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The map label for this gene is apt [H]

Identifier: 116690804

GI number: 116690804

Start: 3081052

End: 3081618

Strand: Reverse

Name: apt [H]

Synonym: Bcen2424_2784

Alternate gene names: 116690804

Gene position: 3081618-3081052 (Counterclockwise)

Preceding gene: 116690805

Following gene: 116690803

Centisome position: 88.45

GC content: 66.31

Gene sequence:

>567_bases
ATGCCGCATTCGTCGCCGGGCGCACCGCTCGATCCGGTCGCCTTCATCCACAGCCAGATCCGCACGGTGCCCGACTGGCC
GCAGCCCGGCGTGCAGTTCCGCGACATTACGACGCTGCTGCAGAGCCCGAAGGCGCTGCGCATCCTCGTCGACCTGTTCG
TCGAACGCTATGTCGACGCGAAGCTCGACTACGTCGCGGGGCTCGATGCGCGCGGCTTCATCATCGCGCCGATCGTCGCA
TACGAGCTGAGCGTCGGCTTCGTGCCGATCCGCAAGGTCGGCAAGCTGCCGTACAAGACGCGTTCGGAGTCGTACGACCT
CGAATACGGCAGCGCGACGGTCGAGATCCACGAAGATGCGTGCAAGCCCGGCGACCGCGTGATCATCATGGACGACCTGA
TCGCGACCGGCGGCACGATGATGGCGGGGCGCAACCTGCTGCAGCGGCTCGGCGCGGAGGTCGTCGAAGGCGCGGCGATC
ATCGACCTGCCGGACCTTGGCGGCTCGACGCTGCTGCGCAACGCCGGACTGACGGTCTATACCGTTACCGAATTTTCCGG
CCACTGA

Upstream 100 bases:

>100_bases
ATCCGCCGGCCGCGGTTGCGTGAGCCGCGATTCACAACCCGACCCGTATTGATCAGAAACGGTGCCCGATCTTCGCGCAC
CGTTTTTTTCGGAGAGTTTC

Downstream 100 bases:

>100_bases
ACGCCGGTCGTCGGGGTTTGCCGTCCCGGCTGGCCTCGGTTCACGCTCGGTTCACCGCTTGGTTCACCTTCCGCAGCGAG
GTCACGATGCCCAACTTCAT

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT [H]

Number of amino acids: Translated: 188; Mature: 187

Protein sequence:

>188_residues
MPHSSPGAPLDPVAFIHSQIRTVPDWPQPGVQFRDITTLLQSPKALRILVDLFVERYVDAKLDYVAGLDARGFIIAPIVA
YELSVGFVPIRKVGKLPYKTRSESYDLEYGSATVEIHEDACKPGDRVIIMDDLIATGGTMMAGRNLLQRLGAEVVEGAAI
IDLPDLGGSTLLRNAGLTVYTVTEFSGH

Sequences:

>Translated_188_residues
MPHSSPGAPLDPVAFIHSQIRTVPDWPQPGVQFRDITTLLQSPKALRILVDLFVERYVDAKLDYVAGLDARGFIIAPIVA
YELSVGFVPIRKVGKLPYKTRSESYDLEYGSATVEIHEDACKPGDRVIIMDDLIATGGTMMAGRNLLQRLGAEVVEGAAI
IDLPDLGGSTLLRNAGLTVYTVTEFSGH
>Mature_187_residues
PHSSPGAPLDPVAFIHSQIRTVPDWPQPGVQFRDITTLLQSPKALRILVDLFVERYVDAKLDYVAGLDARGFIIAPIVAY
ELSVGFVPIRKVGKLPYKTRSESYDLEYGSATVEIHEDACKPGDRVIIMDDLIATGGTMMAGRNLLQRLGAEVVEGAAII
DLPDLGGSTLLRNAGLTVYTVTEFSGH

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis [H]

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4502171, Length=164, Percent_Identity=47.5609756097561, Blast_Score=149, Evalue=1e-36,
Organism=Homo sapiens, GI71773201, Length=129, Percent_Identity=48.062015503876, Blast_Score=124, Evalue=5e-29,
Organism=Escherichia coli, GI1786675, Length=176, Percent_Identity=51.1363636363636, Blast_Score=188, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI17509087, Length=165, Percent_Identity=44.8484848484849, Blast_Score=130, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6323619, Length=164, Percent_Identity=37.1951219512195, Blast_Score=108, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6320649, Length=161, Percent_Identity=34.1614906832298, Blast_Score=87, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17136334, Length=164, Percent_Identity=39.6341463414634, Blast_Score=123, Evalue=6e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005764
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.7 [H]

Molecular weight: Translated: 20421; Mature: 20290

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPHSSPGAPLDPVAFIHSQIRTVPDWPQPGVQFRDITTLLQSPKALRILVDLFVERYVDA
CCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCC
KLDYVAGLDARGFIIAPIVAYELSVGFVPIRKVGKLPYKTRSESYDLEYGSATVEIHEDA
HHHHHHCCCCCCEEEHHHHHHHHHCCCEEHHHHCCCCCCCCCCCCCEECCCEEEEEECCC
CKPGDRVIIMDDLIATGGTMMAGRNLLQRLGAEVVEGAAIIDLPDLGGSTLLRNAGLTVY
CCCCCEEEEEECHHHCCCHHHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHCCCCEEE
TVTEFSGH
EEECCCCC
>Mature Secondary Structure 
PHSSPGAPLDPVAFIHSQIRTVPDWPQPGVQFRDITTLLQSPKALRILVDLFVERYVDA
CCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCC
KLDYVAGLDARGFIIAPIVAYELSVGFVPIRKVGKLPYKTRSESYDLEYGSATVEIHEDA
HHHHHHCCCCCCEEEHHHHHHHHHCCCEEHHHHCCCCCCCCCCCCCEECCCEEEEEECCC
CKPGDRVIIMDDLIATGGTMMAGRNLLQRLGAEVVEGAAIIDLPDLGGSTLLRNAGLTVY
CCCCCEEEEEECHHHCCCHHHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHCCCCEEE
TVTEFSGH
EEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA