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The map label for this gene is pth

Identifier: 116690824

GI number: 116690824

Start: 3100756

End: 3101355

Strand: Direct

Name: pth

Synonym: Bcen2424_2804

Alternate gene names: 116690824

Gene position: 3100756-3101355 (Clockwise)

Preceding gene: 116690823

Following gene: 116690825

Centisome position: 89.0

GC content: 67.0

Gene sequence:

>600_bases
ATGATCAAACTGATCGTCGGCCTCGGCAATCCCGGGGCGGAATACACCGCGACGCGCCACAACGCCGGCTTCTGGCTGAT
CGACCAGCTCGCCCGCGAAGCCGGCACGACGCTGCGCGACGAACGCCGCTTCCACGGCTTCTACGCGAAAGCGCGCCTGC
ACGGCGAGGAAGTCCATCTGCTCGAGCCGCAGACCTACATGAACCGCTCCGGCCAGTCGGTCGTCGCGCTCGCGCAATTC
TTCAAGATCCTGCCTGACCAGATCCTCGTCGCGCACGACGAGCTCGACCTGCCGCCCGGCACCGTGAAGCTGAAGCTCGG
CGGCGGCAGCGGCGGCCACAACGGGCTCAAGGACATCACCGCGCACCTGTCGTCGCAGCAATACTGGCGGCTGCGGATCG
GCATCGGCCATCCGCGCGACTTGATCTCGGAAAGCGCGCGTGCCGGCGCGAAGCCCGACGTCGCGAACTTCGTGCTGAAG
CCGCCGCGCCGCGAGGAACAGGACGTGATCGACGCCTCGATCGAACGCGCGCTTGCCGTGATGCCGATGGTCGTCAAGGG
CGAACTCGACCGCGCGACGATGCAGCTGCATCGCAACTGA

Upstream 100 bases:

>100_bases
TCGATCCGTTTCACGAAACGGTCGACGCAACCCGCCGCGGCTTGCCCGGCGGGTTTTTCTTTTTCTGCGCCCAGGCGGCC
GTTGCCGCCTTCGAAACGTC

Downstream 100 bases:

>100_bases
CCGCACCCGCACCAGCCCGGTAGCGTCGGCCGGCCGGCGCAACCGGGCGGCCTCGCCCGCCCCACCGCGACGCGCACATG
CGGTAATCTGGACGCTTTGC

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH

Number of amino acids: Translated: 199; Mature: 199

Protein sequence:

>199_residues
MIKLIVGLGNPGAEYTATRHNAGFWLIDQLAREAGTTLRDERRFHGFYAKARLHGEEVHLLEPQTYMNRSGQSVVALAQF
FKILPDQILVAHDELDLPPGTVKLKLGGGSGGHNGLKDITAHLSSQQYWRLRIGIGHPRDLISESARAGAKPDVANFVLK
PPRREEQDVIDASIERALAVMPMVVKGELDRATMQLHRN

Sequences:

>Translated_199_residues
MIKLIVGLGNPGAEYTATRHNAGFWLIDQLAREAGTTLRDERRFHGFYAKARLHGEEVHLLEPQTYMNRSGQSVVALAQF
FKILPDQILVAHDELDLPPGTVKLKLGGGSGGHNGLKDITAHLSSQQYWRLRIGIGHPRDLISESARAGAKPDVANFVLK
PPRREEQDVIDASIERALAVMPMVVKGELDRATMQLHRN
>Mature_199_residues
MIKLIVGLGNPGAEYTATRHNAGFWLIDQLAREAGTTLRDERRFHGFYAKARLHGEEVHLLEPQTYMNRSGQSVVALAQF
FKILPDQILVAHDELDLPPGTVKLKLGGGSGGHNGLKDITAHLSSQQYWRLRIGIGHPRDLISESARAGAKPDVANFVLK
PPRREEQDVIDASIERALAVMPMVVKGELDRATMQLHRN

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family

Homologues:

Organism=Homo sapiens, GI50897284, Length=137, Percent_Identity=39.4160583941606, Blast_Score=97, Evalue=1e-20,
Organism=Escherichia coli, GI1787455, Length=197, Percent_Identity=53.8071065989848, Blast_Score=178, Evalue=2e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTH_BURCA (Q1BTG4)

Other databases:

- EMBL:   CP000378
- RefSeq:   YP_622064.1
- ProteinModelPortal:   Q1BTG4
- SMR:   Q1BTG4
- STRING:   Q1BTG4
- GeneID:   4092123
- GenomeReviews:   CP000378_GR
- KEGG:   bcn:Bcen_2190
- eggNOG:   COG0193
- HOGENOM:   HBG610927
- OMA:   SHAGHNG
- ProtClustDB:   PRK05426
- BioCyc:   BCEN331271:BCEN_2190-MONOMER
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_00083
- InterPro:   IPR001328
- InterPro:   IPR018171
- Gene3D:   G3DSA:3.40.50.1470
- PANTHER:   PTHR17224
- TIGRFAMs:   TIGR00447

Pfam domain/function: PF01195 Pept_tRNA_hydro; SSF53178 Pept_tRNA_hydro

EC number: =3.1.1.29

Molecular weight: Translated: 22071; Mature: 22071

Theoretical pI: Translated: 9.45; Mature: 9.45

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKLIVGLGNPGAEYTATRHNAGFWLIDQLAREAGTTLRDERRFHGFYAKARLHGEEVHL
CEEEEEECCCCCCCCEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHEEEEEEECCCEEEE
LEPQTYMNRSGQSVVALAQFFKILPDQILVAHDELDLPPGTVKLKLGGGSGGHNGLKDIT
ECCHHHHCCCCCHHHHHHHHHHHCCHHEEEECCCCCCCCCEEEEEECCCCCCCCHHHHHH
AHLSSQQYWRLRIGIGHPRDLISESARAGAKPDVANFVLKPPRREEQDVIDASIERALAV
HHCCCCCEEEEEEECCCCHHHHHHHHHCCCCCCHHHHEECCCCCCHHHHHHHHHHHHHHH
MPMVVKGELDRATMQLHRN
HHHHCCCCCCHHHHHHCCC
>Mature Secondary Structure
MIKLIVGLGNPGAEYTATRHNAGFWLIDQLAREAGTTLRDERRFHGFYAKARLHGEEVHL
CEEEEEECCCCCCCCEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHEEEEEEECCCEEEE
LEPQTYMNRSGQSVVALAQFFKILPDQILVAHDELDLPPGTVKLKLGGGSGGHNGLKDIT
ECCHHHHCCCCCHHHHHHHHHHHCCHHEEEECCCCCCCCCEEEEEECCCCCCCCHHHHHH
AHLSSQQYWRLRIGIGHPRDLISESARAGAKPDVANFVLKPPRREEQDVIDASIERALAV
HHCCCCCEEEEEEECCCCHHHHHHHHHCCCCCCHHHHEECCCCCCHHHHHHHHHHHHHHH
MPMVVKGELDRATMQLHRN
HHHHCCCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA