Click here to switch to the map view.

The map label for this gene is prlC [H]

Identifier: 116690162

GI number: 116690162

Start: 2378330

End: 2380417

Strand: Direct

Name: prlC [H]

Synonym: Bcen2424_2141

Alternate gene names: 116690162

Gene position: 2378330-2380417 (Clockwise)

Preceding gene: 116690161

Following gene: 116690164

Centisome position: 68.27

GC content: 67.39

Gene sequence:

>2088_bases
ATGTCCGCCAGCGCCAACACCAATCCGCTCCTCGACTTCTCCGGCCTGCCCCGTTTCGGCGAGATCCGCCCGGAACACGT
GACGCCCGCGCTCGATACGCTGCTCGACGCCGCCAGCCGCGCGGTCGAAGCGGCGAGCGCGAGCGACACGCCGTCGACCT
GGGCCGCCGTCGTCGAGACGGTCGAGCAGGCCACGGAGCCGCTCGGCCGCGCATGGGGCATCGTCGGCCATCTGAATGCG
GTCGCCGACACGCCCGAACTGCGCGCCGCCTACGGTGAAAACCTGCCGCGCGTGACCGAGTTCTGGTCGAGCGTCGGCCA
GAATCTCGCGCTGTACGAAAAGTACAAGGCGATCGCCGCGAGCGCCGAATACGCGACGTTGTCCGCCGAGCGCAAGAAGA
TCCTCGACAATGCGCTGCGCGACTTCCGCCTGTCGGGCGCCGAGCTGCCCGAGGACCAGAAGCCGCGCTTCGCGGAACTG
CAGGAACAGCAGGCCGCGCTGTCGAAGGCATTCTCCGATCACGTGCTCGATGCAACCAACGCGTACGCGTACTTCGTCAC
CGACGAAGCCGAGCTGGCTGGCCTGCCCGGCGACGCGATCGAGGCTGCTCGCGAAGCCGCTCAGAAGGACGGCAAGGAAG
GCTGGAAATTCACGCTGCATTTCCCGTCGTACTTCCCGGTGCTGCAGTACGCGGACAACCGCGCGCTGCGCGAGACGCTC
TACCGCGCCTATGCGACGCGCGCGTCGGAGCTCGGGCCGCAGTACGGCGACGGCAAGACCGAATGGGACAACACGGCGAT
CGTCGTCGACGCGCTGAAGCTGCGCCGCGAAGAAGCGCAGATGCTCGGCTACCGCAACTTCGCCGAAGTGTCGCTCGCGC
CGAAGATGGCCGAATCGCCGCAGCAGGTGATCGCATTCCTCGAGGATCTCGCGACGCGCGCGCGCCCGCACGCGGACAAG
GACTGGGACGAGCTGCGCACGTTCGCCGCGAAGGAGCTCGGCCTCGCCGAACTCGCGCCGTGGGACGTCGCATACGCGGC
CGAAAAGCTGCGCCAGCAGCGCTATGCGTTCTCGGAAAACGAGGTCAAGCAGTACTTCCCGGAACCGGCCGCGCTGAAGG
GCCTGTTCACCGTCACCGAAACGCTGTTCGGCGTGAAGATCAAGCCGGACGACGCGCCGGTATGGCACAAGGACGTGCGC
TTCTTCCGCGTCGAGAACCGCGACGGCTCGCTCGTCGCGCAGTTCTATCTCGACCTGTACGCACGCGAAGGCAAGCGCGG
CGGCGCCTGGATGGACGACGCGCGTTCGCGCGCGAAGCGCGGCAGCGACGTGCAGACGCCCGTCGCGTACCTGACCTGCA
ACTTCTCCGCGCCGGTCGGCGGCAAGCCCGCGTGCTTCACGCACGACGAAGTGATCACGCTGTTCCATGAATTCGGCCAC
GGGCTGCATCACATGCTCACGCGCGTCGACGAGCTCGGCGTGTCGGGCATCAACGGTGTCGAATGGGATGCGGTCGAACT
GCCGTCGCAGTTCATGGAAAACTTCTGCTGGGAATGGGACGTGCTGTCGTCGATGTCGTCGCACGTCGATACGGGCGCGT
CGCTGCCGCGCGAGCTGTTCGACAAGATGATCGCCGCGAAGAACTTCCAGAGCGGGCTCGGCACGCTGCGCCAGATCGTG
TTCTCGATGTTCGACATGCTGCTGCACGTCGACTTCGACCCGGCCGGCGCCACCGGCGTGACCGCGTTCGCGCGCGAGAT
CAACGAGCGCTATCACGTGATCCCGCAGGCGGCGTTCTCGCGCTGGCCGAACACGTTCAGCCACATCTTCGCGGGCGGCT
ATGCGGCCGGCTACTACAGCTACAAGTGGGCCGAAGTGCTGTCGGCCGATGCGTACGCGGCGTTCGAGGAAGCGGCCGCC
GCCAGCGGCAGCGTGCTCGACGCGGCAACCGGCACGCGCTATCGCCGCGAAATCCTCGAGGTCGGCGGTAGCCGCCCGGC
GATGGAGTCGTTCAAGGCGTTCCGCGGCCGCGAGCCGCAGATCGACGCGCTGCTGCGCCACAACGGGATGGCCGCGTCCG
CGCACTGA

Upstream 100 bases:

>100_bases
GAAAGCGCACGATGCGCCCCAATAATGTCGGTATCGGGCGCCGCTTCATCGCGCCTCACCCTTTTCATCCCGGTTCATCC
GGCAACAGACAGGGAGTCTT

Downstream 100 bases:

>100_bases
GCGCGCTGCCCGGCCCTTCCAGTTGTTCAGGCTGCATCGACAGGCACCGCTTCGGCGGTGCCTTTTTTCATGGCGCGGGC
GTGTCGTCGCCCACTTCGTC

Product: oligopeptidase A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 695; Mature: 694

Protein sequence:

>695_residues
MSASANTNPLLDFSGLPRFGEIRPEHVTPALDTLLDAASRAVEAASASDTPSTWAAVVETVEQATEPLGRAWGIVGHLNA
VADTPELRAAYGENLPRVTEFWSSVGQNLALYEKYKAIAASAEYATLSAERKKILDNALRDFRLSGAELPEDQKPRFAEL
QEQQAALSKAFSDHVLDATNAYAYFVTDEAELAGLPGDAIEAAREAAQKDGKEGWKFTLHFPSYFPVLQYADNRALRETL
YRAYATRASELGPQYGDGKTEWDNTAIVVDALKLRREEAQMLGYRNFAEVSLAPKMAESPQQVIAFLEDLATRARPHADK
DWDELRTFAAKELGLAELAPWDVAYAAEKLRQQRYAFSENEVKQYFPEPAALKGLFTVTETLFGVKIKPDDAPVWHKDVR
FFRVENRDGSLVAQFYLDLYAREGKRGGAWMDDARSRAKRGSDVQTPVAYLTCNFSAPVGGKPACFTHDEVITLFHEFGH
GLHHMLTRVDELGVSGINGVEWDAVELPSQFMENFCWEWDVLSSMSSHVDTGASLPRELFDKMIAAKNFQSGLGTLRQIV
FSMFDMLLHVDFDPAGATGVTAFAREINERYHVIPQAAFSRWPNTFSHIFAGGYAAGYYSYKWAEVLSADAYAAFEEAAA
ASGSVLDAATGTRYRREILEVGGSRPAMESFKAFRGREPQIDALLRHNGMAASAH

Sequences:

>Translated_695_residues
MSASANTNPLLDFSGLPRFGEIRPEHVTPALDTLLDAASRAVEAASASDTPSTWAAVVETVEQATEPLGRAWGIVGHLNA
VADTPELRAAYGENLPRVTEFWSSVGQNLALYEKYKAIAASAEYATLSAERKKILDNALRDFRLSGAELPEDQKPRFAEL
QEQQAALSKAFSDHVLDATNAYAYFVTDEAELAGLPGDAIEAAREAAQKDGKEGWKFTLHFPSYFPVLQYADNRALRETL
YRAYATRASELGPQYGDGKTEWDNTAIVVDALKLRREEAQMLGYRNFAEVSLAPKMAESPQQVIAFLEDLATRARPHADK
DWDELRTFAAKELGLAELAPWDVAYAAEKLRQQRYAFSENEVKQYFPEPAALKGLFTVTETLFGVKIKPDDAPVWHKDVR
FFRVENRDGSLVAQFYLDLYAREGKRGGAWMDDARSRAKRGSDVQTPVAYLTCNFSAPVGGKPACFTHDEVITLFHEFGH
GLHHMLTRVDELGVSGINGVEWDAVELPSQFMENFCWEWDVLSSMSSHVDTGASLPRELFDKMIAAKNFQSGLGTLRQIV
FSMFDMLLHVDFDPAGATGVTAFAREINERYHVIPQAAFSRWPNTFSHIFAGGYAAGYYSYKWAEVLSADAYAAFEEAAA
ASGSVLDAATGTRYRREILEVGGSRPAMESFKAFRGREPQIDALLRHNGMAASAH
>Mature_694_residues
SASANTNPLLDFSGLPRFGEIRPEHVTPALDTLLDAASRAVEAASASDTPSTWAAVVETVEQATEPLGRAWGIVGHLNAV
ADTPELRAAYGENLPRVTEFWSSVGQNLALYEKYKAIAASAEYATLSAERKKILDNALRDFRLSGAELPEDQKPRFAELQ
EQQAALSKAFSDHVLDATNAYAYFVTDEAELAGLPGDAIEAAREAAQKDGKEGWKFTLHFPSYFPVLQYADNRALRETLY
RAYATRASELGPQYGDGKTEWDNTAIVVDALKLRREEAQMLGYRNFAEVSLAPKMAESPQQVIAFLEDLATRARPHADKD
WDELRTFAAKELGLAELAPWDVAYAAEKLRQQRYAFSENEVKQYFPEPAALKGLFTVTETLFGVKIKPDDAPVWHKDVRF
FRVENRDGSLVAQFYLDLYAREGKRGGAWMDDARSRAKRGSDVQTPVAYLTCNFSAPVGGKPACFTHDEVITLFHEFGHG
LHHMLTRVDELGVSGINGVEWDAVELPSQFMENFCWEWDVLSSMSSHVDTGASLPRELFDKMIAAKNFQSGLGTLRQIVF
SMFDMLLHVDFDPAGATGVTAFAREINERYHVIPQAAFSRWPNTFSHIFAGGYAAGYYSYKWAEVLSADAYAAFEEAAAA
SGSVLDAATGTRYRREILEVGGSRPAMESFKAFRGREPQIDALLRHNGMAASAH

Specific function: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=621, Percent_Identity=31.0789049919485, Blast_Score=292, Evalue=6e-79,
Organism=Homo sapiens, GI14149738, Length=630, Percent_Identity=30.6349206349206, Blast_Score=277, Evalue=2e-74,
Organism=Homo sapiens, GI156105687, Length=650, Percent_Identity=25.2307692307692, Blast_Score=180, Evalue=4e-45,
Organism=Escherichia coli, GI1789913, Length=686, Percent_Identity=50.7288629737609, Blast_Score=696, Evalue=0.0,
Organism=Escherichia coli, GI1787819, Length=691, Percent_Identity=30.1013024602026, Blast_Score=273, Evalue=3e-74,
Organism=Caenorhabditis elegans, GI71999758, Length=526, Percent_Identity=25.8555133079848, Blast_Score=142, Evalue=8e-34,
Organism=Saccharomyces cerevisiae, GI6319793, Length=694, Percent_Identity=28.8184438040346, Blast_Score=279, Evalue=1e-75,
Organism=Saccharomyces cerevisiae, GI6322715, Length=702, Percent_Identity=22.7920227920228, Blast_Score=139, Evalue=2e-33,
Organism=Drosophila melanogaster, GI21356111, Length=693, Percent_Identity=26.8398268398268, Blast_Score=242, Evalue=6e-64,
Organism=Drosophila melanogaster, GI20129717, Length=564, Percent_Identity=25.177304964539, Blast_Score=159, Evalue=6e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.24.70 [H]

