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The map label for this gene is zwf [H]

Identifier: 116688990

GI number: 116688990

Start: 1073920

End: 1075389

Strand: Reverse

Name: zwf [H]

Synonym: Bcen2424_0967

Alternate gene names: 116688990

Gene position: 1075389-1073920 (Counterclockwise)

Preceding gene: 116688995

Following gene: 116688989

Centisome position: 30.87

GC content: 66.53

Gene sequence:

>1470_bases
ATGCATACCGATTCCAGCTTTACCTTCGTACTTTTCGGCGGCACCGGCGATTTGTCGATGCGCAAGATCCTGCCCGCGCT
GTTCGAAGCGCACCGTGCGAACATGCTGGCGGACGGCGGTCGGATCGTGGCCGTCGCACGACACGAATCGGATCGGGCGG
GCTATCTCGAATGGGTCGACACGCACGTGAAGCCGCATGCGGCGAAGGCGGCCGGCAACGCGTTCGACGACGCGGCCTGG
AAGTCGTTTCTCGACCGCATCGAGTACGTGAAGCTCGATCTCGGCCGCGCGGAGGACTACGTCGTGCTGCGCGACGCGAT
CGCATCGCTGCCCGGCATCCGCGTGTTCTATCTCGCGACCGGCCCGTCGCTGTTCGTGCCGATCTGCAAGGCGCTCGCGT
CGGTCGGCCTGAACGAAGGCTCGCGCATCGTGCTGGAGAAGCCGCTCGGCTACGACCTGAAGTCGTCCAACGCGATCAAC
GACGCGGTCGGCGAGATCTTCGCGGAAGGCCAGATCTACCGGATCGACCACTACCTCGGCAAGGAGCCGGTACAGAACCT
GCTCGCGCTGCGCTTCGGCAATGCGCTGTTCGAGCCGCTGTGGCGCCGCGAATGGGTCGAGAGCATCCAGATCACGATCG
CGGAAGAGCTCGGCGTCGAGGCGCGCGGCGATTTCTACGACAATACGGGCGCGCTGCGCGACATGGTGCAGAACCACCTG
CTCCAGCTGCTGTCGATCGTCGCGATGGAGCCGCCGCACTCGATGGATTCCGACTCGGTACGCGACGAGAAGCTGCGCGT
GCTGCGCGCGCTGAAGCCGATCGATCCGCGCGACATCGGCAAGGTCGCGGTGCGCGGCCAGTATCATGCGGGCGTGATCA
AAGGCGCGCAGGTGCCGGCCTACGCGACCGAGCCGGGCGTGAAGCCCGACAGCCAGACCGAAACCTTCGTCGCGCTGAAG
GTCGAGATCGAGAACTGGCGCTGGGCCGGCGTGCCGTTCTTCCTGCGCACCGGCAAGCGTCTGGCCGACCGCGTCGCGGA
GATCGTCGTCAACTTCCGCCCGGTGCCGCATTCGGCGCTCGGGCCGACCGCGCTGCGCCCCGGTTCGAACCGTCTCGTGA
TCCGGCTGCAGCCGAACGAGACGATCCGCCTGTACTGCCTCGCGAAACAGCCGGGCGAAGGGATGAACCTCGCGAGCGTG
CACCTCGACCTCGCGTTCGACCAGTTCTTCAAGGAAGGGCAGATGGAGGCGTACCAGCGCCTGCTGCTCGACGTGATCAA
CGGCCGGCTCGCCCTGTTCGTGCGTCGCGACGAGCAGGAAGCCGCCTGGCAATGGGTCGAGCCGATCCTGAACGAATGGG
CGCGCACGCTCAAGCCGCCGAAGCCGTACGCGGCGGGCACGTGGGGGCCGGCCGCGTCGAGCGCGATGCTCGCGCAGCAC
GACACCTGCTGGCTCGAAGAAGAAAACTGA

Upstream 100 bases:

>100_bases
TACCCCTTGCGGCGGATTGTAGTTAAACTACAATTCAGTGTCAAAAATATTTTTATCGCACTACGGATCGCTTCCAGCAC
CCCCAACACGGCGGAGACAC

Downstream 100 bases:

>100_bases
TGCAAACCGTTGCGGCGTACGCCACCGTACGCGGCAACGCGCCTCACGATTCGTACGATTTGAACAGACAAAGCAGTCCG
GAGGAGATGTGATCGAGATC

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 489; Mature: 489

Protein sequence:

>489_residues
MHTDSSFTFVLFGGTGDLSMRKILPALFEAHRANMLADGGRIVAVARHESDRAGYLEWVDTHVKPHAAKAAGNAFDDAAW
KSFLDRIEYVKLDLGRAEDYVVLRDAIASLPGIRVFYLATGPSLFVPICKALASVGLNEGSRIVLEKPLGYDLKSSNAIN
DAVGEIFAEGQIYRIDHYLGKEPVQNLLALRFGNALFEPLWRREWVESIQITIAEELGVEARGDFYDNTGALRDMVQNHL
LQLLSIVAMEPPHSMDSDSVRDEKLRVLRALKPIDPRDIGKVAVRGQYHAGVIKGAQVPAYATEPGVKPDSQTETFVALK
VEIENWRWAGVPFFLRTGKRLADRVAEIVVNFRPVPHSALGPTALRPGSNRLVIRLQPNETIRLYCLAKQPGEGMNLASV
HLDLAFDQFFKEGQMEAYQRLLLDVINGRLALFVRRDEQEAAWQWVEPILNEWARTLKPPKPYAAGTWGPAASSAMLAQH
DTCWLEEEN

Sequences:

>Translated_489_residues
MHTDSSFTFVLFGGTGDLSMRKILPALFEAHRANMLADGGRIVAVARHESDRAGYLEWVDTHVKPHAAKAAGNAFDDAAW
KSFLDRIEYVKLDLGRAEDYVVLRDAIASLPGIRVFYLATGPSLFVPICKALASVGLNEGSRIVLEKPLGYDLKSSNAIN
DAVGEIFAEGQIYRIDHYLGKEPVQNLLALRFGNALFEPLWRREWVESIQITIAEELGVEARGDFYDNTGALRDMVQNHL
LQLLSIVAMEPPHSMDSDSVRDEKLRVLRALKPIDPRDIGKVAVRGQYHAGVIKGAQVPAYATEPGVKPDSQTETFVALK
VEIENWRWAGVPFFLRTGKRLADRVAEIVVNFRPVPHSALGPTALRPGSNRLVIRLQPNETIRLYCLAKQPGEGMNLASV
HLDLAFDQFFKEGQMEAYQRLLLDVINGRLALFVRRDEQEAAWQWVEPILNEWARTLKPPKPYAAGTWGPAASSAMLAQH
DTCWLEEEN
>Mature_489_residues
MHTDSSFTFVLFGGTGDLSMRKILPALFEAHRANMLADGGRIVAVARHESDRAGYLEWVDTHVKPHAAKAAGNAFDDAAW
KSFLDRIEYVKLDLGRAEDYVVLRDAIASLPGIRVFYLATGPSLFVPICKALASVGLNEGSRIVLEKPLGYDLKSSNAIN
DAVGEIFAEGQIYRIDHYLGKEPVQNLLALRFGNALFEPLWRREWVESIQITIAEELGVEARGDFYDNTGALRDMVQNHL
LQLLSIVAMEPPHSMDSDSVRDEKLRVLRALKPIDPRDIGKVAVRGQYHAGVIKGAQVPAYATEPGVKPDSQTETFVALK
VEIENWRWAGVPFFLRTGKRLADRVAEIVVNFRPVPHSALGPTALRPGSNRLVIRLQPNETIRLYCLAKQPGEGMNLASV
HLDLAFDQFFKEGQMEAYQRLLLDVINGRLALFVRRDEQEAAWQWVEPILNEWARTLKPPKPYAAGTWGPAASSAMLAQH
DTCWLEEEN

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI108773793, Length=490, Percent_Identity=35.5102040816327, Blast_Score=296, Evalue=4e-80,
Organism=Homo sapiens, GI109389365, Length=490, Percent_Identity=35.5102040816327, Blast_Score=295, Evalue=5e-80,
Organism=Homo sapiens, GI52145310, Length=364, Percent_Identity=34.0659340659341, Blast_Score=157, Evalue=1e-38,
Organism=Escherichia coli, GI1788158, Length=491, Percent_Identity=43.7881873727088, Blast_Score=423, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI17538218, Length=490, Percent_Identity=35.3061224489796, Blast_Score=312, Evalue=2e-85,
Organism=Saccharomyces cerevisiae, GI6324088, Length=488, Percent_Identity=35.4508196721311, Blast_Score=293, Evalue=5e-80,
Organism=Drosophila melanogaster, GI24643350, Length=488, Percent_Identity=35.4508196721311, Blast_Score=290, Evalue=1e-78,
Organism=Drosophila melanogaster, GI24643352, Length=488, Percent_Identity=35.4508196721311, Blast_Score=290, Evalue=2e-78,
Organism=Drosophila melanogaster, GI221513548, Length=486, Percent_Identity=30.6584362139918, Blast_Score=213, Evalue=3e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 54571; Mature: 54571

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHTDSSFTFVLFGGTGDLSMRKILPALFEAHRANMLADGGRIVAVARHESDRAGYLEWVD
CCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCEEECCCEEEEEEECCCCCCCHHHHHH
THVKPHAAKAAGNAFDDAAWKSFLDRIEYVKLDLGRAEDYVVLRDAIASLPGIRVFYLAT
HCCCCCHHHHCCCCCHHHHHHHHHHHHHEEEEECCCCCCEEHHHHHHHHCCCCEEEEEEC
GPSLFVPICKALASVGLNEGSRIVLEKPLGYDLKSSNAINDAVGEIFAEGQIYRIDHYLG
CCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHCCEEEEEHHHCC
KEPVQNLLALRFGNALFEPLWRREWVESIQITIAEELGVEARGDFYDNTGALRDMVQNHL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHCCCCCCCCCCCCCHHHHHHHHHHH
LQLLSIVAMEPPHSMDSDSVRDEKLRVLRALKPIDPRDIGKVAVRGQYHAGVIKGAQVPA
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCEEECCCCCC
YATEPGVKPDSQTETFVALKVEIENWRWAGVPFFLRTGKRLADRVAEIVVNFRPVPHSAL
CCCCCCCCCCCCCCEEEEEEEEECCEEECCCHHHHHCCHHHHHHHHHHHHHCCCCCCCCC
GPTALRPGSNRLVIRLQPNETIRLYCLAKQPGEGMNLASVHLDLAFDQFFKEGQMEAYQR
CCCCCCCCCCEEEEEECCCCEEEEEEEECCCCCCCCEEEEEEHHHHHHHHHCCHHHHHHH
LLLDVINGRLALFVRRDEQEAAWQWVEPILNEWARTLKPPKPYAAGTWGPAASSAMLAQH
HHHHHHCCEEEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHCC
DTCWLEEEN
CCEEEECCC
>Mature Secondary Structure
MHTDSSFTFVLFGGTGDLSMRKILPALFEAHRANMLADGGRIVAVARHESDRAGYLEWVD
CCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCEEECCCEEEEEEECCCCCCCHHHHHH
THVKPHAAKAAGNAFDDAAWKSFLDRIEYVKLDLGRAEDYVVLRDAIASLPGIRVFYLAT
HCCCCCHHHHCCCCCHHHHHHHHHHHHHEEEEECCCCCCEEHHHHHHHHCCCCEEEEEEC
GPSLFVPICKALASVGLNEGSRIVLEKPLGYDLKSSNAINDAVGEIFAEGQIYRIDHYLG
CCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHCCEEEEEHHHCC
KEPVQNLLALRFGNALFEPLWRREWVESIQITIAEELGVEARGDFYDNTGALRDMVQNHL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHCCCCCCCCCCCCCHHHHHHHHHHH
LQLLSIVAMEPPHSMDSDSVRDEKLRVLRALKPIDPRDIGKVAVRGQYHAGVIKGAQVPA
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCEEECCCCCC
YATEPGVKPDSQTETFVALKVEIENWRWAGVPFFLRTGKRLADRVAEIVVNFRPVPHSAL
CCCCCCCCCCCCCCEEEEEEEEECCEEECCCHHHHHCCHHHHHHHHHHHHHCCCCCCCCC
GPTALRPGSNRLVIRLQPNETIRLYCLAKQPGEGMNLASVHLDLAFDQFFKEGQMEAYQR
CCCCCCCCCCEEEEEECCCCEEEEEEEECCCCCCCCEEEEEEHHHHHHHHHCCHHHHHHH
LLLDVINGRLALFVRRDEQEAAWQWVEPILNEWARTLKPPKPYAAGTWGPAASSAMLAQH
HHHHHHCCEEEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHCC
DTCWLEEEN
CCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10400573; 11481430 [H]