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The map label for this gene is cyaA [H]

Identifier: 116690091

GI number: 116690091

Start: 2296291

End: 2298297

Strand: Reverse

Name: cyaA [H]

Synonym: Bcen2424_2070

Alternate gene names: 116690091

Gene position: 2298297-2296291 (Counterclockwise)

Preceding gene: 116690092

Following gene: 116690090

Centisome position: 65.97

GC content: 63.43

Gene sequence:

>2007_bases
ATGTTCGGCAAACTCACACTCTCGGCGATCCCGTTCGATCAGCCCATCATCATGGGGGCCGGCGCCTTCATGGGTCTGGT
CGTGCTGGGCATTCTCGCCGCGCTGACGATCACCGGCCGCTGGAAATGGCTGTGGACGGAATGGCTGACCACGGTCGACC
ACAAGAGACTCGGCGTGATGTACATCATCGTCGCGCTGATCATGCTGCTGCGCGGCTTCGCCGACGCGATCATGATGCGC
ATGCAACTCGCGCTCGCGTACAACGCGCCCGGCTACCTGCCGCCGCACCACTATGACCAGATCTTCACGGCGCACGGCGT
GATCATGATCTTCTTCATGGCGATGGTGTTCATGGTCGGCCTGATGAACCTGGTCGTGCCGCTGCAGATCGGCGCGCGCG
ACGTCGCGTTCCCGTTCATCAACTCGCTGTCGTTCTGGATGACGGCGGTCAGCGCGATCCTGATCAACCTGTCGCTCGTG
ATCGGCGAATTCGCGCAGACGGGCTGGCTCGCGTACCCGCCGCTGTCGGAGCTGCAGTTCAGTCCGGGGGTAGGGGTCGA
CTACTACCTGTGGGCGCTGCAGATCTCGGGCGTCGGCACGCTGCTGACCGGCGTGAACTTCTTCGTGACGATCATCAAGA
TGCGCGCGCCGGGCATGACGCTGATGAAGATGCCCGTGTTCACGTGGACGGCCCTGTGCACGAACGTGCTGATCATGGCG
TCGTTCCCGATCCTGACCGCGACGCTCGCGCTGCTCGGCCTCGACCGTTACCTCGGCATGCACTTCTTCACGAACGATGC
CGGCGGCAATGCGATGCTGTACCTGAACCTGATCTGGGCGTGGGGCCATCCGGAGGTGTACATCCTGATCCTGCCGGCGT
TCGGGATCTTCTCGGAAGTCATCGCGACGTTCGCGAAGAAGCCGCTGTTCGGCTACAAGACGATGGTGTACGCGACCTGC
GCGATCATGGTGCTGTCGTTCCTCGTGTGGCTGCATCACTTCTTCACGATGGGCTCGGGCGCGAACGTGAATGCGTTCTT
CGGGATCATGACGATGATCATCGCGATTCCGACCGGCGTGAAGGTGTTCAACTGGCTGTTCACGATGTACCGCGGCCGGA
TCGAATTCACGACGCCCGTGCTGTGGACGATCGGCTTCATGGTCACGTTCACGCTCGGCGGCATGACCGGCGTGATGATG
GCGATTCCGGGCGCGGACTTCGTGCTGCACAACAGCCTGTTCCTGATCGCGCACTTCCACAACGTGATCATCGGCGGTGT
GCTGTTCGGCTATCTGGCGGGCTTCAACTACTGGTTCCCGAAGGCGTTCGGCTTCAAGCTGAACGAGAAGCTCGGCAAGG
CCGCGTTCTGGTTCTGGCAGGTCGGCTTCTACGTCGCGTTCGTGCCGCTCTACGTGCTCGGCTTCATGGGCATGACGCGC
CGCCTGAACCACTACGACAACCCGGCCTGGCATCCGTGGCTGCTGGTCGCCGCGTTCGGCGCCGTGCTGATCGCGATCGG
CATCGCGTGCCAGCTGCTGCAGCTGGTGGTCAGCATCCGCAACCGCCATCTGCCCGAGTACCGCGACACGACGGGCGACC
CGTGGGGTGGTCGCACGCTGGAGTGGGCGACCTCGTCGCCGCCGGCCGACTACAACTTCGCGGTGATCCCGCAAGTGCGC
ACGCTGGATGCGTATGCGGACATGAAGGCACGCGGTGAAGGCCGGCCGAACCCGGCGACGTTCCGCGACATCCACATGCC
GTCGAATACTTGCGCGGGCCTCGTGATCGCGGTCTTCAGTCTGGTGCTCGGCTTCGCGCTGGTGTGGCACATCTGGTGGA
TGGCGATCGGCGGGCTCGTCGGGATCATCGCGACGCTCGTGATCTACAGCTCGCGCGATAACGACGGCTATTACATCCCT
GCGTCGACGGTGCGCAAGACCGAAGACAAGCAGCCGACGCGGCGCACGGCCGCGCGCGTCGACGACGTGGAACTGGAGGC
CAACTGA

Upstream 100 bases:

>100_bases
GTCGGTCGATCCGCGGCTCTTCCACAACATCATCGCGAAATACAACGATGGCCACGTCCTCGACCTGAAGGACGCCGCCT
GCGGCACGAAGGGGTAACGC

Downstream 100 bases:

>100_bases
TGTTGCAGAAAACCTTGAGCGCAACCCTGCTCGAACACGACGACCATCCGCCGTCGCATTCGGTGTTCGGGTTCTGGCTG
TATCTGATGACCGACTGCGT

Product: cytochrome-c oxidase

Products: NA

Alternate protein names: Cytochrome A1 subunit 1; Oxidase BA(3) subunit 1; Ubiquinol oxidase polypeptide I [H]

Number of amino acids: Translated: 668; Mature: 668

Protein sequence:

>668_residues
MFGKLTLSAIPFDQPIIMGAGAFMGLVVLGILAALTITGRWKWLWTEWLTTVDHKRLGVMYIIVALIMLLRGFADAIMMR
MQLALAYNAPGYLPPHHYDQIFTAHGVIMIFFMAMVFMVGLMNLVVPLQIGARDVAFPFINSLSFWMTAVSAILINLSLV
IGEFAQTGWLAYPPLSELQFSPGVGVDYYLWALQISGVGTLLTGVNFFVTIIKMRAPGMTLMKMPVFTWTALCTNVLIMA
SFPILTATLALLGLDRYLGMHFFTNDAGGNAMLYLNLIWAWGHPEVYILILPAFGIFSEVIATFAKKPLFGYKTMVYATC
AIMVLSFLVWLHHFFTMGSGANVNAFFGIMTMIIAIPTGVKVFNWLFTMYRGRIEFTTPVLWTIGFMVTFTLGGMTGVMM
AIPGADFVLHNSLFLIAHFHNVIIGGVLFGYLAGFNYWFPKAFGFKLNEKLGKAAFWFWQVGFYVAFVPLYVLGFMGMTR
RLNHYDNPAWHPWLLVAAFGAVLIAIGIACQLLQLVVSIRNRHLPEYRDTTGDPWGGRTLEWATSSPPADYNFAVIPQVR
TLDAYADMKARGEGRPNPATFRDIHMPSNTCAGLVIAVFSLVLGFALVWHIWWMAIGGLVGIIATLVIYSSRDNDGYYIP
ASTVRKTEDKQPTRRTAARVDDVELEAN

Sequences:

>Translated_668_residues
MFGKLTLSAIPFDQPIIMGAGAFMGLVVLGILAALTITGRWKWLWTEWLTTVDHKRLGVMYIIVALIMLLRGFADAIMMR
MQLALAYNAPGYLPPHHYDQIFTAHGVIMIFFMAMVFMVGLMNLVVPLQIGARDVAFPFINSLSFWMTAVSAILINLSLV
IGEFAQTGWLAYPPLSELQFSPGVGVDYYLWALQISGVGTLLTGVNFFVTIIKMRAPGMTLMKMPVFTWTALCTNVLIMA
SFPILTATLALLGLDRYLGMHFFTNDAGGNAMLYLNLIWAWGHPEVYILILPAFGIFSEVIATFAKKPLFGYKTMVYATC
AIMVLSFLVWLHHFFTMGSGANVNAFFGIMTMIIAIPTGVKVFNWLFTMYRGRIEFTTPVLWTIGFMVTFTLGGMTGVMM
AIPGADFVLHNSLFLIAHFHNVIIGGVLFGYLAGFNYWFPKAFGFKLNEKLGKAAFWFWQVGFYVAFVPLYVLGFMGMTR
RLNHYDNPAWHPWLLVAAFGAVLIAIGIACQLLQLVVSIRNRHLPEYRDTTGDPWGGRTLEWATSSPPADYNFAVIPQVR
TLDAYADMKARGEGRPNPATFRDIHMPSNTCAGLVIAVFSLVLGFALVWHIWWMAIGGLVGIIATLVIYSSRDNDGYYIP
ASTVRKTEDKQPTRRTAARVDDVELEAN
>Mature_668_residues
MFGKLTLSAIPFDQPIIMGAGAFMGLVVLGILAALTITGRWKWLWTEWLTTVDHKRLGVMYIIVALIMLLRGFADAIMMR
MQLALAYNAPGYLPPHHYDQIFTAHGVIMIFFMAMVFMVGLMNLVVPLQIGARDVAFPFINSLSFWMTAVSAILINLSLV
IGEFAQTGWLAYPPLSELQFSPGVGVDYYLWALQISGVGTLLTGVNFFVTIIKMRAPGMTLMKMPVFTWTALCTNVLIMA
SFPILTATLALLGLDRYLGMHFFTNDAGGNAMLYLNLIWAWGHPEVYILILPAFGIFSEVIATFAKKPLFGYKTMVYATC
AIMVLSFLVWLHHFFTMGSGANVNAFFGIMTMIIAIPTGVKVFNWLFTMYRGRIEFTTPVLWTIGFMVTFTLGGMTGVMM
AIPGADFVLHNSLFLIAHFHNVIIGGVLFGYLAGFNYWFPKAFGFKLNEKLGKAAFWFWQVGFYVAFVPLYVLGFMGMTR
RLNHYDNPAWHPWLLVAAFGAVLIAIGIACQLLQLVVSIRNRHLPEYRDTTGDPWGGRTLEWATSSPPADYNFAVIPQVR
TLDAYADMKARGEGRPNPATFRDIHMPSNTCAGLVIAVFSLVLGFALVWHIWWMAIGGLVGIIATLVIYSSRDNDGYYIP
ASTVRKTEDKQPTRRTAARVDDVELEAN

Specific function: Catalytic subunit of the enzyme. Electrons originating in a quinol are transferred to the bimetallic center formed by heme a and copper B [H]

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family [H]

Homologues:

Organism=Homo sapiens, GI251831109, Length=509, Percent_Identity=38.1139489194499, Blast_Score=324, Evalue=2e-88,
Organism=Escherichia coli, GI1786634, Length=663, Percent_Identity=67.7224736048265, Blast_Score=933, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6226519, Length=537, Percent_Identity=37.9888268156425, Blast_Score=355, Evalue=1e-98,
Organism=Saccharomyces cerevisiae, GI6226524, Length=325, Percent_Identity=42.4615384615385, Blast_Score=251, Evalue=2e-67,
Organism=Saccharomyces cerevisiae, GI6226523, Length=245, Percent_Identity=34.2857142857143, Blast_Score=137, Evalue=6e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000883
- InterPro:   IPR014207 [H]

Pfam domain/function: PF00115 COX1 [H]

EC number: 1.10.3.-

Molecular weight: Translated: 74490; Mature: 74490

Theoretical pI: Translated: 9.04; Mature: 9.04

Prosite motif: PS50855 COX1 ; PS00077 COX1_CUB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
5.4 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFGKLTLSAIPFDQPIIMGAGAFMGLVVLGILAALTITGRWKWLWTEWLTTVDHKRLGVM
CCCCEEEEECCCCCCCEECCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
YIIVALIMLLRGFADAIMMRMQLALAYNAPGYLPPHHYDQIFTAHGVIMIFFMAMVFMVG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LMNLVVPLQIGARDVAFPFINSLSFWMTAVSAILINLSLVIGEFAQTGWLAYPPLSELQF
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCHHHCCC
SPGVGVDYYLWALQISGVGTLLTGVNFFVTIIKMRAPGMTLMKMPVFTWTALCTNVLIMA
CCCCCCHHEEEEEEECCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
SFPILTATLALLGLDRYLGMHFFTNDAGGNAMLYLNLIWAWGHPEVYILILPAFGIFSEV
HHHHHHHHHHHHHHHHHHCCCEEECCCCCCEEEEEEEEEECCCCCEEEEEECHHHHHHHH
IATFAKKPLFGYKTMVYATCAIMVLSFLVWLHHFFTMGSGANVNAFFGIMTMIIAIPTGV
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCH
KVFNWLFTMYRGRIEFTTPVLWTIGFMVTFTLGGMTGVMMAIPGADFVLHNSLFLIAHFH
HHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHCCHHHHHHCCCCCCCHHHCCHHHHHHHH
NVIIGGVLFGYLAGFNYWFPKAFGFKLNEKLGKAAFWFWQVGFYVAFVPLYVLGFMGMTR
HHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLNHYDNPAWHPWLLVAAFGAVLIAIGIACQLLQLVVSIRNRHLPEYRDTTGDPWGGRTL
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEE
EWATSSPPADYNFAVIPQVRTLDAYADMKARGEGRPNPATFRDIHMPSNTCAGLVIAVFS
EECCCCCCCCCCEEECCCHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHH
LVLGFALVWHIWWMAIGGLVGIIATLVIYSSRDNDGYYIPASTVRKTEDKQPTRRTAARV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCEEECHHHHHCCCCCCHHHHHHHCC
DDVELEAN
CCEEECCC
>Mature Secondary Structure
MFGKLTLSAIPFDQPIIMGAGAFMGLVVLGILAALTITGRWKWLWTEWLTTVDHKRLGVM
CCCCEEEEECCCCCCCEECCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
YIIVALIMLLRGFADAIMMRMQLALAYNAPGYLPPHHYDQIFTAHGVIMIFFMAMVFMVG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LMNLVVPLQIGARDVAFPFINSLSFWMTAVSAILINLSLVIGEFAQTGWLAYPPLSELQF
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCHHHCCC
SPGVGVDYYLWALQISGVGTLLTGVNFFVTIIKMRAPGMTLMKMPVFTWTALCTNVLIMA
CCCCCCHHEEEEEEECCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
SFPILTATLALLGLDRYLGMHFFTNDAGGNAMLYLNLIWAWGHPEVYILILPAFGIFSEV
HHHHHHHHHHHHHHHHHHCCCEEECCCCCCEEEEEEEEEECCCCCEEEEEECHHHHHHHH
IATFAKKPLFGYKTMVYATCAIMVLSFLVWLHHFFTMGSGANVNAFFGIMTMIIAIPTGV
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCH
KVFNWLFTMYRGRIEFTTPVLWTIGFMVTFTLGGMTGVMMAIPGADFVLHNSLFLIAHFH
HHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHCCHHHHHHCCCCCCCHHHCCHHHHHHHH
NVIIGGVLFGYLAGFNYWFPKAFGFKLNEKLGKAAFWFWQVGFYVAFVPLYVLGFMGMTR
HHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLNHYDNPAWHPWLLVAAFGAVLIAIGIACQLLQLVVSIRNRHLPEYRDTTGDPWGGRTL
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEE
EWATSSPPADYNFAVIPQVRTLDAYADMKARGEGRPNPATFRDIHMPSNTCAGLVIAVFS
EECCCCCCCCCCEEECCCHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHH
LVLGFALVWHIWWMAIGGLVGIIATLVIYSSRDNDGYYIPASTVRKTEDKQPTRRTAARV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCEEECHHHHHCCCCCCHHHHHHHCC
DDVELEAN
CCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Protoheme IX (Heme B55 and B562); Copper B. [C]

Metal ions: Fe; Cu [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Oxidoreductases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8392509 [H]