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The map label for this gene is hmrR [H]

Identifier: 116690238

GI number: 116690238

Start: 2467531

End: 2467935

Strand: Reverse

Name: hmrR [H]

Synonym: Bcen2424_2217

Alternate gene names: 116690238

Gene position: 2467935-2467531 (Counterclockwise)

Preceding gene: 116690243

Following gene: 116690237

Centisome position: 70.84

GC content: 58.52

Gene sequence:

>405_bases
ATGAATATCGGCGACGCGTCGCGCGAATCCGGCGTCAGTGCAAAAATGATCCGGTACTACGAACAGGTCGGTCTTCTTGC
GCCCAGCAAACGGACCGATGCCGGCTACCGAATCTATGGGTCAGACGAAATCCATATCCTGCGGTTCATCCGTCAGGCGC
GACGACTTGGCTTTCTCGTCGAAGACATTCGCAAGCTGCTGATGCTCTGGCAGGATCGCTCACGCGCCAGCGCTGAAGTG
AAATCGATTGCTCTCGAGCACGTGGCCGAACTCGACAGACGTATCGCCGAATTGAGCGACATGCGCGACACGCTGGTCGA
TCTGGCCGCGCACTGTCATGGTGACGGTCGGCCCGAATGCCCGATTTTGGCGCGCTTGGCTGACCCTATCGGCGACCCAA
ATTAG

Upstream 100 bases:

>100_bases
CCGGAACGAAACCACGCGATTTGATACGATCGAACAGTCGTCGATGAGGGTATCGTCGACGTTCGCGTTCGAAACCAGGG
CTTCATGAAGAGGGCGGGGA

Downstream 100 bases:

>100_bases
TGCGCGCTCTCGCGCCTCAAAACAGGCTTCGACCCAACATCTATATAAATCAATGAGTTAGATGCGGTTCGCATGCCAAC
ATTCCAAAATGGAATGGGTG

Product: MerR family transcriptional regulator

Products: NA

Alternate protein names: Copper efflux regulator; Copper export regulator [H]

Number of amino acids: Translated: 134; Mature: 134

Protein sequence:

>134_residues
MNIGDASRESGVSAKMIRYYEQVGLLAPSKRTDAGYRIYGSDEIHILRFIRQARRLGFLVEDIRKLLMLWQDRSRASAEV
KSIALEHVAELDRRIAELSDMRDTLVDLAAHCHGDGRPECPILARLADPIGDPN

Sequences:

>Translated_134_residues
MNIGDASRESGVSAKMIRYYEQVGLLAPSKRTDAGYRIYGSDEIHILRFIRQARRLGFLVEDIRKLLMLWQDRSRASAEV
KSIALEHVAELDRRIAELSDMRDTLVDLAAHCHGDGRPECPILARLADPIGDPN
>Mature_134_residues
MNIGDASRESGVSAKMIRYYEQVGLLAPSKRTDAGYRIYGSDEIHILRFIRQARRLGFLVEDIRKLLMLWQDRSRASAEV
KSIALEHVAELDRRIAELSDMRDTLVDLAAHCHGDGRPECPILARLADPIGDPN

Specific function: Regulates the transcription of actP. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations. In the absence of copper, it negatively regulates the transcription of actP [H]

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786695, Length=127, Percent_Identity=44.0944881889764, Blast_Score=116, Evalue=4e-28,
Organism=Escherichia coli, GI1789687, Length=127, Percent_Identity=37.007874015748, Blast_Score=79, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011789
- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 15116; Mature: 15116

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: PS00552 HTH_MERR_1 ; PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIGDASRESGVSAKMIRYYEQVGLLAPSKRTDAGYRIYGSDEIHILRFIRQARRLGFLV
CCCCCCCHHCCCHHHHHHHHHHHCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHH
EDIRKLLMLWQDRSRASAEVKSIALEHVAELDRRIAELSDMRDTLVDLAAHCHGDGRPEC
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
PILARLADPIGDPN
HHHHHHHHCCCCCC
>Mature Secondary Structure
MNIGDASRESGVSAKMIRYYEQVGLLAPSKRTDAGYRIYGSDEIHILRFIRQARRLGFLV
CCCCCCCHHCCCHHHHHHHHHHHCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHH
EDIRKLLMLWQDRSRASAEVKSIALEHVAELDRRIAELSDMRDTLVDLAAHCHGDGRPEC
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
PILARLADPIGDPN
HHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11936079 [H]