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The map label for this gene is atoC [H]

Identifier: 116689162

GI number: 116689162

Start: 1250165

End: 1251550

Strand: Reverse

Name: atoC [H]

Synonym: Bcen2424_1140

Alternate gene names: 116689162

Gene position: 1251550-1250165 (Counterclockwise)

Preceding gene: 116689163

Following gene: 116689139

Centisome position: 35.92

GC content: 69.12

Gene sequence:

>1386_bases
ATGCCACACGCCCTGATTGTCGAAGACGATCCCAACAGCCTGTCAGGCCTCACCGCGCTGCTCGCCGCAGACGGCTTCTC
GGTCGACACGGCCACGTCGCTCGCTGAAGCGCGCACGGCGCTCGGCCGCTCGATTCCCGACGTCGTGCTCGTCGACCTGA
ACCTGCCGGACGGCAGCGGGTTCGATCTGCTCCAGCACCTGCCGCAGCAACAGCCGAACGGCTCGCTGCCCGTGATCGTG
CTGACGGGCAACGCGACGGTCGAGAGCGCCATCGAGGGGCTGCGTCACGGCATCTGGGACTACCTGCTGAAGCCAATCAA
CATCCCGCGCCTGCGCAGCCTGCTCGCGCGGATTCCCCGCCCGTACGAACTGATCGACGAAGTGCAGTCGCTACGTGCGT
CGCTGCGCCATCTCGGCCGCTTCGGCGCGCTGGTCGGCCGCAGCGACGCGATGCAGCACGTGTACGACATGATCGAGCAC
AACGCCCGCACCGAAACGGCCGTGCTGTTCTCGGGCGAAGCCGGCACCGGCAAGAAGCTGGCGGCACGCACGCTGCACGA
CCTGAGCCGGCGCCGCAAGGGGCCGTTCGTCTCGTTCGACTGCCGCATGCTCGTGCAGGCCGGCCGGCACGGCGCGTCGC
TCGACAGCGTGCTGTTCGGCCATGAGCGCGGCGCGTTCGACGGCGCCGAGCGCCGCGAGACGGGCCTGTTCGAGCAAGCC
GGCGGCGGCACGCTGTTCCTCGACGAAATCACCGCACTACCGCTCGTGCTGCAGGAAGCGCTGCTGCATGCACTCGATTC
GCAGAACTTCATGCGGATCGGTGGCACGAGCTCGATCACCAGCGATTTCCGGCTGATCGCGGCCACCCGCCGCCCGGCGC
GCGAAGCGGTGGCGAACGGCACGCTGCGCGAGGATCTGTGGCTGCGCCTCGACGCGGCGTCGATCACGATGCCGCCGCTG
CGCGAGCGCGACGGCGATGCGCTCGCGATCGCGGACGCGCAGATCGACGAACTGAACCGGGATGCGCGCGCAACCGGCCG
CAGCACGACCGACAAGCGCGCGGCCCCGGGCTTCGTGCGCGAATGCCTGTCGTACGAATGGCCGGGCAACGTGCGCGAAC
TGCAGGAGCGCGTGCGTTTCGCGTACGACGCATCGGGCGACTTCATCGAGACGCTGCGCGCGGGCGAAGCCAGCTTCTCC
GCCGGCGCCGCGCTGAACGGCAGCAGCGTGCAGATCAAGGTGGGCACCCCGCTGTCCGACGTCGAGGATCTGCTGATCCG
TGCGACGCTAGACGCGGTCGGCGGGACGCGCCACCGCGCGGCGACGCTGCTCGGCATCAGCCCGAAGACGCTGTACAACA
AGCTGCAGCGAATGAAGGTGAACTGA

Upstream 100 bases:

>100_bases
GTGACGCGTTCGGCGGGGCATAAAATCAGTCTTTAATCCGACATGCGGCTGCGGCCCGCTGGCCGACAGCCCGCCTCTCT
TGACTCGACTCGCGTCCACC

Downstream 100 bases:

>100_bases
GTGGGGCGGCCCCTGGATACGGGCGCTGGTCGGATCTGACCGTTAGTTGCGTGTAAATCCGTTCCAGCGACGACCCGAAT
CAGGCCATCGCGCTCGGTAA

Product: two component, sigma54 specific, Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 461; Mature: 460

Protein sequence:

>461_residues
MPHALIVEDDPNSLSGLTALLAADGFSVDTATSLAEARTALGRSIPDVVLVDLNLPDGSGFDLLQHLPQQQPNGSLPVIV
LTGNATVESAIEGLRHGIWDYLLKPINIPRLRSLLARIPRPYELIDEVQSLRASLRHLGRFGALVGRSDAMQHVYDMIEH
NARTETAVLFSGEAGTGKKLAARTLHDLSRRRKGPFVSFDCRMLVQAGRHGASLDSVLFGHERGAFDGAERRETGLFEQA
GGGTLFLDEITALPLVLQEALLHALDSQNFMRIGGTSSITSDFRLIAATRRPAREAVANGTLREDLWLRLDAASITMPPL
RERDGDALAIADAQIDELNRDARATGRSTTDKRAAPGFVRECLSYEWPGNVRELQERVRFAYDASGDFIETLRAGEASFS
AGAALNGSSVQIKVGTPLSDVEDLLIRATLDAVGGTRHRAATLLGISPKTLYNKLQRMKVN

Sequences:

>Translated_461_residues
MPHALIVEDDPNSLSGLTALLAADGFSVDTATSLAEARTALGRSIPDVVLVDLNLPDGSGFDLLQHLPQQQPNGSLPVIV
LTGNATVESAIEGLRHGIWDYLLKPINIPRLRSLLARIPRPYELIDEVQSLRASLRHLGRFGALVGRSDAMQHVYDMIEH
NARTETAVLFSGEAGTGKKLAARTLHDLSRRRKGPFVSFDCRMLVQAGRHGASLDSVLFGHERGAFDGAERRETGLFEQA
GGGTLFLDEITALPLVLQEALLHALDSQNFMRIGGTSSITSDFRLIAATRRPAREAVANGTLREDLWLRLDAASITMPPL
RERDGDALAIADAQIDELNRDARATGRSTTDKRAAPGFVRECLSYEWPGNVRELQERVRFAYDASGDFIETLRAGEASFS
AGAALNGSSVQIKVGTPLSDVEDLLIRATLDAVGGTRHRAATLLGISPKTLYNKLQRMKVN
>Mature_460_residues
PHALIVEDDPNSLSGLTALLAADGFSVDTATSLAEARTALGRSIPDVVLVDLNLPDGSGFDLLQHLPQQQPNGSLPVIVL
TGNATVESAIEGLRHGIWDYLLKPINIPRLRSLLARIPRPYELIDEVQSLRASLRHLGRFGALVGRSDAMQHVYDMIEHN
ARTETAVLFSGEAGTGKKLAARTLHDLSRRRKGPFVSFDCRMLVQAGRHGASLDSVLFGHERGAFDGAERRETGLFEQAG
GGTLFLDEITALPLVLQEALLHALDSQNFMRIGGTSSITSDFRLIAATRRPAREAVANGTLREDLWLRLDAASITMPPLR
ERDGDALAIADAQIDELNRDARATGRSTTDKRAAPGFVRECLSYEWPGNVRELQERVRFAYDASGDFIETLRAGEASFSA
GAALNGSSVQIKVGTPLSDVEDLLIRATLDAVGGTRHRAATLLGISPKTLYNKLQRMKVN

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=462, Percent_Identity=35.0649350649351, Blast_Score=250, Evalue=1e-67,
Organism=Escherichia coli, GI1790437, Length=459, Percent_Identity=35.9477124183007, Blast_Score=243, Evalue=2e-65,
Organism=Escherichia coli, GI1790299, Length=477, Percent_Identity=32.9140461215933, Blast_Score=215, Evalue=5e-57,
Organism=Escherichia coli, GI1788905, Length=373, Percent_Identity=34.0482573726542, Blast_Score=193, Evalue=2e-50,
Organism=Escherichia coli, GI1789087, Length=259, Percent_Identity=41.6988416988417, Blast_Score=176, Evalue=3e-45,
Organism=Escherichia coli, GI87082117, Length=340, Percent_Identity=36.1764705882353, Blast_Score=170, Evalue=1e-43,
Organism=Escherichia coli, GI1789233, Length=329, Percent_Identity=33.434650455927, Blast_Score=169, Evalue=4e-43,
Organism=Escherichia coli, GI87081872, Length=331, Percent_Identity=33.2326283987915, Blast_Score=167, Evalue=2e-42,
Organism=Escherichia coli, GI1786524, Length=343, Percent_Identity=34.1107871720117, Blast_Score=152, Evalue=5e-38,
Organism=Escherichia coli, GI87082152, Length=247, Percent_Identity=37.6518218623482, Blast_Score=142, Evalue=6e-35,
Organism=Escherichia coli, GI1789828, Length=282, Percent_Identity=35.1063829787234, Blast_Score=121, Evalue=1e-28,
Organism=Escherichia coli, GI1787583, Length=238, Percent_Identity=31.0924369747899, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI87081858, Length=302, Percent_Identity=29.4701986754967, Blast_Score=101, Evalue=8e-23,
Organism=Escherichia coli, GI1786599, Length=132, Percent_Identity=31.0606060606061, Blast_Score=68, Evalue=9e-13,
Organism=Escherichia coli, GI1786838, Length=132, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1790552, Length=117, Percent_Identity=36.7521367521368, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1787229, Length=123, Percent_Identity=33.3333333333333, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 50022; Mature: 49891

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPHALIVEDDPNSLSGLTALLAADGFSVDTATSLAEARTALGRSIPDVVLVDLNLPDGSG
CCCEEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCC
FDLLQHLPQQQPNGSLPVIVLTGNATVESAIEGLRHGIWDYLLKPINIPRLRSLLARIPR
HHHHHHCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCC
PYELIDEVQSLRASLRHLGRFGALVGRSDAMQHVYDMIEHNARTETAVLFSGEAGTGKKL
CHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHH
AARTLHDLSRRRKGPFVSFDCRMLVQAGRHGASLDSVLFGHERGAFDGAERRETGLFEQA
HHHHHHHHHHHCCCCEEEHHHHHHHHCCCCCCCHHHHHHCCCCCCCCCCHHHHCCCHHHC
GGGTLFLDEITALPLVLQEALLHALDSQNFMRIGGTSSITSDFRLIAATRRPAREAVANG
CCCEEEHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHEEEHHCCHHHHHHHCC
TLREDLWLRLDAASITMPPLRERDGDALAIADAQIDELNRDARATGRSTTDKRAAPGFVR
CHHHHHEEEEECCCCCCCCCCCCCCCEEEEECCHHHHHCCHHHHCCCCCCCCCCCCHHHH
ECLSYEWPGNVRELQERVRFAYDASGDFIETLRAGEASFSAGAALNGSSVQIKVGTPLSD
HHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCEECCCEEEEEECCCHHH
VEDLLIRATLDAVGGTRHRAATLLGISPKTLYNKLQRMKVN
HHHHHHHHHHHHHCCCHHHHEEEECCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
PHALIVEDDPNSLSGLTALLAADGFSVDTATSLAEARTALGRSIPDVVLVDLNLPDGSG
CCEEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCC
FDLLQHLPQQQPNGSLPVIVLTGNATVESAIEGLRHGIWDYLLKPINIPRLRSLLARIPR
HHHHHHCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCC
PYELIDEVQSLRASLRHLGRFGALVGRSDAMQHVYDMIEHNARTETAVLFSGEAGTGKKL
CHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHH
AARTLHDLSRRRKGPFVSFDCRMLVQAGRHGASLDSVLFGHERGAFDGAERRETGLFEQA
HHHHHHHHHHHCCCCEEEHHHHHHHHCCCCCCCHHHHHHCCCCCCCCCCHHHHCCCHHHC
GGGTLFLDEITALPLVLQEALLHALDSQNFMRIGGTSSITSDFRLIAATRRPAREAVANG
CCCEEEHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHEEEHHCCHHHHHHHCC
TLREDLWLRLDAASITMPPLRERDGDALAIADAQIDELNRDARATGRSTTDKRAAPGFVR
CHHHHHEEEEECCCCCCCCCCCCCCCEEEEECCHHHHHCCHHHHCCCCCCCCCCCCHHHH
ECLSYEWPGNVRELQERVRFAYDASGDFIETLRAGEASFSAGAALNGSSVQIKVGTPLSD
HHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCEECCCEEEEEECCCHHH
VEDLLIRATLDAVGGTRHRAATLLGISPKTLYNKLQRMKVN
HHHHHHHHHHHHHCCCHHHHEEEECCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]