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The map label for this gene is fadA [H]

Identifier: 116690739

GI number: 116690739

Start: 3011480

End: 3012679

Strand: Reverse

Name: fadA [H]

Synonym: Bcen2424_2719

Alternate gene names: 116690739

Gene position: 3012679-3011480 (Counterclockwise)

Preceding gene: 116690740

Following gene: 116690738

Centisome position: 86.47

GC content: 67.92

Gene sequence:

>1200_bases
ATGAGCAAACAACTGCAAGACGCATACATCGTCGCCGCCAGCCGCACGCCGATCGGCAAGGCCCCGCGCGGTGTCTTCAA
GAACACGCGCCCCGACGAGCTGCTGGTTCACGCGATCAAGTCGGCCGTCGCGCAGGTGCCCGGTCTCGACACGAAGGTGA
TCGAGGACGCGATCATCGGCTGCGCGATTCCGGAAGCCGAGCAGGGCCTGAACGTCGCGCGCATGGGCGCGCTGCTCGCC
GGGCTGCCGCAGACGGTCGGCGGCGTGACGGTCAACCGCTTCTGCGCGTCGGGCATCACCGCGCTCGCGATGGCGGCCGA
CCGCATCCGTGTGGGCGAATCGGACGCGATCTTCGCGGGCGGCTGCGAATCGATGAGCATGGTGCCGATGATGGGCAACA
AGCCGTCGATGTCGCCGCACATCTTCGATCGCAGCGAAGACTTCGGCATCGCGTACGGGATGGGCCTGACGGCCGAGCGC
GTCGCCGAACAGTGGAAGGTGAGCCGCGACGACCAGGACGCGTTCTCGGTCGAGTCGCACCGCAAGGCGCTCGCCGCGCA
GCAGGCCGGCGAGTTCGGCGACGAAATCGCTGCGTACACGATCACCGAGCGGTTCCCGAACCTCGCGACCGGTGAGGTCG
ACGTGAAGACGCGCGAGATCAAGCTCGACGAAGGTCCGCGCGCGGATACGTCGCTCGAAGGTCTCGCGAAGCTGCGCACG
GTATTCGCGAACAAGGGCTCGGTCACGGCCGGCAACAGCTCGCAGACGTCGGACGGCGCGGGTGCGCTGCTCGTCGTGTC
GGAGAAGGTGCTGAAGGAATTCAACCTGACGCCGCTCGCGCGCTTCGTGAGCTTCGCGGTGCGCGGCGTGCCGCCGGAAA
TCATGGGGATCGGTCCGAAGGAAGCGATTCCGGCCGCGCTGAAGGCCGCGGGCCTGAAGCAGGACGATCTCGACTGGATC
GAGCTGAACGAAGCGTTCGCCGCGCAATCGCTGGCGGTGATGCGCGATCTCGGCCTCGATCCGTCGAAGGTCAACCCGAT
GGGCGGCGCGATCGCACTGGGCCACCCGCTCGGCGCGACCGGCGCGATCCGCGCGGCGACCGTCGTGCACGGCCTGCGCC
GCCGCAACCTGAAGTACGGGATGGTCACGATGTGCGTCGGCACCGGCATGGGTGCGGCGGGCATCATCGAACGCCTGTAA

Upstream 100 bases:

>100_bases
GTCGAGCTGCTCGGTACGCAGAAGACGCAGGAACGGATCATGGGCATGTTGCAGACCGGCAAGCCGGTGCGTAACTGAGC
GAGCAGACAAGGAGTCTGAA

Downstream 100 bases:

>100_bases
GCGGGACACGACGAGAAGCGACGACGGTGCGCGGGCCACGAGCTCGCGCACCGTTTTTTCATTCCGGTAGAGACAGTTCA
AGGAGACGGTTGTGGCCGAC

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 399; Mature: 398

Protein sequence:

