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The map label for this gene is aceK [H]

Identifier: 116690944

GI number: 116690944

Start: 3234325

End: 3236142

Strand: Direct

Name: aceK [H]

Synonym: Bcen2424_2926

Alternate gene names: 116690944

Gene position: 3234325-3236142 (Clockwise)

Preceding gene: 116690942

Following gene: 116690945

Centisome position: 92.84

GC content: 63.2

Gene sequence:

>1818_bases
ATGAATCACTTCCCCAAACTGCTGTCGTCGCAGATCGGTTTCGACGTCGCGCAGACGATGCTCGAATACTTCGATCGCCA
TTACCGGATCTTCCGCGAAGCGGCGGTCGATGCGAAGACGCTGTTCGAGCGCGGCGACTGGCACGGGCTGCAGCGGCTCG
CGCGCGAGCGGATCACGTCGTACGACGAGCGCGTGAAGGAATGCGTCGAGGTGCTGGAAGACGAATACGACGCGGAGAAC
ATCGACGACGAAGTGTGGCAGCAGATCAAGCTGCACTATATCGGCCTGCTCACGTCGCACCGCCAGCCCGAGTGCGCGGA
AACCTTCTTCAATTCGGTGTGCTGCAAGATCCTGCACCGCTCGTATTTCAGCAACGATTTCATCTTCGTGCGCCCGGCGA
TCTCGACCGAGTATCTGGAGAACGACGAACCGGCCGCGAAACCGACCTACCGCGCGTACTATCCGGGCACCGACGGGCTC
GCGGTCACGCTCGAGCGCATCGTCACGAACTTCCAGCTCGACCCGCCGTTCGAGGATCTCACGCGCGACATCGGCTGCGT
GATGCAGGCGATCGACGACGAATTCGGCCACTTCGACGAAGCGCCGAATTTCCAGATCCACGTGCTGTCGTCGCTGTTCT
TCCGCAACAAGAGCGCGTACATCGTCGGCCGCATCATCAACGCCGACCGCGTGCTGCCGTTCGCGGTGCCGATCCGCCAC
GTGCGTCCCGGCGTGCTCGCGCTCGACACCGTGCTGCTGCGCCGCGACCTGCTGCAGATCATCTTCAGCTTCTCGCATTC
GTACTTCCTCGTCGACATGGGCGTGCCGTCCGCGTACGTGGATTTCCTCTGCACGATCATGCCGGGCAAGCCGAAGGCCG
AGATCTACACGTCGGTCGGGCTGCAGAAGCAGGGCAAGAACCTGTTCTACCGCGACCTCCTGCACCATCTGTCGCATTCG
AGCGACCGCTTCATCATCGCGCCCGGGATCAAGGGCCTCGTGATGCTCGTGTTCACGCTGCCGTCGTTCCCGTACGTGTT
CAAGATCATCAAGGACCACTTCCCGCCGCCGAAGGAAACGACGCGCGCGCAGATCATGGAGAAGTACCAGCTCGTGAAGC
GCCACGACCGGCTCGGTCGGATGGCCGACACGCTCGAGTATTCGAGCGTCGCGCTGCCGCTCGCGCGGCTCGATCACGCG
CTCGTGCGCGAACTCGAGAAGGAAGTGCCGTCGCTGCTCGAATACGAGGACGACAAGCTCGTGATCAAGCACCTGTACAT
CGAGCGCCGGATGACGCCGCTGAACCTGTACCTGCAGAACGGCAGCGACGCGGACGTCGAGCACGGCGTGAAGGAATACG
GCAACGCGGTGAAGGAGCTGATGAAGGCGAACATCTTCCCCGGCGACATGCTGTACAAGAACTTCGGCGTCACGCGCCAC
GGCCGCGTCGTGTTCTACGACTACGACGAGATCGAATACCTGACCGACTGCAACGTGCGGCGCGTGCCGCCGCCGCGCAA
CGAGGAAGACGAGCTGTCCGGCGAACCGTGGTATACCGTCGGCCCGCACGACATCTTTCCGGAGACCTACGGGCCGTTCC
TGCTCGGCGACCCGCGCGTGCGCAGCGTCTTCATGAAGCATCACGCGGACTTTTTCGATCCCGCGCTGTGGCAGGCGAGC
AAGGACAAGCTGATGCAGGGCGAACTGCCCGATTTTTATCCGTACGACGCGACCCTGCGCTTTAGCGTGCGCTACCCCGC
GCGCTTCGGCGCGACGGGCGAGAACGACGGCGCAGGCGACGCGCAGCGCGCCGCCTGA

Upstream 100 bases:

>100_bases
GATTGACGACTGTTCGCGCGTCACCTCGAAAGTCATTGAAACGCCGACTTGGGCGCTAAAATGGCGGGTGCTTACAGCCC
CTTGAACGAGCCTGCACGCG

Downstream 100 bases:

