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The map label for this gene is nadC [H]

Identifier: 116690525

GI number: 116690525

Start: 2773683

End: 2774564

Strand: Reverse

Name: nadC [H]

Synonym: Bcen2424_2505

Alternate gene names: 116690525

Gene position: 2774564-2773683 (Counterclockwise)

Preceding gene: 116690526

Following gene: 116690520

Centisome position: 79.64

GC content: 67.8

Gene sequence:

>882_bases
ATGAGCAACGCCGTATCCCCGCTGTTCGAAGCCGTCCGCGCCCAATACGGCGCGGCATTCGACGAAGCGATCGCGCGTAA
CGTGGCCGACGCGATCGCCGAAGACGTCGGCACCGGCGACCAGACCGGGCGGCTCGTGCCGGCCGGCGAGCGGCGCCGTG
CGCGGATCATCGTGCGCGAGGAAGCCGTGCTGTGCGGCGTACCGTGGTTCGAGGGCGTGATCGCCCGGATCGATTCGTCG
ATCGTCGTGCAATGGCGCTATCGCGAAGGCGACCGGATGACGCCTGATTCGATCGTCTGCGAACTCGAAGGGCCGGCGCG
CGCGTTGCTGACGGCCGAGCGCAACGGGCTGAATTTCCTGCAACTGCTGTCGGGTGTCGCGACGGCGACGCGCCGTTACG
TCGAACGCGTCGAAGGCACGCGCGCGAAGATCCTCGATACGCGCAAGACGCTGCCGGGGCTGCGGCTCGCGCAGAAGTAC
GCAGTGCGCGTGGGCGGCGGCGAGAACCAGCGGCTCGCGCTGTACGACGGCATCCTGATCAAGGAGAACCACATCGCGGC
GGCAGGCGGTGTCGGCGAGGCGCTCGATGCGGCGTTCGCGCTGGAGTCAGGTGTGCCGGTGCAGATCGAAGTCGAGACGC
TCGCGCAGCTCGACACGGCGCTCGCGCATCGCGCGCAGTCGGTGCTGCTCGACAACTTCACGCTCGACATGATGCGCGAA
GCGGTGCGCGTGGCGGATGGCAAGGCCGTGCTCGAAGTCTCCGGCGGCGTCAATTTCGATACGGTGCGTGCGTTCGCGGA
GACGGGCGTCGATCGGATCTCGATCGGCGCGCTGACGAAGGACGTGCGGGCGACCGACTATTCGATGCGAATCGTCGACT
GA

Upstream 100 bases:

>100_bases
TCGACCGGATGCTCGAATTCGCGGCTGCGCACAAGAAGCGCGTGCAGGCGAGCGGCGATCTGCAGCGCGACCAGTCGCTG
TTCGCGAACGTGGGGGCGGC

Downstream 100 bases:

>100_bases
CCGAACGTCGTCCGATCAGACAAAAAGCCGTTGGCGCGCAAACGCCAACGGCTTTTTTCTTGTGCTGCGGCCGCCGCCGG
GCAGGGCGGCGCGCCGCTCA

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 293; Mature: 292

Protein sequence:

>293_residues
MSNAVSPLFEAVRAQYGAAFDEAIARNVADAIAEDVGTGDQTGRLVPAGERRRARIIVREEAVLCGVPWFEGVIARIDSS
IVVQWRYREGDRMTPDSIVCELEGPARALLTAERNGLNFLQLLSGVATATRRYVERVEGTRAKILDTRKTLPGLRLAQKY
AVRVGGGENQRLALYDGILIKENHIAAAGGVGEALDAAFALESGVPVQIEVETLAQLDTALAHRAQSVLLDNFTLDMMRE
AVRVADGKAVLEVSGGVNFDTVRAFAETGVDRISIGALTKDVRATDYSMRIVD

Sequences:

>Translated_293_residues
MSNAVSPLFEAVRAQYGAAFDEAIARNVADAIAEDVGTGDQTGRLVPAGERRRARIIVREEAVLCGVPWFEGVIARIDSS
IVVQWRYREGDRMTPDSIVCELEGPARALLTAERNGLNFLQLLSGVATATRRYVERVEGTRAKILDTRKTLPGLRLAQKY
AVRVGGGENQRLALYDGILIKENHIAAAGGVGEALDAAFALESGVPVQIEVETLAQLDTALAHRAQSVLLDNFTLDMMRE
AVRVADGKAVLEVSGGVNFDTVRAFAETGVDRISIGALTKDVRATDYSMRIVD
>Mature_292_residues
SNAVSPLFEAVRAQYGAAFDEAIARNVADAIAEDVGTGDQTGRLVPAGERRRARIIVREEAVLCGVPWFEGVIARIDSSI
VVQWRYREGDRMTPDSIVCELEGPARALLTAERNGLNFLQLLSGVATATRRYVERVEGTRAKILDTRKTLPGLRLAQKYA
VRVGGGENQRLALYDGILIKENHIAAAGGVGEALDAAFALESGVPVQIEVETLAQLDTALAHRAQSVLLDNFTLDMMREA
VRVADGKAVLEVSGGVNFDTVRAFAETGVDRISIGALTKDVRATDYSMRIVD

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=257, Percent_Identity=34.2412451361868, Blast_Score=130, Evalue=1e-30,
Organism=Escherichia coli, GI1786299, Length=270, Percent_Identity=51.4814814814815, Blast_Score=244, Evalue=5e-66,
Organism=Saccharomyces cerevisiae, GI6321162, Length=301, Percent_Identity=30.5647840531561, Blast_Score=146, Evalue=4e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 31667; Mature: 31536

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNAVSPLFEAVRAQYGAAFDEAIARNVADAIAEDVGTGDQTGRLVPAGERRRARIIVRE
CCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEE
EAVLCGVPWFEGVIARIDSSIVVQWRYREGDRMTPDSIVCELEGPARALLTAERNGLNFL
CEEEECCCHHHHHHHHCCCEEEEEEEECCCCCCCCCCEEEEECCCHHEEEEECCCCCHHH
QLLSGVATATRRYVERVEGTRAKILDTRKTLPGLRLAQKYAVRVGGGENQRLALYDGILI
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHEEEECCCCCCEEEEECCEEE
KENHIAAAGGVGEALDAAFALESGVPVQIEVETLAQLDTALAHRAQSVLLDNFTLDMMRE
ECCCEEECCCCHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVRVADGKAVLEVSGGVNFDTVRAFAETGVDRISIGALTKDVRATDYSMRIVD
HHHHCCCCEEEEECCCCCHHHHHHHHHCCCCEEEHHHHHHCCCCCCEEEEEEC
>Mature Secondary Structure 
SNAVSPLFEAVRAQYGAAFDEAIARNVADAIAEDVGTGDQTGRLVPAGERRRARIIVRE
CCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEE
EAVLCGVPWFEGVIARIDSSIVVQWRYREGDRMTPDSIVCELEGPARALLTAERNGLNFL
CEEEECCCHHHHHHHHCCCEEEEEEEECCCCCCCCCCEEEEECCCHHEEEEECCCCCHHH
QLLSGVATATRRYVERVEGTRAKILDTRKTLPGLRLAQKYAVRVGGGENQRLALYDGILI
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHEEEECCCCCCEEEEECCEEE
KENHIAAAGGVGEALDAAFALESGVPVQIEVETLAQLDTALAHRAQSVLLDNFTLDMMRE
ECCCEEECCCCHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVRVADGKAVLEVSGGVNFDTVRAFAETGVDRISIGALTKDVRATDYSMRIVD
HHHHCCCCEEEEECCCCCHHHHHHHHHCCCCEEEHHHHHHCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043; 2430961; 8419294 [H]