Click here to switch to the map view.

The map label for this gene is hutU [H]

Identifier: 116690191

GI number: 116690191

Start: 2416790

End: 2418478

Strand: Reverse

Name: hutU [H]

Synonym: Bcen2424_2170

Alternate gene names: 116690191

Gene position: 2418478-2416790 (Counterclockwise)

Preceding gene: 116690192

Following gene: 116690190

Centisome position: 69.42

GC content: 66.37

Gene sequence:

>1689_bases
ATGAACCATCCGAAACACATCGATCCCCGTCTCGATCCGACGCGCACGATCCGCGCGCCGCGAGGCAGCGAAAAGACCTG
CAAGACCTGGCTGGCCGAAGCGGCCTACCGGATGATTCAGAACAACCTCGACCCGGAAGTCGCCGAGCATCCGCATGCGC
TCGTCGTGTACGGCGGTATCGGCCGTGCTGCGCGTAACTGGGAATGCTATGACCAGATCCTCGCGTCGCTGAAGGATCTC
GAGGAAAACGAAACGCTGCTGATCCAGTCGGGCAAGCCGGTCGGCGTGTTCCGCACGCACAAGGATGCGCCGCGCGTGCT
GCTCGCGAACTCGAACCTGGTGCCGCACTGGGCGAACTGGGATCACTTCCACGAACTCGACCGCAAGGGCCTGATGATGT
ACGGCCAGATGACGGCCGGCAGCTGGATCTACATCGGCAGCCAGGGCATCGTGCAGGGCACCTACGAAACGTTCTTCTCC
GTCGCGAACCAGCACTTCAACGGCGATCCGTCGGGCCGCTGGATCCTGACGGGCGGCCTCGGCGGGATGGGCGGCGCGCA
GCCGCTGGCCGCGACGATGGCCGGCTTCTCGATGATCGCGGTCGAATGCGACGAGACGCGCATCGACTTCCGCCTGAAGA
CGCGCTACGTCGACAAGAAGGCGACGACGCTCGACGAAGCGCTCGGCATGATCGACGAAGCGAAGCGCACCGGCAAGCCG
GTGTCGATCGGCCTGCTCGGCAACGCGGCCGACGTGTTCGCGGAACTCGTCACGCGCGGCATTACGCCGGACTGCGTGAC
CGACCAGACGAGCGCGCACGACCCGATCAACGGCTACCTGCCGCAAGGCTGGACCGTCGCGCAATGGCGCGAAGCGCAGA
AGGTCGACCCGCAGAGCATCGTGAAGGTCGCGAAGCAGTCGATGGCCGTCCAGGTGCGCGCGATGCTCGCGCTGCAGGAA
CGCGGCGCGGCGACGCTCGACTACGGCAACAACATCCGCCAGATGGCGCTGGAAATGGGCGTCGAGAACGCCTTCGACTT
CCCGGGCTTCGTGCCGGCGTACATCCGCCCGCTGTTCTGCGAAGGCAAGGGCCCGTTCCGCTGGGTCGCGCTGTCCGGCG
ATCCGGAAGACATCTACAAGACCGACCAGAAGGTGAAGGAGCTGATCCCCGACGATCCGCACCTGCACAACTGGCTCGAC
ATGGCGCGTGAGCGTATCGCGTTCCAGGGCCTGCCGGCGCGGATCTGCTGGGTCGGCGTGAAGGATCGCTATCGCCTCGG
CCAGGCGTTCAACGAGATGGTGAAGAACGGCGAACTGAAGGCGCCGATCGTGATCGGTCGCGATCACCTCGATACGGGTT
CGGTCGCGAGCCCGAACCGCGAGACGGAATCGATGAAGGACGGCTCGGACGCCGTGAGCGACTGGCCGCTGCTGAACGCG
CTGCTGAACACCGCGGGCGGCGCATCGTGGGTGTCGCTGCACCATGGCGGCGGCGTCGGCATGGGCTTCTCGCAGCACTC
GGGCGTCGTGATCGTCGCCGACGGCACGGCTGACGCGCACGAGCGTCTCGGTCGCGTGCTGCTGAACGATCCGGCCACGG
GCGTGATGCGCCATGCGGATGCCGGCTACGAACTCGCGCAGCAGACGGCCCGCGAAGCCGGCCTGAAGCTGCCGATGCTC
GGCCGCTGA

Upstream 100 bases:

>100_bases
CGCCTCGGTGGCGAATTTGTGGCATCCCGGCAGCCGTTATCGCTTCACCGGGCATTTCTGATTCCTATTTGATCTTCAAT
TTCCTTCGGGAGCAGTCGTC

Downstream 100 bases:

>100_bases
GCATGACGGCGCTCGACCACGCGCCGGGGAATGCGACGCTGGCCGCCGCGCTGATCCGCGCGGCGGATCTCGTCGCGTCG
CCGTGGAAGAACGGCGGCGG

Product: urocanate hydratase

Products: NA

Alternate protein names: Urocanase; Imidazolonepropionate hydrolase [H]

Number of amino acids: Translated: 562; Mature: 562

Protein sequence:

>562_residues
MNHPKHIDPRLDPTRTIRAPRGSEKTCKTWLAEAAYRMIQNNLDPEVAEHPHALVVYGGIGRAARNWECYDQILASLKDL
EENETLLIQSGKPVGVFRTHKDAPRVLLANSNLVPHWANWDHFHELDRKGLMMYGQMTAGSWIYIGSQGIVQGTYETFFS
VANQHFNGDPSGRWILTGGLGGMGGAQPLAATMAGFSMIAVECDETRIDFRLKTRYVDKKATTLDEALGMIDEAKRTGKP
VSIGLLGNAADVFAELVTRGITPDCVTDQTSAHDPINGYLPQGWTVAQWREAQKVDPQSIVKVAKQSMAVQVRAMLALQE
RGAATLDYGNNIRQMALEMGVENAFDFPGFVPAYIRPLFCEGKGPFRWVALSGDPEDIYKTDQKVKELIPDDPHLHNWLD
MARERIAFQGLPARICWVGVKDRYRLGQAFNEMVKNGELKAPIVIGRDHLDTGSVASPNRETESMKDGSDAVSDWPLLNA
LLNTAGGASWVSLHHGGGVGMGFSQHSGVVIVADGTADAHERLGRVLLNDPATGVMRHADAGYELAQQTAREAGLKLPML
GR

Sequences:

>Translated_562_residues
MNHPKHIDPRLDPTRTIRAPRGSEKTCKTWLAEAAYRMIQNNLDPEVAEHPHALVVYGGIGRAARNWECYDQILASLKDL
EENETLLIQSGKPVGVFRTHKDAPRVLLANSNLVPHWANWDHFHELDRKGLMMYGQMTAGSWIYIGSQGIVQGTYETFFS
VANQHFNGDPSGRWILTGGLGGMGGAQPLAATMAGFSMIAVECDETRIDFRLKTRYVDKKATTLDEALGMIDEAKRTGKP
VSIGLLGNAADVFAELVTRGITPDCVTDQTSAHDPINGYLPQGWTVAQWREAQKVDPQSIVKVAKQSMAVQVRAMLALQE
RGAATLDYGNNIRQMALEMGVENAFDFPGFVPAYIRPLFCEGKGPFRWVALSGDPEDIYKTDQKVKELIPDDPHLHNWLD
MARERIAFQGLPARICWVGVKDRYRLGQAFNEMVKNGELKAPIVIGRDHLDTGSVASPNRETESMKDGSDAVSDWPLLNA
LLNTAGGASWVSLHHGGGVGMGFSQHSGVVIVADGTADAHERLGRVLLNDPATGVMRHADAGYELAQQTAREAGLKLPML
GR
>Mature_562_residues
MNHPKHIDPRLDPTRTIRAPRGSEKTCKTWLAEAAYRMIQNNLDPEVAEHPHALVVYGGIGRAARNWECYDQILASLKDL
EENETLLIQSGKPVGVFRTHKDAPRVLLANSNLVPHWANWDHFHELDRKGLMMYGQMTAGSWIYIGSQGIVQGTYETFFS
VANQHFNGDPSGRWILTGGLGGMGGAQPLAATMAGFSMIAVECDETRIDFRLKTRYVDKKATTLDEALGMIDEAKRTGKP
VSIGLLGNAADVFAELVTRGITPDCVTDQTSAHDPINGYLPQGWTVAQWREAQKVDPQSIVKVAKQSMAVQVRAMLALQE
RGAATLDYGNNIRQMALEMGVENAFDFPGFVPAYIRPLFCEGKGPFRWVALSGDPEDIYKTDQKVKELIPDDPHLHNWLD
MARERIAFQGLPARICWVGVKDRYRLGQAFNEMVKNGELKAPIVIGRDHLDTGSVASPNRETESMKDGSDAVSDWPLLNA
LLNTAGGASWVSLHHGGGVGMGFSQHSGVVIVADGTADAHERLGRVLLNDPATGVMRHADAGYELAQQTAREAGLKLPML
GR

Specific function: Unknown

COG id: COG2987

COG function: function code E; Urocanate hydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the urocanase family [H]

Homologues:

Organism=Homo sapiens, GI21389467, Length=576, Percent_Identity=33.8541666666667, Blast_Score=308, Evalue=1e-83,
Organism=Homo sapiens, GI260306182, Length=636, Percent_Identity=30.9748427672956, Blast_Score=278, Evalue=8e-75,
Organism=Caenorhabditis elegans, GI71997891, Length=571, Percent_Identity=34.8511383537653, Blast_Score=316, Evalue=2e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000193 [H]

Pfam domain/function: PF01175 Urocanase [H]

EC number: =4.2.1.49 [H]

Molecular weight: Translated: 61723; Mature: 61723

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS01233 UROCANASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHPKHIDPRLDPTRTIRAPRGSEKTCKTWLAEAAYRMIQNNLDPEVAEHPHALVVYGGI
CCCCCCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHCCCCEEEEECCC
GRAARNWECYDQILASLKDLEENETLLIQSGKPVGVFRTHKDAPRVLLANSNLVPHWANW
CCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCEEEEECCCCCCEEEEECCCCCCCCCCC
DHFHELDRKGLMMYGQMTAGSWIYIGSQGIVQGTYETFFSVANQHFNGDPSGRWILTGGL
HHHHHHCCCCEEEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEECCC
GGMGGAQPLAATMAGFSMIAVECDETRIDFRLKTRYVDKKATTLDEALGMIDEAKRTGKP
CCCCCCHHHHHHHCCCEEEEEEECCCEEEEEEEEEECCHHHHHHHHHHHHHHHHHHCCCC
VSIGLLGNAADVFAELVTRGITPDCVTDQTSAHDPINGYLPQGWTVAQWREAQKVDPQSI
EEEEEECCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHH
VKVAKQSMAVQVRAMLALQERGAATLDYGNNIRQMALEMGVENAFDFPGFVPAYIRPLFC
HHHHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHCCCCCCCCCCCCHHHHCEEEE
EGKGPFRWVALSGDPEDIYKTDQKVKELIPDDPHLHNWLDMARERIAFQGLPARICWVGV
CCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECC
KDRYRLGQAFNEMVKNGELKAPIVIGRDHLDTGSVASPNRETESMKDGSDAVSDWPLLNA
HHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHH
LLNTAGGASWVSLHHGGGVGMGFSQHSGVVIVADGTADAHERLGRVLLNDPATGVMRHAD
HHHCCCCCEEEEEECCCCCCCCCCCCCCEEEEECCCCHHHHHHCCEEECCCCHHHHHHCC
AGYELAQQTAREAGLKLPMLGR
CCHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MNHPKHIDPRLDPTRTIRAPRGSEKTCKTWLAEAAYRMIQNNLDPEVAEHPHALVVYGGI
CCCCCCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHCCCCEEEEECCC
GRAARNWECYDQILASLKDLEENETLLIQSGKPVGVFRTHKDAPRVLLANSNLVPHWANW
CCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCEEEEECCCCCCEEEEECCCCCCCCCCC
DHFHELDRKGLMMYGQMTAGSWIYIGSQGIVQGTYETFFSVANQHFNGDPSGRWILTGGL
HHHHHHCCCCEEEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEECCC
GGMGGAQPLAATMAGFSMIAVECDETRIDFRLKTRYVDKKATTLDEALGMIDEAKRTGKP
CCCCCCHHHHHHHCCCEEEEEEECCCEEEEEEEEEECCHHHHHHHHHHHHHHHHHHCCCC
VSIGLLGNAADVFAELVTRGITPDCVTDQTSAHDPINGYLPQGWTVAQWREAQKVDPQSI
EEEEEECCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHH
VKVAKQSMAVQVRAMLALQERGAATLDYGNNIRQMALEMGVENAFDFPGFVPAYIRPLFC
HHHHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHCCCCCCCCCCCCHHHHCEEEE
EGKGPFRWVALSGDPEDIYKTDQKVKELIPDDPHLHNWLDMARERIAFQGLPARICWVGV
CCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECC
KDRYRLGQAFNEMVKNGELKAPIVIGRDHLDTGSVASPNRETESMKDGSDAVSDWPLLNA
HHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHH
LLNTAGGASWVSLHHGGGVGMGFSQHSGVVIVADGTADAHERLGRVLLNDPATGVMRHAD
HHHCCCCCEEEEEECCCCCCCCCCCCCCEEEEECCCCHHHHHHCCEEECCCCHHHHHHCC
AGYELAQQTAREAGLKLPMLGR
CCHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14500782 [H]