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The map label for this gene is trpE [H]

Identifier: 116688558

GI number: 116688558

Start: 593869

End: 595362

Strand: Reverse

Name: trpE [H]

Synonym: Bcen2424_0534

Alternate gene names: 116688558

Gene position: 595362-593869 (Counterclockwise)

Preceding gene: 116688559

Following gene: 116688557

Centisome position: 17.09

GC content: 66.2

Gene sequence:

>1494_bases
ATGACCGAACTCGAATTCCAATCGCTGGCGAACGAAGGCTACAACCGCATCCCGCTGATCGCGGAAGCCCTTGCCGATCT
CGAAACGCCGCTGTCCCTCTACCTGAAGCTGGCCCAGCCCGAACGTGCGGGCGCCAACTCGTTCCTGCTCGAATCGGTGG
TCGGCGGCGAGCGTTTCGGCCGCTACTCGTTCATCGGCCTGCCGGCCCGCACGCTCGTGCGCACCCGCAACGGCGTGTCG
GAAGTGGTACGCGACGGCCAGGTCGTCGAGACTCACGACGGCGATCCGTTCCAGTTCATCGAATCGTTCCAGGCCCGCTT
CAAGGTCGCGCAGCGCCCGGGCCTGCCGCGTTTCTGCGGCGGCCTCGCCGGCTACTTCGGCTACGACGCGGTGCGCTACA
TCGAGAAGAAGCTCGCGAACACCGCGCCGCGCGACGATCTCGGCCTGCCCGACATCCAGTTGCTGCTGACCGAGGAAGTC
GCGGTGATCGACAACCTCGCCGGCAAGCTCTACCTGATCATCTACGCGGACCCGGGCCAGCCCGAAGCGTATGCGAAGGC
GAAACAGCGCCTGCGCGAACTGAAGCAGCGCCTGCGCACGACCGTGCAGCCGCCCGTCACGTCGGCGAGCGTGCGCACCG
AGACGTTCCGCGAATTCAAGAAGGACGACTACCTGGCCGCCGTGCGCCAGGCGAAGGAATACATCGCGGCCGGCGAGCTG
ATGCAGATCCAGGTCGGCCAGCGGCTCACGAAGCCGTACCGCGACAATCCGCTGTCGCTGTACCGCGCGCTGCGTTCGCT
GAATCCGTCGCCGTACATGTATTACTACAACTTCGGCGATTTCCACGTGGTCGGCGCGTCGCCGGAAATCCTGGTGCGCC
AGGAAAAGCGCGGCGAAGACCAGATCGTCACGATCCGGCCGCTGGCCGGCACGCGCCCGCGCGGCAACACGCCCGAGCGC
GACGCGGAACTCGCGACCGAGCTGCTCAACGATCCGAAGGAGATCGCCGAGCACGTGATGCTGATCGACCTCGCGCGCAA
CGACGTCGGCCGCATCGCGGAAATCGGCTCGGTGCAGGTGACCGACAAGATGGTGATCGAGAAGTACTCGCACGTGCAGC
ACATCGTCAGCTCGGTCGAAGGCAAGCTGAAGCCCGGCATGACGAACTACGACGTGCTGCGCGCGACGTTCCCGGCCGGC
ACGCTGTCCGGCGCGCCGAAAGTGCGCGCGATGGAACTGATCGACGAGCTCGAGCCGGTCAAGCGCGGGCTGTACGGCGG
CGCGGTCGGCTACCTGTCGTTCTCGGGCGAGATGGATCTCGCAATCGCGATCCGCACGGGCCTGATCCACAACGGCAACC
TGTACGTGCAAGCGGCGGCCGGCGTCGTCGCGGATTCGGTGCCCGAATCCGAATGGCAAGAGACCGAGAACAAGGCGCGC
GCGGTGCTGCGTGCGGCCGAACAGGTCCAGGACGGCCTCGATAGCGACTTCTGA

Upstream 100 bases:

>100_bases
ACAGGCACTTCTCGATCGACCGCCCTTTCGCCGACGGCCACCCGCGCAGCGTCAAGTGATCCCTGGCGCACGCGCCGCTC
GTCCCGAACAGGACCGGAAC

Downstream 100 bases:

>100_bases
CCGGAGACTGACCATGCTGCTCATGATCGACAACTACGACTCGTTTACCTACAACCTGGTCCAGTACTTCGGCGAACTCG
GCGAGGACGTGCGTACCTAC

Product: anthranilate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 497; Mature: 496

Protein sequence:

>497_residues
MTELEFQSLANEGYNRIPLIAEALADLETPLSLYLKLAQPERAGANSFLLESVVGGERFGRYSFIGLPARTLVRTRNGVS
EVVRDGQVVETHDGDPFQFIESFQARFKVAQRPGLPRFCGGLAGYFGYDAVRYIEKKLANTAPRDDLGLPDIQLLLTEEV
AVIDNLAGKLYLIIYADPGQPEAYAKAKQRLRELKQRLRTTVQPPVTSASVRTETFREFKKDDYLAAVRQAKEYIAAGEL
MQIQVGQRLTKPYRDNPLSLYRALRSLNPSPYMYYYNFGDFHVVGASPEILVRQEKRGEDQIVTIRPLAGTRPRGNTPER
DAELATELLNDPKEIAEHVMLIDLARNDVGRIAEIGSVQVTDKMVIEKYSHVQHIVSSVEGKLKPGMTNYDVLRATFPAG
TLSGAPKVRAMELIDELEPVKRGLYGGAVGYLSFSGEMDLAIAIRTGLIHNGNLYVQAAAGVVADSVPESEWQETENKAR
AVLRAAEQVQDGLDSDF

Sequences:

>Translated_497_residues
MTELEFQSLANEGYNRIPLIAEALADLETPLSLYLKLAQPERAGANSFLLESVVGGERFGRYSFIGLPARTLVRTRNGVS
EVVRDGQVVETHDGDPFQFIESFQARFKVAQRPGLPRFCGGLAGYFGYDAVRYIEKKLANTAPRDDLGLPDIQLLLTEEV
AVIDNLAGKLYLIIYADPGQPEAYAKAKQRLRELKQRLRTTVQPPVTSASVRTETFREFKKDDYLAAVRQAKEYIAAGEL
MQIQVGQRLTKPYRDNPLSLYRALRSLNPSPYMYYYNFGDFHVVGASPEILVRQEKRGEDQIVTIRPLAGTRPRGNTPER
DAELATELLNDPKEIAEHVMLIDLARNDVGRIAEIGSVQVTDKMVIEKYSHVQHIVSSVEGKLKPGMTNYDVLRATFPAG
TLSGAPKVRAMELIDELEPVKRGLYGGAVGYLSFSGEMDLAIAIRTGLIHNGNLYVQAAAGVVADSVPESEWQETENKAR
AVLRAAEQVQDGLDSDF
>Mature_496_residues
TELEFQSLANEGYNRIPLIAEALADLETPLSLYLKLAQPERAGANSFLLESVVGGERFGRYSFIGLPARTLVRTRNGVSE
VVRDGQVVETHDGDPFQFIESFQARFKVAQRPGLPRFCGGLAGYFGYDAVRYIEKKLANTAPRDDLGLPDIQLLLTEEVA
VIDNLAGKLYLIIYADPGQPEAYAKAKQRLRELKQRLRTTVQPPVTSASVRTETFREFKKDDYLAAVRQAKEYIAAGELM
QIQVGQRLTKPYRDNPLSLYRALRSLNPSPYMYYYNFGDFHVVGASPEILVRQEKRGEDQIVTIRPLAGTRPRGNTPERD
AELATELLNDPKEIAEHVMLIDLARNDVGRIAEIGSVQVTDKMVIEKYSHVQHIVSSVEGKLKPGMTNYDVLRATFPAGT
LSGAPKVRAMELIDELEPVKRGLYGGAVGYLSFSGEMDLAIAIRTGLIHNGNLYVQAAAGVVADSVPESEWQETENKARA
VLRAAEQVQDGLDSDF

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=379, Percent_Identity=41.4248021108179, Blast_Score=245, Evalue=4e-66,
Organism=Escherichia coli, GI1788114, Length=445, Percent_Identity=31.9101123595506, Blast_Score=231, Evalue=7e-62,
Organism=Escherichia coli, GI87082077, Length=275, Percent_Identity=28, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1786809, Length=225, Percent_Identity=30.2222222222222, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6320935, Length=465, Percent_Identity=40.6451612903226, Blast_Score=315, Evalue=9e-87,
Organism=Saccharomyces cerevisiae, GI6324361, Length=501, Percent_Identity=26.3473053892216, Blast_Score=127, Evalue=5e-30,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005256
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 55181; Mature: 55050

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTELEFQSLANEGYNRIPLIAEALADLETPLSLYLKLAQPERAGANSFLLESVVGGERFG
CCCCHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHEEECCCCCCCCHHHHHHHHHCCHHCC
RYSFIGLPARTLVRTRNGVSEVVRDGQVVETHDGDPFQFIESFQARFKVAQRPGLPRFCG
CEEEECCCHHHHHHHHCCHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHH
GLAGYFGYDAVRYIEKKLANTAPRDDLGLPDIQLLLTEEVAVIDNLAGKLYLIIYADPGQ
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCC
PEAYAKAKQRLRELKQRLRTTVQPPVTSASVRTETFREFKKDDYLAAVRQAKEYIAAGEL
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
MQIQVGQRLTKPYRDNPLSLYRALRSLNPSPYMYYYNFGDFHVVGASPEILVRQEKRGED
EEEHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCEEEECCCCCEEEECCCCCCC
QIVTIRPLAGTRPRGNTPERDAELATELLNDPKEIAEHVMLIDLARNDVGRIAEIGSVQV
CEEEEEECCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHCCCEEE
TDKMVIEKYSHVQHIVSSVEGKLKPGMTNYDVLRATFPAGTLSGAPKVRAMELIDELEPV
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHEEECCCCCCCCCCCHHHHHHHHHHHHH
KRGLYGGAVGYLSFSGEMDLAIAIRTGLIHNGNLYVQAAAGVVADSVPESEWQETENKAR
HHHHCCCEEEEEEECCCCEEEEEEEECEEECCCEEEEECCCHHHCCCCCHHHHHHHHHHH
AVLRAAEQVQDGLDSDF
HHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TELEFQSLANEGYNRIPLIAEALADLETPLSLYLKLAQPERAGANSFLLESVVGGERFG
CCCHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHEEECCCCCCCCHHHHHHHHHCCHHCC
RYSFIGLPARTLVRTRNGVSEVVRDGQVVETHDGDPFQFIESFQARFKVAQRPGLPRFCG
CEEEECCCHHHHHHHHCCHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHH
GLAGYFGYDAVRYIEKKLANTAPRDDLGLPDIQLLLTEEVAVIDNLAGKLYLIIYADPGQ
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCC
PEAYAKAKQRLRELKQRLRTTVQPPVTSASVRTETFREFKKDDYLAAVRQAKEYIAAGEL
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
MQIQVGQRLTKPYRDNPLSLYRALRSLNPSPYMYYYNFGDFHVVGASPEILVRQEKRGED
EEEHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCEEEECCCCCEEEECCCCCCC
QIVTIRPLAGTRPRGNTPERDAELATELLNDPKEIAEHVMLIDLARNDVGRIAEIGSVQV
CEEEEEECCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHCCCEEE
TDKMVIEKYSHVQHIVSSVEGKLKPGMTNYDVLRATFPAGTLSGAPKVRAMELIDELEPV
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHEEECCCCCCCCCCCHHHHHHHHHHHHH
KRGLYGGAVGYLSFSGEMDLAIAIRTGLIHNGNLYVQAAAGVVADSVPESEWQETENKAR
HHHHCCCEEEEEEECCCCEEEEEEEECEEECCCEEEEECCCHHHCCCCCHHHHHHHHHHH
AVLRAAEQVQDGLDSDF
HHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10417653 [H]