Click here to switch to the map view.

The map label for this gene is 116688844

Identifier: 116688844

GI number: 116688844

Start: 920871

End: 922175

Strand: Direct

Name: 116688844

Synonym: Bcen2424_0821

Alternate gene names: NA

Gene position: 920871-922175 (Clockwise)

Preceding gene: 116688843

Following gene: 116688851

Centisome position: 26.43

GC content: 67.51

Gene sequence:

>1305_bases
ATGAGCGACACCCAAGACTGGCGCGCGACGCTCGACCCGGCTCGCAAGAGCTGGATCGACACGGCGAACGATCCCGCGTG
CGATTTCCCGATCCAGAACCTGCCGTTCGGGATCTTCAGCGATGCGAAGCAGGGCGTGCGCCGTGCCGGCGTTGCACTGG
GCGACCAGATCGTCGATCTCGCGGCACTCGCGCGTGCGGGCCTCGTGACGCTGCCGGCCGGCGCCGACGTGTTCGCCGCG
CCGACGCTCAACGCGTTCATCGCGCTCGGCCGCGATGCATGGCGCAGCGTACGCTCGCAACTGTCGGCGCTGTTCTCGCG
CGACAACGCGACGCTGCGTGACGATGCGGCGCTGCGCGCGCAGGTACTCGTCGCGCAGCGCGACGCGACGCTGCATCTGC
CGGTCGAGATTCCCGGCTACACCGATTTCTATTCGTCGAAGGAGCACGCGACCAACGTCGGCTCGATGTTCCGTGATCCG
AAGAATGCGCTGCTGCCGAACTGGTCGGAGATGCCGATCGGCTACAACGGCCGCGCGTCGTCGGTGGTCGTGAGCGGCAC
GCCGGTGCGGCGCCCGAACGGGCAACTGAAGCTGCCCGACCAGGAGCGTCCGGTGTTCGGTGCGTGCCGCAAGCTCGACA
TCGAACTGGAGACGGGCTTCATCGTCGGCAAGGGCAACGCACTCGGCGAGCCGATCGCGTGCGAGGACGCGGAAGCGCAT
ATCTTCGGGATGGTGCTGCTGAACGACTGGAGCGCGCGCGACATCCAGCAGTGGGAATACGTGCCGCTCGGGCCGTTCAA
CTCGAAGGGCTTCGCGACGACGATCTCGCCGTGGATCGTCACGCTCGACGCGCTCGAACCGTTCCGCGTCGCGCAGCCGG
AGCAGTCGCCGCAGCCGCTCGCGTATCTGCGGCATGCGGGCAAGCATGCGTTCGATATCGCGCTGGAAGTGACGCTGCGC
GCAGAGGGTGCGGCCGAGGCCACGTCGATCTGCCGCACCAACTTCAAGCACATGTACTGGACGATGGCGCAGCAGCTCGC
GCATCACACGGTGGCCGGCTGCAACACGCGCGTGGGCGACCTGATGGGTTCGGGCACGATCAGCGGGCCGACCAAGGATT
CGTTCGGCAGCCTGCTCGAACTGACGTGGAACGGCAAGGAGCCGGTCGCGCTGAACGGCGGCGGCAGCCGCACGTTCATC
GAGGACGGCGACGAGCTGACGCTCGCGGGCTGGTGCCAGGGCGAGGGGTATCGCGTCGGCTTCGGTACGTGTGCAGGCAA
GATTTTGCCGGCACGCAGCGTGTGA

Upstream 100 bases:

>100_bases
TGATTCGGCCGACGCGCTACGCGCTCGACACCGCGCAGCTGCAGGCCGACTACTTCGAATGCTGGCAAGGCATCAAGAAA
CACTTCAATCCGGAGCAACG

Downstream 100 bases:

>100_bases
CGGATCGCAGCGCGAAATGTGACGTATAGGTCACGCGTAGAGGACGGCCCGCATTGCGCAGGCCGTTGTCGTTTACCGGA
GGAAGAGCGCGAGCGGGCCG

Product: fumarylacetoacetase

Products: acetoacetate; fumarate

Alternate protein names: Fumarylacetoacetate Hydrolase; Hydroxylase; Fumarylacetoacetate Hydrolase Family Protein; 2-Hydroxyhepta-2 4-Diene-1 7-Dioate Isomerase; Fumarylacetoacetase Hydrolase; LOW QUALITY PROTEIN Fumarylacetoacetase

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MSDTQDWRATLDPARKSWIDTANDPACDFPIQNLPFGIFSDAKQGVRRAGVALGDQIVDLAALARAGLVTLPAGADVFAA
PTLNAFIALGRDAWRSVRSQLSALFSRDNATLRDDAALRAQVLVAQRDATLHLPVEIPGYTDFYSSKEHATNVGSMFRDP
KNALLPNWSEMPIGYNGRASSVVVSGTPVRRPNGQLKLPDQERPVFGACRKLDIELETGFIVGKGNALGEPIACEDAEAH
IFGMVLLNDWSARDIQQWEYVPLGPFNSKGFATTISPWIVTLDALEPFRVAQPEQSPQPLAYLRHAGKHAFDIALEVTLR
AEGAAEATSICRTNFKHMYWTMAQQLAHHTVAGCNTRVGDLMGSGTISGPTKDSFGSLLELTWNGKEPVALNGGGSRTFI
EDGDELTLAGWCQGEGYRVGFGTCAGKILPARSV

Sequences:

>Translated_434_residues
MSDTQDWRATLDPARKSWIDTANDPACDFPIQNLPFGIFSDAKQGVRRAGVALGDQIVDLAALARAGLVTLPAGADVFAA
PTLNAFIALGRDAWRSVRSQLSALFSRDNATLRDDAALRAQVLVAQRDATLHLPVEIPGYTDFYSSKEHATNVGSMFRDP
KNALLPNWSEMPIGYNGRASSVVVSGTPVRRPNGQLKLPDQERPVFGACRKLDIELETGFIVGKGNALGEPIACEDAEAH
IFGMVLLNDWSARDIQQWEYVPLGPFNSKGFATTISPWIVTLDALEPFRVAQPEQSPQPLAYLRHAGKHAFDIALEVTLR
AEGAAEATSICRTNFKHMYWTMAQQLAHHTVAGCNTRVGDLMGSGTISGPTKDSFGSLLELTWNGKEPVALNGGGSRTFI
EDGDELTLAGWCQGEGYRVGFGTCAGKILPARSV
>Mature_433_residues
SDTQDWRATLDPARKSWIDTANDPACDFPIQNLPFGIFSDAKQGVRRAGVALGDQIVDLAALARAGLVTLPAGADVFAAP
TLNAFIALGRDAWRSVRSQLSALFSRDNATLRDDAALRAQVLVAQRDATLHLPVEIPGYTDFYSSKEHATNVGSMFRDPK
NALLPNWSEMPIGYNGRASSVVVSGTPVRRPNGQLKLPDQERPVFGACRKLDIELETGFIVGKGNALGEPIACEDAEAHI
FGMVLLNDWSARDIQQWEYVPLGPFNSKGFATTISPWIVTLDALEPFRVAQPEQSPQPLAYLRHAGKHAFDIALEVTLRA
EGAAEATSICRTNFKHMYWTMAQQLAHHTVAGCNTRVGDLMGSGTISGPTKDSFGSLLELTWNGKEPVALNGGGSRTFIE
DGDELTLAGWCQGEGYRVGFGTCAGKILPARSV

Specific function: Unknown

COG id: COG0179

COG function: function code Q; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557587, Length=418, Percent_Identity=58.133971291866, Blast_Score=515, Evalue=1e-146,
Organism=Caenorhabditis elegans, GI17568863, Length=418, Percent_Identity=55.5023923444976, Blast_Score=472, Evalue=1e-133,
Organism=Drosophila melanogaster, GI24657182, Length=409, Percent_Identity=52.5672371638142, Blast_Score=431, Evalue=1e-121,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 3.7.1.2

Molecular weight: Translated: 46924; Mature: 46793

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDTQDWRATLDPARKSWIDTANDPACDFPIQNLPFGIFSDAKQGVRRAGVALGDQIVDL
CCCCCCHHHHCCHHHHHHCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
AALARAGLVTLPAGADVFAAPTLNAFIALGRDAWRSVRSQLSALFSRDNATLRDDAALRA
HHHHHCCEEEECCCCCEEECCHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHE
QVLVAQRDATLHLPVEIPGYTDFYSSKEHATNVGSMFRDPKNALLPNWSEMPIGYNGRAS
EEEEEECCCEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCC
SVVVSGTPVRRPNGQLKLPDQERPVFGACRKLDIELETGFIVGKGNALGEPIACEDAEAH
EEEEECCCCCCCCCCEECCCCCCCHHHHHEEEEEEEECCEEEECCCCCCCCCCCCCCCCE
IFGMVLLNDWSARDIQQWEYVPLGPFNSKGFATTISPWIVTLDALEPFRVAQPEQSPQPL
EEEEEEECCCCCCCCCCCCEEECCCCCCCCCEEECCCEEEEEECCCCCCCCCCCCCCCHH
AYLRHAGKHAFDIALEVTLRAEGAAEATSICRTNFKHMYWTMAQQLAHHTVAGCNTRVGD
HHHHHCCCCEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
LMGSGTISGPTKDSFGSLLELTWNGKEPVALNGGGSRTFIEDGDELTLAGWCQGEGYRVG
HCCCCCCCCCCCCCCCCEEEEEECCCCCEEECCCCCCCEECCCCEEEEEEEECCCCEEEE
FGTCAGKILPARSV
HHHCCCCEECCCCC
>Mature Secondary Structure 
SDTQDWRATLDPARKSWIDTANDPACDFPIQNLPFGIFSDAKQGVRRAGVALGDQIVDL
CCCCCHHHHCCHHHHHHCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
AALARAGLVTLPAGADVFAAPTLNAFIALGRDAWRSVRSQLSALFSRDNATLRDDAALRA
HHHHHCCEEEECCCCCEEECCHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHE
QVLVAQRDATLHLPVEIPGYTDFYSSKEHATNVGSMFRDPKNALLPNWSEMPIGYNGRAS
EEEEEECCCEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCC
SVVVSGTPVRRPNGQLKLPDQERPVFGACRKLDIELETGFIVGKGNALGEPIACEDAEAH
EEEEECCCCCCCCCCEECCCCCCCHHHHHEEEEEEEECCEEEECCCCCCCCCCCCCCCCE
IFGMVLLNDWSARDIQQWEYVPLGPFNSKGFATTISPWIVTLDALEPFRVAQPEQSPQPL
EEEEEEECCCCCCCCCCCCEEECCCCCCCCCEEECCCEEEEEECCCCCCCCCCCCCCCHH
AYLRHAGKHAFDIALEVTLRAEGAAEATSICRTNFKHMYWTMAQQLAHHTVAGCNTRVGD
HHHHHCCCCEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
LMGSGTISGPTKDSFGSLLELTWNGKEPVALNGGGSRTFIEDGDELTLAGWCQGEGYRVG
HCCCCCCCCCCCCCCCCEEEEEECCCCCEEECCCCCCCEECCCCEEEEEEEECCCCEEEE
FGTCAGKILPARSV
HHHCCCCEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-fumarylacetoacetate; H2O

Specific reaction: 4-fumarylacetoacetate + H2O = acetoacetate + fumarate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA