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The map label for this gene is aes [H]

Identifier: 116689919

GI number: 116689919

Start: 2102072

End: 2103088

Strand: Reverse

Name: aes [H]

Synonym: Bcen2424_1898

Alternate gene names: 116689919

Gene position: 2103088-2102072 (Counterclockwise)

Preceding gene: 116689920

Following gene: 116689918

Centisome position: 60.37

GC content: 68.44

Gene sequence:

>1017_bases
ATGTCACGCTTGTCCGCTTTGTCCGTTCACGGCGCCACGCCGGCGCCGTCCATACCGATGCCGCTGAATCCGAAGATCGC
CCAGGTGCTCGACATGATCGAGCGCGCGAAACGTCCGTCGTATCACCATCAGACGCCGCAGCAGGCCCGCGCCGCATACG
AGAAGAGCGCGCCGATCCTCGACGTCGCGCCGGCGCCGATGCATTCGGTGGAGGAATGCGTGGTGCCGACGCGCGACGGC
CGCACGATCGGCGCGCGGCTGTATCTGCCGGTCGCGCCGAGCCTGGCGGAGCCGCTGCCCGCGCTCGTCTATTACCACGG
CGGCGGCTTCACGGTCGGCAGCGTCGACACGCATGATGCGCTGTGTCGGATGTTCGCGCACGATGCGCAATGCGCGGTGC
TGTCTGTCGGCTACCGGCTCGCGCCCGAACACAGGTTTCCGACCGCGGTGAACGACGCGGACGACGCATTGCAGTGGCTG
CATCGCGAAGCCGCCACGTTCGGCATCGACGCCGCGCGGCTGGCGGTCGGCGGCGACAGTGCGGGCGGCACGCTCGCGAC
GGTCTGCGCGGTGCTCGCGCGCGACGCGGGCATTCGTCTTGCGCTGCAACTGCTGATCTATCCGGGCGTGACGCGTTACC
AGGACACCGAATCGCACGCACGGCTCGCCAACGGCTACCTGTTGACGCAGGACACGATCCAGTGGTTCTTCACGCAGTAC
GTGCGCGATCAGGCCGATCGCGACGACTGGCGTTTCGCGCCGCTCGACGGCACGCGCGATGCGCCGTCGTTCGCGGGCGT
CGCGCCGGCGTGGATCGCGACGGCCGAATACGATCCGCTGAGCGACGAGGGCGCCGCGTACGCGGACAAGTTGCGCGTGG
CCGGCAACGCGGTCACGCTGGTCTGCTATCCGGGGATGATCCACGAATTCTTCAAGATGGGCGGCTACGTGCCGGAGGTG
CGGGCCGCGCATGCCGATGCGGTCGCGGCACTGAAGGCTGCATTCGACGAGGTTTGA

Upstream 100 bases:

>100_bases
ATGCACGGCCCTGTCTCTTCGATGAGGCAGGGCCGTTTCGTTTTGCAGCCCGGATGCCGGCACACCGCGCGCCGCGCCGG
TCCGGCCCCCGCGTGGCATC

Downstream 100 bases:

>100_bases
CGGCGAGCGCCCGAAGGCGCGCACGCCGCGGGAGGATGGCGATGACGAATGGCGCGGGCGGGGTGGAAACGGGCGACTGG
ACGGTCCTGGGCGGCGATGC

Product: alpha/beta hydrolase domain-containing protein

Products: alcohol; a carboxylate [C]

Alternate protein names: NA

Number of amino acids: Translated: 338; Mature: 337

Protein sequence:

>338_residues
MSRLSALSVHGATPAPSIPMPLNPKIAQVLDMIERAKRPSYHHQTPQQARAAYEKSAPILDVAPAPMHSVEECVVPTRDG
RTIGARLYLPVAPSLAEPLPALVYYHGGGFTVGSVDTHDALCRMFAHDAQCAVLSVGYRLAPEHRFPTAVNDADDALQWL
HREAATFGIDAARLAVGGDSAGGTLATVCAVLARDAGIRLALQLLIYPGVTRYQDTESHARLANGYLLTQDTIQWFFTQY
VRDQADRDDWRFAPLDGTRDAPSFAGVAPAWIATAEYDPLSDEGAAYADKLRVAGNAVTLVCYPGMIHEFFKMGGYVPEV
RAAHADAVAALKAAFDEV

Sequences:

>Translated_338_residues
MSRLSALSVHGATPAPSIPMPLNPKIAQVLDMIERAKRPSYHHQTPQQARAAYEKSAPILDVAPAPMHSVEECVVPTRDG
RTIGARLYLPVAPSLAEPLPALVYYHGGGFTVGSVDTHDALCRMFAHDAQCAVLSVGYRLAPEHRFPTAVNDADDALQWL
HREAATFGIDAARLAVGGDSAGGTLATVCAVLARDAGIRLALQLLIYPGVTRYQDTESHARLANGYLLTQDTIQWFFTQY
VRDQADRDDWRFAPLDGTRDAPSFAGVAPAWIATAEYDPLSDEGAAYADKLRVAGNAVTLVCYPGMIHEFFKMGGYVPEV
RAAHADAVAALKAAFDEV
>Mature_337_residues
SRLSALSVHGATPAPSIPMPLNPKIAQVLDMIERAKRPSYHHQTPQQARAAYEKSAPILDVAPAPMHSVEECVVPTRDGR
TIGARLYLPVAPSLAEPLPALVYYHGGGFTVGSVDTHDALCRMFAHDAQCAVLSVGYRLAPEHRFPTAVNDADDALQWLH
REAATFGIDAARLAVGGDSAGGTLATVCAVLARDAGIRLALQLLIYPGVTRYQDTESHARLANGYLLTQDTIQWFFTQYV
RDQADRDDWRFAPLDGTRDAPSFAGVAPAWIATAEYDPLSDEGAAYADKLRVAGNAVTLVCYPGMIHEFFKMGGYVPEVR
AAHADAVAALKAAFDEV

Specific function: Displays esterase activity towards short chain fatty esters (acyl chain length of up to 8 carbons). Able to hydrolyze triacetylglycerol (triacetin) and tributyrylglycerol (tributyrin), but not trioleylglycerol (triolein) or cholesterol oleate. Negatively

COG id: COG0657

COG function: function code I; Esterase/lipase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'GDXG' lipolytic enzyme family [H]

Homologues:

Organism=Homo sapiens, GI68299767, Length=299, Percent_Identity=29.4314381270903, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI206597554, Length=175, Percent_Identity=36.5714285714286, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI157041239, Length=161, Percent_Identity=37.2670807453416, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI61966717, Length=205, Percent_Identity=30.7317073170732, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI68051721, Length=272, Percent_Identity=26.8382352941176, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI226423947, Length=280, Percent_Identity=25.7142857142857, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI21328446, Length=121, Percent_Identity=31.404958677686, Blast_Score=69, Evalue=8e-12,
Organism=Escherichia coli, GI1786682, Length=256, Percent_Identity=34.765625, Blast_Score=129, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI71996133, Length=311, Percent_Identity=26.6881028938907, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17540028, Length=149, Percent_Identity=34.2281879194631, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17567059, Length=269, Percent_Identity=30.8550185873606, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI72001146, Length=111, Percent_Identity=39.6396396396396, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24656084, Length=122, Percent_Identity=35.2459016393443, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24656076, Length=122, Percent_Identity=35.2459016393443, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI20130169, Length=122, Percent_Identity=35.2459016393443, Blast_Score=72, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013094
- InterPro:   IPR002168 [H]

Pfam domain/function: PF07859 Abhydrolase_3 [H]

EC number: 3.1.1.- [C]

Molecular weight: Translated: 36452; Mature: 36320

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRLSALSVHGATPAPSIPMPLNPKIAQVLDMIERAKRPSYHHQTPQQARAAYEKSAPIL
CCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCEE
DVAPAPMHSVEECVVPTRDGRTIGARLYLPVAPSLAEPLPALVYYHGGGFTVGSVDTHDA
EECCCCHHHHHHHCCCCCCCCEEEEEEEEECCCHHHCCCCEEEEEECCCEEECCCCHHHH
LCRMFAHDAQCAVLSVGYRLAPEHRFPTAVNDADDALQWLHREAATFGIDAARLAVGGDS
HHHHHHCCCCEEEEECCCEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHEEEECCCC
AGGTLATVCAVLARDAGIRLALQLLIYPGVTRYQDTESHARLANGYLLTQDTIQWFFTQY
CCCHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCHHHHHHHCCEEEEHHHHHHHHHHH
VRDQADRDDWRFAPLDGTRDAPSFAGVAPAWIATAEYDPLSDEGAAYADKLRVAGNAVTL
HHHCCCCCCCEEECCCCCCCCCCCCCCCHHHEEECCCCCCCCCCCHHHHHHEECCCEEEE
VCYPGMIHEFFKMGGYVPEVRAAHADAVAALKAAFDEV
EECCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SRLSALSVHGATPAPSIPMPLNPKIAQVLDMIERAKRPSYHHQTPQQARAAYEKSAPIL
CCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCEE
DVAPAPMHSVEECVVPTRDGRTIGARLYLPVAPSLAEPLPALVYYHGGGFTVGSVDTHDA
EECCCCHHHHHHHCCCCCCCCEEEEEEEEECCCHHHCCCCEEEEEECCCEEECCCCHHHH
LCRMFAHDAQCAVLSVGYRLAPEHRFPTAVNDADDALQWLHREAATFGIDAARLAVGGDS
HHHHHHCCCCEEEEECCCEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHEEEECCCC
AGGTLATVCAVLARDAGIRLALQLLIYPGVTRYQDTESHARLANGYLLTQDTIQWFFTQY
CCCHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCHHHHHHHCCEEEEHHHHHHHHHHH
VRDQADRDDWRFAPLDGTRDAPSFAGVAPAWIATAEYDPLSDEGAAYADKLRVAGNAVTL
HHHCCCCCCCEEECCCCCCCCCCCCCCCHHHEEECCCCCCCCCCCHHHHHHEECCCEEEE
VCYPGMIHEFFKMGGYVPEVRAAHADAVAALKAAFDEV
EECCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Carboxylic ester; H2O [C]

Specific reaction: Carboxylic ester + H2O = an alcohol + carboxylate [C]

General reaction: Hydrolase; Acting on ester bonds; Carboxylic ester hydrolases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA