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The map label for this gene is kefB [H]

Identifier: 116690805

GI number: 116690805

Start: 3081696

End: 3083702

Strand: Reverse

Name: kefB [H]

Synonym: Bcen2424_2785

Alternate gene names: 116690805

Gene position: 3083702-3081696 (Counterclockwise)

Preceding gene: 116690817

Following gene: 116690804

Centisome position: 88.51

GC content: 68.11

Gene sequence:

>2007_bases
GTGATTTCCCCGCTCGAAATGACCCTGCTGCTGCTGCTGGCCTCAGTGGTGGGCGTCGTCGTATTCCGCTCGTTGAACCT
GCCGCCGATGCTCGGCTACCTGACCGTCGGCATCCTGGTCGGCCCGCACGCATTCGGCGTCGCGGCGGATCTCGAACGGG
CCGAGCACCTCGCGGAATTCGGCGTGGTGTTCCTGATGTTTTCGATCGGCCTCGAATTCTCGCTGGCGAAGCTGAGGTCG
ATGCAGCGGCTCGTGTTCGGCCTCGGCCTCTTGCAGGTCGTCGCGACCCTCGTGCTCGCGCTCGTGCTCGGCGCGCTGTT
CGAGCACTGGGTGCACATCACATGGCAGGGCAGCATCGCGCTCGGCGGCGCGCTCGCGATGTCGTCGACGGCGATCGTGT
CGAAGATGCTCGCCGAGCGGCTCGAGATCGAGACCGAGCACGGCCGCAACATCTTCGGCGTGCTGCTGTTCCAGGATCTC
GCGGTGGTGCCGCTCTTGATCGTGATCGCCGCGTTCGGCGCGGAATCGTCGAAGGATCTCGCGCTCACGCTAGGCTTCGC
GGCGGTCAAGATCGTGATCGCGCTCGCGCTGCTGCTCGTCATCGGCCAGCGCTTCATGACGCGCTGGCTCAACGTCGTCG
CGCGGCGCCGCTCGCAGGAGCTGTTCGTGCTGAACCTGCTGCTCGTCACGCTCGGCGCCGCGTTCATCACCGACCGCTTC
GGGCTGTCGCTCGCGCTCGGCGCGTTCATCGCCGGGATGCTCATTTCCGAGACGCCGTTCCGCCATCAGGTGGAGGAGGA
CATCAAGCCGTTCCGCGACGTGCTGCTCGGCCTGTTCTTCGTGACGACGGGGATGCTGCTCGATCCGCGCGTGATCTGGG
AGCATCCGTTGATCGTGCTCGGCTTCTTCGTCGGGCAGATCCTGTTCAAGGCGACGATGATCGCCGGGCTCGCGCGGCTG
TTCGGCGCGACGCCGGGCGTCGCGATGCGCACCGGCATCGGCCTCGCGCAGGCCGGCGAATTCGGCTTCGTGCTGCTGAA
CCTGATCCTCGACCGGCATCTCGTCGATTCGACGCTGCTGCAGGCGATCCTCGCGTCGATGCTGCTGTCGATGCTCGCCG
CGCCGTTCCTGATCCAGAACGCCGACCGCATCGTGATGCGGCTGTCGTCGACGGAATGGATGCAGCAGTCGCTGCAGATG
ACGCGGATCGCGACGCAAAGCCTCAAGCAGCGCGGCCACGTGATCATCTGCGGCTACGGCCGCGCCGGGCAGAACCTCGC
GCGCATGCTCGAACAGGAAGGCATTTCGTACGTCGCGCTCGACCTCGACCCCGATCGCGTGAGTGCTGCGGCGACCGCCG
GCGAATCGGTCGTGTTCGGCGACGCGGCGCGCCGCGAGTCGCTGCTCGCGGCCGGTATCCACCGGGCGGCGGCCGTCGCG
ATTACCTACGCGAACACGCCGTCCGCGCTGCGCGTGCTGCATCACGTGCACGAGCTCGAGCCGACGCTGCCCGCGATCGT
GCGTACCGTCGACGATGCCGATCTCGAGAAGCTGCTTGCTGCCGGCGCGACCGAGGTGATTCCGGAGATCGTCGAGGGCA
GCCTGATGCTCGCGTCGCACACGCTGGTGCTGGTCGGCGTGCCGATGCGCAAGGTCGTGCGGCGCGTCGAGGAGATGCGC
GACGAGCGCTACAGCCTGCTGCGCGGCTATTTCCGCGGCGCGGACGATGCGGACGACGACGATCACGAGCAGGTGCGGCT
ACAATCGGTGCCGGTCGATGCGCGCGCGGACGCGGTCGGGCGTTCGCTGGAAGAACTCGGGCTGTACGCGCTCGGGCTGG
AAGTCACGGCGATCCGCCGGCACGGCATCCGCGGCGTCGAACCCGATCCGCAGACCAAGCTGCGCGCGAGCGACATCGTG
GTGCTGCGCGGGCTGCCCGAGGCGCTCGCGCTCGCGGAGGAGCGGTTGTCGCGCCATCGGCGCGATCCGCCGGCCGCGGT
TGCGTGA

Upstream 100 bases:

>100_bases
GTTCGCCGCGCCGGCCTTCGGACTCGTCCGAAGCAGCCTGTCCACCGCCACCACCCGCGCCCGCATTGCCGTGGCCCCGA
CGAACGAGGATGCTTCGCCT

Downstream 100 bases:

>100_bases
GCCGCGATTCACAACCCGACCCGTATTGATCAGAAACGGTGCCCGATCTTCGCGCACCGTTTTTTTCGGAGAGTTTCATG
CCGCATTCGTCGCCGGGCGC

Product: sodium/hydrogen exchanger

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter; NEM-activatable K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 668; Mature: 668

Protein sequence:

>668_residues
MISPLEMTLLLLLASVVGVVVFRSLNLPPMLGYLTVGILVGPHAFGVAADLERAEHLAEFGVVFLMFSIGLEFSLAKLRS
MQRLVFGLGLLQVVATLVLALVLGALFEHWVHITWQGSIALGGALAMSSTAIVSKMLAERLEIETEHGRNIFGVLLFQDL
AVVPLLIVIAAFGAESSKDLALTLGFAAVKIVIALALLLVIGQRFMTRWLNVVARRRSQELFVLNLLLVTLGAAFITDRF
GLSLALGAFIAGMLISETPFRHQVEEDIKPFRDVLLGLFFVTTGMLLDPRVIWEHPLIVLGFFVGQILFKATMIAGLARL
FGATPGVAMRTGIGLAQAGEFGFVLLNLILDRHLVDSTLLQAILASMLLSMLAAPFLIQNADRIVMRLSSTEWMQQSLQM
TRIATQSLKQRGHVIICGYGRAGQNLARMLEQEGISYVALDLDPDRVSAAATAGESVVFGDAARRESLLAAGIHRAAAVA
ITYANTPSALRVLHHVHELEPTLPAIVRTVDDADLEKLLAAGATEVIPEIVEGSLMLASHTLVLVGVPMRKVVRRVEEMR
DERYSLLRGYFRGADDADDDDHEQVRLQSVPVDARADAVGRSLEELGLYALGLEVTAIRRHGIRGVEPDPQTKLRASDIV
VLRGLPEALALAEERLSRHRRDPPAAVA

Sequences:

>Translated_668_residues
MISPLEMTLLLLLASVVGVVVFRSLNLPPMLGYLTVGILVGPHAFGVAADLERAEHLAEFGVVFLMFSIGLEFSLAKLRS
MQRLVFGLGLLQVVATLVLALVLGALFEHWVHITWQGSIALGGALAMSSTAIVSKMLAERLEIETEHGRNIFGVLLFQDL
AVVPLLIVIAAFGAESSKDLALTLGFAAVKIVIALALLLVIGQRFMTRWLNVVARRRSQELFVLNLLLVTLGAAFITDRF
GLSLALGAFIAGMLISETPFRHQVEEDIKPFRDVLLGLFFVTTGMLLDPRVIWEHPLIVLGFFVGQILFKATMIAGLARL
FGATPGVAMRTGIGLAQAGEFGFVLLNLILDRHLVDSTLLQAILASMLLSMLAAPFLIQNADRIVMRLSSTEWMQQSLQM
TRIATQSLKQRGHVIICGYGRAGQNLARMLEQEGISYVALDLDPDRVSAAATAGESVVFGDAARRESLLAAGIHRAAAVA
ITYANTPSALRVLHHVHELEPTLPAIVRTVDDADLEKLLAAGATEVIPEIVEGSLMLASHTLVLVGVPMRKVVRRVEEMR
DERYSLLRGYFRGADDADDDDHEQVRLQSVPVDARADAVGRSLEELGLYALGLEVTAIRRHGIRGVEPDPQTKLRASDIV
VLRGLPEALALAEERLSRHRRDPPAAVA
>Mature_668_residues
MISPLEMTLLLLLASVVGVVVFRSLNLPPMLGYLTVGILVGPHAFGVAADLERAEHLAEFGVVFLMFSIGLEFSLAKLRS
MQRLVFGLGLLQVVATLVLALVLGALFEHWVHITWQGSIALGGALAMSSTAIVSKMLAERLEIETEHGRNIFGVLLFQDL
AVVPLLIVIAAFGAESSKDLALTLGFAAVKIVIALALLLVIGQRFMTRWLNVVARRRSQELFVLNLLLVTLGAAFITDRF
GLSLALGAFIAGMLISETPFRHQVEEDIKPFRDVLLGLFFVTTGMLLDPRVIWEHPLIVLGFFVGQILFKATMIAGLARL
FGATPGVAMRTGIGLAQAGEFGFVLLNLILDRHLVDSTLLQAILASMLLSMLAAPFLIQNADRIVMRLSSTEWMQQSLQM
TRIATQSLKQRGHVIICGYGRAGQNLARMLEQEGISYVALDLDPDRVSAAATAGESVVFGDAARRESLLAAGIHRAAAVA
ITYANTPSALRVLHHVHELEPTLPAIVRTVDDADLEKLLAAGATEVIPEIVEGSLMLASHTLVLVGVPMRKVVRRVEEMR
DERYSLLRGYFRGADDADDDDHEQVRLQSVPVDARADAVGRSLEELGLYALGLEVTAIRRHGIRGVEPDPQTKLRASDIV
VLRGLPEALALAEERLSRHRRDPPAAVA

Specific function: Transport system that facilitates potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=343, Percent_Identity=28.2798833819242, Blast_Score=103, Evalue=5e-22,
Organism=Escherichia coli, GI1786232, Length=512, Percent_Identity=33.3984375, Blast_Score=244, Evalue=2e-65,
Organism=Escherichia coli, GI1789749, Length=550, Percent_Identity=32, Blast_Score=239, Evalue=6e-64,
Organism=Escherichia coli, GI1786685, Length=535, Percent_Identity=30.0934579439252, Blast_Score=199, Evalue=5e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR020884
- InterPro:   IPR004771
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 72580; Mature: 72580

Theoretical pI: Translated: 6.47; Mature: 6.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISPLEMTLLLLLASVVGVVVFRSLNLPPMLGYLTVGILVGPHAFGVAADLERAEHLAEF
CCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
GVVFLMFSIGLEFSLAKLRSMQRLVFGLGLLQVVATLVLALVLGALFEHWVHITWQGSIA
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCEE
LGGALAMSSTAIVSKMLAERLEIETEHGRNIFGVLLFQDLAVVPLLIVIAAFGAESSKDL
ECHHHHHHHHHHHHHHHHHHHHCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
ALTLGFAAVKIVIALALLLVIGQRFMTRWLNVVARRRSQELFVLNLLLVTLGAAFITDRF
EEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
GLSLALGAFIAGMLISETPFRHQVEEDIKPFRDVLLGLFFVTTGMLLDPRVIWEHPLIVL
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCHHHHH
GFFVGQILFKATMIAGLARLFGATPGVAMRTGIGLAQAGEFGFVLLNLILDRHLVDSTLL
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCHHCCCCHHHHHHHHHHHHHHHHHHHH
QAILASMLLSMLAAPFLIQNADRIVMRLSSTEWMQQSLQMTRIATQSLKQRGHVIICGYG
HHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECC
RAGQNLARMLEQEGISYVALDLDPDRVSAAATAGESVVFGDAARRESLLAAGIHRAAAVA
CCCHHHHHHHHHCCCCEEEEECCHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHEEE
ITYANTPSALRVLHHVHELEPTLPAIVRTVDDADLEKLLAAGATEVIPEIVEGSLMLASH
EEECCCHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHCCCHHEEEC
TLVLVGVPMRKVVRRVEEMRDERYSLLRGYFRGADDADDDDHEQVRLQSVPVDARADAVG
CEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHEEHHCCCCCCHHHHHH
RSLEELGLYALGLEVTAIRRHGIRGVEPDPQTKLRASDIVVLRGLPEALALAEERLSRHR
CCHHHHCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHC
RDPPAAVA
CCCCCCCC
>Mature Secondary Structure
MISPLEMTLLLLLASVVGVVVFRSLNLPPMLGYLTVGILVGPHAFGVAADLERAEHLAEF
CCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
GVVFLMFSIGLEFSLAKLRSMQRLVFGLGLLQVVATLVLALVLGALFEHWVHITWQGSIA
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCEE
LGGALAMSSTAIVSKMLAERLEIETEHGRNIFGVLLFQDLAVVPLLIVIAAFGAESSKDL
ECHHHHHHHHHHHHHHHHHHHHCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
ALTLGFAAVKIVIALALLLVIGQRFMTRWLNVVARRRSQELFVLNLLLVTLGAAFITDRF
EEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
GLSLALGAFIAGMLISETPFRHQVEEDIKPFRDVLLGLFFVTTGMLLDPRVIWEHPLIVL
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCHHHHH
GFFVGQILFKATMIAGLARLFGATPGVAMRTGIGLAQAGEFGFVLLNLILDRHLVDSTLL
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCHHCCCCHHHHHHHHHHHHHHHHHHHH
QAILASMLLSMLAAPFLIQNADRIVMRLSSTEWMQQSLQMTRIATQSLKQRGHVIICGYG
HHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECC
RAGQNLARMLEQEGISYVALDLDPDRVSAAATAGESVVFGDAARRESLLAAGIHRAAAVA
CCCHHHHHHHHHCCCCEEEEECCHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHEEE
ITYANTPSALRVLHHVHELEPTLPAIVRTVDDADLEKLLAAGATEVIPEIVEGSLMLASH
EEECCCHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHCCCHHEEEC
TLVLVGVPMRKVVRRVEEMRDERYSLLRGYFRGADDADDDDHEQVRLQSVPVDARADAVG
CEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHEEHHCCCCCCHHHHHH
RSLEELGLYALGLEVTAIRRHGIRGVEPDPQTKLRASDIVVLRGLPEALALAEERLSRHR
CCHHHHCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHC
RDPPAAVA
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA