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The map label for this gene is mmcD [H]

Identifier: 116688961

GI number: 116688961

Start: 1046942

End: 1047751

Strand: Direct

Name: mmcD [H]

Synonym: Bcen2424_0938

Alternate gene names: 116688961

Gene position: 1046942-1047751 (Clockwise)

Preceding gene: 116688960

Following gene: 116688965

Centisome position: 30.05

GC content: 70.25

Gene sequence:

>810_bases
ATGACCGACATGACGAAACACGACGGAGCGTCGAGCGTGACGGTCGATTGGATCGGCGAGCGGATCGCGCGCGTGCGGTT
CGGGAATCCGGCGCGACGGCATGCGCTCGACGCGCCGTTGCTCGATGCCCTCGTCGCGCATCTCGATGCGTTGGCCGGGC
ACCGTCCGCCGCCGGTCGTGATCCTGTCCAACGACGGCAGCGGCGACGTGTGGAGCGCGGGGCACGACCTGCGCGAACTG
GCCGACGACCGCGATCCGCTCGCGTACGGCAAACCGCTCGAACGCGCGCTGCGGCGCGTGCGGACCTATCCGGGCGCGGT
GATCGCGGCGGTGGCCGGATCGGCGTGGGGCGGGGCGGTCGATCTCGTGATGAGCTGCGATCTCGTCGTCGCGGCGCGCG
ACGCGCGTTTCGCGATGACGCCCGCGAACATCGGCCTGCCGTATTCGACGAGCGGCCTGCTGCGCTTCTACGACAACCTG
CCGATCCATGTGCTCAAGGAGATGTTCTTCTGCGCGCAGCCGCTCGATGCGGAACGCGCCGCGCATCACGGGCTCGTGAA
CCGGCTGGCTGACGCGGGCGGGGTCGACGACGCGGCGCTCGACGTCGCGCGCACGATTGCCGCGAAGGCGCCGCTCGCGG
TGCACGCGGTGAAGGAGCAGTTGCGCGTGCTGCAGGATGCACGGCCGTTGCCGGCCGACGCATTCGAACGAATCACCGAG
CTGCGTCGCCTAGCGTGCGAAGGCGCGGATTTCGACGAAGGGTTGCGCGCGTTCGCGGAGCGGCGTGCGCCGGTGTTTCG
TGGGGCCTAG

Upstream 100 bases:

>100_bases
TCGATGTGCTGCGCGAAGCCGGCTACGGCGACGACGCGATCGACGCACTGCTGGCCGGGCGCGCGATCTTCCAGGCCGAT
GCGGTGGCGGAGGCCGTGCA

Downstream 100 bases:

>100_bases
ACGATCACGCGACGGCCGGTGCGATGATGGCGGCGGCGCGTTACACCCCGCCGAGCGTGTGCACACCCACGAGCAGCAGC
GCGCCGATCGCGATCAGCAG

Product: methylmalonyl-CoA decarboxylase

Products: NA

Alternate protein names: MMCD; Transcarboxylase [H]

Number of amino acids: Translated: 269; Mature: 268

Protein sequence:

>269_residues
MTDMTKHDGASSVTVDWIGERIARVRFGNPARRHALDAPLLDALVAHLDALAGHRPPPVVILSNDGSGDVWSAGHDLREL
ADDRDPLAYGKPLERALRRVRTYPGAVIAAVAGSAWGGAVDLVMSCDLVVAARDARFAMTPANIGLPYSTSGLLRFYDNL
PIHVLKEMFFCAQPLDAERAAHHGLVNRLADAGGVDDAALDVARTIAAKAPLAVHAVKEQLRVLQDARPLPADAFERITE
LRRLACEGADFDEGLRAFAERRAPVFRGA

Sequences:

