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The map label for this gene is rmlA1 [H]

Identifier: 116688895

GI number: 116688895

Start: 975996

End: 976889

Strand: Direct

Name: rmlA1 [H]

Synonym: Bcen2424_0872

Alternate gene names: 116688895

Gene position: 975996-976889 (Clockwise)

Preceding gene: 116688894

Following gene: 116688896

Centisome position: 28.01

GC content: 61.74

Gene sequence:

>894_bases
ATGGCACGTAAAGGCATCATTCTCGCCGGCGGTTCCGGCACCCGGCTGTATCCGATCACGCACGTCGTCTCGAAGCAGCT
TCTGCCGGTGTACGACAAGCCGATGATCTACTACCCGCTGTCGACGTTGATGATCGCGGGCATTCGCGACGTGTTGATCA
TCTCGACGCCGCAGGACACGCCGCGCTTCGAGTCGATGCTCGGCGACGGCAGCCAGTGGGGGATGAACATCCAGTACGCG
GTGCAGCCGTCGCCCGACGGTCTCGCGCAGGCGTTCATCATCGGCAAGGAGTTCGTCGGCAACGATCCGTCGGCGCTGAT
CCTCGGCGACAACATCTTTTACGGTCACGATCTCGCGAAGCAGCTCGAGCGCGCGCATGCGCAGGAAACGGGCGCGACCG
TGTTCGCGTATCACGTGCACGACCCGGAACGTTACGGCGTCGTCGAATTCGACAAGTCGTTCCGCGCGTTGTCGATCGAG
GAGAAGCCCGCGAAGCCGCGTTCGAACTACGCGGTGACGGGCCTGTACTTCTACGACAACCAGGTGTGCGACATCGCGGC
CGACATCAAGCCGTCGCCGCGCGGCGAGCTCGAAATCACCGACGTCAACTCGCGCTATCTCGACAGCGGCGCGCTGAACG
TCGAGATCATGGGGCGTGGCTACGCTTGGCTCGATACCGGCACGCACGATTCGCTGATCGAGGCGGCCAGTTTCATCGCG
ACGCTGCAGAAGCGGCAAGGTCTCGTGGTTGCCTGTCCGGAAGAGATCGCGTATCGCCGCAACTGGATCGACGCGGAACA
AGTGCTGAAGCTCGCCCAGCCACTCGCGAAGAACGCATACGGTCAGTACCTGAAGAACATTCTTACGGATCAAGTCGCAT
GGCCATCCAAGTAA

Upstream 100 bases:

>100_bases
GGTATCTCGACAACCAGGTGTGGGCCGATGAGGTCGCATCGGGCGAGTACCGCAAGTGGGTCGAGACGAACTACGCGAAA
CGCACGTGAGGAGAGAAGCG

Downstream 100 bases:

>100_bases
CGGCAACGGCGCTGCCCGAAGTCAAGATCATCGAGCCGAAGGTGTTCGGCGACGCGCGCGGGTTCTTCTACGAAAGCTTC
AACGGGAAGGAATTCGCCGA

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: G1P-TT 1; dTDP-glucose pyrophosphorylase 1; dTDP-glucose synthase 1 [H]

Number of amino acids: Translated: 297; Mature: 296

Protein sequence:

>297_residues
MARKGIILAGGSGTRLYPITHVVSKQLLPVYDKPMIYYPLSTLMIAGIRDVLIISTPQDTPRFESMLGDGSQWGMNIQYA
VQPSPDGLAQAFIIGKEFVGNDPSALILGDNIFYGHDLAKQLERAHAQETGATVFAYHVHDPERYGVVEFDKSFRALSIE
EKPAKPRSNYAVTGLYFYDNQVCDIAADIKPSPRGELEITDVNSRYLDSGALNVEIMGRGYAWLDTGTHDSLIEAASFIA
TLQKRQGLVVACPEEIAYRRNWIDAEQVLKLAQPLAKNAYGQYLKNILTDQVAWPSK

Sequences:

>Translated_297_residues
MARKGIILAGGSGTRLYPITHVVSKQLLPVYDKPMIYYPLSTLMIAGIRDVLIISTPQDTPRFESMLGDGSQWGMNIQYA
VQPSPDGLAQAFIIGKEFVGNDPSALILGDNIFYGHDLAKQLERAHAQETGATVFAYHVHDPERYGVVEFDKSFRALSIE
EKPAKPRSNYAVTGLYFYDNQVCDIAADIKPSPRGELEITDVNSRYLDSGALNVEIMGRGYAWLDTGTHDSLIEAASFIA
TLQKRQGLVVACPEEIAYRRNWIDAEQVLKLAQPLAKNAYGQYLKNILTDQVAWPSK
>Mature_296_residues
ARKGIILAGGSGTRLYPITHVVSKQLLPVYDKPMIYYPLSTLMIAGIRDVLIISTPQDTPRFESMLGDGSQWGMNIQYAV
QPSPDGLAQAFIIGKEFVGNDPSALILGDNIFYGHDLAKQLERAHAQETGATVFAYHVHDPERYGVVEFDKSFRALSIEE
KPAKPRSNYAVTGLYFYDNQVCDIAADIKPSPRGELEITDVNSRYLDSGALNVEIMGRGYAWLDTGTHDSLIEAASFIAT
LQKRQGLVVACPEEIAYRRNWIDAEQVLKLAQPLAKNAYGQYLKNILTDQVAWPSK

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788351, Length=288, Percent_Identity=74.3055555555556, Blast_Score=460, Evalue=1e-131,
Organism=Escherichia coli, GI1790224, Length=285, Percent_Identity=63.859649122807, Blast_Score=398, Evalue=1e-112,
Organism=Escherichia coli, GI1787488, Length=235, Percent_Identity=25.9574468085106, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI133931050, Length=184, Percent_Identity=25, Blast_Score=71, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6320148, Length=248, Percent_Identity=29.0322580645161, Blast_Score=84, Evalue=3e-17,
Organism=Drosophila melanogaster, GI21355443, Length=245, Percent_Identity=24.0816326530612, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24644084, Length=245, Percent_Identity=24.0816326530612, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 32944; Mature: 32813

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARKGIILAGGSGTRLYPITHVVSKQLLPVYDKPMIYYPLSTLMIAGIRDVLIISTPQDT
CCCCCEEEECCCCCEEEEHHHHHHHHCCCCCCCCEEEECHHHHHHHCCCEEEEEECCCCC
PRFESMLGDGSQWGMNIQYAVQPSPDGLAQAFIIGKEFVGNDPSALILGDNIFYGHDLAK
HHHHHHHCCCCCCCCEEEEEECCCCCHHHHHEEECHHHCCCCCCEEEEECCEEECHHHHH
QLERAHAQETGATVFAYHVHDPERYGVVEFDKSFRALSIEEKPAKPRSNYAVTGLYFYDN
HHHHHHHHHCCCEEEEEEECCCCCCCEEEECCCCEEEECCCCCCCCCCCEEEEEEEEECC
QVCDIAADIKPSPRGELEITDVNSRYLDSGALNVEIMGRGYAWLDTGTHDSLIEAASFIA
CEEEEEECCCCCCCCCEEEEECCCCEECCCCEEEEEEECCEEEEECCCCHHHHHHHHHHH
TLQKRQGLVVACPEEIAYRRNWIDAEQVLKLAQPLAKNAYGQYLKNILTDQVAWPSK
HHHHCCCEEEECCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
ARKGIILAGGSGTRLYPITHVVSKQLLPVYDKPMIYYPLSTLMIAGIRDVLIISTPQDT
CCCCEEEECCCCCEEEEHHHHHHHHCCCCCCCCEEEECHHHHHHHCCCEEEEEECCCCC
PRFESMLGDGSQWGMNIQYAVQPSPDGLAQAFIIGKEFVGNDPSALILGDNIFYGHDLAK
HHHHHHHCCCCCCCCEEEEEECCCCCHHHHHEEECHHHCCCCCCEEEEECCEEECHHHHH
QLERAHAQETGATVFAYHVHDPERYGVVEFDKSFRALSIEEKPAKPRSNYAVTGLYFYDN
HHHHHHHHHCCCEEEEEEECCCCCCCEEEECCCCEEEECCCCCCCCCCCEEEEEEEEECC
QVCDIAADIKPSPRGELEITDVNSRYLDSGALNVEIMGRGYAWLDTGTHDSLIEAASFIA
CEEEEEECCCCCCCCCEEEEECCCCEECCCCEEEEEEECCEEEEECCCCHHHHHHHHHHH
TLQKRQGLVVACPEEIAYRRNWIDAEQVLKLAQPLAKNAYGQYLKNILTDQVAWPSK
HHHHCCCEEEECCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7517391; 9097040; 9278503; 7517390 [H]