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The map label for this gene is kbl [C]

Identifier: 116694765

GI number: 116694765

Start: 926237

End: 927436

Strand: Direct

Name: kbl [C]

Synonym: H16_B0819

Alternate gene names: 116694765

Gene position: 926237-927436 (Clockwise)

Preceding gene: 116694763

Following gene: 116694766

Centisome position: 31.8

GC content: 66.75

Gene sequence:

>1200_bases
ATGTCGAATGCCGAGGCATTCTATGCATCCATCCGTACCGAACTCGAAAGCATCCGCGCGGCGGGGCTGTTCAAGAACGA
GCGCGTGATCGCCACGCCGCAGGGTGCGCGGGTGCGCACCACCGACGGCCGCGAGGTCATCAACCTGTGCGCCAACAACT
ACCTTGGCTTGTCGTCGCACCCGCAGGTGATCGAGGCCGCGCATGAAGCGCTGCGCACGCATGGCTTCGGGCTGAGCTCG
GTGCGCTTTATCTGCGGCACGCAAGACCTGCACAAGACGCTGGAGGCGCGGCTGTCGGCCTTCCTCGGCACCGAGGACAC
CATCCTCTATGGCTCGGCCTTCGATGCCAATGGCGGTTTGTTCGAAACGCTGCTGGGCGCGGAAGACGCGGTCATCAGCG
ATGCGCTCAACCATGCCTCGATCATCGACGGCGTCCGCCTGTCCAAGGCGCGCCGCTACCGCTACCAGCACAACGACATG
GACGACCTGCGCGTGCAACTGGAGCAGGCGCGGGCCGACGGCGCGCGCTACACGCTGGTGTTTTCCGACGGCGTGTTCTC
GATGGACGGCACCGTGGCGCGGCTCGACGAGATGCGCGCGATCTGCGACGAGTACGGCGCGCTGCTGGGCATAGATGAAT
GCCATGCCACCGGTTTCATGGGCCAGCGCGGGCGCGGCACGCATGAGGCGCGCGGCGTGTTCGGCAAGATCGACATCATT
ACCGGCACGCTGGGCAAGGCGCTGGGTGGCGCCTCCGGCGGCTTCACCAGCGCGCGCAAGGAAGTGGTGGCACTGCTGCG
CCAGCGTTCGCGGCCGTATTTGTTCTCCAACACCGTGGCGCCGGCCATCGTGGGCGCGTCGATCGCGGTGCTCGATATCC
TGGAAGCCAGCACCGAGCTGCGCGACCGGCTGGAGGGCAATACCAGGTTCTTCCGCGCGGGACTGGACCGGTTGGGCTTC
GACGTCAAGGCGGGCGACCACCCGATCATCCCGATCATGGTCTACGACGCCGACAAGGCGCAGCAACTGGCGCAGCGCCT
GCTGGAGCTGGGCGTGTACGTGGTCGGCTTCTTCTACCCGGTGGTACCCAAGGGCCAGGCGCGCATCCGCGTGCAGATGA
GCGCGCTGCATGACGAGGCCGCGCTGCAGGCGGCGCTGGATGCCTTCGGCCAGGCTGGCCGTGAACTGGGGCTGATCTGA

Upstream 100 bases:

>100_bases
TAATGTTCGTTATATTGCGCAAAATGTTCGATATACAGAACGTGTTCGATTTATCGATCGAATCCTAGCATATCCCTCGC
ACACCAACGGGAGCCAAGCC

Downstream 100 bases:

>100_bases
TGGAAGCTGGCAAACCGAAGATCCTGATTGTCGGCGCCAACGGCCAGATCGGGTCTGAACTGGCACTGGCGCTGGCCGAG
CGCTACGGGCGCACCAACGT

Product: 2-amino-3-ketobutyrate coenzyme A ligase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 399; Mature: 398

Protein sequence:

>399_residues
MSNAEAFYASIRTELESIRAAGLFKNERVIATPQGARVRTTDGREVINLCANNYLGLSSHPQVIEAAHEALRTHGFGLSS
VRFICGTQDLHKTLEARLSAFLGTEDTILYGSAFDANGGLFETLLGAEDAVISDALNHASIIDGVRLSKARRYRYQHNDM
DDLRVQLEQARADGARYTLVFSDGVFSMDGTVARLDEMRAICDEYGALLGIDECHATGFMGQRGRGTHEARGVFGKIDII
TGTLGKALGGASGGFTSARKEVVALLRQRSRPYLFSNTVAPAIVGASIAVLDILEASTELRDRLEGNTRFFRAGLDRLGF
DVKAGDHPIIPIMVYDADKAQQLAQRLLELGVYVVGFFYPVVPKGQARIRVQMSALHDEAALQAALDAFGQAGRELGLI

Sequences:

>Translated_399_residues
MSNAEAFYASIRTELESIRAAGLFKNERVIATPQGARVRTTDGREVINLCANNYLGLSSHPQVIEAAHEALRTHGFGLSS
VRFICGTQDLHKTLEARLSAFLGTEDTILYGSAFDANGGLFETLLGAEDAVISDALNHASIIDGVRLSKARRYRYQHNDM
DDLRVQLEQARADGARYTLVFSDGVFSMDGTVARLDEMRAICDEYGALLGIDECHATGFMGQRGRGTHEARGVFGKIDII
TGTLGKALGGASGGFTSARKEVVALLRQRSRPYLFSNTVAPAIVGASIAVLDILEASTELRDRLEGNTRFFRAGLDRLGF
DVKAGDHPIIPIMVYDADKAQQLAQRLLELGVYVVGFFYPVVPKGQARIRVQMSALHDEAALQAALDAFGQAGRELGLI
>Mature_398_residues
SNAEAFYASIRTELESIRAAGLFKNERVIATPQGARVRTTDGREVINLCANNYLGLSSHPQVIEAAHEALRTHGFGLSSV
RFICGTQDLHKTLEARLSAFLGTEDTILYGSAFDANGGLFETLLGAEDAVISDALNHASIIDGVRLSKARRYRYQHNDMD
DLRVQLEQARADGARYTLVFSDGVFSMDGTVARLDEMRAICDEYGALLGIDECHATGFMGQRGRGTHEARGVFGKIDIIT
GTLGKALGGASGGFTSARKEVVALLRQRSRPYLFSNTVAPAIVGASIAVLDILEASTELRDRLEGNTRFFRAGLDRLGFD
VKAGDHPIIPIMVYDADKAQQLAQRLLELGVYVVGFFYPVVPKGQARIRVQMSALHDEAALQAALDAFGQAGRELGLI

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=383, Percent_Identity=54.0469973890339, Blast_Score=417, Evalue=1e-116,
Organism=Homo sapiens, GI284448556, Length=409, Percent_Identity=50.6112469437653, Blast_Score=407, Evalue=1e-113,
Organism=Homo sapiens, GI83977440, Length=362, Percent_Identity=34.8066298342541, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI83977442, Length=362, Percent_Identity=34.8066298342541, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI83977444, Length=362, Percent_Identity=34.8066298342541, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI4758668, Length=371, Percent_Identity=33.6927223719677, Blast_Score=189, Evalue=3e-48,
Organism=Homo sapiens, GI4502025, Length=362, Percent_Identity=33.1491712707182, Blast_Score=189, Evalue=4e-48,
Organism=Homo sapiens, GI40316939, Length=362, Percent_Identity=33.1491712707182, Blast_Score=189, Evalue=4e-48,
Organism=Homo sapiens, GI119220554, Length=373, Percent_Identity=32.9758713136729, Blast_Score=186, Evalue=4e-47,
Organism=Homo sapiens, GI5454084, Length=281, Percent_Identity=30.6049822064057, Blast_Score=114, Evalue=2e-25,
Organism=Escherichia coli, GI1790046, Length=393, Percent_Identity=61.323155216285, Blast_Score=502, Evalue=1e-143,
Organism=Escherichia coli, GI1786993, Length=349, Percent_Identity=33.2378223495702, Blast_Score=176, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI71994529, Length=396, Percent_Identity=54.2929292929293, Blast_Score=437, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI32566772, Length=369, Percent_Identity=32.520325203252, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17560914, Length=366, Percent_Identity=30.6010928961749, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17560912, Length=366, Percent_Identity=30.6010928961749, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI71982617, Length=267, Percent_Identity=25.8426966292135, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71982625, Length=267, Percent_Identity=25.8426966292135, Blast_Score=93, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6320438, Length=392, Percent_Identity=29.5918367346939, Blast_Score=183, Evalue=4e-47,
Organism=Saccharomyces cerevisiae, GI6320267, Length=369, Percent_Identity=32.2493224932249, Blast_Score=177, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6323954, Length=273, Percent_Identity=28.9377289377289, Blast_Score=114, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24662918, Length=389, Percent_Identity=52.6992287917738, Blast_Score=429, Evalue=1e-120,
Organism=Drosophila melanogaster, GI17137420, Length=341, Percent_Identity=34.8973607038123, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI17136286, Length=371, Percent_Identity=33.4231805929919, Blast_Score=185, Evalue=4e-47,
Organism=Drosophila melanogaster, GI24653280, Length=389, Percent_Identity=26.2210796915167, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24653276, Length=389, Percent_Identity=26.2210796915167, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24653278, Length=389, Percent_Identity=26.2210796915167, Blast_Score=115, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011282
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 43269; Mature: 43137

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNAEAFYASIRTELESIRAAGLFKNERVIATPQGARVRTTDGREVINLCANNYLGLSSH
CCCHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCEEEECCHHHHHHHHHCCCCCCCCC
PQVIEAAHEALRTHGFGLSSVRFICGTQDLHKTLEARLSAFLGTEDTILYGSAFDANGGL
HHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCH
FETLLGAEDAVISDALNHASIIDGVRLSKARRYRYQHNDMDDLRVQLEQARADGARYTLV
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEE
FSDGVFSMDGTVARLDEMRAICDEYGALLGIDECHATGFMGQRGRGTHEARGVFGKIDII
EECCEEECCCHHHHHHHHHHHHHHHHCEECCHHHHHCCCCCCCCCCCHHHCCCEEEEEEE
TGTLGKALGGASGGFTSARKEVVALLRQRSRPYLFSNTVAPAIVGASIAVLDILEASTEL
ECHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHH
RDRLEGNTRFFRAGLDRLGFDVKAGDHPIIPIMVYDADKAQQLAQRLLELGVYVVGFFYP
HHHHCCCHHHHHHHHHHHCCEEECCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHH
VVPKGQARIRVQMSALHDEAALQAALDAFGQAGRELGLI
CCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCHHCCCC
>Mature Secondary Structure 
SNAEAFYASIRTELESIRAAGLFKNERVIATPQGARVRTTDGREVINLCANNYLGLSSH
CCHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCEEEECCHHHHHHHHHCCCCCCCCC
PQVIEAAHEALRTHGFGLSSVRFICGTQDLHKTLEARLSAFLGTEDTILYGSAFDANGGL
HHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCH
FETLLGAEDAVISDALNHASIIDGVRLSKARRYRYQHNDMDDLRVQLEQARADGARYTLV
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEE
FSDGVFSMDGTVARLDEMRAICDEYGALLGIDECHATGFMGQRGRGTHEARGVFGKIDII
EECCEEECCCHHHHHHHHHHHHHHHHCEECCHHHHHCCCCCCCCCCCHHHCCCEEEEEEE
TGTLGKALGGASGGFTSARKEVVALLRQRSRPYLFSNTVAPAIVGASIAVLDILEASTEL
ECHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHH
RDRLEGNTRFFRAGLDRLGFDVKAGDHPIIPIMVYDADKAQQLAQRLLELGVYVVGFFYP
HHHHCCCHHHHHHHHHHHCCEEECCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHH
VVPKGQARIRVQMSALHDEAALQAALDAFGQAGRELGLI
CCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]