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The map label for this gene is thlA [H]

Identifier: 116694334

GI number: 116694334

Start: 432791

End: 433969

Strand: Direct

Name: thlA [H]

Synonym: H16_B0381

Alternate gene names: 116694334

Gene position: 432791-433969 (Clockwise)

Preceding gene: 116694333

Following gene: 116694335

Centisome position: 14.86

GC content: 70.91

Gene sequence:

>1179_bases
ATGCTGAACAACAAGGAATCCATCGTCATCGTCGGCGCGAAGCGCACGCCGATCGGCGCGTTCAATGGCTCGCTGTCGGC
GTTCAAGGCGCCGGAGCTTGGTGCCGTGGCCATCCGTGCCGCCGTCGCGCAGGCGGGGGTCGATCCGGCTTCGGTCGACG
AAGCCATCATGGGCCTGTGCCTGTTTGCCAACGTCGGCCAGGCACCGGCGCGGCAGGCGGTGCTCGGCGCCGGGCTGCCC
ACCTCTACGCCGGCCACCACTATCAGCAAGATGTGCGGCTCGGCCATGAAGTCCGTGATGCTCGCGCATGACCTGCTGCT
TGCCGGCACCTGCAACGTGGCGGTGGCGGGCGGCATGGAGTCGATGACCAACGCGCCGTACATCGTCCCGCGCGGCCGAT
ACGGCTACCGCCTTGGGCACGGCCAGTTCCTCGACCACATGTACTGCGACGGGCTGGAGGACGCCTACGAAGGCCACCTG
ATGGGCTACTACGCAGACCTCGCCGCCGAGGCGCGCGGCATGGGCCGCGAGGCACAGGATGCGTACGCCCGCGAGAGCCT
GCTGCGCGCGCAGGCGGCGGTCGCCGAAGGGCGCTTCCGCGACGAGATTGCGCCCGTCACGCTCAAGCGCGGCGGCGAGT
TTGCCGAGGACGAGACGCCGGGCCAGTGCGACGCCGCCAGGCTGCCGAAACTGAAGGCCGTGTTCCGCGACGGCGGCTCG
GTGACTGCCGGCAATGCCTCGTCGATCTCCGACGGTGCCGCCGCGCTGGTGCTGATGCGCGAGCGCGATGCCATCCGCGA
GGGCCTTGCGCCGCTGGCCCGCATCGTCGCCCACGCCACCCACGCCAACCCGCCGCAGCAGTTCGCCGACGCGCCGGTGC
TCGCCGCGCGCCGCGTGCTCGACAAGGCGGGCTGGACCGCGCGCGACGTCGATCTCTATGAAGTCAACGAGGCGTTTGCC
GTGGTGACGATGATCGCGCTGGACGAGCTTGGCATCGGCCACGACCGCCTCAACGTCAACGGCGGCGCCTGCGCGCTCGG
TCATCCGGTCGGGGCGACCGGGGCCCGCCTGCTGGTGACGCTGGTCCACGCGCTGCAGCAGCGCGGCCTGAAGCGCGGGC
TCGCCAGCCTGTGCCTGGGCGGTGGCGAAGCCACGGCCATCGGCCTCGAACTGTGCTGA

Upstream 100 bases:

>100_bases
AAGCTGATCGGTGACGCGCTGTTCGCGCAGAGCGGCGCGTCGAGCCAGGTGATTCTCGACTTCGCGCGCACCCAGCTCGC
ATTCCACGCCTGAGGCCACC

Downstream 100 bases:

>100_bases
GGAGCCGGCCATGAGCGTTCTGCATCGCATCGAGAACGGCGTCGGCTGGCTGACCATGGACCGCCCGGCGGCCATGAACA
GCCTGAACCGCGAGATGGCC

Product: Acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MLNNKESIVIVGAKRTPIGAFNGSLSAFKAPELGAVAIRAAVAQAGVDPASVDEAIMGLCLFANVGQAPARQAVLGAGLP
TSTPATTISKMCGSAMKSVMLAHDLLLAGTCNVAVAGGMESMTNAPYIVPRGRYGYRLGHGQFLDHMYCDGLEDAYEGHL
MGYYADLAAEARGMGREAQDAYARESLLRAQAAVAEGRFRDEIAPVTLKRGGEFAEDETPGQCDAARLPKLKAVFRDGGS
VTAGNASSISDGAAALVLMRERDAIREGLAPLARIVAHATHANPPQQFADAPVLAARRVLDKAGWTARDVDLYEVNEAFA
VVTMIALDELGIGHDRLNVNGGACALGHPVGATGARLLVTLVHALQQRGLKRGLASLCLGGGEATAIGLELC

Sequences:

>Translated_392_residues
MLNNKESIVIVGAKRTPIGAFNGSLSAFKAPELGAVAIRAAVAQAGVDPASVDEAIMGLCLFANVGQAPARQAVLGAGLP
TSTPATTISKMCGSAMKSVMLAHDLLLAGTCNVAVAGGMESMTNAPYIVPRGRYGYRLGHGQFLDHMYCDGLEDAYEGHL
MGYYADLAAEARGMGREAQDAYARESLLRAQAAVAEGRFRDEIAPVTLKRGGEFAEDETPGQCDAARLPKLKAVFRDGGS
VTAGNASSISDGAAALVLMRERDAIREGLAPLARIVAHATHANPPQQFADAPVLAARRVLDKAGWTARDVDLYEVNEAFA
VVTMIALDELGIGHDRLNVNGGACALGHPVGATGARLLVTLVHALQQRGLKRGLASLCLGGGEATAIGLELC
>Mature_392_residues
MLNNKESIVIVGAKRTPIGAFNGSLSAFKAPELGAVAIRAAVAQAGVDPASVDEAIMGLCLFANVGQAPARQAVLGAGLP
TSTPATTISKMCGSAMKSVMLAHDLLLAGTCNVAVAGGMESMTNAPYIVPRGRYGYRLGHGQFLDHMYCDGLEDAYEGHL
MGYYADLAAEARGMGREAQDAYARESLLRAQAAVAEGRFRDEIAPVTLKRGGEFAEDETPGQCDAARLPKLKAVFRDGGS
VTAGNASSISDGAAALVLMRERDAIREGLAPLARIVAHATHANPPQQFADAPVLAARRVLDKAGWTARDVDLYEVNEAFA
VVTMIALDELGIGHDRLNVNGGACALGHPVGATGARLLVTLVHALQQRGLKRGLASLCLGGGEATAIGLELC

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4557237, Length=390, Percent_Identity=47.4358974358974, Blast_Score=328, Evalue=6e-90,
Organism=Homo sapiens, GI148539872, Length=393, Percent_Identity=43.0025445292621, Blast_Score=295, Evalue=6e-80,
Organism=Homo sapiens, GI167614485, Length=393, Percent_Identity=37.6590330788804, Blast_Score=238, Evalue=7e-63,
Organism=Homo sapiens, GI4501853, Length=394, Percent_Identity=32.994923857868, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI4504327, Length=423, Percent_Identity=29.7872340425532, Blast_Score=148, Evalue=8e-36,
Organism=Homo sapiens, GI194353979, Length=390, Percent_Identity=24.8717948717949, Blast_Score=89, Evalue=8e-18,
Organism=Escherichia coli, GI87082165, Length=390, Percent_Identity=44.6153846153846, Blast_Score=313, Evalue=1e-86,
Organism=Escherichia coli, GI1788554, Length=390, Percent_Identity=47.6923076923077, Blast_Score=310, Evalue=1e-85,
Organism=Escherichia coli, GI1787663, Length=389, Percent_Identity=37.7892030848329, Blast_Score=214, Evalue=8e-57,
Organism=Escherichia coli, GI48994986, Length=401, Percent_Identity=33.9152119700748, Blast_Score=188, Evalue=5e-49,
Organism=Escherichia coli, GI1788683, Length=413, Percent_Identity=29.7820823244552, Blast_Score=138, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI25147385, Length=392, Percent_Identity=40.3061224489796, Blast_Score=283, Evalue=1e-76,
Organism=Caenorhabditis elegans, GI17535921, Length=391, Percent_Identity=41.4322250639386, Blast_Score=269, Evalue=2e-72,
Organism=Caenorhabditis elegans, GI133906874, Length=387, Percent_Identity=40.3100775193798, Blast_Score=254, Evalue=6e-68,
Organism=Caenorhabditis elegans, GI17535917, Length=398, Percent_Identity=33.4170854271357, Blast_Score=197, Evalue=7e-51,
Organism=Caenorhabditis elegans, GI17551802, Length=425, Percent_Identity=29.6470588235294, Blast_Score=156, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6325229, Length=394, Percent_Identity=44.6700507614213, Blast_Score=303, Evalue=4e-83,
Organism=Saccharomyces cerevisiae, GI6322031, Length=388, Percent_Identity=31.4432989690722, Blast_Score=169, Evalue=9e-43,
Organism=Drosophila melanogaster, GI24655093, Length=387, Percent_Identity=45.9948320413437, Blast_Score=323, Evalue=1e-88,
Organism=Drosophila melanogaster, GI24640423, Length=388, Percent_Identity=44.8453608247423, Blast_Score=298, Evalue=3e-81,
Organism=Drosophila melanogaster, GI17648125, Length=391, Percent_Identity=37.5959079283887, Blast_Score=230, Evalue=1e-60,
Organism=Drosophila melanogaster, GI17137578, Length=423, Percent_Identity=28.1323877068558, Blast_Score=141, Evalue=7e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 40714; Mature: 40714

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS00098 THIOLASE_1 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNNKESIVIVGAKRTPIGAFNGSLSAFKAPELGAVAIRAAVAQAGVDPASVDEAIMGLC
CCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHH
LFANVGQAPARQAVLGAGLPTSTPATTISKMCGSAMKSVMLAHDLLLAGTCNVAVAGGME
HHHCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHH
SMTNAPYIVPRGRYGYRLGHGQFLDHMYCDGLEDAYEGHLMGYYADLAAEARGMGREAQD
HHCCCCEEEECCCCCEEECCCHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHCCCCHHHH
AYARESLLRAQAAVAEGRFRDEIAPVTLKRGGEFAEDETPGQCDAARLPKLKAVFRDGGS
HHHHHHHHHHHHHHHCCHHHHCCCCEEEECCCCCCCCCCCCCCCHHHCCHHHHHHHCCCC
VTAGNASSISDGAAALVLMRERDAIREGLAPLARIVAHATHANPPQQFADAPVLAARRVL
EECCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHH
DKAGWTARDVDLYEVNEAFAVVTMIALDELGIGHDRLNVNGGACALGHPVGATGARLLVT
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCEEECCCCCCCHHHHHHHH
LVHALQQRGLKRGLASLCLGGGEATAIGLELC
HHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEC
>Mature Secondary Structure
MLNNKESIVIVGAKRTPIGAFNGSLSAFKAPELGAVAIRAAVAQAGVDPASVDEAIMGLC
CCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHH
LFANVGQAPARQAVLGAGLPTSTPATTISKMCGSAMKSVMLAHDLLLAGTCNVAVAGGME
HHHCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHH
SMTNAPYIVPRGRYGYRLGHGQFLDHMYCDGLEDAYEGHLMGYYADLAAEARGMGREAQD
HHCCCCEEEECCCCCEEECCCHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHCCCCHHHH
AYARESLLRAQAAVAEGRFRDEIAPVTLKRGGEFAEDETPGQCDAARLPKLKAVFRDGGS
HHHHHHHHHHHHHHHCCHHHHCCCCEEEECCCCCCCCCCCCCCCHHHCCHHHHHHHCCCC
VTAGNASSISDGAAALVLMRERDAIREGLAPLARIVAHATHANPPQQFADAPVLAARRVL
EECCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHH
DKAGWTARDVDLYEVNEAFAVVTMIALDELGIGHDRLNVNGGACALGHPVGATGARLLVT
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCEEECCCCCCCHHHHHHHH
LVHALQQRGLKRGLASLCLGGGEATAIGLELC
HHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7867955; 11075929; 11466286; 1685080 [H]