>100_bases
CGCCGGCCACACCCCGATCCGATATCGACTTGATTTCCGCCAACGGAATCCACACCGATGACTACCCAAGACAATCCGCT
TTCACATCTGTTCGACAACA

Product: bifunctional isocitrate dehydrogenase kinase/phosphatase protein

Products: NA

Alternate protein names: IDH kinase/phosphatase; IDHK/P [H]

Number of amino acids: Translated: 605; Mature: 605

Protein sequence:

>605_residues
MNHFPKLLSSQIGFDVAQTMLEYFDRHYRIFREAAVDAKTLFERGDWHGLQRLARERITSYDERVKECVEVLEDEYDAEN
IDDEVWQQIKLHYIGLLTSHRQPECAETFFNSVCCKILHRSYFSNDFIFVRPAISTEYLENDEPAAKPTYRAYYPGTDGL
AVTLERIVTNFQLDPPFEDLTRDIGCVMQAIDDEFGHFDEAPNFQIHVLSSLFFRNKSAYIVGRIINADRVLPFAVPIRH
VRPGVLALDTVLLRRDLLQIIFSFSHSYFLVDMGVPSAYVDFLCTIMPGKPKAEIYTSVGLQKQGKNLFYRDLLHHLSHS
SDRFIIAPGIKGLVMLVFTLPSFPYVFKIIKDHFPPPKETTRAQIMEKYQLVKRHDRLGRMADTLEYSSVALPLARLDHA
LVRELEKEVPSLLEYEDDKLVIKHLYIERRMTPLNLYLQNGSDADVEHGVKEYGNAVKELMKANIFPGDMLYKNFGVTRH
GRVVFYDYDEIEYLTDCNVRRVPPPRNEEDELSGEPWYTVGPHDIFPETYGPFLLGDPRVRSVFMKHHADFFDPALWQAS
KDKLMQGELPDFYPYDATLRFSVRYPARFGATGENDGAGDAQRAA

Sequences:

>Translated_605_residues
MNHFPKLLSSQIGFDVAQTMLEYFDRHYRIFREAAVDAKTLFERGDWHGLQRLARERITSYDERVKECVEVLEDEYDAEN
IDDEVWQQIKLHYIGLLTSHRQPECAETFFNSVCCKILHRSYFSNDFIFVRPAISTEYLENDEPAAKPTYRAYYPGTDGL
AVTLERIVTNFQLDPPFEDLTRDIGCVMQAIDDEFGHFDEAPNFQIHVLSSLFFRNKSAYIVGRIINADRVLPFAVPIRH
VRPGVLALDTVLLRRDLLQIIFSFSHSYFLVDMGVPSAYVDFLCTIMPGKPKAEIYTSVGLQKQGKNLFYRDLLHHLSHS
SDRFIIAPGIKGLVMLVFTLPSFPYVFKIIKDHFPPPKETTRAQIMEKYQLVKRHDRLGRMADTLEYSSVALPLARLDHA
LVRELEKEVPSLLEYEDDKLVIKHLYIERRMTPLNLYLQNGSDADVEHGVKEYGNAVKELMKANIFPGDMLYKNFGVTRH
GRVVFYDYDEIEYLTDCNVRRVPPPRNEEDELSGEPWYTVGPHDIFPETYGPFLLGDPRVRSVFMKHHADFFDPALWQAS
KDKLMQGELPDFYPYDATLRFSVRYPARFGATGENDGAGDAQRAA
>Mature_605_residues
MNHFPKLLSSQIGFDVAQTMLEYFDRHYRIFREAAVDAKTLFERGDWHGLQRLARERITSYDERVKECVEVLEDEYDAEN
IDDEVWQQIKLHYIGLLTSHRQPECAETFFNSVCCKILHRSYFSNDFIFVRPAISTEYLENDEPAAKPTYRAYYPGTDGL
AVTLERIVTNFQLDPPFEDLTRDIGCVMQAIDDEFGHFDEAPNFQIHVLSSLFFRNKSAYIVGRIINADRVLPFAVPIRH
VRPGVLALDTVLLRRDLLQIIFSFSHSYFLVDMGVPSAYVDFLCTIMPGKPKAEIYTSVGLQKQGKNLFYRDLLHHLSHS
SDRFIIAPGIKGLVMLVFTLPSFPYVFKIIKDHFPPPKETTRAQIMEKYQLVKRHDRLGRMADTLEYSSVALPLARLDHA
LVRELEKEVPSLLEYEDDKLVIKHLYIERRMTPLNLYLQNGSDADVEHGVKEYGNAVKELMKANIFPGDMLYKNFGVTRH
GRVVFYDYDEIEYLTDCNVRRVPPPRNEEDELSGEPWYTVGPHDIFPETYGPFLLGDPRVRSVFMKHHADFFDPALWQAS
KDKLMQGELPDFYPYDATLRFSVRYPARFGATGENDGAGDAQRAA

Specific function: Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source

COG id: COG4579

COG function: function code T; Isocitrate dehydrogenase kinase/phosphatase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AceK family [H]

Homologues:

Organism=Escherichia coli, GI1790446, Length=570, Percent_Identity=41.4035087719298, Blast_Score=456, Evalue=1e-129,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010452
- ProDom:   PD043552 [H]

Pfam domain/function: PF06315 AceK [H]

EC number: =2.7.11.5 [H]

Molecular weight: Translated: 69950; Mature: 69950

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHFPKLLSSQIGFDVAQTMLEYFDRHYRIFREAAVDAKTLFERGDWHGLQRLARERITS
CCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
YDERVKECVEVLEDEYDAENIDDEVWQQIKLHYIGLLTSHRQPECAETFFNSVCCKILHR
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
SYFSNDFIFVRPAISTEYLENDEPAAKPTYRAYYPGTDGLAVTLERIVTNFQLDPPFEDL
HHCCCCEEEEECCCCHHHHCCCCCCCCCCCEEECCCCCCHHHHHHHHHHCCCCCCCHHHH
TRDIGCVMQAIDDEFGHFDEAPNFQIHVLSSLFFRNKSAYIVGRIINADRVLPFAVPIRH
HHHHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHH
VRPGVLALDTVLLRRDLLQIIFSFSHSYFLVDMGVPSAYVDFLCTIMPGKPKAEIYTSVG
CCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCCCCHHHHHHCC
LQKQGKNLFYRDLLHHLSHSSDRFIIAPGIKGLVMLVFTLPSFPYVFKIIKDHFPPPKET
CHHCCCCHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHH
TRAQIMEKYQLVKRHDRLGRMADTLEYSSVALPLARLDHALVRELEKEVPSLLEYEDDKL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
VIKHLYIERRMTPLNLYLQNGSDADVEHGVKEYGNAVKELMKANIFPGDMLYKNFGVTRH
HHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCC
GRVVFYDYDEIEYLTDCNVRRVPPPRNEEDELSGEPWYTVGPHDIFPETYGPFLLGDPRV
CEEEEEECCCHHHHHCCCCCCCCCCCCCCCCCCCCCCEECCCHHCCCCCCCCCEECCHHH
RSVFMKHHADFFDPALWQASKDKLMQGELPDFYPYDATLRFSVRYPARFGATGENDGAGD
HHHHHHHCCCCCCHHHHHCCHHHHHCCCCCCCCCCCCEEEEEEECCHHCCCCCCCCCCCC
AQRAA
HHCCC
>Mature Secondary Structure
MNHFPKLLSSQIGFDVAQTMLEYFDRHYRIFREAAVDAKTLFERGDWHGLQRLARERITS
CCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
YDERVKECVEVLEDEYDAENIDDEVWQQIKLHYIGLLTSHRQPECAETFFNSVCCKILHR
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
SYFSNDFIFVRPAISTEYLENDEPAAKPTYRAYYPGTDGLAVTLERIVTNFQLDPPFEDL
HHCCCCEEEEECCCCHHHHCCCCCCCCCCCEEECCCCCCHHHHHHHHHHCCCCCCCHHHH
TRDIGCVMQAIDDEFGHFDEAPNFQIHVLSSLFFRNKSAYIVGRIINADRVLPFAVPIRH
HHHHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHH
VRPGVLALDTVLLRRDLLQIIFSFSHSYFLVDMGVPSAYVDFLCTIMPGKPKAEIYTSVG
CCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCCCCHHHHHHCC
LQKQGKNLFYRDLLHHLSHSSDRFIIAPGIKGLVMLVFTLPSFPYVFKIIKDHFPPPKET
CHHCCCCHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHH
TRAQIMEKYQLVKRHDRLGRMADTLEYSSVALPLARLDHALVRELEKEVPSLLEYEDDKL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
VIKHLYIERRMTPLNLYLQNGSDADVEHGVKEYGNAVKELMKANIFPGDMLYKNFGVTRH
HHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCC
GRVVFYDYDEIEYLTDCNVRRVPPPRNEEDELSGEPWYTVGPHDIFPETYGPFLLGDPRV
CEEEEEECCCHHHHHCCCCCCCCCCCCCCCCCCCCCCEECCCHHCCCCCCCCCEECCHHH
RSVFMKHHADFFDPALWQASKDKLMQGELPDFYPYDATLRFSVRYPARFGATGENDGAGD
HHHHHHHCCCCCCHHHHHCCHHHHHCCCCCCCCCCCCEEEEEEECCHHCCCCCCCCCCCC
AQRAA
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA