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The map label for this gene is guaA [H]

Identifier: 116690010

GI number: 116690010

Start: 2204975

End: 2206594

Strand: Reverse

Name: guaA [H]

Synonym: Bcen2424_1989

Alternate gene names: 116690010

Gene position: 2206594-2204975 (Counterclockwise)

Preceding gene: 116690011

Following gene: 116690005

Centisome position: 63.34

GC content: 65.86

Gene sequence:

>1620_bases
ATGCACGACAAAATCCTGATTCTCGACTTCGGTTCGCAAGTCACCCAACTGATTGCACGGCGCGTGCGTGAAGCGCACGT
CTACTGCGAAATCCATCCGAACGACGTGTCCGACGACTTCGTCCGCGAGTTCGCGCCGAAGGCGGTGATCCTGTCGGGCA
GCCACGCGAGCACGTACGAAGACCATCAACTGCGCGCGCCGCAGGCCGTGTGGGATCTCGGCGTGCCGGTGCTCGGCATC
TGCTACGGCATGCAGACGATGGCCGTGCAGCTCGGCGGCAAGGTCGAGTGGAGCGACCATCGCGAATTCGGCTACGCGGA
AATGCGTGCGCACGGCCATACGCGCCTGCTCGACGGCATCGAGGATTTCACGACGGCCGAAGGCCACGGGATGCTGAAGG
TCTGGATGAGCCACGGCGACAAGGTGGCCGAGCTGCCGCCGGGCTTCGCGCTGATGGCGTCGACGCCGAGCTGCCCGATC
GCCGGCATGGCCGACGAGGCGCGCGGCTACTACGCGGTGCAGTTCCACCCGGAAGTCACGCACACGGTGAAGGGCCGCCA
GATCATCGAGCGCTTCGTGCTGCAGATCGCCGGCGCGAAGCCCGACTGGATCATGAAGAACCACATCGAGGAAGCCGTCG
CGAAGATCCGCGAGCAGGTCGGTGACGAGGAAGTGATTCTCGGCCTGTCGGGCGGCGTCGATTCGAGCGTCGCGGCCGCG
CTGATCCATCGCGCGATCGGCGATCAACTGACCTGCGTGTTCGTCGACCACGGCCTGCTGCGCCTGAACGAAGGCAAGAT
GGTGCTCGACATGTTCGAGGGCCGCCTGCATGCGAAGGTCGTGCACGTCGACGCATCCGACCAGTTCCTCGGCCATCTGG
CCGGCGTGACCGATCCGGAAGCGAAGCGCAAGATCATCGGCCGCGAGTTCGTCGAGGTGTTCCAGGCCGAGGCGAAGAAG
CTGTCGAAGGCGAAGTGGCTCGCGCAGGGCACGATCTACCCGGACGTGGTCGAATCGGGCGGCACGAAGACGAAGAAGGC
GACGACGATCAAGAGCCACCACAACGTCGGCGGCCTGCCGGAAACGCTCGGCCTGAAGCTGCTCGAGCCGCTGCGCGACC
TGTTCAAGGACGAAGTGCGCGAGCTGGGTGTCGCGCTCGGCCTGCCGCCGGAGATGGTGTACCGCCATCCGTTCCCGGGC
CCGGGCCTCGGCGTGCGAATTCTCGGCGAAGTGAAGCGCGAATACGCGGAGCTGCTGCGCCGCGCGGACGCGATCTTCAT
CGAGGAACTGCGCAACACGACCGCGACCGCGCAGGACGCGGCTGCCGGCCTGTGCGGCGAGGCCGACGTCGGCAAGAGCT
GGTACGACCTGACGAGCCAGGCGTTCGCGGTGTTCCTGCCGGTCAAGTCGGTCGGCGTGATGGGCGATGGGCGGACATAC
GACTACGTGACGTCGCTGCGCGCGGTGCAGACGACCGACTTCATGACTGCGCATTGGGCGCATCTGCCGTATGCGCTGCT
CGGTCGCGCGTCGAATCGCATCATCAACGAAGTGCGCGGGATCAATCGGGTCGTGTACGACATCTCGGGGAAGCCGCCGG
CGACGATCGAGTGGGAGTGA

Upstream 100 bases:

>100_bases
TGCGTCGCGCGAGCCGCCTGCCGCCCGACGCCGCTGTCCATGCTTTTGACGCAGCGCTTCGTGCGCTGCTTTTCTTATTC
TCTTCATCCCGTCCGCAGCC

Downstream 100 bases:

>100_bases
ATTGACGTCCTTCGGGGACTAGCGCCAGCCATCGAAAAACTGCGGTAACGAAGCAATGTGTTGCGGCGGCTATCGATGGC
GGCCGGCGTCCGGCGGAACA

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 539; Mature: 539

Protein sequence:

>539_residues
MHDKILILDFGSQVTQLIARRVREAHVYCEIHPNDVSDDFVREFAPKAVILSGSHASTYEDHQLRAPQAVWDLGVPVLGI
CYGMQTMAVQLGGKVEWSDHREFGYAEMRAHGHTRLLDGIEDFTTAEGHGMLKVWMSHGDKVAELPPGFALMASTPSCPI
AGMADEARGYYAVQFHPEVTHTVKGRQIIERFVLQIAGAKPDWIMKNHIEEAVAKIREQVGDEEVILGLSGGVDSSVAAA
LIHRAIGDQLTCVFVDHGLLRLNEGKMVLDMFEGRLHAKVVHVDASDQFLGHLAGVTDPEAKRKIIGREFVEVFQAEAKK
LSKAKWLAQGTIYPDVVESGGTKTKKATTIKSHHNVGGLPETLGLKLLEPLRDLFKDEVRELGVALGLPPEMVYRHPFPG
PGLGVRILGEVKREYAELLRRADAIFIEELRNTTATAQDAAAGLCGEADVGKSWYDLTSQAFAVFLPVKSVGVMGDGRTY
DYVTSLRAVQTTDFMTAHWAHLPYALLGRASNRIINEVRGINRVVYDISGKPPATIEWE

Sequences:

>Translated_539_residues
MHDKILILDFGSQVTQLIARRVREAHVYCEIHPNDVSDDFVREFAPKAVILSGSHASTYEDHQLRAPQAVWDLGVPVLGI
CYGMQTMAVQLGGKVEWSDHREFGYAEMRAHGHTRLLDGIEDFTTAEGHGMLKVWMSHGDKVAELPPGFALMASTPSCPI
AGMADEARGYYAVQFHPEVTHTVKGRQIIERFVLQIAGAKPDWIMKNHIEEAVAKIREQVGDEEVILGLSGGVDSSVAAA
LIHRAIGDQLTCVFVDHGLLRLNEGKMVLDMFEGRLHAKVVHVDASDQFLGHLAGVTDPEAKRKIIGREFVEVFQAEAKK
LSKAKWLAQGTIYPDVVESGGTKTKKATTIKSHHNVGGLPETLGLKLLEPLRDLFKDEVRELGVALGLPPEMVYRHPFPG
PGLGVRILGEVKREYAELLRRADAIFIEELRNTTATAQDAAAGLCGEADVGKSWYDLTSQAFAVFLPVKSVGVMGDGRTY
DYVTSLRAVQTTDFMTAHWAHLPYALLGRASNRIINEVRGINRVVYDISGKPPATIEWE
>Mature_539_residues
MHDKILILDFGSQVTQLIARRVREAHVYCEIHPNDVSDDFVREFAPKAVILSGSHASTYEDHQLRAPQAVWDLGVPVLGI
CYGMQTMAVQLGGKVEWSDHREFGYAEMRAHGHTRLLDGIEDFTTAEGHGMLKVWMSHGDKVAELPPGFALMASTPSCPI
AGMADEARGYYAVQFHPEVTHTVKGRQIIERFVLQIAGAKPDWIMKNHIEEAVAKIREQVGDEEVILGLSGGVDSSVAAA
LIHRAIGDQLTCVFVDHGLLRLNEGKMVLDMFEGRLHAKVVHVDASDQFLGHLAGVTDPEAKRKIIGREFVEVFQAEAKK
LSKAKWLAQGTIYPDVVESGGTKTKKATTIKSHHNVGGLPETLGLKLLEPLRDLFKDEVRELGVALGLPPEMVYRHPFPG
PGLGVRILGEVKREYAELLRRADAIFIEELRNTTATAQDAAAGLCGEADVGKSWYDLTSQAFAVFLPVKSVGVMGDGRTY
DYVTSLRAVQTTDFMTAHWAHLPYALLGRASNRIINEVRGINRVVYDISGKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=563, Percent_Identity=34.4582593250444, Blast_Score=275, Evalue=9e-74,
Organism=Escherichia coli, GI1788854, Length=536, Percent_Identity=64.365671641791, Blast_Score=691, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71992710, Length=579, Percent_Identity=33.8514680483592, Blast_Score=278, Evalue=7e-75,
Organism=Caenorhabditis elegans, GI71992717, Length=579, Percent_Identity=33.8514680483592, Blast_Score=278, Evalue=8e-75,
Organism=Caenorhabditis elegans, GI133901714, Length=579, Percent_Identity=33.8514680483592, Blast_Score=277, Evalue=9e-75,
Organism=Saccharomyces cerevisiae, GI6323873, Length=548, Percent_Identity=47.6277372262774, Blast_Score=494, Evalue=1e-140,
Organism=Drosophila melanogaster, GI281365319, Length=560, Percent_Identity=34.8214285714286, Blast_Score=277, Evalue=1e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 59391; Mature: 59391

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHDKILILDFGSQVTQLIARRVREAHVYCEIHPNDVSDDFVREFAPKAVILSGSHASTYE
CCCCEEEEECCHHHHHHHHHHHHHCEEEEEECCCCCCHHHHHHHCCCEEEEECCCCCCCC
DHQLRAPQAVWDLGVPVLGICYGMQTMAVQLGGKVEWSDHREFGYAEMRAHGHTRLLDGI
CCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHCCEEEECCCCCCCHHHHHHCCCHHHHHHH
EDFTTAEGHGMLKVWMSHGDKVAELPPGFALMASTPSCPIAGMADEARGYYAVQFHPEVT
HHHCCCCCCCEEEEEECCCCEEECCCCCEEEEECCCCCCCCCCCCCCCCEEEEEECCCHH
HTVKGRQIIERFVLQIAGAKPDWIMKNHIEEAVAKIREQVGDEEVILGLSGGVDSSVAAA
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHH
LIHRAIGDQLTCVFVDHGLLRLNEGKMVLDMFEGRLHAKVVHVDASDQFLGHLAGVTDPE
HHHHHHCCCEEEEEEECCEEEECCCCEEEEHHCCCEEEEEEEECCCHHHHHHHCCCCCHH
AKRKIIGREFVEVFQAEAKKLSKAKWLAQGTIYPDVVESGGTKTKKATTIKSHHNVGGLP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCEEEECCCCCCCCCC
ETLGLKLLEPLRDLFKDEVRELGVALGLPPEMVYRHPFPGPGLGVRILGEVKREYAELLR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHH
RADAIFIEELRNTTATAQDAAAGLCGEADVGKSWYDLTSQAFAVFLPVKSVGVMGDGRTY
HHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHEEEEEEHHHHCCCCCCCCH
DYVTSLRAVQTTDFMTAHWAHLPYALLGRASNRIINEVRGINRVVYDISGKPPATIEWE
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCEECC
>Mature Secondary Structure
MHDKILILDFGSQVTQLIARRVREAHVYCEIHPNDVSDDFVREFAPKAVILSGSHASTYE
CCCCEEEEECCHHHHHHHHHHHHHCEEEEEECCCCCCHHHHHHHCCCEEEEECCCCCCCC
DHQLRAPQAVWDLGVPVLGICYGMQTMAVQLGGKVEWSDHREFGYAEMRAHGHTRLLDGI
CCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHCCEEEECCCCCCCHHHHHHCCCHHHHHHH
EDFTTAEGHGMLKVWMSHGDKVAELPPGFALMASTPSCPIAGMADEARGYYAVQFHPEVT
HHHCCCCCCCEEEEEECCCCEEECCCCCEEEEECCCCCCCCCCCCCCCCEEEEEECCCHH
HTVKGRQIIERFVLQIAGAKPDWIMKNHIEEAVAKIREQVGDEEVILGLSGGVDSSVAAA
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHH
LIHRAIGDQLTCVFVDHGLLRLNEGKMVLDMFEGRLHAKVVHVDASDQFLGHLAGVTDPE
HHHHHHCCCEEEEEEECCEEEECCCCEEEEHHCCCEEEEEEEECCCHHHHHHHCCCCCHH
AKRKIIGREFVEVFQAEAKKLSKAKWLAQGTIYPDVVESGGTKTKKATTIKSHHNVGGLP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCEEEECCCCCCCCCC
ETLGLKLLEPLRDLFKDEVRELGVALGLPPEMVYRHPFPGPGLGVRILGEVKREYAELLR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHH
RADAIFIEELRNTTATAQDAAAGLCGEADVGKSWYDLTSQAFAVFLPVKSVGVMGDGRTY
HHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHEEEEEEHHHHCCCCCCCCH
DYVTSLRAVQTTDFMTAHWAHLPYALLGRASNRIINEVRGINRVVYDISGKPPATIEWE
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA