisome position: 43.29

GC content: 69.57

Gene sequence:

>1242_bases
ATGCAGCAGCAGAAACGACGTACTTTGATTGCCCTCGCCATCGTCGTGGTGCTGGGCGCCGGCGTGGCCGGCTCGATCTT
GCGCCCGTGGCATGGAGGCGAAGCCCATGCCAACACCCCGCCGCCCGCGCCGGCGATTGAAGTGGCCGCCGTGGTCGGCC
AGACCATCACCGAGTGGGATGAGTTCTCCGGACGGGTCGAGGCCGTGGAGCGCGTCGAGATCCGCCCGCGCGTCGGCGGC
ACCATTGACGCCGTGCACTTCCGCGAGGGCGCGCTGGTGAAGAAGGGCGACCCGCTCTTCACGATTGACCCGCGTCCTTA
TGCCGCGGAAGTCGCCCGTGCCGACGCCGCGCTGGGCGCGGCGCAGGTGCGCGCCGCCCATGCGCAGAGCGAACAGACGC
GCGCCCAGCGGCTGCTGGACGACAACGCGATCTCGAAGCGCGAGTTCGACGAGCGCATCAACGCGGCCCGCGAAACCAGT
GCCAACGTGCGGGCTGCCCAGGCGCAGCTGGAAACCGCACGCCTGAACCTGGCCTACACCCGCATCACCGCGCCGGTCGC
CGGGCGCGTGTCGCGCGCCGAGATCACCGTCGGCAACCTGGTGGCTGCGGGCACGGGCTCGCCGGCCCTGACCACGGTGG
TGTCGGTGTCGCCGATCTATGCCAGTTTCGAGATCGACGAGCAGAGCTACCTGCGCTACACCGCGCCGGGTGCCGGCGGT
GGCCAGCCCAACCTGCCGGTCTACCTGGGCCTGGCCAACGAGGACGGCAATCCGCATGAGGGCAAGATCCAGTCGGTCGA
CAACCGCCTGGACCCGCGCAGCGGCACCATCCGCGTGCGCGCGGTGTTCCAGAACGAAGACGGGCGCCTGCTGCCGGGAC
TGTACGCCAAGGTCAAGCTGGGCGGCGGCGCGCCGCATGCGGCGGTGCTGGTCAATGACCGCGCCATCGGCACCGACCAG
GGCAAGAAGTTCGTGCTGGTGGTCGACAAGACCAACAAGCTGGTCTACCGCGAAGTGGAACTGGGGCCTAACCATGACGG
CCTGCGCGTGGTGCGCAAGGGCCTGAAGCCGGGCGAGACCATCGTCGTCAATGGCCTGCAGCGCGTGCGGCCGGGCGACA
CGGTCCAGCCCAAGCCGGTGGCGATGGCCTTCCGCAGCGAACTGGAACCACGCGGCACTACGCCTGACCGCAAGCAGGCT
GCGAGCGAGAAGGGCGAAGCCGACGTGAAGCCGGTGAGCTGA

Upstream 100 bases:

>100_bases
TCAGTTTGGCCATGGTTCCGGTCCGCCCACGCGGACCGGCAGGCGGCGTTCGGCCATTTGCTTTTCCGGTTGAAGAAAAC
CCGATCCAGGAGTTTGAGAA

Downstream 100 bases:

>100_bases
GTCATGCGAGCCGATGGTTTGCTCCCCTCTCCCGCTGAGGGGAGAGGGAGCCGGCCTGAGCGATGTTTGATTCCGTCGCT
TATGGTAACCACGTGAACCC

Product: cation/multidrug efflux system, mebrane-fusion component

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 413; Mature: 413

Protein sequence:

>413_residues
MQQQKRRTLIALAIVVVLGAGVAGSILRPWHGGEAHANTPPPAPAIEVAAVVGQTITEWDEFSGRVEAVERVEIRPRVGG
TIDAVHFREGALVKKGDPLFTIDPRPYAAEVARADAALGAAQVRAAHAQSEQTRAQRLLDDNAISKREFDERINAARETS
ANVRAAQAQLETARLNLAYTRITAPVAGRVSRAEITVGNLVAAGTGSPALTTVVSVSPIYASFEIDEQSYLRYTAPGAGG
GQPNLPVYLGLANEDGNPHEGKIQSVDNRLDPRSGTIRVRAVFQNEDGRLLPGLYAKVKLGGGAPHAAVLVNDRAIGTDQ
GKKFVLVVDKTNKLVYREVELGPNHDGLRVVRKGLKPGETIVVNGLQRVRPGDTVQPKPVAMAFRSELEPRGTTPDRKQA
ASEKGEADVKPVS

Sequences:

