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The map label for this gene is prs [H]

Identifier: 116690822

GI number: 116690822

Start: 3098909

End: 3099871

Strand: Direct

Name: prs [H]

Synonym: Bcen2424_2802

Alternate gene names: 116690822

Gene position: 3098909-3099871 (Clockwise)

Preceding gene: 116690821

Following gene: 116690823

Centisome position: 88.95

GC content: 63.14

Gene sequence:

>963_bases
ATGAGCAGCCACAGCCATGATGGCCTGATGGTCTTTACTGGCAACGCGAATCCCGCGCTCGCCCAGGAAGTCGTCAATAT
CCTTGGTATCCCCCTCGGCAAAGCAATGGTCAGCCGTTTCTCCGACGGCGAGATCCAGGTCGAGATCCAGGAAAACGTGC
GCGGCAAGGACGTCTTCGTCCTGCAATCCACGTGCGCACCGGCGAACGACAACCTGATGGAACTGATGATCATGGTCGAT
GCGCTCAAGCGCGCATCCGCTGGCCGGATCACCGCTGCCATCCCCTACTTCGGCTATGCGCGTCAGGATCGTCGCCCGCG
TTCGGCGCGCGTCGCGATCTCGGCGAAGATCGTCGCGAACATGCTGGAAATCGCCGGCGTCGAGCGGATCATCACGATGG
ATCTGCACGCCGACCAGATTCAGGGCTTCTTCGACATCCCGGTCGACAACATCTACGCGACGCCGATCCTGCTGGGCGAC
CTGCGCAAGCAGAACTACTCGGATCTGCTCGTCGTGTCGCCGGACGTCGGCGGCGTGGTGCGTGCCCGGGCACTCGCGAA
GCAGCTGAACTGCGATCTCGCGATCATCGACAAGCGTCGCCCGAAGGCGAACGTCGCCGAAGTGATGAACATCATCGGTG
AAGTCGAAGGCCGCACCTGCGTGATCATGGACGACATGGTCGATACGGCAGGCACGCTCTGCAAGGCTGCACAAGTGCTG
AAGGAGCGCGGCGCGAAGCAGGTTTTTGCCTACGCGACGCACCCGGTGCTGTCGGGCGGCGCCGCCGAGCGTATCGCCGC
GTCGGAACTCGACGAGCTGGTCGTCACCGATACGATCCCGCTGTCGGCCGAATCGCTGGCGTGCTCGAAGATCCGCTCGC
TGACGAGCGCGAGCCTGCTGGCCGAGACGTTCTCGCGGATTCGCCGCGGCGATTCGGTGATGTCGCTGTTCGCGGAATCC
TGA

Upstream 100 bases:

>100_bases
AAGGCACCGGATTTTGATTCCGGCATGCGAGGGTTCGAGTCCTTCCTCCCCTGCCAAAAATTTTCCCGCATTTCCCGCCC
AAGCCTGAAGCAGGTGCACG

Downstream 100 bases:

>100_bases
TCGCGAATCGACGGAACGAAGCATGCGCAGAAAGCGAAGCGGCAACGCTTCGCTTTTTGCACAATCGGACGGGATAGACG
AAACCCCGGCCGTTTCATCG

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 320; Mature: 319

Protein sequence:

>320_residues
MSSHSHDGLMVFTGNANPALAQEVVNILGIPLGKAMVSRFSDGEIQVEIQENVRGKDVFVLQSTCAPANDNLMELMIMVD
ALKRASAGRITAAIPYFGYARQDRRPRSARVAISAKIVANMLEIAGVERIITMDLHADQIQGFFDIPVDNIYATPILLGD
LRKQNYSDLLVVSPDVGGVVRARALAKQLNCDLAIIDKRRPKANVAEVMNIIGEVEGRTCVIMDDMVDTAGTLCKAAQVL
KERGAKQVFAYATHPVLSGGAAERIAASELDELVVTDTIPLSAESLACSKIRSLTSASLLAETFSRIRRGDSVMSLFAES

Sequences:

