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The map label for this gene is mco [H]

Identifier: 116690541

GI number: 116690541

Start: 2793077

End: 2794684

Strand: Reverse

Name: mco [H]

Synonym: Bcen2424_2521

Alternate gene names: 116690541

Gene position: 2794684-2793077 (Counterclockwise)

Preceding gene: 116690543

Following gene: 116690539

Centisome position: 80.22

GC content: 70.96

Gene sequence:

>1608_bases
ATGAGACGGAGAACCTTCCTGTCGCGCGCCATCGGCGTCGCGGCCGCGTCGCTGTTCGCGCGCACCGCGTCGGCGCAGCA
TGCCGGTCACGCGGGCATGGCCGGCATGGATTCGATGGACGACATGCCGGGCATGTCGGGTATGTCAGGGATGTCGGCGC
ACGCGCAGCACGGCCAGCCCGCGCCGGCCGCGCTCGCGGCCGCCGACGCGCTGCCGGCCGGCGCGCCGCTCGCGACGTTG
CGCACGCTCGCCAACGAAAGCCGTGAGCCCGGCACGTTCCGGGCCACGCTGGTCGCTCAACCGGTGGCGCGACCGCTGCT
GCGCGGCGCGCGGCCGACGACGTTCTGGCAGTTCGGTACCGGTACGCAAGGCCCCGTGGTCGGCCCGCTGATCGACGTGC
GCGAGGGCGATACGGTCGAGATCCGGTTCGTGAACAAGCTGCCGCAGCCGTCGACGATCCACTGGCACGGCCTGCCCGTG
CCGCCGGACCAGGACGGCAATCCGTCCGATCCCGTCGCGCCCGGCGCGTCGCGCGTGTATCGCTTCACGCTGCCGAAGGG
CAGCGCCGGGACTTACTGGTACCACCCGCATCCGCACATGATGACCGCCGAGCAGGTGTTCCGCGGGCTGGCCGGCCCGT
TCGTCGTGCGCGCCGCGGACGATCCGCTAGCCGGCTGGCCCGAGCGTCACCTGTTCGTGTCGGACCTGAAGCTTGCACGC
GACGGCACGATTGCGCCGAACGACATGATGGACTGGATGAACGGCCGGGAAGGTCAATTCGTCCTGGTCAACGGCGCGCG
CCGGCCGCGCATCGACGTCGCGAGCGACGAGCGCTGGCGTGTCTGGAATGCATGCAGCGCGCGCTACCTGCGCATCGCGT
TCGACGACGGCCGCGTGTTCGAGCACGCAGGCACCGACGGCGGATTGTTCGGCACGGCGCGGCGCGTGACGTCGCTGCTG
ATCGCGCCGGGCGAGCGCGCGGAGTTGCTGGTGCGCGCCGGCGACCGCGCGTCGCGCGCGGTGCTGCAGGCGGCCGAGTA
CGACCGCCGCAAGATGGCGATGTCGCACGACGACGGCCACGGCAGCCTGCCGCCCGATCCGGCGCTGGCGCTGGCCGATG
TCGCGTTTGCGCCCGCCGAGGCCCGTGTGCTGCCTGCCACGCTGCGCGCGGTGCCGCCGCTCGGCGAACCGGTCGCGCAC
AAGACGGTCGCGTTCGGCGAGGAAATGGACATGGACGCGATGATGAAGGGCGCGGCGCACGGCCGCCCGGCAGGCATGCG
CTTCACGATCAACGGCGACACCTACGCGCCGCACCGCGCGACGCTGACGAGCCGCCGCGGCGACGTCGAGCGCTGGGAGA
TCCGCAATACGACGGACATGGACCACCCATTCCACCTGCACGGCACGCAGTTCCAGGTGATCGAGCGGGCATCGGCCGGT
TCGCGCACGAGCGAGCCGTTCCGCGCGTGGCGCGATACCGTGAACGTGCGCAGCGGTGAAACCGTGTCGCTGCTCGTCAC
GCAAGACATGCCCGGCGAGCGCATGTTTCATTGCCACATTCTCGAACACGAGGATCTCGGCATGATGGGTACGCTGAAGG
TCGTGTAA

Upstream 100 bases:

>100_bases
CCCGCGGGGGCGGCGGCGTTTTTCGATCCGGCCCTGCGGTTATGATGACGCGACCGTCGCGGCTGTCGCGCGGCGCTGCA
TGAACAACGAGGATCGATTG

Downstream 100 bases:

>100_bases
CGAAGCCGCGGATATGTTTCACATGCGGATTCGATATCCGATCTGCATGCGTGACAAGACAATGTGTGTTCAATTATCGG
GATTGAACGAAAAGGCCGGC

Product: multicopper oxidase, type 3

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 535; Mature: 535

Protein sequence:

>535_residues
MRRRTFLSRAIGVAAASLFARTASAQHAGHAGMAGMDSMDDMPGMSGMSGMSAHAQHGQPAPAALAAADALPAGAPLATL
RTLANESREPGTFRATLVAQPVARPLLRGARPTTFWQFGTGTQGPVVGPLIDVREGDTVEIRFVNKLPQPSTIHWHGLPV
PPDQDGNPSDPVAPGASRVYRFTLPKGSAGTYWYHPHPHMMTAEQVFRGLAGPFVVRAADDPLAGWPERHLFVSDLKLAR
DGTIAPNDMMDWMNGREGQFVLVNGARRPRIDVASDERWRVWNACSARYLRIAFDDGRVFEHAGTDGGLFGTARRVTSLL
IAPGERAELLVRAGDRASRAVLQAAEYDRRKMAMSHDDGHGSLPPDPALALADVAFAPAEARVLPATLRAVPPLGEPVAH
KTVAFGEEMDMDAMMKGAAHGRPAGMRFTINGDTYAPHRATLTSRRGDVERWEIRNTTDMDHPFHLHGTQFQVIERASAG
SRTSEPFRAWRDTVNVRSGETVSLLVTQDMPGERMFHCHILEHEDLGMMGTLKVV

Sequences:

>Translated_535_residues
MRRRTFLSRAIGVAAASLFARTASAQHAGHAGMAGMDSMDDMPGMSGMSGMSAHAQHGQPAPAALAAADALPAGAPLATL
RTLANESREPGTFRATLVAQPVARPLLRGARPTTFWQFGTGTQGPVVGPLIDVREGDTVEIRFVNKLPQPSTIHWHGLPV
PPDQDGNPSDPVAPGASRVYRFTLPKGSAGTYWYHPHPHMMTAEQVFRGLAGPFVVRAADDPLAGWPERHLFVSDLKLAR
DGTIAPNDMMDWMNGREGQFVLVNGARRPRIDVASDERWRVWNACSARYLRIAFDDGRVFEHAGTDGGLFGTARRVTSLL
IAPGERAELLVRAGDRASRAVLQAAEYDRRKMAMSHDDGHGSLPPDPALALADVAFAPAEARVLPATLRAVPPLGEPVAH
KTVAFGEEMDMDAMMKGAAHGRPAGMRFTINGDTYAPHRATLTSRRGDVERWEIRNTTDMDHPFHLHGTQFQVIERASAG
SRTSEPFRAWRDTVNVRSGETVSLLVTQDMPGERMFHCHILEHEDLGMMGTLKVV
>Mature_535_residues
MRRRTFLSRAIGVAAASLFARTASAQHAGHAGMAGMDSMDDMPGMSGMSGMSAHAQHGQPAPAALAAADALPAGAPLATL
RTLANESREPGTFRATLVAQPVARPLLRGARPTTFWQFGTGTQGPVVGPLIDVREGDTVEIRFVNKLPQPSTIHWHGLPV
PPDQDGNPSDPVAPGASRVYRFTLPKGSAGTYWYHPHPHMMTAEQVFRGLAGPFVVRAADDPLAGWPERHLFVSDLKLAR
DGTIAPNDMMDWMNGREGQFVLVNGARRPRIDVASDERWRVWNACSARYLRIAFDDGRVFEHAGTDGGLFGTARRVTSLL
IAPGERAELLVRAGDRASRAVLQAAEYDRRKMAMSHDDGHGSLPPDPALALADVAFAPAEARVLPATLRAVPPLGEPVAH
KTVAFGEEMDMDAMMKGAAHGRPAGMRFTINGDTYAPHRATLTSRRGDVERWEIRNTTDMDHPFHLHGTQFQVIERASAG
SRTSEPFRAWRDTVNVRSGETVSLLVTQDMPGERMFHCHILEHEDLGMMGTLKVV

Specific function: May be involved in copper homeostasis and oxidative stress response [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=473, Percent_Identity=31.9238900634249, Blast_Score=180, Evalue=2e-46,
Organism=Escherichia coli, GI1789394, Length=441, Percent_Identity=28.5714285714286, Blast_Score=121, Evalue=9e-29,
Organism=Drosophila melanogaster, GI24650186, Length=529, Percent_Identity=23.4404536862004, Blast_Score=92, Evalue=1e-18,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR002355
- InterPro:   IPR008972 [H]

Pfam domain/function: PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 58111; Mature: 58111

Theoretical pI: Translated: 7.68; Mature: 7.68

Prosite motif: PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRRTFLSRAIGVAAASLFARTASAQHAGHAGMAGMDSMDDMPGMSGMSGMSAHAQHGQP
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCC
APAALAAADALPAGAPLATLRTLANESREPGTFRATLVAQPVARPLLRGARPTTFWQFGT
CCHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHCCCCCEEEEECC
GTQGPVVGPLIDVREGDTVEIRFVNKLPQPSTIHWHGLPVPPDQDGNPSDPVAPGASRVY
CCCCCCCCCEEECCCCCEEEEEEECCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCEE
RFTLPKGSAGTYWYHPHPHMMTAEQVFRGLAGPFVVRAADDPLAGWPERHLFVSDLKLAR
EEECCCCCCCCEEECCCCCCCCHHHHHHHCCCCEEEEECCCCCCCCCCCCEEHHHHEECC
DGTIAPNDMMDWMNGREGQFVLVNGARRPRIDVASDERWRVWNACSARYLRIAFDDGRVF
CCCCCCHHHHHHHCCCCCCEEEEECCCCCCEECCCCCCEEEECCCCCEEEEEEECCCEEE
EHAGTDGGLFGTARRVTSLLIAPGERAELLVRAGDRASRAVLQAAEYDRRKMAMSHDDGH
EECCCCCCCHHHHHHHHHEEECCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCC
GSLPPDPALALADVAFAPAEARVLPATLRAVPPLGEPVAHKTVAFGEEMDMDAMMKGAAH
CCCCCCHHHHHHHHHCCCCCCEEEHHHHHHCCCCCCCHHHHHHHCCCCCCHHHHHHCCCC
GRPAGMRFTINGDTYAPHRATLTSRRGDVERWEIRNTTDMDHPFHLHGTQFQVIERASAG
CCCCCEEEEECCCCCCCCCHHHHCCCCCCCEEEECCCCCCCCCEEECCCCEEEEECCCCC
SRTSEPFRAWRDTVNVRSGETVSLLVTQDMPGERMFHCHILEHEDLGMMGTLKVV
CCCCHHHHHHHHHCCCCCCCEEEEEEECCCCCCCEEEEEEECCCCCCCCEEEEEC
>Mature Secondary Structure
MRRRTFLSRAIGVAAASLFARTASAQHAGHAGMAGMDSMDDMPGMSGMSGMSAHAQHGQP
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCC
APAALAAADALPAGAPLATLRTLANESREPGTFRATLVAQPVARPLLRGARPTTFWQFGT
CCHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHCCCCCEEEEECC
GTQGPVVGPLIDVREGDTVEIRFVNKLPQPSTIHWHGLPVPPDQDGNPSDPVAPGASRVY
CCCCCCCCCEEECCCCCEEEEEEECCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCEE
RFTLPKGSAGTYWYHPHPHMMTAEQVFRGLAGPFVVRAADDPLAGWPERHLFVSDLKLAR
EEECCCCCCCCEEECCCCCCCCHHHHHHHCCCCEEEEECCCCCCCCCCCCEEHHHHEECC
DGTIAPNDMMDWMNGREGQFVLVNGARRPRIDVASDERWRVWNACSARYLRIAFDDGRVF
CCCCCCHHHHHHHCCCCCCEEEEECCCCCCEECCCCCCEEEECCCCCEEEEEEECCCEEE
EHAGTDGGLFGTARRVTSLLIAPGERAELLVRAGDRASRAVLQAAEYDRRKMAMSHDDGH
EECCCCCCCHHHHHHHHHEEECCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCC
GSLPPDPALALADVAFAPAEARVLPATLRAVPPLGEPVAHKTVAFGEEMDMDAMMKGAAH
CCCCCCHHHHHHHHHCCCCCCEEEHHHHHHCCCCCCCHHHHHHHCCCCCCHHHHHHCCCC
GRPAGMRFTINGDTYAPHRATLTSRRGDVERWEIRNTTDMDHPFHLHGTQFQVIERASAG
CCCCCEEEEECCCCCCCCCHHHHCCCCCCCEEEECCCCCCCCCEEECCCCEEEEECCCCC
SRTSEPFRAWRDTVNVRSGETVSLLVTQDMPGERMFHCHILEHEDLGMMGTLKVV
CCCCHHHHHHHHHCCCCCCCEEEEEEECCCCCCCEEEEEEECCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA