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The map label for this gene is hutH [H]

Identifier: 116690193

GI number: 116690193

Start: 2419218

End: 2420741

Strand: Reverse

Name: hutH [H]

Synonym: Bcen2424_2172

Alternate gene names: 116690193

Gene position: 2420741-2419218 (Counterclockwise)

Preceding gene: 116690195

Following gene: 116690192

Centisome position: 69.48

GC content: 68.96

Gene sequence:

>1524_bases
ATGATTACGTTGACCCCCGGCCACCTGACCCTTCCGCAACTGCGCCGGATCGCCCGCGAACCCGTGCAACTGAAGCTCGA
CCCGGCCAGCTTCGCGAAGATCGACGCGGGCGCGAAGGCCGTCGCCGACATCGCCGCGAAGGGTGAGCCGGCCTACGGCA
TCAATACGGGCTTCGGTCGTCTGGCCAGCACCCACATCCCGCACGACCAGCTCGAACTGCTGCAGAAGAACCTCGTGCTG
TCGCATGCGGTCGGCGTGGGCGAGCCGATGGCGCGTTCGTCGGTGCGCCTGCTGTTGGCGCTGAAGCTGTCGAGCCTCGG
CCGCGGCCACTCGGGCATCCGCCGTGAAGTGATGGATGCGCTGATCACGCTGTTCAACGCCGACGTGCTGCCGCTGATCC
CGGTGAAGGGTTCGGTCGGCGCATCGGGCGACCTCGCGCCGCTCGCGCACATGTCGGCCGTGCTGCTCGGCGTCGGCGAA
GTGTTCATCCGCGGCGAGCGCGCGAGTGCGCTCGACGGTCTGCGCGTCGCGGGCCTCGCGCCGCTGACGCTGCAGGCGAA
GGAAGGCCTCGCGCTCCTGAACGGCACGCAGGCGTCGACCGCGCTGGCGCTCGACAACATGTTCGCGATCGAGGACCTGT
ACCGCACCGCGCTCGTCGCCGGCGCGCTGTCGGTCGACGCGGCAGCCGGTTCGGTGAAGCCGTTCGACGCGCGTATCCAC
GAACTGCGCGGCCATCAAGGCCAGATCGACGCGGCCGCGTCGTACCGCGAACTGCTCGAAGGCTCGCCGATCAACCAGTC
GCACCGCGACTGCGACAAGGTGCAGGACCCGTACAGCCTGCGCTGCCAGCCGCAGGTGATGGGCGCGTGCCTGGACCAGA
TGCGCCATGCGGCCGACGTGCTGCTGGTCGAAGCGAACGCCGTGTCGGACAATCCGCTGATCTTCCCGGACACCGGCGAA
GTGCTGTCGGGCGGCAACTTCCACGCTGAACCCGTCGCGTTCGCGGCCGACAACCTCGCGCTCGCCGCGGCGGAAATCGG
CGCGCTGGCCGAGCGCCGCATCGCGCTGCTGATCGATGCGACGCTGTCGGGCCTGCCCCCGTTCCTCGTGAAGGACGGCG
GCGTGAACTCCGGCTTCATGATCGCGCACGTGACGGCCGCCGCCCTCGCGTCGGAAAACAAGACGCTCGCGCACCCGGCA
TCGGTCGACTCGCTGCCGACCTCGGCCAACCAGGAAGACCACGTGTCGATGGCGACGTTCGCCGCGCGCAAGCTCGCCGA
CATCGCGGACAACACGAAGCACATCCTCGCGATCGAACTGCTGGCCGCCGCGCAGGGCGTCGACCTGCGCGCGCCGTACC
ACACGAGCCCGAAGCTCGCGCCGGTGATGGAGACGATTCGCGGCAAGGTCGCGCACTACGAACTCGACCACTACTTCGCA
CCGGACATCGCGGTGATCGCGAAGCTGGTCGGCGAGCGCGCGTTCGCGAAGGTCGCGCCGTTCTCGTTCGCGTCGGAACA
GTAA

Upstream 100 bases:

>100_bases
GAAACTCCTGAGGCCGGAATATTGAAAAACGGGTTGTCTAGACAAGTTCCGATGGCTACACTTCAATCCATTCCGAACTT
GTCTAGACAGGATTGCTCAC

Downstream 100 bases:

>100_bases
GCCGATGAGTGCGCCGGTCTACCAGGAGATCAAGGATTTCATCCTGGCCCGCATCCATGCCGGCGAGTGGGAGGAGGGCG
ACCAGGTGCCGTCCGAGAAC

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 507; Mature: 507

Protein sequence:

>507_residues
MITLTPGHLTLPQLRRIAREPVQLKLDPASFAKIDAGAKAVADIAAKGEPAYGINTGFGRLASTHIPHDQLELLQKNLVL
SHAVGVGEPMARSSVRLLLALKLSSLGRGHSGIRREVMDALITLFNADVLPLIPVKGSVGASGDLAPLAHMSAVLLGVGE
VFIRGERASALDGLRVAGLAPLTLQAKEGLALLNGTQASTALALDNMFAIEDLYRTALVAGALSVDAAAGSVKPFDARIH
ELRGHQGQIDAAASYRELLEGSPINQSHRDCDKVQDPYSLRCQPQVMGACLDQMRHAADVLLVEANAVSDNPLIFPDTGE
VLSGGNFHAEPVAFAADNLALAAAEIGALAERRIALLIDATLSGLPPFLVKDGGVNSGFMIAHVTAAALASENKTLAHPA
SVDSLPTSANQEDHVSMATFAARKLADIADNTKHILAIELLAAAQGVDLRAPYHTSPKLAPVMETIRGKVAHYELDHYFA
PDIAVIAKLVGERAFAKVAPFSFASEQ

