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The map label for this gene is cobC [H]

Identifier: 116690469

GI number: 116690469

Start: 2721737

End: 2722753

Strand: Direct

Name: cobC [H]

Synonym: Bcen2424_2449

Alternate gene names: 116690469

Gene position: 2721737-2722753 (Clockwise)

Preceding gene: 116690468

Following gene: 116690470

Centisome position: 78.12

GC content: 73.84

Gene sequence:

>1017_bases
ATGTCTGATTCATCCATCGCGCACGGCGGCAACCTGCATGAAGCCGCCCGCCGCCACGGCATTCCGTACGACGCGTGGCT
CGACCTGTCGACCGGCATCAATCCGGTCGGCTACCCGGTGCCGCCCGTGCCGGCCGACGCATGGCGCCGGCTGCCCGACG
ACGGCGACGGTCTCGCGGCCTGTGCCGCGCAGCACTACCACGCGCCCGATGCCGCGCACGTGCTGCCGGTTGCCGGCAGC
CAGGCCGCGATCCGCGCGTTGCCCGCGTTGCTGCCGGCCGGCGACGCCGGCGTCGCGGCGCTCGCGTACGGCGAATACGC
GCCCGCGTTCGCGCGCCACGGCCATCGCGTCGTCACGCTCGATATCCACGCCGATACGCTGCCCGCAACGCTGCGCCACA
TCATCGTCGGGAATCCGAATAATCCGACGGCCGAGTGCGTGCCGACCGCGCGCCTGCTCGGCTGGCATGCGCAACTGGCG
GCACGCGGCGGCACGCTGATCGTCGACGAAGCGTTCGCCGATACGGGCGCCGCGCCCTCGCTCGCGCCGCGGGTCGATCG
TCCGGGGCTCGTCGTGCTGCGCTCGGTCGGCAAGTTCTTCGGGCTTGCCGGCATTCGCGCGGGCTTCGTGCTCACGCATC
CCGCGCTGATCGCCGCGCTGCGCGACACGCTCGGCGCGTGGACGGTCGGCGGCCCCGCGCGCCACGCGGTCGCCGCGGCG
TTCGCCGATCGCGCATGGCAAGCTGCCGCCCGTGAGCGGCTCGCGGCCGACGGCGAACGATTGGCCGCGCTGCTGCGTGC
GCACGGCTTCGCGGTTCGCGCGACGCCGCTCTTCAGCTGGAGCGACGACCCGCGCGCCGCGGCGCTGCATGCCGCGCTCG
CGGCACGCGGAATCTGGACGCGGCACTTCCCGGCGCCGTCGAGCGTACGCATCGGCCTGCCGGCGAGCGAAGCCGAATGG
CAGCGCCTCGGCGACGCGCTCGCGCATTGCGTGCCGCTGCTGAAGGCATCCGCATGA

Upstream 100 bases:

>100_bases
GCCCTTCACATCGTCGCCGCGCTGTCGCTGGTCACGCGCACGCTCGCGCTGTGGCTCGCGCTGCTGGTCGCGAGCGGCGC
ACTCGTCATGGCCACCCATC

Downstream 100 bases:

>100_bases
GCGCCCCCATGTTCCGCCGGCTCGCGCCGGCCGCGCTGCTGGCCGCGCTCGCTCACGCACCGCTCGTCCACGCCGACGTC
ACGACCCGCGACGACGCCGG

Product: putative threonine-phosphate decarboxylase

Products: NA

Alternate protein names: L-threonine-O-3-phosphate decarboxylase [H]

Number of amino acids: Translated: 338; Mature: 337

Protein sequence:

>338_residues
MSDSSIAHGGNLHEAARRHGIPYDAWLDLSTGINPVGYPVPPVPADAWRRLPDDGDGLAACAAQHYHAPDAAHVLPVAGS
QAAIRALPALLPAGDAGVAALAYGEYAPAFARHGHRVVTLDIHADTLPATLRHIIVGNPNNPTAECVPTARLLGWHAQLA
ARGGTLIVDEAFADTGAAPSLAPRVDRPGLVVLRSVGKFFGLAGIRAGFVLTHPALIAALRDTLGAWTVGGPARHAVAAA
FADRAWQAAARERLAADGERLAALLRAHGFAVRATPLFSWSDDPRAAALHAALAARGIWTRHFPAPSSVRIGLPASEAEW
QRLGDALAHCVPLLKASA

Sequences:

>Translated_338_residues
MSDSSIAHGGNLHEAARRHGIPYDAWLDLSTGINPVGYPVPPVPADAWRRLPDDGDGLAACAAQHYHAPDAAHVLPVAGS
QAAIRALPALLPAGDAGVAALAYGEYAPAFARHGHRVVTLDIHADTLPATLRHIIVGNPNNPTAECVPTARLLGWHAQLA
ARGGTLIVDEAFADTGAAPSLAPRVDRPGLVVLRSVGKFFGLAGIRAGFVLTHPALIAALRDTLGAWTVGGPARHAVAAA
FADRAWQAAARERLAADGERLAALLRAHGFAVRATPLFSWSDDPRAAALHAALAARGIWTRHFPAPSSVRIGLPASEAEW
QRLGDALAHCVPLLKASA
>Mature_337_residues
SDSSIAHGGNLHEAARRHGIPYDAWLDLSTGINPVGYPVPPVPADAWRRLPDDGDGLAACAAQHYHAPDAAHVLPVAGSQ
AAIRALPALLPAGDAGVAALAYGEYAPAFARHGHRVVTLDIHADTLPATLRHIIVGNPNNPTAECVPTARLLGWHAQLAA
RGGTLIVDEAFADTGAAPSLAPRVDRPGLVVLRSVGKFFGLAGIRAGFVLTHPALIAALRDTLGAWTVGGPARHAVAAAF
ADRAWQAAARERLAADGERLAALLRAHGFAVRATPLFSWSDDPRAAALHAALAARGIWTRHFPAPSSVRIGLPASEAEWQ
RLGDALAHCVPLLKASA

Specific function: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1- amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin [H]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005860
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.1.1.81 [H]

Molecular weight: Translated: 35177; Mature: 35046

Theoretical pI: Translated: 8.19; Mature: 8.19

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.3 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDSSIAHGGNLHEAARRHGIPYDAWLDLSTGINPVGYPVPPVPADAWRRLPDDGDGLAA
CCCCCCCCCCCHHHHHHHCCCCCHHEEECCCCCCCCCCCCCCCCHHHHHCCCCCCCCHHH
CAAQHYHAPDAAHVLPVAGSQAAIRALPALLPAGDAGVAALAYGEYAPAFARHGHRVVTL
HHHHHCCCCCCCEEEECCCCHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHCCCEEEEE
DIHADTLPATLRHIIVGNPNNPTAECVPTARLLGWHAQLAARGGTLIVDEAFADTGAAPS
EECCCHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCC
LAPRVDRPGLVVLRSVGKFFGLAGIRAGFVLTHPALIAALRDTLGAWTVGGPARHAVAAA
CCCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
FADRAWQAAARERLAADGERLAALLRAHGFAVRATPLFSWSDDPRAAALHAALAARGIWT
HHHHHHHHHHHHHHHCCHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHHCCCCE
RHFPAPSSVRIGLPASEAEWQRLGDALAHCVPLLKASA
ECCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SDSSIAHGGNLHEAARRHGIPYDAWLDLSTGINPVGYPVPPVPADAWRRLPDDGDGLAA
CCCCCCCCCCHHHHHHHCCCCCHHEEECCCCCCCCCCCCCCCCHHHHHCCCCCCCCHHH
CAAQHYHAPDAAHVLPVAGSQAAIRALPALLPAGDAGVAALAYGEYAPAFARHGHRVVTL
HHHHHCCCCCCCEEEECCCCHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHCCCEEEEE
DIHADTLPATLRHIIVGNPNNPTAECVPTARLLGWHAQLAARGGTLIVDEAFADTGAAPS
EECCCHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCC
LAPRVDRPGLVVLRSVGKFFGLAGIRAGFVLTHPALIAALRDTLGAWTVGGPARHAVAAA
CCCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
FADRAWQAAARERLAADGERLAALLRAHGFAVRATPLFSWSDDPRAAALHAALAARGIWT
HHHHHHHHHHHHHHHCCHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHHCCCCE
RHFPAPSSVRIGLPASEAEWQRLGDALAHCVPLLKASA
ECCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]