| Definition | Ralstonia eutropha H16 chromosome 2, complete sequence. |
|---|---|
| Accession | NC_008314 |
| Length | 2,912,490 |
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The map label for this gene is fabG [C]
Identifier: 116694638
GI number: 116694638
Start: 766618
End: 767532
Strand: Direct
Name: fabG [C]
Synonym: H16_B0687
Alternate gene names: 116694638
Gene position: 766618-767532 (Clockwise)
Preceding gene: 116694636
Following gene: 116694639
Centisome position: 26.32
GC content: 66.45
Gene sequence:
>915_bases ATGAGCGGTTTGATGGCAGGCAAGGTCGCGCTGGTGACGGGCGCAGGTGGTGGAATCGGGCGCGGCATCGCGCTGGCACT GGCCGCCGCCGGCGCCAAGGTGGTGGTCAACGACCTCGGCGTGTCGATGACCGGCGAGGGCGGCGACGCCGGCCCCGCTC AGCGCGTGGTGGAGGAAATCCGCGCCGCCGGCGGCGAGGCCGTGGCCAATACCGACAGCGTGTCGACCTGGAACGGCGCC AATGCCATCGTGCAATGCGCGCTGGACAACTTCGGCCGCATCGACGCCGTGGTCAACAACGCCGGCAACCTGCGCGACCG CATGTTCTTCAAGATGAATGAAGAAGAATGGCGCTCGGTGATCGACGTGCACCTGCACGGCACCTTCTTCGTCAGCCGCG CCGCGGCCAGCTACTTCAAGGACCAGGAGAGCGGCGCCTACGTGCACATGACCTCGACCTCGGGCCTGATCGGCAACCTG GGCCAGGCCAACTACTCGGCGGCCAAGCTGGGCATTGCCGCGCTGTCCAAGTCGATCGCGCTGGACATGCAGCGCTTCAA TGTGCGCTCGAACTGCATCGCGCCGTTCGCCTGGAGCCGCATGACCAGCTCGATCCCGGCCGAAACGCCGGAAGAGAAAG CGCGCGTGGCCAAGCTGCAGAAGATGGAAGCCGGCAAGATCGCGCCGGTGGCGGTCTACCTTGCCAGCCCGGCCGCCAGC GAAGTCAACGGCCAGATCTTCGCGGTGCGTGCCAACGAGATCATCCTGATGAGCCAGCCGCGCCCGGTGCGCTCGGTGCA CATGAGCGATGGCTGGACGCCTGAAACCGTGGGCGAGATCGCCATGCCGGCGATGCGCAACAGCTTCTTCAAGCTGGAGC GTTCGCCCGATGTGATCAGCTGGGACCCGATCTGA
Upstream 100 bases:
>100_bases CCGGATTGACCGCACCGGCGGGCGAATGCCCGCGGCGCAGGGGTGTTTCGCCGGGTTTGCGGTCGGTGACCGCACAAAAA GTATTCAGAGGAGCAACGCA
Downstream 100 bases:
>100_bases TGGCGGGCAGCCAGGCCGCGGCGCACGGCGCGCTTGCCGGCGTGCGGGTGCTGGACCTGTCGCGCATCCTGGCCGGTCCC TGGTGCGCGCAGAACCTGGC
Product: Short-chain dehydrogenase
Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]
Alternate protein names: NA
Number of amino acids: Translated: 304; Mature: 303
Protein sequence:
>304_residues MSGLMAGKVALVTGAGGGIGRGIALALAAAGAKVVVNDLGVSMTGEGGDAGPAQRVVEEIRAAGGEAVANTDSVSTWNGA NAIVQCALDNFGRIDAVVNNAGNLRDRMFFKMNEEEWRSVIDVHLHGTFFVSRAAASYFKDQESGAYVHMTSTSGLIGNL GQANYSAAKLGIAALSKSIALDMQRFNVRSNCIAPFAWSRMTSSIPAETPEEKARVAKLQKMEAGKIAPVAVYLASPAAS EVNGQIFAVRANEIILMSQPRPVRSVHMSDGWTPETVGEIAMPAMRNSFFKLERSPDVISWDPI
Sequences:
>Translated_304_residues MSGLMAGKVALVTGAGGGIGRGIALALAAAGAKVVVNDLGVSMTGEGGDAGPAQRVVEEIRAAGGEAVANTDSVSTWNGA NAIVQCALDNFGRIDAVVNNAGNLRDRMFFKMNEEEWRSVIDVHLHGTFFVSRAAASYFKDQESGAYVHMTSTSGLIGNL GQANYSAAKLGIAALSKSIALDMQRFNVRSNCIAPFAWSRMTSSIPAETPEEKARVAKLQKMEAGKIAPVAVYLASPAAS EVNGQIFAVRANEIILMSQPRPVRSVHMSDGWTPETVGEIAMPAMRNSFFKLERSPDVISWDPI >Mature_303_residues SGLMAGKVALVTGAGGGIGRGIALALAAAGAKVVVNDLGVSMTGEGGDAGPAQRVVEEIRAAGGEAVANTDSVSTWNGAN AIVQCALDNFGRIDAVVNNAGNLRDRMFFKMNEEEWRSVIDVHLHGTFFVSRAAASYFKDQESGAYVHMTSTSGLIGNLG QANYSAAKLGIAALSKSIALDMQRFNVRSNCIAPFAWSRMTSSIPAETPEEKARVAKLQKMEAGKIAPVAVYLASPAASE VNGQIFAVRANEIILMSQPRPVRSVHMSDGWTPETVGEIAMPAMRNSFFKLERSPDVISWDPI
Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]
COG id: COG1028
COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI4504505, Length=273, Percent_Identity=45.0549450549451, Blast_Score=203, Evalue=2e-52, Organism=Homo sapiens, GI15277342, Length=247, Percent_Identity=31.1740890688259, Blast_Score=107, Evalue=9e-24, Organism=Homo sapiens, GI19923817, Length=307, Percent_Identity=26.0586319218241, Blast_Score=89, Evalue=7e-18, Organism=Homo sapiens, GI40254992, Length=244, Percent_Identity=27.4590163934426, Blast_Score=81, Evalue=1e-15, Organism=Homo sapiens, GI32483357, Length=260, Percent_Identity=27.3076923076923, Blast_Score=77, Evalue=2e-14, Organism=Homo sapiens, GI10190704, Length=255, Percent_Identity=28.6274509803922, Blast_Score=75, Evalue=6e-14, Organism=Homo sapiens, GI59889578, Length=174, Percent_Identity=28.1609195402299, Blast_Score=75, Evalue=7e-14, Organism=Homo sapiens, GI31542939, Length=208, Percent_Identity=31.25, Blast_Score=74, Evalue=2e-13, Organism=Homo sapiens, GI4758504, Length=215, Percent_Identity=30.2325581395349, Blast_Score=74, Evalue=2e-13, Organism=Homo sapiens, GI209862901, Length=266, Percent_Identity=26.3157894736842, Blast_Score=67, Evalue=2e-11, Organism=Homo sapiens, GI19923983, Length=266, Percent_Identity=26.3157894736842, Blast_Score=67, Evalue=2e-11, Organism=Homo sapiens, GI40807363, Length=242, Percent_Identity=24.7933884297521, Blast_Score=65, Evalue=5e-11, Organism=Homo sapiens, GI83715985, Length=191, Percent_Identity=30.8900523560209, Blast_Score=65, Evalue=6e-11, Organism=Homo sapiens, GI224922801, Length=183, Percent_Identity=30.6010928961749, Blast_Score=65, Evalue=8e-11, Organism=Escherichia coli, GI1787335, Length=251, Percent_Identity=34.6613545816733, Blast_Score=117, Evalue=1e-27, Organism=Escherichia coli, GI1789208, Length=254, Percent_Identity=29.9212598425197, Blast_Score=106, Evalue=2e-24, Organism=Escherichia coli, GI1787905, Length=248, Percent_Identity=31.4516129032258, Blast_Score=105, Evalue=4e-24, Organism=Escherichia coli, GI1790717, Length=253, Percent_Identity=29.6442687747036, Blast_Score=103, Evalue=2e-23, Organism=Escherichia coli, GI87082160, Length=257, Percent_Identity=28.0155642023346, Blast_Score=100, Evalue=1e-22, Organism=Escherichia coli, GI87082100, Length=253, Percent_Identity=28.4584980237154, Blast_Score=94, Evalue=1e-20, Organism=Escherichia coli, GI1788459, Length=260, Percent_Identity=28.0769230769231, Blast_Score=82, Evalue=4e-17, Organism=Escherichia coli, GI1786812, Length=257, Percent_Identity=26.8482490272374, Blast_Score=73, Evalue=3e-14, Organism=Escherichia coli, GI2367175, Length=245, Percent_Identity=30.6122448979592, Blast_Score=73, Evalue=3e-14, Organism=Escherichia coli, GI1787526, Length=258, Percent_Identity=25.1937984496124, Blast_Score=70, Evalue=1e-13, Organism=Escherichia coli, GI1789057, Length=267, Percent_Identity=25.4681647940075, Blast_Score=65, Evalue=4e-12, Organism=Escherichia coli, GI1789378, Length=266, Percent_Identity=25.9398496240602, Blast_Score=62, Evalue=4e-11, Organism=Caenorhabditis elegans, GI17568967, Length=247, Percent_Identity=42.5101214574899, Blast_Score=191, Evalue=4e-49, Organism=Caenorhabditis elegans, GI25147288, Length=258, Percent_Identity=35.2713178294574, Blast_Score=119, Evalue=2e-27, Organism=Caenorhabditis elegans, GI17555706, Length=257, Percent_Identity=30.3501945525292, Blast_Score=99, Evalue=2e-21, Organism=Caenorhabditis elegans, GI17560676, Length=255, Percent_Identity=28.6274509803922, Blast_Score=87, Evalue=1e-17, Organism=Caenorhabditis elegans, GI17564282, Length=219, Percent_Identity=26.027397260274, Blast_Score=82, Evalue=3e-16, Organism=Caenorhabditis elegans, GI17538182, Length=213, Percent_Identity=33.3333333333333, Blast_Score=76, Evalue=2e-14, Organism=Caenorhabditis elegans, GI193203117, Length=193, Percent_Identity=25.3886010362694, Blast_Score=73, Evalue=2e-13, Organism=Caenorhabditis elegans, GI193203115, Length=191, Percent_Identity=25.6544502617801, Blast_Score=72, Evalue=3e-13, Organism=Caenorhabditis elegans, GI17561402, Length=252, Percent_Identity=24.6031746031746, Blast_Score=70, Evalue=1e-12, Organism=Caenorhabditis elegans, GI71994600, Length=265, Percent_Identity=25.6603773584906, Blast_Score=70, Evalue=1e-12, Organism=Caenorhabditis elegans, GI17544670, Length=289, Percent_Identity=24.5674740484429, Blast_Score=70, Evalue=2e-12, Organism=Caenorhabditis elegans, GI71997099, Length=204, Percent_Identity=28.921568627451, Blast_Score=69, Evalue=3e-12, Organism=Caenorhabditis elegans, GI17562906, Length=204, Percent_Identity=27.9411764705882, Blast_Score=69, Evalue=4e-12, Organism=Caenorhabditis elegans, GI17559104, Length=199, Percent_Identity=28.643216080402, Blast_Score=68, Evalue=6e-12, Organism=Caenorhabditis elegans, GI17508895, Length=193, Percent_Identity=26.4248704663212, Blast_Score=67, Evalue=8e-12, Organism=Caenorhabditis elegans, GI17531453, Length=200, Percent_Identity=27.5, Blast_Score=67, Evalue=1e-11, Organism=Caenorhabditis elegans, GI72000259, Length=211, Percent_Identity=30.3317535545024, Blast_Score=65, Evalue=5e-11, Organism=Caenorhabditis elegans, GI17562908, Length=199, Percent_Identity=25.1256281407035, Blast_Score=65, Evalue=5e-11, Organism=Caenorhabditis elegans, GI17555612, Length=203, Percent_Identity=29.064039408867, Blast_Score=64, Evalue=9e-11, Organism=Caenorhabditis elegans, GI71994604, Length=266, Percent_Identity=25.187969924812, Blast_Score=64, Evalue=1e-10, Organism=Saccharomyces cerevisiae, GI6322861, Length=273, Percent_Identity=42.4908424908425, Blast_Score=197, Evalue=1e-51, Organism=Saccharomyces cerevisiae, GI6324126, Length=251, Percent_Identity=31.8725099601594, Blast_Score=87, Evalue=4e-18, Organism=Drosophila melanogaster, GI18859837, Length=282, Percent_Identity=41.8439716312057, Blast_Score=189, Evalue=3e-48, Organism=Drosophila melanogaster, GI24639444, Length=248, Percent_Identity=36.2903225806452, Blast_Score=125, Evalue=3e-29, Organism=Drosophila melanogaster, GI17737361, Length=225, Percent_Identity=30.2222222222222, Blast_Score=86, Evalue=3e-17, Organism=Drosophila melanogaster, GI23397609, Length=256, Percent_Identity=27.734375, Blast_Score=79, Evalue=3e-15, Organism=Drosophila melanogaster, GI281364892, Length=213, Percent_Identity=26.2910798122066, Blast_Score=75, Evalue=7e-14, Organism=Drosophila melanogaster, GI24649181, Length=184, Percent_Identity=28.2608695652174, Blast_Score=69, Evalue=3e-12, Organism=Drosophila melanogaster, GI24640492, Length=222, Percent_Identity=23.4234234234234, Blast_Score=69, Evalue=3e-12, Organism=Drosophila melanogaster, GI21355319, Length=248, Percent_Identity=26.6129032258064, Blast_Score=68, Evalue=9e-12, Organism=Drosophila melanogaster, GI24644339, Length=192, Percent_Identity=26.0416666666667, Blast_Score=66, Evalue=3e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: 1.1.1.100 [C]
Molecular weight: Translated: 32118; Mature: 31987
Theoretical pI: Translated: 6.95; Mature: 6.95
Prosite motif: PS00061 ADH_SHORT
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.7 %Cys (Translated Protein) 4.3 %Met (Translated Protein) 4.9 %Cys+Met (Translated Protein) 0.7 %Cys (Mature Protein) 4.0 %Met (Mature Protein) 4.6 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MSGLMAGKVALVTGAGGGIGRGIALALAAAGAKVVVNDLGVSMTGEGGDAGPAQRVVEEI CCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEECCEEEECCCCCCCHHHHHHHHH RAAGGEAVANTDSVSTWNGANAIVQCALDNFGRIDAVVNNAGNLRDRMFFKMNEEEWRSV HHCCCCEECCCCCCCCCCCCHHHEEEHHHCCCCCHHHHCCCCCCCHHEEEEECHHHHHCE IDVHLHGTFFVSRAAASYFKDQESGAYVHMTSTSGLIGNLGQANYSAAKLGIAALSKSIA EEEEECHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHH LDMQRFNVRSNCIAPFAWSRMTSSIPAETPEEKARVAKLQKMEAGKIAPVAVYLASPAAS HHHHHHCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCC EVNGQIFAVRANEIILMSQPRPVRSVHMSDGWTPETVGEIAMPAMRNSFFKLERSPDVIS CCCCEEEEEECCEEEEEECCCCCEEEECCCCCCHHHHHHHHHHHHHCCCEEECCCCCEEE WDPI CCCC >Mature Secondary Structure SGLMAGKVALVTGAGGGIGRGIALALAAAGAKVVVNDLGVSMTGEGGDAGPAQRVVEEI CCCCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEECCEEEECCCCCCCHHHHHHHHH RAAGGEAVANTDSVSTWNGANAIVQCALDNFGRIDAVVNNAGNLRDRMFFKMNEEEWRSV HHCCCCEECCCCCCCCCCCCHHHEEEHHHCCCCCHHHHCCCCCCCHHEEEEECHHHHHCE IDVHLHGTFFVSRAAASYFKDQESGAYVHMTSTSGLIGNLGQANYSAAKLGIAALSKSIA EEEEECHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHH LDMQRFNVRSNCIAPFAWSRMTSSIPAETPEEKARVAKLQKMEAGKIAPVAVYLASPAAS HHHHHHCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCC EVNGQIFAVRANEIILMSQPRPVRSVHMSDGWTPETVGEIAMPAMRNSFFKLERSPDVIS CCCCEEEEEECCEEEEEECCCCCEEEECCCCCCHHHHHHHHHHHHHCCCEEECCCCCEEE WDPI CCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NADPH [C]
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]
Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]
General reaction: Redox reaction [C]
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 9634230 [H]