>399_residues
MSKQLQDAYIVAASRTPIGKAPRGVFKNTRPDELLVHAIKSAVAQVPGLDTKVIEDAIIGCAIPEAEQGLNVARMGALLA
GLPQTVGGVTVNRFCASGITALAMAADRIRVGESDAIFAGGCESMSMVPMMGNKPSMSPHIFDRSEDFGIAYGMGLTAER
VAEQWKVSRDDQDAFSVESHRKALAAQQAGEFGDEIAAYTITERFPNLATGEVDVKTREIKLDEGPRADTSLEGLAKLRT
VFANKGSVTAGNSSQTSDGAGALLVVSEKVLKEFNLTPLARFVSFAVRGVPPEIMGIGPKEAIPAALKAAGLKQDDLDWI
ELNEAFAAQSLAVMRDLGLDPSKVNPMGGAIALGHPLGATGAIRAATVVHGLRRRNLKYGMVTMCVGTGMGAAGIIERL

Sequences:

>Translated_399_residues
MSKQLQDAYIVAASRTPIGKAPRGVFKNTRPDELLVHAIKSAVAQVPGLDTKVIEDAIIGCAIPEAEQGLNVARMGALLA
GLPQTVGGVTVNRFCASGITALAMAADRIRVGESDAIFAGGCESMSMVPMMGNKPSMSPHIFDRSEDFGIAYGMGLTAER
VAEQWKVSRDDQDAFSVESHRKALAAQQAGEFGDEIAAYTITERFPNLATGEVDVKTREIKLDEGPRADTSLEGLAKLRT
VFANKGSVTAGNSSQTSDGAGALLVVSEKVLKEFNLTPLARFVSFAVRGVPPEIMGIGPKEAIPAALKAAGLKQDDLDWI
ELNEAFAAQSLAVMRDLGLDPSKVNPMGGAIALGHPLGATGAIRAATVVHGLRRRNLKYGMVTMCVGTGMGAAGIIERL
>Mature_398_residues
SKQLQDAYIVAASRTPIGKAPRGVFKNTRPDELLVHAIKSAVAQVPGLDTKVIEDAIIGCAIPEAEQGLNVARMGALLAG
LPQTVGGVTVNRFCASGITALAMAADRIRVGESDAIFAGGCESMSMVPMMGNKPSMSPHIFDRSEDFGIAYGMGLTAERV
AEQWKVSRDDQDAFSVESHRKALAAQQAGEFGDEIAAYTITERFPNLATGEVDVKTREIKLDEGPRADTSLEGLAKLRTV
FANKGSVTAGNSSQTSDGAGALLVVSEKVLKEFNLTPLARFVSFAVRGVPPEIMGIGPKEAIPAALKAAGLKQDDLDWIE
LNEAFAAQSLAVMRDLGLDPSKVNPMGGAIALGHPLGATGAIRAATVVHGLRRRNLKYGMVTMCVGTGMGAAGIIERL

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=392, Percent_Identity=43.6224489795918, Blast_Score=286, Evalue=3e-77,
Organism=Homo sapiens, GI167614485, Length=407, Percent_Identity=38.8206388206388, Blast_Score=265, Evalue=7e-71,
Organism=Homo sapiens, GI148539872, Length=341, Percent_Identity=39.8826979472141, Blast_Score=231, Evalue=8e-61,
Organism=Homo sapiens, GI4557237, Length=405, Percent_Identity=36.2962962962963, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI194353979, Length=392, Percent_Identity=33.6734693877551, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI4504327, Length=440, Percent_Identity=31.1363636363636, Blast_Score=151, Evalue=8e-37,
Organism=Escherichia coli, GI1787663, Length=412, Percent_Identity=43.6893203883495, Blast_Score=299, Evalue=2e-82,
Organism=Escherichia coli, GI48994986, Length=402, Percent_Identity=42.5373134328358, Blast_Score=278, Evalue=5e-76,
Organism=Escherichia coli, GI1788554, Length=406, Percent_Identity=39.9014778325123, Blast_Score=258, Evalue=4e-70,
Organism=Escherichia coli, GI87082165, Length=404, Percent_Identity=39.3564356435644, Blast_Score=252, Evalue=4e-68,
Organism=Escherichia coli, GI1788683, Length=379, Percent_Identity=32.4538258575198, Blast_Score=157, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI133906874, Length=401, Percent_Identity=41.645885286783, Blast_Score=275, Evalue=3e-74,
Organism=Caenorhabditis elegans, GI25147385, Length=402, Percent_Identity=33.3333333333333, Blast_Score=205, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI17535921, Length=407, Percent_Identity=36.1179361179361, Blast_Score=198, Evalue=4e-51,
Organism=Caenorhabditis elegans, GI17551802, Length=441, Percent_Identity=30.6122448979592, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17535917, Length=398, Percent_Identity=30.1507537688442, Blast_Score=155, Evalue=5e-38,
Organism=Saccharomyces cerevisiae, GI6322031, Length=407, Percent_Identity=39.8034398034398, Blast_Score=273, Evalue=4e-74,
Organism=Saccharomyces cerevisiae, GI6325229, Length=407, Percent_Identity=39.0663390663391, Blast_Score=233, Evalue=5e-62,
Organism=Drosophila melanogaster, GI24655093, Length=404, Percent_Identity=38.6138613861386, Blast_Score=254, Evalue=5e-68,
Organism=Drosophila melanogaster, GI17648125, Length=410, Percent_Identity=39.2682926829268, Blast_Score=251, Evalue=7e-67,
Organism=Drosophila melanogaster, GI24640423, Length=409, Percent_Identity=33.9853300733496, Blast_Score=205, Evalue=5e-53,
Organism=Drosophila melanogaster, GI17137578, Length=442, Percent_Identity=32.1266968325792, Blast_Score=157, Evalue=1e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 41929; Mature: 41798

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKQLQDAYIVAASRTPIGKAPRGVFKNTRPDELLVHAIKSAVAQVPGLDTKVIEDAIIG
CCCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
CAIPEAEQGLNVARMGALLAGLPQTVGGVTVNRFCASGITALAMAADRIRVGESDAIFAG
CCCCCHHHCCCHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEC
GCESMSMVPMMGNKPSMSPHIFDRSEDFGIAYGMGLTAERVAEQWKVSRDDQDAFSVESH
CCCCCEECCCCCCCCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHCCCCCCCHHHHHHHH
RKALAAQQAGEFGDEIAAYTITERFPNLATGEVDVKTREIKLDEGPRADTSLEGLAKLRT
HHHHHHHHHHHHHHHHHHEEHHHHCCCCCCCEEEEEEEEEEECCCCCCCCHHHHHHHHHH
VFANKGSVTAGNSSQTSDGAGALLVVSEKVLKEFNLTPLARFVSFAVRGVPPEIMGIGPK
HHHCCCCEECCCCCCCCCCCCEEEEEEHHHHHHCCCCHHHHHHHHHHCCCCHHHHCCCCH
EAIPAALKAAGLKQDDLDWIELNEAFAAQSLAVMRDLGLDPSKVNPMGGAIALGHPLGAT
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCC
GAIRAATVVHGLRRRNLKYGMVTMCVGTGMGAAGIIERL
HHHHHHHHHHHHHHCCCCCCCEEEEHHCCCCHHHHHHCC
>Mature Secondary Structure 
SKQLQDAYIVAASRTPIGKAPRGVFKNTRPDELLVHAIKSAVAQVPGLDTKVIEDAIIG
CCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
CAIPEAEQGLNVARMGALLAGLPQTVGGVTVNRFCASGITALAMAADRIRVGESDAIFAG
CCCCCHHHCCCHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEC
GCESMSMVPMMGNKPSMSPHIFDRSEDFGIAYGMGLTAERVAEQWKVSRDDQDAFSVESH
CCCCCEECCCCCCCCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHCCCCCCCHHHHHHHH
RKALAAQQAGEFGDEIAAYTITERFPNLATGEVDVKTREIKLDEGPRADTSLEGLAKLRT
HHHHHHHHHHHHHHHHHHEEHHHHCCCCCCCEEEEEEEEEEECCCCCCCCHHHHHHHHHH
VFANKGSVTAGNSSQTSDGAGALLVVSEKVLKEFNLTPLARFVSFAVRGVPPEIMGIGPK
HHHCCCCEECCCCCCCCCCCCEEEEEEHHHHHHCCCCHHHHHHHHHHCCCCHHHHCCCCH
EAIPAALKAAGLKQDDLDWIELNEAFAAQSLAVMRDLGLDPSKVNPMGGAIALGHPLGAT
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCC
GAIRAATVVHGLRRRNLKYGMVTMCVGTGMGAAGIIERL
HHHHHHHHHHHHHHCCCCCCCEEEEHHCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]