>Translated_320_residues
MSSHSHDGLMVFTGNANPALAQEVVNILGIPLGKAMVSRFSDGEIQVEIQENVRGKDVFVLQSTCAPANDNLMELMIMVD
ALKRASAGRITAAIPYFGYARQDRRPRSARVAISAKIVANMLEIAGVERIITMDLHADQIQGFFDIPVDNIYATPILLGD
LRKQNYSDLLVVSPDVGGVVRARALAKQLNCDLAIIDKRRPKANVAEVMNIIGEVEGRTCVIMDDMVDTAGTLCKAAQVL
KERGAKQVFAYATHPVLSGGAAERIAASELDELVVTDTIPLSAESLACSKIRSLTSASLLAETFSRIRRGDSVMSLFAES
>Mature_319_residues
SSHSHDGLMVFTGNANPALAQEVVNILGIPLGKAMVSRFSDGEIQVEIQENVRGKDVFVLQSTCAPANDNLMELMIMVDA
LKRASAGRITAAIPYFGYARQDRRPRSARVAISAKIVANMLEIAGVERIITMDLHADQIQGFFDIPVDNIYATPILLGDL
RKQNYSDLLVVSPDVGGVVRARALAKQLNCDLAIIDKRRPKANVAEVMNIIGEVEGRTCVIMDDMVDTAGTLCKAAQVLK
ERGAKQVFAYATHPVLSGGAAERIAASELDELVVTDTIPLSAESLACSKIRSLTSASLLAETFSRIRRGDSVMSLFAES

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506129, Length=314, Percent_Identity=47.1337579617834, Blast_Score=299, Evalue=3e-81,
Organism=Homo sapiens, GI4506127, Length=314, Percent_Identity=47.7707006369427, Blast_Score=298, Evalue=3e-81,
Organism=Homo sapiens, GI28557709, Length=314, Percent_Identity=47.7707006369427, Blast_Score=298, Evalue=5e-81,
Organism=Homo sapiens, GI84875539, Length=315, Percent_Identity=46.6666666666667, Blast_Score=297, Evalue=1e-80,
Organism=Homo sapiens, GI4506133, Length=346, Percent_Identity=36.4161849710983, Blast_Score=209, Evalue=3e-54,
Organism=Homo sapiens, GI194018537, Length=345, Percent_Identity=37.3913043478261, Blast_Score=207, Evalue=9e-54,
Organism=Homo sapiens, GI310128524, Length=149, Percent_Identity=36.241610738255, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI310115209, Length=149, Percent_Identity=36.241610738255, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI310118259, Length=149, Percent_Identity=36.241610738255, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI310119946, Length=149, Percent_Identity=36.241610738255, Blast_Score=99, Evalue=5e-21,
Organism=Escherichia coli, GI1787458, Length=310, Percent_Identity=63.2258064516129, Blast_Score=412, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI17554702, Length=314, Percent_Identity=46.8152866242038, Blast_Score=298, Evalue=3e-81,
Organism=Caenorhabditis elegans, GI25149168, Length=314, Percent_Identity=46.8152866242038, Blast_Score=298, Evalue=4e-81,
Organism=Caenorhabditis elegans, GI17554704, Length=311, Percent_Identity=47.2668810289389, Blast_Score=297, Evalue=4e-81,
Organism=Caenorhabditis elegans, GI71989924, Length=314, Percent_Identity=46.8152866242038, Blast_Score=297, Evalue=5e-81,
Organism=Caenorhabditis elegans, GI17570245, Length=339, Percent_Identity=33.3333333333333, Blast_Score=202, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6320946, Length=319, Percent_Identity=42.9467084639498, Blast_Score=265, Evalue=5e-72,
Organism=Saccharomyces cerevisiae, GI6319403, Length=318, Percent_Identity=43.0817610062893, Blast_Score=263, Evalue=3e-71,
Organism=Saccharomyces cerevisiae, GI6321776, Length=300, Percent_Identity=46.3333333333333, Blast_Score=263, Evalue=3e-71,
Organism=Saccharomyces cerevisiae, GI6322667, Length=196, Percent_Identity=43.3673469387755, Blast_Score=160, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6324511, Length=108, Percent_Identity=39.8148148148148, Blast_Score=95, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21355239, Length=313, Percent_Identity=47.6038338658147, Blast_Score=291, Evalue=5e-79,
Organism=Drosophila melanogaster, GI45551540, Length=335, Percent_Identity=44.4776119402985, Blast_Score=282, Evalue=3e-76,
Organism=Drosophila melanogaster, GI24651458, Length=362, Percent_Identity=33.7016574585635, Blast_Score=208, Evalue=3e-54,
Organism=Drosophila melanogaster, GI24651456, Length=362, Percent_Identity=33.7016574585635, Blast_Score=208, Evalue=3e-54,
Organism=Drosophila melanogaster, GI281362873, Length=362, Percent_Identity=33.7016574585635, Blast_Score=207, Evalue=5e-54,
Organism=Drosophila melanogaster, GI24651454, Length=362, Percent_Identity=33.7016574585635, Blast_Score=207, Evalue=5e-54,
Organism=Drosophila melanogaster, GI24651462, Length=210, Percent_Identity=38.0952380952381, Blast_Score=144, Evalue=7e-35,
Organism=Drosophila melanogaster, GI24651464, Length=210, Percent_Identity=38.0952380952381, Blast_Score=144, Evalue=7e-35,
Organism=Drosophila melanogaster, GI45552010, Length=210, Percent_Identity=38.0952380952381, Blast_Score=144, Evalue=8e-35,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 34517; Mature: 34386

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00114 PRPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSHSHDGLMVFTGNANPALAQEVVNILGIPLGKAMVSRFSDGEIQVEIQENVRGKDVFV
CCCCCCCCEEEEECCCCHHHHHHHHHHHCCCHHHHHHHCCCCCEEEEEEECCCCCCEEEE
LQSTCAPANDNLMELMIMVDALKRASAGRITAAIPYFGYARQDRRPRSARVAISAKIVAN
EECCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCHHEEEEHHHHHHH
MLEIAGVERIITMDLHADQIQGFFDIPVDNIYATPILLGDLRKQNYSDLLVVSPDVGGVV
HHHHCCCCEEEEEECCHHHHCCEEECCCCCEEECHHHHHHHHCCCCCCEEEECCCCCHHH
RARALAKQLNCDLAIIDKRRPKANVAEVMNIIGEVEGRTCVIMDDMVDTAGTLCKAAQVL
HHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHH
KERGAKQVFAYATHPVLSGGAAERIAASELDELVVTDTIPLSAESLACSKIRSLTSASLL
HHCCCHHEEHEECCCHHCCCCHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHH
AETFSRIRRGDSVMSLFAES
HHHHHHHHCCCHHHHHHHCC
>Mature Secondary Structure 
SSHSHDGLMVFTGNANPALAQEVVNILGIPLGKAMVSRFSDGEIQVEIQENVRGKDVFV
CCCCCCCEEEEECCCCHHHHHHHHHHHCCCHHHHHHHCCCCCEEEEEEECCCCCCEEEE
LQSTCAPANDNLMELMIMVDALKRASAGRITAAIPYFGYARQDRRPRSARVAISAKIVAN
EECCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCHHEEEEHHHHHHH
MLEIAGVERIITMDLHADQIQGFFDIPVDNIYATPILLGDLRKQNYSDLLVVSPDVGGVV
HHHHCCCCEEEEEECCHHHHCCEEECCCCCEEECHHHHHHHHCCCCCCEEEECCCCCHHH
RARALAKQLNCDLAIIDKRRPKANVAEVMNIIGEVEGRTCVIMDDMVDTAGTLCKAAQVL
HHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHH
KERGAKQVFAYATHPVLSGGAAERIAASELDELVVTDTIPLSAESLACSKIRSLTSASLL
HHCCCHHEEHEECCCHHCCCCHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHH
AETFSRIRRGDSVMSLFAES
HHHHHHHHCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]