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The map label for this gene is hbd [H]

Identifier: 116689286

GI number: 116689286

Start: 1396123

End: 1397040

Strand: Direct

Name: hbd [H]

Synonym: Bcen2424_1264

Alternate gene names: 116689286

Gene position: 1396123-1397040 (Clockwise)

Preceding gene: 116689283

Following gene: 116689289

Centisome position: 40.07

GC content: 69.17

Gene sequence:

>918_bases
ATGGACATTCGACGTATCGCGATCGTCGGCGCCGGCGTGATCGGCGCGAGCTGGGCCGCTTTCTACCTGACGCAGGGCTT
CGACGTCGTCGCGACCGACCCGGCGCCGCAAGCCAATGCACGGCTGCGCGACGCGCTCGCCGCATTCCTCGGCGAGCGGG
CCGCCGAGCTTTGCGCGCGGCTGTCGTTCGACGCCGATCTCGTGCGCGCGCTCGACGGCGTCGATTTCGTGCAAGAGAAC
GGCCCCGAGCGACTCGACCTGAAGCGTGCGCTCTATCGCCAGATGGACGACGTGCTGCCCGCGCACGTGCCGATCGCGTC
GAGCTCGTCGGGCCTGAAGATGTCCGAGATCCAGACGGCCTGCGCGAAGCATCCGGAACGCTGCCTGATCGCGCATCCGT
TCAATCCGCCGCACCTGATCCCGCTCGTCGAGCTGGTCGGCGGCGACGCGACCAGCCCGGACGTGATCGCGCGCGTGAAG
CAGTTCTACGATGCGCTCGGCAAGCAGACGATCGTGCTGAACAAGGAGATGACCGGCCACGTGGCGAACCGGCTCGCGGC
CGCGCTGTTCCGCGAGGTGTATCACCTCGTCGGCGAAGGCGTCGTGAGCGTCGCCGATGCGGACAAGGCGGTCGCGTGGG
GCCCCGGCCTGCGCTGGGGGCTGATGGGGCAGTGCCTGACCTATCACCTCGGCGGCGGCGCGGGCGGGATCGCGCACTTC
CTCGAACACCTGTCGGGGCCGATCACGAGCTGGTGGGACGACCTCGGCACGCCGTCGTTCGATCCGGAAGTCGATCGCAA
GCTGACCGACGAGCTGCGCGCGATCCAGGGCGAGCGCTCGATGCAGGCACTGGCAGCGGAGCGCGATCGGCTGCTCGTCG
AACTGATCGACGCGCGACGCCGCAGCTTCCTGCCCTGA

Upstream 100 bases:

>100_bases
CATTTCAAGAGGGAATCTGCAGTCCGCGTCGACGCCTGCGCGCGGGATTCGATGCGACAATCGCCGCGGCATATCCGCAG
ACCAACCACACGGGACAACC

Downstream 100 bases:

>100_bases
TCTTGATCTTGATCCTGATCTGGTCGCGCGCCGCGGCGCCACCGGTCATTGCTGCGACGTCGCCTGGCTGGCGGGCGGCA
CGTGGGCCAGCCATGCCGGG

Product: 3-hydroxyacyl-CoA dehydrogenase, NAD-binding

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MDIRRIAIVGAGVIGASWAAFYLTQGFDVVATDPAPQANARLRDALAAFLGERAAELCARLSFDADLVRALDGVDFVQEN
GPERLDLKRALYRQMDDVLPAHVPIASSSSGLKMSEIQTACAKHPERCLIAHPFNPPHLIPLVELVGGDATSPDVIARVK
QFYDALGKQTIVLNKEMTGHVANRLAAALFREVYHLVGEGVVSVADADKAVAWGPGLRWGLMGQCLTYHLGGGAGGIAHF
LEHLSGPITSWWDDLGTPSFDPEVDRKLTDELRAIQGERSMQALAAERDRLLVELIDARRRSFLP

Sequences:

>Translated_305_residues
MDIRRIAIVGAGVIGASWAAFYLTQGFDVVATDPAPQANARLRDALAAFLGERAAELCARLSFDADLVRALDGVDFVQEN
GPERLDLKRALYRQMDDVLPAHVPIASSSSGLKMSEIQTACAKHPERCLIAHPFNPPHLIPLVELVGGDATSPDVIARVK
QFYDALGKQTIVLNKEMTGHVANRLAAALFREVYHLVGEGVVSVADADKAVAWGPGLRWGLMGQCLTYHLGGGAGGIAHF
LEHLSGPITSWWDDLGTPSFDPEVDRKLTDELRAIQGERSMQALAAERDRLLVELIDARRRSFLP
>Mature_305_residues
MDIRRIAIVGAGVIGASWAAFYLTQGFDVVATDPAPQANARLRDALAAFLGERAAELCARLSFDADLVRALDGVDFVQEN
GPERLDLKRALYRQMDDVLPAHVPIASSSSGLKMSEIQTACAKHPERCLIAHPFNPPHLIPLVELVGGDATSPDVIARVK
QFYDALGKQTIVLNKEMTGHVANRLAAALFREVYHLVGEGVVSVADADKAVAWGPGLRWGLMGQCLTYHLGGGAGGIAHF
LEHLSGPITSWWDDLGTPSFDPEVDRKLTDELRAIQGERSMQALAAERDRLLVELIDARRRSFLP

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI115430219, Length=282, Percent_Identity=33.3333333333333, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI20127408, Length=210, Percent_Identity=29.0476190476191, Blast_Score=78, Evalue=9e-15,
Organism=Homo sapiens, GI296179429, Length=233, Percent_Identity=25.3218884120172, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI296179427, Length=226, Percent_Identity=23.0088495575221, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1787661, Length=243, Percent_Identity=28.8065843621399, Blast_Score=95, Evalue=5e-21,
Organism=Escherichia coli, GI1790281, Length=130, Percent_Identity=31.5384615384615, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI115533614, Length=249, Percent_Identity=32.9317269076305, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI193203623, Length=249, Percent_Identity=32.9317269076305, Blast_Score=127, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI17553560, Length=229, Percent_Identity=24.8908296943231, Blast_Score=78, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI25144276, Length=208, Percent_Identity=27.8846153846154, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17508951, Length=208, Percent_Identity=27.8846153846154, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17508953, Length=208, Percent_Identity=27.8846153846154, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17558304, Length=211, Percent_Identity=27.4881516587678, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17549919, Length=233, Percent_Identity=23.6051502145923, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI20129993, Length=315, Percent_Identity=32.0634920634921, Blast_Score=158, Evalue=4e-39,
Organism=Drosophila melanogaster, GI45549573, Length=284, Percent_Identity=32.0422535211268, Blast_Score=152, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24583077, Length=208, Percent_Identity=25, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24583079, Length=208, Percent_Identity=25, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI19921000, Length=208, Percent_Identity=25, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 33120; Mature: 33120

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIRRIAIVGAGVIGASWAAFYLTQGFDVVATDPAPQANARLRDALAAFLGERAAELCAR
CCCEEEEEEECCHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LSFDADLVRALDGVDFVQENGPERLDLKRALYRQMDDVLPAHVPIASSSSGLKMSEIQTA
HCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHH
CAKHPERCLIAHPFNPPHLIPLVELVGGDATSPDVIARVKQFYDALGKQTIVLNKEMTGH
HHCCCCCEEEECCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCEEEECCHHHHH
VANRLAAALFREVYHLVGEGVVSVADADKAVAWGPGLRWGLMGQCLTYHLGGGAGGIAHF
HHHHHHHHHHHHHHHHHCCCCEEECCCCCCEECCCCCCHHHHHHHHHHHCCCCCCHHHHH
LEHLSGPITSWWDDLGTPSFDPEVDRKLTDELRAIQGERSMQALAAERDRLLVELIDARR
HHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHH
RSFLP
HCCCC
>Mature Secondary Structure
MDIRRIAIVGAGVIGASWAAFYLTQGFDVVATDPAPQANARLRDALAAFLGERAAELCAR
CCCEEEEEEECCHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LSFDADLVRALDGVDFVQENGPERLDLKRALYRQMDDVLPAHVPIASSSSGLKMSEIQTA
HCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHH
CAKHPERCLIAHPFNPPHLIPLVELVGGDATSPDVIARVKQFYDALGKQTIVLNKEMTGH
HHCCCCCEEEECCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCEEEECCHHHHH
VANRLAAALFREVYHLVGEGVVSVADADKAVAWGPGLRWGLMGQCLTYHLGGGAGGIAHF
HHHHHHHHHHHHHHHHHCCCCEEECCCCCCEECCCCCCHHHHHHHHHHHCCCCCCHHHHH
LEHLSGPITSWWDDLGTPSFDPEVDRKLTDELRAIQGERSMQALAAERDRLLVELIDARR
HHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHH
RSFLP
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]