Molecular weight: Translated: 76976; Mature: 76844

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSASANTNPLLDFSGLPRFGEIRPEHVTPALDTLLDAASRAVEAASASDTPSTWAAVVET
CCCCCCCCCCCCCCCCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
VEQATEPLGRAWGIVGHLNAVADTPELRAAYGENLPRVTEFWSSVGQNLALYEKYKAIAA
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHH
SAEYATLSAERKKILDNALRDFRLSGAELPEDQKPRFAELQEQQAALSKAFSDHVLDATN
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
AYAYFVTDEAELAGLPGDAIEAAREAAQKDGKEGWKFTLHFPSYFPVLQYADNRALRETL
CEEEEEECCHHHCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHCCHHHHHHH
YRAYATRASELGPQYGDGKTEWDNTAIVVDALKLRREEAQMLGYRNFAEVSLAPKMAESP
HHHHHHHHHHCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHCCCCHHHHHCCCHHHCCH
QQVIAFLEDLATRARPHADKDWDELRTFAAKELGLAELAPWDVAYAAEKLRQQRYAFSEN
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHCCCHH
EVKQYFPEPAALKGLFTVTETLFGVKIKPDDAPVWHKDVRFFRVENRDGSLVAQFYLDLY
HHHHHCCCHHHHHHHHHHHHHHHCCEECCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHH
AREGKRGGAWMDDARSRAKRGSDVQTPVAYLTCNFSAPVGGKPACFTHDEVITLFHEFGH
HHCCCCCCCCHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCEECHHHHHHHHHHHHH
GLHHMLTRVDELGVSGINGVEWDAVELPSQFMENFCWEWDVLSSMSSHVDTGASLPRELF
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHH
DKMIAAKNFQSGLGTLRQIVFSMFDMLLHVDFDPAGATGVTAFAREINERYHVIPQAAFS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHH
RWPNTFSHIFAGGYAAGYYSYKWAEVLSADAYAAFEEAAAASGSVLDAATGTRYRREILE
HCCHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHH
VGGSRPAMESFKAFRGREPQIDALLRHNGMAASAH
CCCCCHHHHHHHHHCCCCCCHHHHHHCCCCCCCCC
>Mature Secondary Structure 
SASANTNPLLDFSGLPRFGEIRPEHVTPALDTLLDAASRAVEAASASDTPSTWAAVVET
CCCCCCCCCCCCCCCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
VEQATEPLGRAWGIVGHLNAVADTPELRAAYGENLPRVTEFWSSVGQNLALYEKYKAIAA
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHH
SAEYATLSAERKKILDNALRDFRLSGAELPEDQKPRFAELQEQQAALSKAFSDHVLDATN
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
AYAYFVTDEAELAGLPGDAIEAAREAAQKDGKEGWKFTLHFPSYFPVLQYADNRALRETL
CEEEEEECCHHHCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHCCHHHHHHH
YRAYATRASELGPQYGDGKTEWDNTAIVVDALKLRREEAQMLGYRNFAEVSLAPKMAESP
HHHHHHHHHHCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHCCCCHHHHHCCCHHHCCH
QQVIAFLEDLATRARPHADKDWDELRTFAAKELGLAELAPWDVAYAAEKLRQQRYAFSEN
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHCCCHH
EVKQYFPEPAALKGLFTVTETLFGVKIKPDDAPVWHKDVRFFRVENRDGSLVAQFYLDLY
HHHHHCCCHHHHHHHHHHHHHHHCCEECCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHH
AREGKRGGAWMDDARSRAKRGSDVQTPVAYLTCNFSAPVGGKPACFTHDEVITLFHEFGH
HHCCCCCCCCHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCEECHHHHHHHHHHHHH
GLHHMLTRVDELGVSGINGVEWDAVELPSQFMENFCWEWDVLSSMSSHVDTGASLPRELF
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHH
DKMIAAKNFQSGLGTLRQIVFSMFDMLLHVDFDPAGATGVTAFAREINERYHVIPQAAFS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHH
RWPNTFSHIFAGGYAAGYYSYKWAEVLSADAYAAFEEAAAASGSVLDAATGTRYRREILE
HCCHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHH
VGGSRPAMESFKAFRGREPQIDALLRHNGMAASAH
CCCCCHHHHHHHHHCCCCCCHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1325967; 8366062; 8041620; 9278503 [H]