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The map label for this gene is bvgA [H]

Identifier: 116694085

GI number: 116694085

Start: 143464

End: 144093

Strand: Direct

Name: bvgA [H]

Synonym: H16_B0125

Alternate gene names: 116694085

Gene position: 143464-144093 (Clockwise)

Preceding gene: 116694083

Following gene: 116694087

Centisome position: 4.93

GC content: 65.87

Gene sequence:

>630_bases
ATGACAACCATCCTGATCGTTGACGACCATCCGGCGATGCGGCTGGTGCTCAGGCACCATCTGCTGCAGCTGCTTGGCGT
AGACGAGGTGATCGAAGCAGACAACGGACAGTGCGCCATCGAGCTGGTGCGCGCGCGCACGCCGGACCTCGTGCTGCTCG
ACCTGGACATCCCGCGCTCCAGCGGGCTGGATGTGGCGCCGCGCCTGCGCGCGATCCATCCGCAGGTGCGCATTCTGGTG
GTGACGGCGCTGGACCCGGCGGTGTTCATCAGCCGGTCATGGCAGGCCGGTGCGCAGGGCTTCGTCAGCAAGACCCAGGA
CATCAAGGAAATCCTGCGTGCGGTCGAGGCGGTGCTGGCGGGCTATACCGTGTTCCCGGTGCTCAGCCGCGGCGGCGCGC
CGCGCCAGGCCATGTCGGCGGATGAGGAGATCCTGCGGCGCCTTTCCGACAAGGAACTGGTGGTGCTGCAGATGCTGGCG
CGCGGCATGTCCTACAAGGCCATCAGCGCCAGCCTCTTTATCAGCAACAAGACCGTGAGCAGCTACAAGGCACGCATCAT
GGGTAAGCTGCAGGTCTCGTCCCTGGTGGAGCTGGTGGACTTTGCGCGGCGTTGCCGGCTGACCCCCTGA

Upstream 100 bases:

>100_bases
CTGGCGCAGCATCGCGCCCCGCGTGTTAATCGCCCTGCCATCCCATGCCCGGGCAGAATGCGCGCCGTCGCCGATGCGTT
CCCGGACTACGAAGCCACGC

Downstream 100 bases:

>100_bases
TCTCGGTCCATATCATTAGACATCGTATGACTTGGCGGCCGCACCCATCCAGTGCGCGCGCGTCGCTCAGCCTTGGGCGC
CGGCCGGCGCCGAGGCCTTG

Product: response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 209; Mature: 208

Protein sequence:

>209_residues
MTTILIVDDHPAMRLVLRHHLLQLLGVDEVIEADNGQCAIELVRARTPDLVLLDLDIPRSSGLDVAPRLRAIHPQVRILV
VTALDPAVFISRSWQAGAQGFVSKTQDIKEILRAVEAVLAGYTVFPVLSRGGAPRQAMSADEEILRRLSDKELVVLQMLA
RGMSYKAISASLFISNKTVSSYKARIMGKLQVSSLVELVDFARRCRLTP

Sequences:

>Translated_209_residues
MTTILIVDDHPAMRLVLRHHLLQLLGVDEVIEADNGQCAIELVRARTPDLVLLDLDIPRSSGLDVAPRLRAIHPQVRILV
VTALDPAVFISRSWQAGAQGFVSKTQDIKEILRAVEAVLAGYTVFPVLSRGGAPRQAMSADEEILRRLSDKELVVLQMLA
RGMSYKAISASLFISNKTVSSYKARIMGKLQVSSLVELVDFARRCRLTP
>Mature_208_residues
TTILIVDDHPAMRLVLRHHLLQLLGVDEVIEADNGQCAIELVRARTPDLVLLDLDIPRSSGLDVAPRLRAIHPQVRILVV
TALDPAVFISRSWQAGAQGFVSKTQDIKEILRAVEAVLAGYTVFPVLSRGGAPRQAMSADEEILRRLSDKELVVLQMLAR
GMSYKAISASLFISNKTVSSYKARIMGKLQVSSLVELVDFARRCRLTP

Specific function: Member of the two-component regulatory system BvgS/BvgA. Activates the transcription of virulence genes [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786747, Length=202, Percent_Identity=34.6534653465347, Blast_Score=145, Evalue=2e-36,
Organism=Escherichia coli, GI1788712, Length=204, Percent_Identity=34.8039215686275, Blast_Score=124, Evalue=4e-30,
Organism=Escherichia coli, GI1788222, Length=206, Percent_Identity=30.0970873786408, Blast_Score=97, Evalue=9e-22,
Organism=Escherichia coli, GI1788521, Length=194, Percent_Identity=35.0515463917526, Blast_Score=92, Evalue=2e-20,
Organism=Escherichia coli, GI1790102, Length=208, Percent_Identity=30.7692307692308, Blast_Score=76, Evalue=1e-15,
Organism=Escherichia coli, GI1787473, Length=185, Percent_Identity=30.2702702702703, Blast_Score=66, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789
- InterPro:   IPR011990
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 23062; Mature: 22931

Theoretical pI: Translated: 9.63; Mature: 9.63

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTILIVDDHPAMRLVLRHHLLQLLGVDEVIEADNGQCAIELVRARTPDLVLLDLDIPRS
CEEEEEECCCHHHHHHHHHHHHHHHCHHHHHHCCCCCEEEEEEECCCCCEEEEEECCCCC
SGLDVAPRLRAIHPQVRILVVTALDPAVFISRSWQAGAQGFVSKTQDIKEILRAVEAVLA
CCCCCCHHHHHCCCCEEEEEEEECCCHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHC
GYTVFPVLSRGGAPRQAMSADEEILRRLSDKELVVLQMLARGMSYKAISASLFISNKTVS
CHHHHHHHHCCCCCHHHHCHHHHHHHHCCCCHHHHHHHHHCCCCCCEEEEEEEEECCHHH
SYKARIMGKLQVSSLVELVDFARRCRLTP
HHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TTILIVDDHPAMRLVLRHHLLQLLGVDEVIEADNGQCAIELVRARTPDLVLLDLDIPRS
EEEEEECCCHHHHHHHHHHHHHHHCHHHHHHCCCCCEEEEEEECCCCCEEEEEECCCCC
SGLDVAPRLRAIHPQVRILVVTALDPAVFISRSWQAGAQGFVSKTQDIKEILRAVEAVLA
CCCCCCHHHHHCCCCEEEEEEEECCCHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHC
GYTVFPVLSRGGAPRQAMSADEEILRRLSDKELVVLQMLARGMSYKAISASLFISNKTVS
CHHHHHHHHCCCCCHHHHCHHHHHHHHCCCCHHHHHHHHHCCCCCCEEEEEEEEECCHHH
SYKARIMGKLQVSSLVELVDFARRCRLTP
HHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1791760; 12910271 [H]