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The map label for this gene is hemF [H]

Identifier: 116690317

GI number: 116690317

Start: 2552068

End: 2553039

Strand: Direct

Name: hemF [H]

Synonym: Bcen2424_2296

Alternate gene names: 116690317

Gene position: 2552068-2553039 (Clockwise)

Preceding gene: 116690316

Following gene: 116690318

Centisome position: 73.25

GC content: 67.9

Gene sequence:

>972_bases
ATGCTTTTTTTACGGCCCTCGCGTCAGGCGGGGGCAGCCAGTCCAGACATGACCGATTCGACCTACGACGTGGCGCGTGT
GCGCACGTACCTCCAGGGCCTGCAGACACGGATCGCCGACGCGCTCGGCGCGCTCGACGGCACGCCGCTCGCGACCGACA
CGTGGCAGCGCGGGCCGGCCGAACGCCTGCGCGGCGGCGGCTGCACGCGGATTCTCGAAGGCGGCCGCGTGTTCGAACGC
GCGGGAATCGGCTTTTCCGACGTCGCGGGCGACGCGCTGCCGCCGTCGGCGAGCGCGGCGCGCCCGCAGCTCGCGGGCCG
CGGCTTCGAGGCGCTCGGCGTGTCGCTGGTGCTGCACCCGCGCAATCCGTACTGCCCGACCGTGCACATGAACGTGCGGA
TGCTGATCGCGACGAAACCAGGCGAGGCGCCCGTGTTCTGGTTCGGCGGCGGCATGGATCTGACACCGGTTTACGGTTTC
GAGGACGACGCGCGGCATTTCCACCAGACCTGCAAGGACGCGCTCGACCCGTTCGGCGCCGAGCTCTACCCGCGCTTCAA
GCAATGGTGCGACGAATATTTCTTCCTGAAGCACCGCAACGAGACGCGCGGCATCGGCGGGATTTTCTTCGACGACTTCT
CGGAGCCCGGTTTCGAACGCTCGTTTGACATGATGCAAAGTGTCGGCGATGCGTTCCTGAACGCTTACCTGCCGATCGTC
GAGCGCCGCGCCGAGCTGCCGTACGGCGAGCGCGAGCGCGACTTCCAGGCCTACCGCCGCGGCCGCTACGTCGAATTCAA
CCTCGTGTTCGACCGCGGCACGCTGTTCGGCCTGCAAAGCGGCGGCCGGACCGAGTCGATCCTGATGTCGATGCCGCCGG
TCGCGAACTGGCGCTACAACTGGCAACCCGAGCCGGGTTCGCCGGAAGCGCGCCTCTATAGCGACTTCCTCGTGCCGCGC
GACTGGGTCTGA

Upstream 100 bases:

>100_bases
TTTCGCGCGCTCAACCGCAAGAGCACGTGACGTCGTGATCGCCGCCCCGCGCCCGCACGGCGGCGGCCCCTCTGCCGGGG
TTCGATAGAATGCCCGGCAG

Downstream 100 bases:

>100_bases
ACCCGCGCGTGCCGCTGCCCCAACGAAAGGACGCGTTTCTGGACACCACCGCCCGCCCCGCCCCGCTGCCGCGTCGTATC
GGCTTGCTGGGCGGTACCTT

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 323; Mature: 323

Protein sequence:

>323_residues
MLFLRPSRQAGAASPDMTDSTYDVARVRTYLQGLQTRIADALGALDGTPLATDTWQRGPAERLRGGGCTRILEGGRVFER
AGIGFSDVAGDALPPSASAARPQLAGRGFEALGVSLVLHPRNPYCPTVHMNVRMLIATKPGEAPVFWFGGGMDLTPVYGF
EDDARHFHQTCKDALDPFGAELYPRFKQWCDEYFFLKHRNETRGIGGIFFDDFSEPGFERSFDMMQSVGDAFLNAYLPIV
ERRAELPYGERERDFQAYRRGRYVEFNLVFDRGTLFGLQSGGRTESILMSMPPVANWRYNWQPEPGSPEARLYSDFLVPR
DWV

Sequences:

>Translated_323_residues
MLFLRPSRQAGAASPDMTDSTYDVARVRTYLQGLQTRIADALGALDGTPLATDTWQRGPAERLRGGGCTRILEGGRVFER
AGIGFSDVAGDALPPSASAARPQLAGRGFEALGVSLVLHPRNPYCPTVHMNVRMLIATKPGEAPVFWFGGGMDLTPVYGF
EDDARHFHQTCKDALDPFGAELYPRFKQWCDEYFFLKHRNETRGIGGIFFDDFSEPGFERSFDMMQSVGDAFLNAYLPIV
ERRAELPYGERERDFQAYRRGRYVEFNLVFDRGTLFGLQSGGRTESILMSMPPVANWRYNWQPEPGSPEARLYSDFLVPR
DWV
>Mature_323_residues
MLFLRPSRQAGAASPDMTDSTYDVARVRTYLQGLQTRIADALGALDGTPLATDTWQRGPAERLRGGGCTRILEGGRVFER
AGIGFSDVAGDALPPSASAARPQLAGRGFEALGVSLVLHPRNPYCPTVHMNVRMLIATKPGEAPVFWFGGGMDLTPVYGF
EDDARHFHQTCKDALDPFGAELYPRFKQWCDEYFFLKHRNETRGIGGIFFDDFSEPGFERSFDMMQSVGDAFLNAYLPIV
ERRAELPYGERERDFQAYRRGRYVEFNLVFDRGTLFGLQSGGRTESILMSMPPVANWRYNWQPEPGSPEARLYSDFLVPR
DWV

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III [H]

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI41393599, Length=302, Percent_Identity=44.7019867549669, Blast_Score=254, Evalue=9e-68,
Organism=Escherichia coli, GI1788777, Length=301, Percent_Identity=62.4584717607973, Blast_Score=394, Evalue=1e-111,
Organism=Saccharomyces cerevisiae, GI6320249, Length=319, Percent_Identity=45.4545454545455, Blast_Score=278, Evalue=1e-75,
Organism=Drosophila melanogaster, GI17864388, Length=312, Percent_Identity=46.7948717948718, Blast_Score=266, Evalue=1e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001260
- InterPro:   IPR018375 [H]

Pfam domain/function: PF01218 Coprogen_oxidas [H]

EC number: =1.3.3.3 [H]

Molecular weight: Translated: 36304; Mature: 36304

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: PS01021 COPROGEN_OXIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFLRPSRQAGAASPDMTDSTYDVARVRTYLQGLQTRIADALGALDGTPLATDTWQRGPA
CEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCH
ERLRGGGCTRILEGGRVFERAGIGFSDVAGDALPPSASAARPQLAGRGFEALGVSLVLHP
HHHCCCCCHHHHCCCCEEHHCCCCHHHHCCCCCCCCCCCCCCHHHCCCHHHCCEEEEEEC
RNPYCPTVHMNVRMLIATKPGEAPVFWFGGGMDLTPVYGFEDDARHFHQTCKDALDPFGA
CCCCCCEEEEEEEEEEEECCCCCCEEEECCCCCCCEECCCCHHHHHHHHHHHHHHCCCCH
ELYPRFKQWCDEYFFLKHRNETRGIGGIFFDDFSEPGFERSFDMMQSVGDAFLNAYLPIV
HHHHHHHHHHHHHHEECCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
ERRAELPYGERERDFQAYRRGRYVEFNLVFDRGTLFGLQSGGRTESILMSMPPVANWRYN
HHHHCCCCCCCHHHHHHHHCCCEEEEEEEEECCEEEEECCCCCCCEEEEECCCCCCCEEC
WQPEPGSPEARLYSDFLVPRDWV
CCCCCCCCHHHHHHHHCCCCCCC
>Mature Secondary Structure
MLFLRPSRQAGAASPDMTDSTYDVARVRTYLQGLQTRIADALGALDGTPLATDTWQRGPA
CEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCH
ERLRGGGCTRILEGGRVFERAGIGFSDVAGDALPPSASAARPQLAGRGFEALGVSLVLHP
HHHCCCCCHHHHCCCCEEHHCCCCHHHHCCCCCCCCCCCCCCHHHCCCHHHCCEEEEEEC
RNPYCPTVHMNVRMLIATKPGEAPVFWFGGGMDLTPVYGFEDDARHFHQTCKDALDPFGA
CCCCCCEEEEEEEEEEEECCCCCCEEEECCCCCCCEECCCCHHHHHHHHHHHHHHCCCCH
ELYPRFKQWCDEYFFLKHRNETRGIGGIFFDDFSEPGFERSFDMMQSVGDAFLNAYLPIV
HHHHHHHHHHHHHHEECCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
ERRAELPYGERERDFQAYRRGRYVEFNLVFDRGTLFGLQSGGRTESILMSMPPVANWRYN
HHHHCCCCCCCHHHHHHHHCCCEEEEEEEEECCEEEEECCCCCCCEEEEECCCCCCCEEC
WQPEPGSPEARLYSDFLVPRDWV
CCCCCCCCHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA