Click here to switch to the map view.

The map label for this gene is selB [H]

Identifier: 116694892

GI number: 116694892

Start: 1067571

End: 1069481

Strand: Direct

Name: selB [H]

Synonym: H16_B0947

Alternate gene names: 116694892

Gene position: 1067571-1069481 (Clockwise)

Preceding gene: 116694890

Following gene: 116694893

Centisome position: 36.65

GC content: 67.87

Gene sequence:

>1911_bases
ATGATCGTCGGCACGGCAGGACATATCGATCATGGCAAGACCTGCCTGGTCAGGGCGCTGTCGGGCATGGATACCGACCG
CCTGGAGGAAAGGAAGGCGCGCGGCTTCTCGATCGAGCTTGGCTATGCGTACGTGCCGCTCGAGAACGGCGACGTGCTCG
GCCTGGTCGATGTCCCGGGCCATCAAAAGCTGATTCACACCATGGCCGCGGGCGCATGCGGCATCGACTTCGCGCTGCTC
GTGGTCGCCGCCGATGACGGCGTGATGCCGCAAACGCGCGAGCACCTGGCCATTGTGCAACTGCTCGGCATCCGGCGCGG
CGCGATCGCGTTGACCAAGGTAGATCGCGTGAATGACGTGCGGCTACGGCAGGTGCGTGAGGAGATCGCGTCTTTCCGGC
GCGGCAGCATGCTGGAAGACGCCCCGGTTTTTGAAACCTGTGCAATGCGCGCCGACGACCCGGGTGTGAACGCGTTGAAG
CGGCACCTGCATGCGGCGGCGGCCGCGTCGCGAACGAAGCGCGACGACGGGCTGTTCCGCCTTGCGGTTGACCGGGTCTT
CACGCTTGCCGGGCAGGGGACGATCGTGACGGGAACCGTGGTGTCCGGGCGCATCCATGTCGGCGACAGGGTGTTGCTCG
CGCCGAAGAACGAGTCTGTGCGCGTGAGCGGCATCCATGCGCAGAATCGTCCTGCTGCTGCCGGGCGGGCGGGGCAGCGC
TGCGCGCTGAACCTGGCCGGCATCGACAAGGGCGCGATCGAGCGCGGTGACTGGGTGGTCGATGTGCGCCTGGCGCAGGC
GTCGGAGCGCATCGATGTGATGCTGACCCTGTTGCCGGACGCCCCTGCGCTGGAGCACTGGGCGCCCATGCATGTTCACC
TGGGCACGCAGCACCAGGTGGCGCATGTCGCGCTGCTCGATGGCCCGACGCTTGCGCCCGGCCAGCGCGCGCGCGTGCAG
CTTGTGTTCGAGCGGCCGGTATGCGCGCTGCCTGGCGATCCCTTTGTCGTGAGGAACGCGCAGGCCAGCCGCACCATCGG
CGGCGGCGATGTACTGGATCCGTTCGCGCCCGCGCGCAAGCGCCGTTCCCCGGCGCGGCTGGCTTGGCTCGACGCGATGC
AGGCCATGCTTGACACCGGATCGGTCGGGGCATTGCTCGAGCAGGCGCCACACGGGCTGTCGCGCGCATTGCTGGAACGC
CTGAGCGGCATGCCGGCGGCGGCCATCGAGCTGCCGTGTGACACGCGCGTGATCGAACTTCCGGGCAACGATGCCTTGCT
GGTGTCCGGCGCGGCGTGGCGGGCGCTGACGGGGCGATTGACCACTGCGCTCCGGCAATTCCACCAACGCTCGCCGGATG
TGCTTGGCCCGGAGGTGGCGCGCTTGCGCAGGATCGCTGCACCGCTGGCGCAAGACGCGTTGTGGTGCGCGCTCGTCGAT
GACGCCTGCGCGCGCGGCGAGATCGTCCGGACCGGCCCCTGGCTGCACCTGCCTGAGCACACCGTGACGCTCGACGACGC
GGATCGCACGCTCGCCGCGACGCTGCAGCAGGACATGAAAGCGGGGCGCTTCGATCCGCCATGGGTGCGCGAGCTGGCGA
GCGCGCATGGCGTGCCGGAGGACAAGGTGCGGCAACTGATGCGCAAGCTCGCGCGTCATGGCGAGACGTTTCAGGTCGTG
CATGACCTGTTCTATGATCCGGAGGCTATTCGCGAGCTGGCCTTGCTCGCCGCTGTCGACGCCAGCAAGAACGCCGGTAC
GGTCGTCGCCGGGGCATTTCGCAATGCCACCGGACTCGGACGAAAGCGTGCGGTTCAGGTCCTGGAGTTTTTTGACCGTG
TTGGCTATACGCGCTTCGACCGTGGCCGCCATCTGGTGCGCACGGACAGTCGTTGGCTGGAGTTGCTCTGA