>Translated_269_residues
MTDMTKHDGASSVTVDWIGERIARVRFGNPARRHALDAPLLDALVAHLDALAGHRPPPVVILSNDGSGDVWSAGHDLREL
ADDRDPLAYGKPLERALRRVRTYPGAVIAAVAGSAWGGAVDLVMSCDLVVAARDARFAMTPANIGLPYSTSGLLRFYDNL
PIHVLKEMFFCAQPLDAERAAHHGLVNRLADAGGVDDAALDVARTIAAKAPLAVHAVKEQLRVLQDARPLPADAFERITE
LRRLACEGADFDEGLRAFAERRAPVFRGA
>Mature_268_residues
TDMTKHDGASSVTVDWIGERIARVRFGNPARRHALDAPLLDALVAHLDALAGHRPPPVVILSNDGSGDVWSAGHDLRELA
DDRDPLAYGKPLERALRRVRTYPGAVIAAVAGSAWGGAVDLVMSCDLVVAARDARFAMTPANIGLPYSTSGLLRFYDNLP
IHVLKEMFFCAQPLDAERAAHHGLVNRLADAGGVDDAALDVARTIAAKAPLAVHAVKEQLRVLQDARPLPADAFERITEL
RRLACEGADFDEGLRAFAERRAPVFRGA

Specific function: Unknown

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI31542718, Length=253, Percent_Identity=30.0395256916996, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI194097323, Length=246, Percent_Identity=24.390243902439, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI70995211, Length=261, Percent_Identity=26.4367816091954, Blast_Score=72, Evalue=4e-13,
Organism=Escherichia coli, GI87082183, Length=250, Percent_Identity=38.4, Blast_Score=192, Evalue=2e-50,
Organism=Escherichia coli, GI1787659, Length=249, Percent_Identity=29.3172690763052, Blast_Score=101, Evalue=5e-23,
Organism=Escherichia coli, GI221142681, Length=213, Percent_Identity=32.8638497652582, Blast_Score=95, Evalue=4e-21,
Organism=Escherichia coli, GI1788597, Length=250, Percent_Identity=26, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17554946, Length=254, Percent_Identity=27.1653543307087, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17540714, Length=201, Percent_Identity=27.8606965174129, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17540306, Length=186, Percent_Identity=31.7204301075269, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI25145438, Length=246, Percent_Identity=28.0487804878049, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17536985, Length=233, Percent_Identity=25.7510729613734, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24653139, Length=260, Percent_Identity=25.7692307692308, Blast_Score=77, Evalue=9e-15,
Organism=Drosophila melanogaster, GI19922422, Length=242, Percent_Identity=27.2727272727273, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI20129971, Length=249, Percent_Identity=25.3012048192771, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24653477, Length=249, Percent_Identity=25.3012048192771, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI19920382, Length=216, Percent_Identity=28.2407407407407, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.1.1.41 [H]

Molecular weight: Translated: 28973; Mature: 28842

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDMTKHDGASSVTVDWIGERIARVRFGNPARRHALDAPLLDALVAHLDALAGHRPPPVV
CCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHCCCCCCEE
ILSNDGSGDVWSAGHDLRELADDRDPLAYGKPLERALRRVRTYPGAVIAAVAGSAWGGAV
EEECCCCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCCCHHH
DLVMSCDLVVAARDARFAMTPANIGLPYSTSGLLRFYDNLPIHVLKEMFFCAQPLDAERA
HHHHHCCEEEEECCCCEEECCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHCCCCCHHHH
AHHGLVNRLADAGGVDDAALDVARTIAAKAPLAVHAVKEQLRVLQDARPLPADAFERITE
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
LRRLACEGADFDEGLRAFAERRAPVFRGA
HHHHHHCCCCHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TDMTKHDGASSVTVDWIGERIARVRFGNPARRHALDAPLLDALVAHLDALAGHRPPPVV
CCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHCCCCCCEE
ILSNDGSGDVWSAGHDLRELADDRDPLAYGKPLERALRRVRTYPGAVIAAVAGSAWGGAV
EEECCCCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCCCHHH
DLVMSCDLVVAARDARFAMTPANIGLPYSTSGLLRFYDNLPIHVLKEMFFCAQPLDAERA
HHHHHCCEEEEECCCCEEECCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHCCCCCHHHH
AHHGLVNRLADAGGVDDAALDVARTIAAKAPLAVHAVKEQLRVLQDARPLPADAFERITE
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
LRRLACEGADFDEGLRAFAERRAPVFRGA
HHHHHHCCCCHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]