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The map label for this gene is fadA [H]

Identifier: 116689925

GI number: 116689925

Start: 2110580

End: 2111758

Strand: Reverse

Name: fadA [H]

Synonym: Bcen2424_1904

Alternate gene names: 116689925

Gene position: 2111758-2110580 (Counterclockwise)

Preceding gene: 116689926

Following gene: 116689924

Centisome position: 60.61

GC content: 69.3

Gene sequence:

>1179_bases
ATGACCGAAGCCGTAATCGTATCGACCGCACGCACGCCGCTGGCGAAATCCTGGCGCGGTGCCTTCAACATGACGCACGG
CGCGACGCTCGGCGGCCACGTGGTCGCGGCCGCGCTCGAACGCGCGAAGCTCGACCCGGCGCGCGTCGAGGACGTGATCA
TGGGCTGCGCGAACCCCGAAGGCGCGACGGGCGCGAACATCGCGCGGCAGATCGCGCTGCGCGCCGGCTTGCCGGTCAGC
GTGCCGGGGATGACGGTGAACCGTTTCTGTTCGTCGGGGCTGCAGACCATCGCGCTGGCCGCGCAGCGGATCATCGCGGG
CGAAGGCGAGGTCTATGTGGCCGGCGGCGTCGAGTCGATCTCGTGCGTGCAGAACGAGATGAACCGGCACATGGTCCAGG
AAGGCTGGCTCGTCCAGCACAAGCCCGAGATCTACTGGAACATGCTGCAGACCGCGGAAAACGTCGCGAAGCGCTACGGG
ATCTCGAAGGAGCGGCAGGATGCCTACGGCGTGCAGTCGCAACTGCGCGCCGCGGCCGCGCAGGAAGCCGGGCGTTTTCG
CGACGAGATCGTGCCGATCACCGTGCTCGCGGGCATCGCCGACAAGGCGACGGGCCGCCTGTTCACGCAGGAAGTGACGG
TCTCGGCCGACGAAGGCATCCGCCCCGACACGACGCTCGAAGGCGTGTCGAAGATCCGTTCGGCGGTGCCGGGCGGCGTG
ATCACCGCGGGCAATGCGAGCCAGTTCTCGGACGGCGCATCGGCATGCGTCGTGATGAGCGCCGACGCCGCGCAGCGCGA
AGGGTTGCAGCCGCTGGGCGCGTTCCGCGGCTTCGCGGTGGCCGGCTGCGAACCGGACGAAATGGGCATCGGCCCGGTGT
TCGCGGTACCCAAGCTGCTGAAGCAGGCCGGGCTGACGGTCGACGACATCGGGCTGTGGGAGCTGAACGAGGCGTTCGCG
GTGCAGGTGCTGTACTGCCGCGACACGCTCGGGATCCCTGAGGACCGCCTGAACGTCAACGGCGGCGCGATCGCGGTCGG
CCATCCGTATGGCGTGTCGGGCGCGCGCCTGACGGGCCATGCGCTGATCGAGGGCAAGCGGCGCGGCGTGAAGTACGCGG
TCGTCACGATGTGCATCGGCGGCGGGCAGGGCGCGGCCGGCCTGTTCGAAATCCTCTGA

Upstream 100 bases:

>100_bases
AGATGCAGGCAGCGGGCGTCGTGCATGCGACGTCCGCGGGCGCGCGCCCGGCGGCGTAGCGCATTTCCCATCCGAATCAG
CAGGACCGAAGGAGACTCGC

Downstream 100 bases:

>100_bases
TCTTTGACCGGCGGCGGCCGCGGTGGCGCTTCGGCGTTACCGCCCGCCGCCGCAGTGAATCGGCGCGGCGCGCGCGCCAT
TCGCAACCAACGGGAAGCAC

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 392; Mature: 391

Protein sequence:

>392_residues
MTEAVIVSTARTPLAKSWRGAFNMTHGATLGGHVVAAALERAKLDPARVEDVIMGCANPEGATGANIARQIALRAGLPVS
VPGMTVNRFCSSGLQTIALAAQRIIAGEGEVYVAGGVESISCVQNEMNRHMVQEGWLVQHKPEIYWNMLQTAENVAKRYG
ISKERQDAYGVQSQLRAAAAQEAGRFRDEIVPITVLAGIADKATGRLFTQEVTVSADEGIRPDTTLEGVSKIRSAVPGGV
ITAGNASQFSDGASACVVMSADAAQREGLQPLGAFRGFAVAGCEPDEMGIGPVFAVPKLLKQAGLTVDDIGLWELNEAFA
VQVLYCRDTLGIPEDRLNVNGGAIAVGHPYGVSGARLTGHALIEGKRRGVKYAVVTMCIGGGQGAAGLFEIL

Sequences:

>Translated_392_residues
MTEAVIVSTARTPLAKSWRGAFNMTHGATLGGHVVAAALERAKLDPARVEDVIMGCANPEGATGANIARQIALRAGLPVS
VPGMTVNRFCSSGLQTIALAAQRIIAGEGEVYVAGGVESISCVQNEMNRHMVQEGWLVQHKPEIYWNMLQTAENVAKRYG
ISKERQDAYGVQSQLRAAAAQEAGRFRDEIVPITVLAGIADKATGRLFTQEVTVSADEGIRPDTTLEGVSKIRSAVPGGV
ITAGNASQFSDGASACVVMSADAAQREGLQPLGAFRGFAVAGCEPDEMGIGPVFAVPKLLKQAGLTVDDIGLWELNEAFA
VQVLYCRDTLGIPEDRLNVNGGAIAVGHPYGVSGARLTGHALIEGKRRGVKYAVVTMCIGGGQGAAGLFEIL
>Mature_391_residues
TEAVIVSTARTPLAKSWRGAFNMTHGATLGGHVVAAALERAKLDPARVEDVIMGCANPEGATGANIARQIALRAGLPVSV
PGMTVNRFCSSGLQTIALAAQRIIAGEGEVYVAGGVESISCVQNEMNRHMVQEGWLVQHKPEIYWNMLQTAENVAKRYGI
SKERQDAYGVQSQLRAAAAQEAGRFRDEIVPITVLAGIADKATGRLFTQEVTVSADEGIRPDTTLEGVSKIRSAVPGGVI
TAGNASQFSDGASACVVMSADAAQREGLQPLGAFRGFAVAGCEPDEMGIGPVFAVPKLLKQAGLTVDDIGLWELNEAFAV
QVLYCRDTLGIPEDRLNVNGGAIAVGHPYGVSGARLTGHALIEGKRRGVKYAVVTMCIGGGQGAAGLFEIL

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=390, Percent_Identity=43.0769230769231, Blast_Score=276, Evalue=2e-74,
Organism=Homo sapiens, GI167614485, Length=397, Percent_Identity=39.7984886649874, Blast_Score=265, Evalue=5e-71,
Organism=Homo sapiens, GI4557237, Length=404, Percent_Identity=37.6237623762376, Blast_Score=247, Evalue=1e-65,
Organism=Homo sapiens, GI148539872, Length=395, Percent_Identity=36.2025316455696, Blast_Score=210, Evalue=1e-54,
Organism=Homo sapiens, GI4504327, Length=434, Percent_Identity=30.184331797235, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI194353979, Length=389, Percent_Identity=32.6478149100257, Blast_Score=164, Evalue=1e-40,
Organism=Escherichia coli, GI48994986, Length=396, Percent_Identity=40.9090909090909, Blast_Score=264, Evalue=7e-72,
Organism=Escherichia coli, GI1787663, Length=412, Percent_Identity=41.504854368932, Blast_Score=261, Evalue=8e-71,
Organism=Escherichia coli, GI1788554, Length=407, Percent_Identity=42.2604422604423, Blast_Score=243, Evalue=2e-65,
Organism=Escherichia coli, GI87082165, Length=406, Percent_Identity=38.9162561576355, Blast_Score=242, Evalue=3e-65,
Organism=Escherichia coli, GI1788683, Length=420, Percent_Identity=30.2380952380952, Blast_Score=171, Evalue=6e-44,
Organism=Caenorhabditis elegans, GI133906874, Length=399, Percent_Identity=38.3458646616541, Blast_Score=240, Evalue=1e-63,
Organism=Caenorhabditis elegans, GI17535921, Length=406, Percent_Identity=37.9310344827586, Blast_Score=217, Evalue=8e-57,
Organism=Caenorhabditis elegans, GI25147385, Length=398, Percent_Identity=33.4170854271357, Blast_Score=195, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI17551802, Length=438, Percent_Identity=30.365296803653, Blast_Score=187, Evalue=7e-48,
Organism=Caenorhabditis elegans, GI17535917, Length=394, Percent_Identity=29.6954314720812, Blast_Score=144, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6322031, Length=396, Percent_Identity=36.6161616161616, Blast_Score=217, Evalue=3e-57,
Organism=Saccharomyces cerevisiae, GI6325229, Length=403, Percent_Identity=32.5062034739454, Blast_Score=177, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24655093, Length=400, Percent_Identity=41.25, Blast_Score=266, Evalue=1e-71,
Organism=Drosophila melanogaster, GI17648125, Length=362, Percent_Identity=40.0552486187845, Blast_Score=238, Evalue=4e-63,
Organism=Drosophila melanogaster, GI24640423, Length=407, Percent_Identity=35.8722358722359, Blast_Score=229, Evalue=2e-60,
Organism=Drosophila melanogaster, GI17137578, Length=433, Percent_Identity=31.6397228637413, Blast_Score=187, Evalue=8e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 41052; Mature: 40921

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3 ; PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEAVIVSTARTPLAKSWRGAFNMTHGATLGGHVVAAALERAKLDPARVEDVIMGCANPE
CCCEEEEECCCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCCC
GATGANIARQIALRAGLPVSVPGMTVNRFCSSGLQTIALAAQRIIAGEGEVYVAGGVESI
CCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHH
SCVQNEMNRHMVQEGWLVQHKPEIYWNMLQTAENVAKRYGISKERQDAYGVQSQLRAAAA
HHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
QEAGRFRDEIVPITVLAGIADKATGRLFTQEVTVSADEGIRPDTTLEGVSKIRSAVPGGV
HHHHHHHHHCEEHHHHHCCHHHHCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCE
ITAGNASQFSDGASACVVMSADAAQREGLQPLGAFRGFAVAGCEPDEMGIGPVFAVPKLL
EECCCCCCCCCCCCEEEEEECCHHHHCCCCHHHHHCCCEEECCCCCCCCCCHHHHHHHHH
KQAGLTVDDIGLWELNEAFAVQVLYCRDTLGIPEDRLNVNGGAIAVGHPYGVSGARLTGH
HHCCCCEECCCCEECCCCCEEEEEEEECCCCCCHHHEECCCCEEEECCCCCCCCCEEECH
ALIEGKRRGVKYAVVTMCIGGGQGAAGLFEIL
HEECCCCCCCEEEEEEEEECCCCCCCHHHHCC
>Mature Secondary Structure 
TEAVIVSTARTPLAKSWRGAFNMTHGATLGGHVVAAALERAKLDPARVEDVIMGCANPE
CCEEEEECCCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCCC
GATGANIARQIALRAGLPVSVPGMTVNRFCSSGLQTIALAAQRIIAGEGEVYVAGGVESI
CCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHH
SCVQNEMNRHMVQEGWLVQHKPEIYWNMLQTAENVAKRYGISKERQDAYGVQSQLRAAAA
HHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
QEAGRFRDEIVPITVLAGIADKATGRLFTQEVTVSADEGIRPDTTLEGVSKIRSAVPGGV
HHHHHHHHHCEEHHHHHCCHHHHCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCE
ITAGNASQFSDGASACVVMSADAAQREGLQPLGAFRGFAVAGCEPDEMGIGPVFAVPKLL
EECCCCCCCCCCCCEEEEEECCHHHHCCCCHHHHHCCCEEECCCCCCCCCCHHHHHHHHH
KQAGLTVDDIGLWELNEAFAVQVLYCRDTLGIPEDRLNVNGGAIAVGHPYGVSGARLTGH
HHCCCCEECCCCEECCCCCEEEEEEEECCCCCCHHHEECCCCEEEECCCCCCCCCEEECH
ALIEGKRRGVKYAVVTMCIGGGQGAAGLFEIL
HEECCCCCCCEEEEEEEEECCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]