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The map label for this gene is ypdF [H]

Identifier: 116691047

GI number: 116691047

Start: 3340976

End: 3342844

Strand: Reverse

Name: ypdF [H]

Synonym: Bcen2424_3029

Alternate gene names: 116691047

Gene position: 3342844-3340976 (Counterclockwise)

Preceding gene: 116691049

Following gene: 116691043

Centisome position: 95.95

GC content: 69.77

Gene sequence:

>1869_bases
ATGAATAACGGGCATCCGATGATCGATCGACTGAAATACAGCTTCTCCGGCCTTCCCCCGTACGACGCGTCCGTCGCCGA
CACGCAGGCCGGCCTGTCGCGCCTGCTCGATGCCGCGCGACTCGACGCGGTGCTGATCACGTCGCAGGACGAATACGTGA
CCGAGTACCTGCCGCGCGGCAACAACCCGCGCTACGCGGTGTCCGGCTTCGACGGCTCGGCCGGCTGCGGGATCTTCCTG
AGCGCGGCGACCGCGCAGGCGCTCGATCTGCCGCCGTTCGTGCTGTTCGTCGACGGCCGCTATCACTTCCAGGCCGACGA
GCAGTGCGATCCGGCGCGCGTGCGCGTCGAGAAGCTCGGCATGAACGTGACGATCTGGCAGGCGATGGCCGACTGGCTGC
TCGCGCATGCGAGCCGGCTCGCGCGGGTCGGCTACGACGCGCGGCGGATCAGCGTCGCGCAGCGCAACCGGCTGTTCGAG
CAGACGCAGGCCGCGTCGCTCGACTGGACGAGCCTCGCCGAGCGCGAGATCGACCGGGCGATCTCGCTGCCGGGCTGGAA
CGTCGAGCGGCCGATCTTCGAGATCCCGGCAGCGATGACCGGCCTGAGCGTCGTGCAGAACCTCGACGCGCTGAACCGCC
GGCTCGCCGCGCATACCGGCGCGGCCGACGGCAAGACGGCGTTCTTCACCTGCGCGTCGGACGATCTCGCGTATCTGCTG
AACAGCCGCGGCTATCACATCCCGAATGCGTCGTCGCACCTCGGCTTCCTGTTCGCGGTCGGCGGGCGGGTGGCTTTGTT
CCTCCCGGAAGGCTGCGACCGCTGCGAGGTCGCGCTCGATTCGTATCCGGCGCTGCAGGTGATCCGGCGCGACGTCGCGG
CGCTCGAGCGCTTCCTCGCGCAGTTCGCCATCGAGCACGTGTGCTACGGCTTCGAATCGGTGAACTGCGCGCTCGTCGAC
GCGGTCAAGCGGGTGTGGCCGCACGCGCGGCATGCCGATTTCAACCCGGTCGAGGCGATGCGGGCGAGCAAGACGCCGGC
GGTGCTCGGCCAGTTCCGCGACGCGTTCGCGCGCAGCTGCGCGGCGATCGCCGAGACGATGCGCTGGGCGAAGACCGGCG
AGCCGGGCGTGCGCCACACCGAGTACGACCTCGCGCGCCGGATCAACGACGCGTACGGCGCACGTTCGGCGGTCGCGCTG
TCGTTTCCGTCGATCGCGGCGAACGGCGCGAACAGCGCGTTCGCGCATTACACGGCGGCGAGCGCCGACGTCGAGCTGAC
CGAAGGCGAACTCGTGCTGCTCGACAGCGGCGCGTACTACGAAGCCGGCTTCGCGACGGACTGCACGCGCGTCGTGCTGC
GCCGCACGCGGCCGGACACGGTCGCGCAGCCGTGGCAGCGCGAGATCTACACGGTCGCGCTGAAGGCCTGCATCAAGGGG
CTCGTCACGCGCTTTCCGGCCACCGCGACGGGCGGCGACGTCGATGCGCTGGTGCGGCAGGTGTGCCGCGACCATGGCCA
CGATTTCGGCCACGGCACCGGGCACGGCGTCGGGATTCACGTGCACGAGGGCGGCGTGCGGTTCGCGCCGGGCGCGACGT
ACGGGCTGGTGCCGAATGCGGTGATTTCGGTCGAGCCGGGCATCTACCTGCCGGGCAAGGGCGGCGTGCGGATCGAGAAC
ATCGTGATCGTGCGGGCGGACGACGCGCAGCCCGGCACCGTGACGTTCGAGAACATCGTGACGGTCGGCTACGACTGGGA
CCTGATCGATCTGGATCTGCTGGACGACGCCGAGCGCGCGTACCTGCGCGACTACGAGCGGCTGTGCGTGGAACGCGGCA
CGCAGGTCACCGCGTGTCCGCTGTTGTAA

Upstream 100 bases:

>100_bases
GCGCGGCCCGGCCGCGCGTCGTGTCGCGCATGACCTGCGCCGCAACGACGTGCCGTGCCCGGCGCGCGATGCCGCGGCAC
GCCGCCGGCCGCCGACAACA

Downstream 100 bases:

>100_bases
CGAAGGGGGAAGCAGCGACGCGGCCGCCGGTCGGCCGCGCGGCGCGCCGTCAGCCGGTCAGCGCGTGAGCGCCGACACGC
GTCCGTCGGGGCCGTACACG

Product: peptidase M24

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 622; Mature: 622

Protein sequence:

>622_residues
MNNGHPMIDRLKYSFSGLPPYDASVADTQAGLSRLLDAARLDAVLITSQDEYVTEYLPRGNNPRYAVSGFDGSAGCGIFL
SAATAQALDLPPFVLFVDGRYHFQADEQCDPARVRVEKLGMNVTIWQAMADWLLAHASRLARVGYDARRISVAQRNRLFE
QTQAASLDWTSLAEREIDRAISLPGWNVERPIFEIPAAMTGLSVVQNLDALNRRLAAHTGAADGKTAFFTCASDDLAYLL
NSRGYHIPNASSHLGFLFAVGGRVALFLPEGCDRCEVALDSYPALQVIRRDVAALERFLAQFAIEHVCYGFESVNCALVD
AVKRVWPHARHADFNPVEAMRASKTPAVLGQFRDAFARSCAAIAETMRWAKTGEPGVRHTEYDLARRINDAYGARSAVAL
SFPSIAANGANSAFAHYTAASADVELTEGELVLLDSGAYYEAGFATDCTRVVLRRTRPDTVAQPWQREIYTVALKACIKG
LVTRFPATATGGDVDALVRQVCRDHGHDFGHGTGHGVGIHVHEGGVRFAPGATYGLVPNAVISVEPGIYLPGKGGVRIEN
IVIVRADDAQPGTVTFENIVTVGYDWDLIDLDLLDDAERAYLRDYERLCVERGTQVTACPLL

Sequences:

>Translated_622_residues
MNNGHPMIDRLKYSFSGLPPYDASVADTQAGLSRLLDAARLDAVLITSQDEYVTEYLPRGNNPRYAVSGFDGSAGCGIFL
SAATAQALDLPPFVLFVDGRYHFQADEQCDPARVRVEKLGMNVTIWQAMADWLLAHASRLARVGYDARRISVAQRNRLFE
QTQAASLDWTSLAEREIDRAISLPGWNVERPIFEIPAAMTGLSVVQNLDALNRRLAAHTGAADGKTAFFTCASDDLAYLL
NSRGYHIPNASSHLGFLFAVGGRVALFLPEGCDRCEVALDSYPALQVIRRDVAALERFLAQFAIEHVCYGFESVNCALVD
AVKRVWPHARHADFNPVEAMRASKTPAVLGQFRDAFARSCAAIAETMRWAKTGEPGVRHTEYDLARRINDAYGARSAVAL
SFPSIAANGANSAFAHYTAASADVELTEGELVLLDSGAYYEAGFATDCTRVVLRRTRPDTVAQPWQREIYTVALKACIKG
LVTRFPATATGGDVDALVRQVCRDHGHDFGHGTGHGVGIHVHEGGVRFAPGATYGLVPNAVISVEPGIYLPGKGGVRIEN
IVIVRADDAQPGTVTFENIVTVGYDWDLIDLDLLDDAERAYLRDYERLCVERGTQVTACPLL
>Mature_622_residues
MNNGHPMIDRLKYSFSGLPPYDASVADTQAGLSRLLDAARLDAVLITSQDEYVTEYLPRGNNPRYAVSGFDGSAGCGIFL
SAATAQALDLPPFVLFVDGRYHFQADEQCDPARVRVEKLGMNVTIWQAMADWLLAHASRLARVGYDARRISVAQRNRLFE
QTQAASLDWTSLAEREIDRAISLPGWNVERPIFEIPAAMTGLSVVQNLDALNRRLAAHTGAADGKTAFFTCASDDLAYLL
NSRGYHIPNASSHLGFLFAVGGRVALFLPEGCDRCEVALDSYPALQVIRRDVAALERFLAQFAIEHVCYGFESVNCALVD
AVKRVWPHARHADFNPVEAMRASKTPAVLGQFRDAFARSCAAIAETMRWAKTGEPGVRHTEYDLARRINDAYGARSAVAL
SFPSIAANGANSAFAHYTAASADVELTEGELVLLDSGAYYEAGFATDCTRVVLRRTRPDTVAQPWQREIYTVALKACIKG
LVTRFPATATGGDVDALVRQVCRDHGHDFGHGTGHGVGIHVHEGGVRFAPGATYGLVPNAVISVEPGIYLPGKGGVRIEN
IVIVRADDAQPGTVTFENIVTVGYDWDLIDLDLLDDAERAYLRDYERLCVERGTQVTACPLL

Specific function: Hydrolyzes the N-terminal methionine when the next amino acid is alanine, proline or serine. The substrate preference for methionyl aminopeptidase activity is Pro > Ala > Ser. Also able to hydrolyze the Xaa-Pro peptide bond when the first amino acid is al

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24 family [H]

Homologues:

Organism=Homo sapiens, GI264681563, Length=593, Percent_Identity=26.8128161888702, Blast_Score=172, Evalue=1e-42,
Organism=Homo sapiens, GI93141226, Length=627, Percent_Identity=26.1562998405104, Blast_Score=165, Evalue=1e-40,
Organism=Homo sapiens, GI264681565, Length=592, Percent_Identity=25.3378378378378, Blast_Score=154, Evalue=3e-37,
Organism=Escherichia coli, GI1788728, Length=235, Percent_Identity=32.3404255319149, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1789275, Length=264, Percent_Identity=30.6818181818182, Blast_Score=82, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17509539, Length=606, Percent_Identity=27.5577557755776, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI25149105, Length=592, Percent_Identity=21.2837837837838, Blast_Score=89, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6322999, Length=635, Percent_Identity=23.7795275590551, Blast_Score=129, Evalue=1e-30,
Organism=Drosophila melanogaster, GI17137632, Length=602, Percent_Identity=26.7441860465116, Blast_Score=146, Evalue=4e-35,
Organism=Drosophila melanogaster, GI161078230, Length=618, Percent_Identity=23.7864077669903, Blast_Score=105, Evalue=1e-22,
Organism=Drosophila melanogaster, GI21357287, Length=618, Percent_Identity=23.7864077669903, Blast_Score=105, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: 3.4.-.- [C]

Molecular weight: Translated: 67783; Mature: 67783

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNGHPMIDRLKYSFSGLPPYDASVADTQAGLSRLLDAARLDAVLITSQDEYVTEYLPRG
CCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHCCCC
NNPRYAVSGFDGSAGCGIFLSAATAQALDLPPFVLFVDGRYHFQADEQCDPARVRVEKLG
CCCCEEEECCCCCCCCCEEEEHHHHHHCCCCCEEEEECCEEEECCCCCCCHHHHHHHHHC
MNVTIWQAMADWLLAHASRLARVGYDARRISVAQRNRLFEQTQAASLDWTSLAEREIDRA
CCEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
ISLPGWNVERPIFEIPAAMTGLSVVQNLDALNRRLAAHTGAADGKTAFFTCASDDLAYLL
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHH
NSRGYHIPNASSHLGFLFAVGGRVALFLPEGCDRCEVALDSYPALQVIRRDVAALERFLA
CCCCCCCCCCCCCCEEEEEECCEEEEEECCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHH
QFAIEHVCYGFESVNCALVDAVKRVWPHARHADFNPVEAMRASKTPAVLGQFRDAFARSC
HHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHH
AAIAETMRWAKTGEPGVRHTEYDLARRINDAYGARSAVALSFPSIAANGANSAFAHYTAA
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCHHCCCCCCCHHEEEEC
SADVELTEGELVLLDSGAYYEAGFATDCTRVVLRRTRPDTVAQPWQREIYTVALKACIKG
CCCEEEECCCEEEEECCCEEECCCCHHHHHHHHHCCCCCHHCCHHHHHHHHHHHHHHHHH
LVTRFPATATGGDVDALVRQVCRDHGHDFGHGTGHGVGIHVHEGGVRFAPGATYGLVPNA
HHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCEEECCCCCCCCCCCC
VISVEPGIYLPGKGGVRIENIVIVRADDAQPGTVTFENIVTVGYDWDLIDLDLLDDAERA
EEEECCCEEECCCCCEEEEEEEEEEECCCCCCEEEEHHEEEECCCCCEEEEECCCCHHHH
YLRDYERLCVERGTQVTACPLL
HHHHHHHHHHHCCCCEEECCCC
>Mature Secondary Structure
MNNGHPMIDRLKYSFSGLPPYDASVADTQAGLSRLLDAARLDAVLITSQDEYVTEYLPRG
CCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHCCCC
NNPRYAVSGFDGSAGCGIFLSAATAQALDLPPFVLFVDGRYHFQADEQCDPARVRVEKLG
CCCCEEEECCCCCCCCCEEEEHHHHHHCCCCCEEEEECCEEEECCCCCCCHHHHHHHHHC
MNVTIWQAMADWLLAHASRLARVGYDARRISVAQRNRLFEQTQAASLDWTSLAEREIDRA
CCEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
ISLPGWNVERPIFEIPAAMTGLSVVQNLDALNRRLAAHTGAADGKTAFFTCASDDLAYLL
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHH
NSRGYHIPNASSHLGFLFAVGGRVALFLPEGCDRCEVALDSYPALQVIRRDVAALERFLA
CCCCCCCCCCCCCCEEEEEECCEEEEEECCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHH
QFAIEHVCYGFESVNCALVDAVKRVWPHARHADFNPVEAMRASKTPAVLGQFRDAFARSC
HHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHH
AAIAETMRWAKTGEPGVRHTEYDLARRINDAYGARSAVALSFPSIAANGANSAFAHYTAA
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCHHCCCCCCCHHEEEEC
SADVELTEGELVLLDSGAYYEAGFATDCTRVVLRRTRPDTVAQPWQREIYTVALKACIKG
CCCEEEECCCEEEEECCCEEECCCCHHHHHHHHHCCCCCHHCCHHHHHHHHHHHHHHHHH
LVTRFPATATGGDVDALVRQVCRDHGHDFGHGTGHGVGIHVHEGGVRFAPGATYGLVPNA
HHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCEEECCCCCCCCCCCC
VISVEPGIYLPGKGGVRIENIVIVRADDAQPGTVTFENIVTVGYDWDLIDLDLLDDAERA
EEEECCCEEECCCCCEEEEEEEEEEECCCCCCEEEEHHEEEECCCCCEEEEECCCCHHHH
YLRDYERLCVERGTQVTACPLL
HHHHHHHHHHHCCCCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]