Upstream 100 bases:

>100_bases
CAAGGATAGGGGAGACCATGCATGATCACGACGAGGATACCCCGGAGACCATCCCTGATGGTCTCCGTCACGTCAGTCTG
CCGGGCTACCTGACGCAGCC

Downstream 100 bases:

>100_bases
CAGGGAAAACCGCCTGCCGCCATTGAGATTCCTGGGAATTCTCAAGCGTTGCGGGGCTCTCCACTCCTCCCTCCTCCCCA
CACTACATCCTTATCCACAA

Product: selenocysteine-specific protein translation elongation factor

Products: NA

Alternate protein names: SelB translation factor [H]

Number of amino acids: Translated: 636; Mature: 636

Protein sequence:

>636_residues
MIVGTAGHIDHGKTCLVRALSGMDTDRLEERKARGFSIELGYAYVPLENGDVLGLVDVPGHQKLIHTMAAGACGIDFALL
VVAADDGVMPQTREHLAIVQLLGIRRGAIALTKVDRVNDVRLRQVREEIASFRRGSMLEDAPVFETCAMRADDPGVNALK
RHLHAAAAASRTKRDDGLFRLAVDRVFTLAGQGTIVTGTVVSGRIHVGDRVLLAPKNESVRVSGIHAQNRPAAAGRAGQR
CALNLAGIDKGAIERGDWVVDVRLAQASERIDVMLTLLPDAPALEHWAPMHVHLGTQHQVAHVALLDGPTLAPGQRARVQ
LVFERPVCALPGDPFVVRNAQASRTIGGGDVLDPFAPARKRRSPARLAWLDAMQAMLDTGSVGALLEQAPHGLSRALLER
LSGMPAAAIELPCDTRVIELPGNDALLVSGAAWRALTGRLTTALRQFHQRSPDVLGPEVARLRRIAAPLAQDALWCALVD
DACARGEIVRTGPWLHLPEHTVTLDDADRTLAATLQQDMKAGRFDPPWVRELASAHGVPEDKVRQLMRKLARHGETFQVV
HDLFYDPEAIRELALLAAVDASKNAGTVVAGAFRNATGLGRKRAVQVLEFFDRVGYTRFDRGRHLVRTDSRWLELL

Sequences:

>Translated_636_residues
MIVGTAGHIDHGKTCLVRALSGMDTDRLEERKARGFSIELGYAYVPLENGDVLGLVDVPGHQKLIHTMAAGACGIDFALL
VVAADDGVMPQTREHLAIVQLLGIRRGAIALTKVDRVNDVRLRQVREEIASFRRGSMLEDAPVFETCAMRADDPGVNALK
RHLHAAAAASRTKRDDGLFRLAVDRVFTLAGQGTIVTGTVVSGRIHVGDRVLLAPKNESVRVSGIHAQNRPAAAGRAGQR
CALNLAGIDKGAIERGDWVVDVRLAQASERIDVMLTLLPDAPALEHWAPMHVHLGTQHQVAHVALLDGPTLAPGQRARVQ
LVFERPVCALPGDPFVVRNAQASRTIGGGDVLDPFAPARKRRSPARLAWLDAMQAMLDTGSVGALLEQAPHGLSRALLER
LSGMPAAAIELPCDTRVIELPGNDALLVSGAAWRALTGRLTTALRQFHQRSPDVLGPEVARLRRIAAPLAQDALWCALVD
DACARGEIVRTGPWLHLPEHTVTLDDADRTLAATLQQDMKAGRFDPPWVRELASAHGVPEDKVRQLMRKLARHGETFQVV
HDLFYDPEAIRELALLAAVDASKNAGTVVAGAFRNATGLGRKRAVQVLEFFDRVGYTRFDRGRHLVRTDSRWLELL
>Mature_636_residues
MIVGTAGHIDHGKTCLVRALSGMDTDRLEERKARGFSIELGYAYVPLENGDVLGLVDVPGHQKLIHTMAAGACGIDFALL
VVAADDGVMPQTREHLAIVQLLGIRRGAIALTKVDRVNDVRLRQVREEIASFRRGSMLEDAPVFETCAMRADDPGVNALK
RHLHAAAAASRTKRDDGLFRLAVDRVFTLAGQGTIVTGTVVSGRIHVGDRVLLAPKNESVRVSGIHAQNRPAAAGRAGQR
CALNLAGIDKGAIERGDWVVDVRLAQASERIDVMLTLLPDAPALEHWAPMHVHLGTQHQVAHVALLDGPTLAPGQRARVQ
LVFERPVCALPGDPFVVRNAQASRTIGGGDVLDPFAPARKRRSPARLAWLDAMQAMLDTGSVGALLEQAPHGLSRALLER
LSGMPAAAIELPCDTRVIELPGNDALLVSGAAWRALTGRLTTALRQFHQRSPDVLGPEVARLRRIAAPLAQDALWCALVD
DACARGEIVRTGPWLHLPEHTVTLDDADRTLAATLQQDMKAGRFDPPWVRELASAHGVPEDKVRQLMRKLARHGETFQVV
HDLFYDPEAIRELALLAAVDASKNAGTVVAGAFRNATGLGRKRAVQVLEFFDRVGYTRFDRGRHLVRTDSRWLELL

Specific function: Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP [H]

COG id: COG3276

COG function: function code J; Selenocysteine-specific translation elongation factor

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. SelB subfamily [H]

Homologues:

Organism=Homo sapiens, GI34147630, Length=395, Percent_Identity=27.5949367088608, Blast_Score=130, Evalue=4e-30,
Organism=Homo sapiens, GI223555963, Length=347, Percent_Identity=27.0893371757925, Blast_Score=100, Evalue=7e-21,
Organism=Homo sapiens, GI5729864, Length=347, Percent_Identity=27.0893371757925, Blast_Score=100, Evalue=8e-21,
Organism=Homo sapiens, GI54607086, Length=295, Percent_Identity=28.8135593220339, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI4503507, Length=183, Percent_Identity=30.0546448087432, Blast_Score=91, Evalue=5e-18,
Organism=Homo sapiens, GI45593140, Length=309, Percent_Identity=23.3009708737864, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI2367247, Length=631, Percent_Identity=38.5103011093502, Blast_Score=367, Evalue=1e-102,
Organism=Escherichia coli, GI1790412, Length=383, Percent_Identity=27.154046997389, Blast_Score=112, Evalue=8e-26,
Organism=Escherichia coli, GI1789737, Length=383, Percent_Identity=27.154046997389, Blast_Score=112, Evalue=9e-26,
Organism=Escherichia coli, GI1789108, Length=248, Percent_Identity=26.6129032258064, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1789559, Length=95, Percent_Identity=41.0526315789474, Blast_Score=70, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI25141371, Length=378, Percent_Identity=26.984126984127, Blast_Score=121, Evalue=9e-28,
Organism=Caenorhabditis elegans, GI17556456, Length=404, Percent_Identity=27.4752475247525, Blast_Score=119, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI17506081, Length=256, Percent_Identity=27.34375, Blast_Score=95, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI17509919, Length=179, Percent_Identity=32.9608938547486, Blast_Score=91, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17565438, Length=379, Percent_Identity=22.1635883905013, Blast_Score=82, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17552884, Length=326, Percent_Identity=24.2331288343558, Blast_Score=77, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17569207, Length=326, Percent_Identity=24.2331288343558, Blast_Score=77, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI71994658, Length=125, Percent_Identity=34.4, Blast_Score=67, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6324761, Length=305, Percent_Identity=30.4918032786885, Blast_Score=113, Evalue=8e-26,
Organism=Saccharomyces cerevisiae, GI6325337, Length=316, Percent_Identity=22.1518987341772, Blast_Score=76, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6319594, Length=316, Percent_Identity=22.1518987341772, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI19921738, Length=381, Percent_Identity=29.6587926509186, Blast_Score=126, Evalue=4e-29,
Organism=Drosophila melanogaster, GI281363316, Length=384, Percent_Identity=26.5625, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI17864358, Length=384, Percent_Identity=26.5625, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI19922690, Length=376, Percent_Identity=28.1914893617021, Blast_Score=103, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24647046, Length=264, Percent_Identity=26.8939393939394, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24647048, Length=259, Percent_Identity=26.6409266409266, Blast_Score=94, Evalue=4e-19,
Organism=Drosophila melanogaster, GI45550900, Length=258, Percent_Identity=25.5813953488372, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI28572034, Length=133, Percent_Identity=38.3458646616541, Blast_Score=76, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015190
- InterPro:   IPR015191
- InterPro:   IPR000795
- InterPro:   IPR004161
- InterPro:   IPR009000
- InterPro:   IPR004535
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2; PF09106 SelB-wing_2; PF09107 SelB-wing_3 [H]

EC number: NA

Molecular weight: Translated: 69016; Mature: 69016

Theoretical pI: Translated: 8.60; Mature: 8.60

Prosite motif: PS00527 RIBOSOMAL_S14

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVGTAGHIDHGKTCLVRALSGMDTDRLEERKARGFSIELGYAYVPLENGDVLGLVDVPG
CEECCCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCEEEECEEEEEECCCCEEEEEECCC
HQKLIHTMAAGACGIDFALLVVAADDGVMPQTREHLAIVQLLGIRRGAIALTKVDRVNDV
HHHHHHHHHCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCHH
RLRQVREEIASFRRGSMLEDAPVFETCAMRADDPGVNALKRHLHAAAAASRTKRDDGLFR
HHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHH
LAVDRVFTLAGQGTIVTGTVVSGRIHVGDRVLLAPKNESVRVSGIHAQNRPAAAGRAGQR
HHHHHHHHCCCCCEEEEEEEEECEEEECCEEEEECCCCCEEEEEEECCCCCCCCCCCCCE
CALNLAGIDKGAIERGDWVVDVRLAQASERIDVMLTLLPDAPALEHWAPMHVHLGTQHQV
EEEEECCCCCCCCCCCCEEEEEEECCCCCCEEEEEEECCCCCCHHHCCCEEEEECCCCCE
AHVALLDGPTLAPGQRARVQLVFERPVCALPGDPFVVRNAQASRTIGGGDVLDPFAPARK
EEEEEECCCCCCCCCCCEEEEEEECCEECCCCCCEEEECCCCCCCCCCCCCCCCCCCHHH
RRSPARLAWLDAMQAMLDTGSVGALLEQAPHGLSRALLERLSGMPAAAIELPCDTRVIEL
CCCCHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHCCCCCEEEECCCCCEEEEE
PGNDALLVSGAAWRALTGRLTTALRQFHQRSPDVLGPEVARLRRIAAPLAQDALWCALVD
CCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
DACARGEIVRTGPWLHLPEHTVTLDDADRTLAATLQQDMKAGRFDPPWVRELASAHGVPE
HHHCCCCEEECCCEEECCCCEEEECCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCH
DKVRQLMRKLARHGETFQVVHDLFYDPEAIRELALLAAVDASKNAGTVVAGAFRNATGLG
HHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCEEEEECHHCCCCCC
RKRAVQVLEFFDRVGYTRFDRGRHLVRTDSRWLELL
HHHHHHHHHHHHHCCCCCHHCCCCEEECCHHHHHCC
>Mature Secondary Structure
MIVGTAGHIDHGKTCLVRALSGMDTDRLEERKARGFSIELGYAYVPLENGDVLGLVDVPG
CEECCCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCEEEECEEEEEECCCCEEEEEECCC
HQKLIHTMAAGACGIDFALLVVAADDGVMPQTREHLAIVQLLGIRRGAIALTKVDRVNDV
HHHHHHHHHCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCHH
RLRQVREEIASFRRGSMLEDAPVFETCAMRADDPGVNALKRHLHAAAAASRTKRDDGLFR
HHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHH
LAVDRVFTLAGQGTIVTGTVVSGRIHVGDRVLLAPKNESVRVSGIHAQNRPAAAGRAGQR
HHHHHHHHCCCCCEEEEEEEEECEEEECCEEEEECCCCCEEEEEEECCCCCCCCCCCCCE
CALNLAGIDKGAIERGDWVVDVRLAQASERIDVMLTLLPDAPALEHWAPMHVHLGTQHQV
EEEEECCCCCCCCCCCCEEEEEEECCCCCCEEEEEEECCCCCCHHHCCCEEEEECCCCCE
AHVALLDGPTLAPGQRARVQLVFERPVCALPGDPFVVRNAQASRTIGGGDVLDPFAPARK
EEEEEECCCCCCCCCCCEEEEEEECCEECCCCCCEEEECCCCCCCCCCCCCCCCCCCHHH
RRSPARLAWLDAMQAMLDTGSVGALLEQAPHGLSRALLERLSGMPAAAIELPCDTRVIEL
CCCCHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHCCCCCEEEECCCCCEEEEE
PGNDALLVSGAAWRALTGRLTTALRQFHQRSPDVLGPEVARLRRIAAPLAQDALWCALVD
CCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
DACARGEIVRTGPWLHLPEHTVTLDDADRTLAATLQQDMKAGRFDPPWVRELASAHGVPE
HHHCCCCEEECCCEEECCCCEEEECCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCH
DKVRQLMRKLARHGETFQVVHDLFYDPEAIRELALLAAVDASKNAGTVVAGAFRNATGLG
HHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCEEEEECHHCCCCCC
RKRAVQVLEFFDRVGYTRFDRGRHLVRTDSRWLELL
HHHHHHHHHHHHHCCCCCHHCCCCEEECCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2531290; 8041620; 9278503; 2140572 [H]