>Translated_413_residues
MQQQKRRTLIALAIVVVLGAGVAGSILRPWHGGEAHANTPPPAPAIEVAAVVGQTITEWDEFSGRVEAVERVEIRPRVGG
TIDAVHFREGALVKKGDPLFTIDPRPYAAEVARADAALGAAQVRAAHAQSEQTRAQRLLDDNAISKREFDERINAARETS
ANVRAAQAQLETARLNLAYTRITAPVAGRVSRAEITVGNLVAAGTGSPALTTVVSVSPIYASFEIDEQSYLRYTAPGAGG
GQPNLPVYLGLANEDGNPHEGKIQSVDNRLDPRSGTIRVRAVFQNEDGRLLPGLYAKVKLGGGAPHAAVLVNDRAIGTDQ
GKKFVLVVDKTNKLVYREVELGPNHDGLRVVRKGLKPGETIVVNGLQRVRPGDTVQPKPVAMAFRSELEPRGTTPDRKQA
ASEKGEADVKPVS
>Mature_413_residues
MQQQKRRTLIALAIVVVLGAGVAGSILRPWHGGEAHANTPPPAPAIEVAAVVGQTITEWDEFSGRVEAVERVEIRPRVGG
TIDAVHFREGALVKKGDPLFTIDPRPYAAEVARADAALGAAQVRAAHAQSEQTRAQRLLDDNAISKREFDERINAARETS
ANVRAAQAQLETARLNLAYTRITAPVAGRVSRAEITVGNLVAAGTGSPALTTVVSVSPIYASFEIDEQSYLRYTAPGAGG
GQPNLPVYLGLANEDGNPHEGKIQSVDNRLDPRSGTIRVRAVFQNEDGRLLPGLYAKVKLGGGAPHAAVLVNDRAIGTDQ
GKKFVLVVDKTNKLVYREVELGPNHDGLRVVRKGLKPGETIVVNGLQRVRPGDTVQPKPVAMAFRSELEPRGTTPDRKQA
ASEKGEADVKPVS

Specific function: May contribute to resistance to some drugs, such as deoxycholate, sodium dodecyl sulfate and nalidixic acid, in the absence of BepD and BepE [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789929, Length=373, Percent_Identity=32.7077747989276, Blast_Score=181, Evalue=8e-47,
Organism=Escherichia coli, GI1786668, Length=384, Percent_Identity=34.375, Blast_Score=175, Evalue=4e-45,
Organism=Escherichia coli, GI1789665, Length=321, Percent_Identity=33.3333333333333, Blast_Score=155, Evalue=6e-39,
Organism=Escherichia coli, GI87082036, Length=345, Percent_Identity=30.1449275362319, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI87081951, Length=175, Percent_Identity=36.5714285714286, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI87081796, Length=381, Percent_Identity=23.8845144356955, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1789637, Length=139, Percent_Identity=34.5323741007194, Blast_Score=65, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 44085; Mature: 44085

Theoretical pI: Translated: 9.90; Mature: 9.90

Prosite motif: PS00626 RCC1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
0.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQQKRRTLIALAIVVVLGAGVAGSILRPWHGGEAHANTPPPAPAIEVAAVVGQTITEWD
CCCHHHHHHHHHHHHHHHCCCCCCHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
EFSGRVEAVERVEIRPRVGGTIDAVHFREGALVKKGDPLFTIDPRPYAAEVARADAALGA
HHCCHHEEEEEEEECCCCCCEEEEEEECCCCEEECCCCEEEECCCCHHHHHHHHHHHHHH
AQVRAAHAQSEQTRAQRLLDDNAISKREFDERINAARETSANVRAAQAQLETARLNLAYT
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEEEEEE
RITAPVAGRVSRAEITVGNLVAAGTGSPALTTVVSVSPIYASFEIDEQSYLRYTAPGAGG
EEECCHHCCCEEEEEEECCEEEECCCCCCEEEEEEECCEEEEEEECCCCEEEEECCCCCC
GQPNLPVYLGLANEDGNPHEGKIQSVDNRLDPRSGTIRVRAVFQNEDGRLLPGLYAKVKL
CCCCCCEEEEEECCCCCCCCCCHHHHHCCCCCCCCEEEEEEEEECCCCCCCCCEEEEEEE
GGGAPHAAVLVNDRAIGTDQGKKFVLVVDKTNKLVYREVELGPNHDGLRVVRKGLKPGET
CCCCCEEEEEEECCEECCCCCCEEEEEEECCCCEEEEEEECCCCCCHHHHHHHCCCCCCE
IVVNGLQRVRPGDTVQPKPVAMAFRSELEPRGTTPDRKQAASEKGEADVKPVS
EEECCHHHCCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MQQQKRRTLIALAIVVVLGAGVAGSILRPWHGGEAHANTPPPAPAIEVAAVVGQTITEWD
CCCHHHHHHHHHHHHHHHCCCCCCHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
EFSGRVEAVERVEIRPRVGGTIDAVHFREGALVKKGDPLFTIDPRPYAAEVARADAALGA
HHCCHHEEEEEEEECCCCCCEEEEEEECCCCEEECCCCEEEECCCCHHHHHHHHHHHHHH
AQVRAAHAQSEQTRAQRLLDDNAISKREFDERINAARETSANVRAAQAQLETARLNLAYT
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEEEEEE
RITAPVAGRVSRAEITVGNLVAAGTGSPALTTVVSVSPIYASFEIDEQSYLRYTAPGAGG
EEECCHHCCCEEEEEEECCEEEECCCCCCEEEEEEECCEEEEEEECCCCEEEEECCCCCC
GQPNLPVYLGLANEDGNPHEGKIQSVDNRLDPRSGTIRVRAVFQNEDGRLLPGLYAKVKL
CCCCCCEEEEEECCCCCCCCCCHHHHHCCCCCCCCEEEEEEEEECCCCCCCCCEEEEEEE
GGGAPHAAVLVNDRAIGTDQGKKFVLVVDKTNKLVYREVELGPNHDGLRVVRKGLKPGET
CCCCCEEEEEEECCEECCCCCCEEEEEEECCCCEEEEEEECCCCCCHHHHHHHCCCCCCE
IVVNGLQRVRPGDTVQPKPVAMAFRSELEPRGTTPDRKQAASEKGEADVKPVS
EEECCHHHCCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12271122 [H]