Sequences:

>Translated_507_residues
MITLTPGHLTLPQLRRIAREPVQLKLDPASFAKIDAGAKAVADIAAKGEPAYGINTGFGRLASTHIPHDQLELLQKNLVL
SHAVGVGEPMARSSVRLLLALKLSSLGRGHSGIRREVMDALITLFNADVLPLIPVKGSVGASGDLAPLAHMSAVLLGVGE
VFIRGERASALDGLRVAGLAPLTLQAKEGLALLNGTQASTALALDNMFAIEDLYRTALVAGALSVDAAAGSVKPFDARIH
ELRGHQGQIDAAASYRELLEGSPINQSHRDCDKVQDPYSLRCQPQVMGACLDQMRHAADVLLVEANAVSDNPLIFPDTGE
VLSGGNFHAEPVAFAADNLALAAAEIGALAERRIALLIDATLSGLPPFLVKDGGVNSGFMIAHVTAAALASENKTLAHPA
SVDSLPTSANQEDHVSMATFAARKLADIADNTKHILAIELLAAAQGVDLRAPYHTSPKLAPVMETIRGKVAHYELDHYFA
PDIAVIAKLVGERAFAKVAPFSFASEQ
>Mature_507_residues
MITLTPGHLTLPQLRRIAREPVQLKLDPASFAKIDAGAKAVADIAAKGEPAYGINTGFGRLASTHIPHDQLELLQKNLVL
SHAVGVGEPMARSSVRLLLALKLSSLGRGHSGIRREVMDALITLFNADVLPLIPVKGSVGASGDLAPLAHMSAVLLGVGE
VFIRGERASALDGLRVAGLAPLTLQAKEGLALLNGTQASTALALDNMFAIEDLYRTALVAGALSVDAAAGSVKPFDARIH
ELRGHQGQIDAAASYRELLEGSPINQSHRDCDKVQDPYSLRCQPQVMGACLDQMRHAADVLLVEANAVSDNPLIFPDTGE
VLSGGNFHAEPVAFAADNLALAAAEIGALAERRIALLIDATLSGLPPFLVKDGGVNSGFMIAHVTAAALASENKTLAHPA
SVDSLPTSANQEDHVSMATFAARKLADIADNTKHILAIELLAAAQGVDLRAPYHTSPKLAPVMETIRGKVAHYELDHYFA
PDIAVIAKLVGERAFAKVAPFSFASEQ

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=503, Percent_Identity=44.3339960238569, Blast_Score=418, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI17567831, Length=501, Percent_Identity=42.7145708582834, Blast_Score=370, Evalue=1e-102,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 53278; Mature: 53278

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS00488 PAL_HISTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITLTPGHLTLPQLRRIAREPVQLKLDPASFAKIDAGAKAVADIAAKGEPAYGINTGFGR
CEEECCCCCCHHHHHHHHCCCCEEEECCHHHHHHCCCHHHHHHHHHCCCCCCCCCCCHHH
LASTHIPHDQLELLQKNLVLSHAVGVGEPMARSSVRLLLALKLSSLGRGHSGIRREVMDA
HHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
LITLFNADVLPLIPVKGSVGASGDLAPLAHMSAVLLGVGEVFIRGERASALDGLRVAGLA
HHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHEEECCCHHHHCCCCCCCCC
PLTLQAKEGLALLNGTQASTALALDNMFAIEDLYRTALVAGALSVDAAAGSVKPFDARIH
CEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
ELRGHQGQIDAAASYRELLEGSPINQSHRDCDKVQDPYSLRCQPQVMGACLDQMRHAADV
HHCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCE
LLVEANAVSDNPLIFPDTGEVLSGGNFHAEPVAFAADNLALAAAEIGALAERRIALLIDA
EEEEECCCCCCCEEECCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHEEEEEEC
TLSGLPPFLVKDGGVNSGFMIAHVTAAALASENKTLAHPASVDSLPTSANQEDHVSMATF
HHCCCCCCEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHH
AARKLADIADNTKHILAIELLAAAQGVDLRAPYHTSPKLAPVMETIRGKVAHYELDHYFA
HHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCHHEEEECCCCCC
PDIAVIAKLVGERAFAKVAPFSFASEQ
CHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MITLTPGHLTLPQLRRIAREPVQLKLDPASFAKIDAGAKAVADIAAKGEPAYGINTGFGR
CEEECCCCCCHHHHHHHHCCCCEEEECCHHHHHHCCCHHHHHHHHHCCCCCCCCCCCHHH
LASTHIPHDQLELLQKNLVLSHAVGVGEPMARSSVRLLLALKLSSLGRGHSGIRREVMDA
HHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
LITLFNADVLPLIPVKGSVGASGDLAPLAHMSAVLLGVGEVFIRGERASALDGLRVAGLA
HHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHEEECCCHHHHCCCCCCCCC
PLTLQAKEGLALLNGTQASTALALDNMFAIEDLYRTALVAGALSVDAAAGSVKPFDARIH
CEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
ELRGHQGQIDAAASYRELLEGSPINQSHRDCDKVQDPYSLRCQPQVMGACLDQMRHAADV
HHCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCE
LLVEANAVSDNPLIFPDTGEVLSGGNFHAEPVAFAADNLALAAAEIGALAERRIALLIDA
EEEEECCCCCCCEEECCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHEEEEEEC
TLSGLPPFLVKDGGVNSGFMIAHVTAAALASENKTLAHPASVDSLPTSANQEDHVSMATF
HHCCCCCCEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHH
AARKLADIADNTKHILAIELLAAAQGVDLRAPYHTSPKLAPVMETIRGKVAHYELDHYFA
HHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCHHEEEECCCCCC
PDIAVIAKLVGERAFAKVAPFSFASEQ
CHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA