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The map label for this gene is pbuX [H]

Identifier: 116694807

GI number: 116694807

Start: 976801

End: 978150

Strand: Direct

Name: pbuX [H]

Synonym: H16_B0861

Alternate gene names: 116694807

Gene position: 976801-978150 (Clockwise)

Preceding gene: 116694802

Following gene: 116694808

Centisome position: 33.54

GC content: 68.96

Gene sequence:

>1350_bases
ATGTCCCACCCCGCCCCCGCGCCGGTGGATGAACGGCTGCCATGGCGGCGCCTGTTTGTCTTCGGGCTTCAACACGTACT
GGTCATGGCCGCGTCGCCGATCGCGTCCGTCTTCCTGATGAGCAAGGCGCTGAACTTCCCGCCCGCGCTGGCGGTGCAGC
TGCTGAGCGCCACCTTTGTGATCTGCGGCCTCGGCACGCTGTTGCAGTCGCTGGGCAAGCGCGGCATCGGTGCCCGGCTG
CCGTTCGTGATGCTGCCCGGCGGCGCCCCGATCGTGCTGTTTATCCTGATCGCGCAGCAGACCGACGTGCAGACCGCTGC
CGGCGCGGTGATCCTGACCGGCGTGTTCTACTTCTGCGTGCTGCCGGTGTTCCGGCGCTGTCTGCGCTATTTCCCGCCGG
TGGTGGTGGGGACGATGCTGCTGCTGGTGGCGATCAACCTGGCGCAGGTATCCGGCAAGCTGGTTGCCGGCCACCCGGCC
GCGGGCAGCACGGTGGACCCGCTCAACCTGCTGCTGGCGTTCGCCACCATTGCCTGCACCGTGGCGGCATCGCGCCTGCT
GTCGGGCATGCTGGCGCAGCTGGCGATCCTGCTGGGGCTGCTGGGCGGTGCGCTGGTGGCCGGGCTGGCCGGCGCGTTCC
AGCCTGGCCATGTGTCGATGTCGCCCGTGTTCGCGTTGCCCACGCCGTTCCCGTTCGGGTGGCCGCATTTCGATGTGGTG
GCGGCAATCCCGCTGATGGTGTTCGCCGTGATCTCGATGGTGGAGGCCACCGGCCAGACGCTGGCGATCAGCGATGCCGT
GGGCCGGCCGGTTGACCAGCAGCGCGACGTGCCGCGCACCATCCGCGCCGATGCGCTGACTTCGCTGCTGGGCGGGATGT
TCGGCACCTCGCTGATCATCACCAGCGGCGAGAACATCGGCATCGTGCGTGCCACCGGCGTGCGCTCGCGCTTCGTCACG
GCGATGTCGGGCGCGATCCTGGTGGTGTTCGGGCTGCTGGTGCCGGTGTCGTCGCTGATCAGCGCGATTCCCGAGGCCGT
GGTCGGCGGTACCGGGCTGGTGGTGTTCTGCATCGTCGGCACCATGGGCATCGACATGCTGCGCAAGGTGGACCTGCGCG
ACCACGCCAATATGTACGTGGTGGCCGTGGCGCTGGCCGTGGGCCTGCTGCCGATCCTGGTGCCCGGCATCTATGGCGGC
CTGCCGGCCAATGTGCGCATCCTGGTGGGCAATGGCGTGGCCATGGGGGCCATTACCGCGGCGCTGCTCAACTTCCTGTT
TTTCCATACGGGCCTGCGAGCCGCGGCAGCGGGCGCGGTTGCCCGCGACGATGCCGCCGCCACGCATTGA

Upstream 100 bases:

>100_bases
TGCGGAAATCGATAATATCTGAGGCGAATTGCGCACAGACGCAGCAAGTGGCTTGCGAGCCACCGGCACAAACGCTCACA
CACCAAACGAGGAGCAAAGC

Downstream 100 bases:

>100_bases
CCCGGCTTCCTGAATTGCAATGACTGATCGTTCTGACTCGACGCCGGCCTGGCCCGGCGATACCAACCCGGCCCTGGTGC
CGGACAGCTTCAGGCAGCCG

Product: NCS2 family nucleobase/cation symporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 449; Mature: 448

Protein sequence:

>449_residues
MSHPAPAPVDERLPWRRLFVFGLQHVLVMAASPIASVFLMSKALNFPPALAVQLLSATFVICGLGTLLQSLGKRGIGARL
PFVMLPGGAPIVLFILIAQQTDVQTAAGAVILTGVFYFCVLPVFRRCLRYFPPVVVGTMLLLVAINLAQVSGKLVAGHPA
AGSTVDPLNLLLAFATIACTVAASRLLSGMLAQLAILLGLLGGALVAGLAGAFQPGHVSMSPVFALPTPFPFGWPHFDVV
AAIPLMVFAVISMVEATGQTLAISDAVGRPVDQQRDVPRTIRADALTSLLGGMFGTSLIITSGENIGIVRATGVRSRFVT
AMSGAILVVFGLLVPVSSLISAIPEAVVGGTGLVVFCIVGTMGIDMLRKVDLRDHANMYVVAVALAVGLLPILVPGIYGG
LPANVRILVGNGVAMGAITAALLNFLFFHTGLRAAAAGAVARDDAAATH

Sequences:

>Translated_449_residues
MSHPAPAPVDERLPWRRLFVFGLQHVLVMAASPIASVFLMSKALNFPPALAVQLLSATFVICGLGTLLQSLGKRGIGARL
PFVMLPGGAPIVLFILIAQQTDVQTAAGAVILTGVFYFCVLPVFRRCLRYFPPVVVGTMLLLVAINLAQVSGKLVAGHPA
AGSTVDPLNLLLAFATIACTVAASRLLSGMLAQLAILLGLLGGALVAGLAGAFQPGHVSMSPVFALPTPFPFGWPHFDVV
AAIPLMVFAVISMVEATGQTLAISDAVGRPVDQQRDVPRTIRADALTSLLGGMFGTSLIITSGENIGIVRATGVRSRFVT
AMSGAILVVFGLLVPVSSLISAIPEAVVGGTGLVVFCIVGTMGIDMLRKVDLRDHANMYVVAVALAVGLLPILVPGIYGG
LPANVRILVGNGVAMGAITAALLNFLFFHTGLRAAAAGAVARDDAAATH
>Mature_448_residues
SHPAPAPVDERLPWRRLFVFGLQHVLVMAASPIASVFLMSKALNFPPALAVQLLSATFVICGLGTLLQSLGKRGIGARLP
FVMLPGGAPIVLFILIAQQTDVQTAAGAVILTGVFYFCVLPVFRRCLRYFPPVVVGTMLLLVAINLAQVSGKLVAGHPAA
GSTVDPLNLLLAFATIACTVAASRLLSGMLAQLAILLGLLGGALVAGLAGAFQPGHVSMSPVFALPTPFPFGWPHFDVVA
AIPLMVFAVISMVEATGQTLAISDAVGRPVDQQRDVPRTIRADALTSLLGGMFGTSLIITSGENIGIVRATGVRSRFVTA
MSGAILVVFGLLVPVSSLISAIPEAVVGGTGLVVFCIVGTMGIDMLRKVDLRDHANMYVVAVALAVGLLPILVPGIYGGL
PANVRILVGNGVAMGAITAALLNFLFFHTGLRAAAAGAVARDDAAATH

Specific function: Transport of xanthine in the cell [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680148, Length=447, Percent_Identity=23.7136465324385, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI40316845, Length=447, Percent_Identity=23.7136465324385, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI44680145, Length=173, Percent_Identity=24.8554913294798, Blast_Score=65, Evalue=9e-11,
Organism=Homo sapiens, GI44680143, Length=173, Percent_Identity=24.8554913294798, Blast_Score=65, Evalue=1e-10,
Organism=Escherichia coli, GI87082181, Length=424, Percent_Identity=31.1320754716981, Blast_Score=195, Evalue=5e-51,
Organism=Escherichia coli, GI1788843, Length=398, Percent_Identity=26.1306532663317, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI87081818, Length=401, Percent_Identity=28.927680798005, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI1790087, Length=440, Percent_Identity=27.5, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI87082178, Length=444, Percent_Identity=24.7747747747748, Blast_Score=88, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17558856, Length=188, Percent_Identity=27.6595744680851, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17542262, Length=174, Percent_Identity=25.8620689655172, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI21356175, Length=447, Percent_Identity=22.1476510067114, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017588
- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 46356; Mature: 46225

Theoretical pI: Translated: 9.95; Mature: 9.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHPAPAPVDERLPWRRLFVFGLQHVLVMAASPIASVFLMSKALNFPPALAVQLLSATFV
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
ICGLGTLLQSLGKRGIGARLPFVMLPGGAPIVLFILIAQQTDVQTAAGAVILTGVFYFCV
HHHHHHHHHHHCCCCCCCCCCEEEECCCCCEEHHHHHHCCCCHHHHHHHHHHHHHHHHHH
LPVFRRCLRYFPPVVVGTMLLLVAINLAQVSGKLVAGHPAAGSTVDPLNLLLAFATIACT
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCHHHHHHHHHHHHHH
VAASRLLSGMLAQLAILLGLLGGALVAGLAGAFQPGHVSMSPVFALPTPFPFGWPHFDVV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCCCHHHHH
AAIPLMVFAVISMVEATGQTLAISDAVGRPVDQQRDVPRTIRADALTSLLGGMFGTSLII
HHHHHHHHHHHHHHHHCCCEEEEEHHHCCCCCHHCCCCHHHHHHHHHHHHHHHHHCEEEE
TSGENIGIVRATGVRSRFVTAMSGAILVVFGLLVPVSSLISAIPEAVVGGTGLVVFCIVG
ECCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
TMGIDMLRKVDLRDHANMYVVAVALAVGLLPILVPGIYGGLPANVRILVGNGVAMGAITA
HHHHHHHHHHCHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHH
ALLNFLFFHTGLRAAAAGAVARDDAAATH
HHHHHHHHHHHHHHHHHCCHHCCCCCCCC
>Mature Secondary Structure 
SHPAPAPVDERLPWRRLFVFGLQHVLVMAASPIASVFLMSKALNFPPALAVQLLSATFV
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
ICGLGTLLQSLGKRGIGARLPFVMLPGGAPIVLFILIAQQTDVQTAAGAVILTGVFYFCV
HHHHHHHHHHHCCCCCCCCCCEEEECCCCCEEHHHHHHCCCCHHHHHHHHHHHHHHHHHH
LPVFRRCLRYFPPVVVGTMLLLVAINLAQVSGKLVAGHPAAGSTVDPLNLLLAFATIACT
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCHHHHHHHHHHHHHH
VAASRLLSGMLAQLAILLGLLGGALVAGLAGAFQPGHVSMSPVFALPTPFPFGWPHFDVV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCCCHHHHH
AAIPLMVFAVISMVEATGQTLAISDAVGRPVDQQRDVPRTIRADALTSLLGGMFGTSLII
HHHHHHHHHHHHHHHHCCCEEEEEHHHCCCCCHHCCCCHHHHHHHHHHHHHHHHHCEEEE
TSGENIGIVRATGVRSRFVTAMSGAILVVFGLLVPVSSLISAIPEAVVGGTGLVVFCIVG
ECCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
TMGIDMLRKVDLRDHANMYVVAVALAVGLLPILVPGIYGGLPANVRILVGNGVAMGAITA
HHHHHHHHHHCHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHH
ALLNFLFFHTGLRAAAAGAVARDDAAATH
HHHHHHHHHHHHHHHHHCCHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9098051; 9384377 [H]