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The map label for this gene is mdtD [H]

Identifier: 116690556

GI number: 116690556

Start: 2811848

End: 2813284

Strand: Direct

Name: mdtD [H]

Synonym: Bcen2424_2536

Alternate gene names: 116690556

Gene position: 2811848-2813284 (Clockwise)

Preceding gene: 116690554

Following gene: 116690557

Centisome position: 80.71

GC content: 67.22

Gene sequence:

>1437_bases
ATGTTCCAACGCCCGCCCGCCGCCGCTCCCGGCGAAAAGAACCTCACCGTGATGCTCTGGCTCGTTGCGACGGGCTTCTT
CATGCAGACGCTCGACGCGACGATCGTCAACACGGCGCTGCCGTCGATGGCCGCGAGCCTCGGCGAATCGCCGCTGCGAA
TGCAATCGGTCGTGATCGCATACTCGCTGACAATGGCGGTGATGATTCCCGTGTCGGGGTGGCTCGCCGATACGTTCGGC
ACGCGGCGCGTGTTCTTCAGCGCGATCCTGGTGTTCTCGCTCGGCTCGCTGCTGTGCGCGAACGCGCATACGCTGACGCA
ACTCGTCGCGTTCCGCGTGGTGCAGGGGGTCGGCGGCGCGATGCTGCTGCCGGTCGGGCGGCTCGCGGTGCTGCGCACCT
TTCCGGCCGAACGCTACCTGCCCGCGCTGTCGTTCGTCGCGATTCCGGGCCTGATCGGCCCGCTGATCGGGCCGACGCTC
GGCGGCTGGCTCGTGAAGATCGCGTCGTGGCACTGGATCTTCCTGATCAACGTGCCGGTCGGCGTCGCGGGCTGCATCGC
GACCTTCTATTCGATGCCCGACTCGCGCAACCCGGCCGCCGGCCGCTTCGACCTGAAGGGCTATCTGCTGCTGACGATCG
GCATGGTCGCGATCTCGCTGTCGCTCGACGGGCTCGCCGATCTCGGCATGCAGCACGCGGCCGTGCTGGTGCTGCTGATC
CTGAGCCTCGCGTGCTTCGTCGCGTACGGACTGTACGCGGTGCGCGCGCCGCAGCCGATCTTCTCGCTGGAGCTGTTCAA
GATCCACACGTTCAGCGTCGGGCTGCTCGGCAACCTGTTCGCGCGGATCGGCAGCGGCGCGATGCCGTACCTGATCCCGC
TGCTGCTGCAGGTGAGCCTCGGCTACTCGGCGTTCGAGGCCGGGCTGATGATGCTGCCGGTCGCGGCGGCCGGCATGTTC
TCGAAGCGGATCATCACGCGGCTGATCACGCAGCACGGCTATCGCAAGGTGCTGCTCGCGAACACGATCATGGTCGGCGT
GATGATGGCGAGCTTCGCGCTGATGCGCGACACGGTGCCGGTGTGGGTGAAGGTCGTGCATCTCGCGCTGTTCGGCGGCT
TCAACTCGATGCAGTTCACCGCGATGAACACGTTGACGCTGAAGGATCTCGGCACCGGCGGCGCGAGCAGCGGCAACAGC
CTGTTCTCGCTCGTGCAGATGCTGTCGATGAGCCTCGGCGTCACGGTCGCCGGCGCGCTGCTCGCAACGTTCACCGGCAT
GCTGCGCACCGTGACGCCGAGCAACACGCTGCCGGCGTTCCATGCGACCTTCATCTGCGTCGGGATCATCACGGCCGCGT
CCGCGTGGATCTTCGCGCAGCTCGCACCCGAGATCCGCAGCACCGCGCGCAAGACCGACCCGTCCGAGCGCGCGTGA

Upstream 100 bases:

>100_bases
CCAGTCCGGTCGGCGGCCACACGACATACCGCGCCGAACCTGCACGGCGCGGCGGCTTTCCCTACAATGTCGGCTGTCCC
GCGCCACCGCCCCCGCCGTC

Downstream 100 bases:

>100_bases
CGCGCGGCGCGCGCCGAATCGGGCCGGAACGCACCATCGCGGTGCAACGCGGCCCGACACGCGTGCGCATGTCGGCAGCG
GCGGGCGGCCGCACACGGCG

Product: EmrB/QacA family drug resistance transporter

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 478; Mature: 478

Protein sequence:

>478_residues
MFQRPPAAAPGEKNLTVMLWLVATGFFMQTLDATIVNTALPSMAASLGESPLRMQSVVIAYSLTMAVMIPVSGWLADTFG
TRRVFFSAILVFSLGSLLCANAHTLTQLVAFRVVQGVGGAMLLPVGRLAVLRTFPAERYLPALSFVAIPGLIGPLIGPTL
GGWLVKIASWHWIFLINVPVGVAGCIATFYSMPDSRNPAAGRFDLKGYLLLTIGMVAISLSLDGLADLGMQHAAVLVLLI
LSLACFVAYGLYAVRAPQPIFSLELFKIHTFSVGLLGNLFARIGSGAMPYLIPLLLQVSLGYSAFEAGLMMLPVAAAGMF
SKRIITRLITQHGYRKVLLANTIMVGVMMASFALMRDTVPVWVKVVHLALFGGFNSMQFTAMNTLTLKDLGTGGASSGNS
LFSLVQMLSMSLGVTVAGALLATFTGMLRTVTPSNTLPAFHATFICVGIITAASAWIFAQLAPEIRSTARKTDPSERA

Sequences:

>Translated_478_residues
MFQRPPAAAPGEKNLTVMLWLVATGFFMQTLDATIVNTALPSMAASLGESPLRMQSVVIAYSLTMAVMIPVSGWLADTFG
TRRVFFSAILVFSLGSLLCANAHTLTQLVAFRVVQGVGGAMLLPVGRLAVLRTFPAERYLPALSFVAIPGLIGPLIGPTL
GGWLVKIASWHWIFLINVPVGVAGCIATFYSMPDSRNPAAGRFDLKGYLLLTIGMVAISLSLDGLADLGMQHAAVLVLLI
LSLACFVAYGLYAVRAPQPIFSLELFKIHTFSVGLLGNLFARIGSGAMPYLIPLLLQVSLGYSAFEAGLMMLPVAAAGMF
SKRIITRLITQHGYRKVLLANTIMVGVMMASFALMRDTVPVWVKVVHLALFGGFNSMQFTAMNTLTLKDLGTGGASSGNS
LFSLVQMLSMSLGVTVAGALLATFTGMLRTVTPSNTLPAFHATFICVGIITAASAWIFAQLAPEIRSTARKTDPSERA
>Mature_478_residues
MFQRPPAAAPGEKNLTVMLWLVATGFFMQTLDATIVNTALPSMAASLGESPLRMQSVVIAYSLTMAVMIPVSGWLADTFG
TRRVFFSAILVFSLGSLLCANAHTLTQLVAFRVVQGVGGAMLLPVGRLAVLRTFPAERYLPALSFVAIPGLIGPLIGPTL
GGWLVKIASWHWIFLINVPVGVAGCIATFYSMPDSRNPAAGRFDLKGYLLLTIGMVAISLSLDGLADLGMQHAAVLVLLI
LSLACFVAYGLYAVRAPQPIFSLELFKIHTFSVGLLGNLFARIGSGAMPYLIPLLLQVSLGYSAFEAGLMMLPVAAAGMF
SKRIITRLITQHGYRKVLLANTIMVGVMMASFALMRDTVPVWVKVVHLALFGGFNSMQFTAMNTLTLKDLGTGGASSGNS
LFSLVQMLSMSLGVTVAGALLATFTGMLRTVTPSNTLPAFHATFICVGIITAASAWIFAQLAPEIRSTARKTDPSERA

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Escherichia coli, GI1790195, Length=469, Percent_Identity=46.6950959488273, Blast_Score=424, Evalue=1e-120,
Organism=Escherichia coli, GI1788392, Length=452, Percent_Identity=48.8938053097345, Blast_Score=389, Evalue=1e-109,
Organism=Escherichia coli, GI1789042, Length=478, Percent_Identity=27.6150627615063, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1788710, Length=325, Percent_Identity=32.3076923076923, Blast_Score=152, Evalue=6e-38,
Organism=Escherichia coli, GI87081983, Length=300, Percent_Identity=31.3333333333333, Blast_Score=126, Evalue=4e-30,
Organism=Escherichia coli, GI1788509, Length=165, Percent_Identity=30.3030303030303, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322958, Length=156, Percent_Identity=32.0512820512821, Blast_Score=70, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6323735, Length=256, Percent_Identity=25.78125, Blast_Score=67, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6325455, Length=125, Percent_Identity=30.4, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 50874; Mature: 50874

Theoretical pI: Translated: 10.33; Mature: 10.33

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQRPPAAAPGEKNLTVMLWLVATGFFMQTLDATIVNTALPSMAASLGESPLRMQSVVIA
CCCCCCCCCCCCCCHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
YSLTMAVMIPVSGWLADTFGTRRVFFSAILVFSLGSLLCANAHTLTQLVAFRVVQGVGGA
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCH
MLLPVGRLAVLRTFPAERYLPALSFVAIPGLIGPLIGPTLGGWLVKIASWHWIFLINVPV
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEEECCC
GVAGCIATFYSMPDSRNPAAGRFDLKGYLLLTIGMVAISLSLDGLADLGMQHAAVLVLLI
HHHHHHHHHHCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSLACFVAYGLYAVRAPQPIFSLELFKIHTFSVGLLGNLFARIGSGAMPYLIPLLLQVSL
HHHHHHHHHHHHHHCCCCCCCEEEEEEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHC
GYSAFEAGLMMLPVAAAGMFSKRIITRLITQHGYRKVLLANTIMVGVMMASFALMRDTVP
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHH
VWVKVVHLALFGGFNSMQFTAMNTLTLKDLGTGGASSGNSLFSLVQMLSMSLGVTVAGAL
HHHHHHHHHHHCCCCCCEEEEEEEEEEHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LATFTGMLRTVTPSNTLPAFHATFICVGIITAASAWIFAQLAPEIRSTARKTDPSERA
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MFQRPPAAAPGEKNLTVMLWLVATGFFMQTLDATIVNTALPSMAASLGESPLRMQSVVIA
CCCCCCCCCCCCCCHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
YSLTMAVMIPVSGWLADTFGTRRVFFSAILVFSLGSLLCANAHTLTQLVAFRVVQGVGGA
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCH
MLLPVGRLAVLRTFPAERYLPALSFVAIPGLIGPLIGPTLGGWLVKIASWHWIFLINVPV
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEEECCC
GVAGCIATFYSMPDSRNPAAGRFDLKGYLLLTIGMVAISLSLDGLADLGMQHAAVLVLLI
HHHHHHHHHHCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSLACFVAYGLYAVRAPQPIFSLELFKIHTFSVGLLGNLFARIGSGAMPYLIPLLLQVSL
HHHHHHHHHHHHHHCCCCCCCEEEEEEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHC
GYSAFEAGLMMLPVAAAGMFSKRIITRLITQHGYRKVLLANTIMVGVMMASFALMRDTVP
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHH
VWVKVVHLALFGGFNSMQFTAMNTLTLKDLGTGGASSGNSLFSLVQMLSMSLGVTVAGAL
HHHHHHHHHHHCCCCCCEEEEEEEEEEHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LATFTGMLRTVTPSNTLPAFHATFICVGIITAASAWIFAQLAPEIRSTARKTDPSERA
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA