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The map label for this gene is hisA [H]

Identifier: 116688454

GI number: 116688454

Start: 479556

End: 480311

Strand: Direct

Name: hisA [H]

Synonym: Bcen2424_0430

Alternate gene names: 116688454

Gene position: 479556-480311 (Clockwise)

Preceding gene: 116688453

Following gene: 116688455

Centisome position: 13.76

GC content: 64.29

Gene sequence:

>756_bases
ATGTTGCTGATTCCGGCCATCGACCTCAAAGACGGTCAGTGTGTGCGCCTCAAACAGGGCGATATGGACCAGGCCACGAT
TTTTTCCGAGGACCCGGCGGCGATGGCCCGCAAGTGGGTCGATCTCGGCGCCCGGCGGCTCCATCTCGTCGACCTGAACG
GCGCATTCGCCGGCAAGCCGAAGAATCTCGAGGCGATCGAAGCGATCCTCGACGAAGTCGGCGACGAAATTCCCGTCCAG
CTCGGCGGCGGCATCCGCAGCCTCGAGACGATCGAGAAGTATCTCGACGCCGGCCTGTCCTACGTGATCATCGGCACCGC
CGCCGTGAAGAACCCGGGCTTCCTGCAGGACGCGTGCACCGCGTTTTCCGGCAGCATCATCGTCGGGCTGGACGCGAAGG
ACGGCAAGGTCGCGACCGACGGCTGGAGCAAGCTGACCGGCCACGAGGTGATCGATCTCGCGAAGAAGTTCGAGGACTAC
GGCGTCGAATCGATCGTCTACACCGATATCGGCCGCGACGGGATGCTGCAGGGCATCAACATCGACGCGACCGTGAAGCT
CGCGCAGGCGGTCGGCATCCCGGTGATCGCCAGCGGCGGCCTGTCGAACCTCCCGGACATCGAGAGCCTGTGCGAAGTGG
AAGAGCACGGCGTCGAAGGCGTGATCTGCGGCCGTGCGATCTACTCCGGCGATCTCGATTTCGCGGCCGCGCAGAAGCGC
GCGGACGAACTGAACGGCGAACTCGACAACGCGTAA

Upstream 100 bases:

>100_bases
AGCGCCGAAAGAGTTGTACTAAACTAGCGAGACGGCGCGGCACCGGTTTGGCCGGTACGCGCCGGATTCTTTTCTTTTTC
CACGACGACACCCGATTGCT

Downstream 100 bases:

>100_bases
CCGCGGTCGTCCCGTTCGCCGGGGCTGCCCGCAGGCGGCCCCGACCGGAAGCCTCGCGCGAGGCTTCCGCAACCGGCCGT
CCCAGCGCGGCATTTGGCGC

Product: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase [H]

Number of amino acids: Translated: 251; Mature: 251

Protein sequence:

>251_residues
MLLIPAIDLKDGQCVRLKQGDMDQATIFSEDPAAMARKWVDLGARRLHLVDLNGAFAGKPKNLEAIEAILDEVGDEIPVQ
LGGGIRSLETIEKYLDAGLSYVIIGTAAVKNPGFLQDACTAFSGSIIVGLDAKDGKVATDGWSKLTGHEVIDLAKKFEDY
GVESIVYTDIGRDGMLQGINIDATVKLAQAVGIPVIASGGLSNLPDIESLCEVEEHGVEGVICGRAIYSGDLDFAAAQKR
ADELNGELDNA

Sequences:

>Translated_251_residues
MLLIPAIDLKDGQCVRLKQGDMDQATIFSEDPAAMARKWVDLGARRLHLVDLNGAFAGKPKNLEAIEAILDEVGDEIPVQ
LGGGIRSLETIEKYLDAGLSYVIIGTAAVKNPGFLQDACTAFSGSIIVGLDAKDGKVATDGWSKLTGHEVIDLAKKFEDY
GVESIVYTDIGRDGMLQGINIDATVKLAQAVGIPVIASGGLSNLPDIESLCEVEEHGVEGVICGRAIYSGDLDFAAAQKR
ADELNGELDNA
>Mature_251_residues
MLLIPAIDLKDGQCVRLKQGDMDQATIFSEDPAAMARKWVDLGARRLHLVDLNGAFAGKPKNLEAIEAILDEVGDEIPVQ
LGGGIRSLETIEKYLDAGLSYVIIGTAAVKNPGFLQDACTAFSGSIIVGLDAKDGKVATDGWSKLTGHEVIDLAKKFEDY
GVESIVYTDIGRDGMLQGINIDATVKLAQAVGIPVIASGGLSNLPDIESLCEVEEHGVEGVICGRAIYSGDLDFAAAQKR
ADELNGELDNA

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family [H]

Homologues:

Organism=Escherichia coli, GI87082028, Length=243, Percent_Identity=32.5102880658436, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1788336, Length=213, Percent_Identity=24.8826291079812, Blast_Score=70, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00977 His_biosynth [H]

EC number: =5.3.1.16 [H]

Molecular weight: Translated: 26570; Mature: 26570

Theoretical pI: Translated: 4.19; Mature: 4.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLIPAIDLKDGQCVRLKQGDMDQATIFSEDPAAMARKWVDLGARRLHLVDLNGAFAGKP
CEEEEEEECCCCCEEEECCCCCCCEEEECCCHHHHHHHHHHCCCCEEEEEEECCCCCCCC
KNLEAIEAILDEVGDEIPVQLGGGIRSLETIEKYLDAGLSYVIIGTAAVKNPGFLQDACT
CCHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHCCCEEEEEEEECCCCCCCHHHHHH
AFSGSIIVGLDAKDGKVATDGWSKLTGHEVIDLAKKFEDYGVESIVYTDIGRDGMLQGIN
HHCCCEEEEEECCCCEEECCCCHHCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCEECCC
IDATVKLAQAVGIPVIASGGLSNLPDIESLCEVEEHGVEGVICGRAIYSGDLDFAAAQKR
CCHHHHHHHHCCCCEEECCCCCCCCCHHHHHHHHHCCCCEEEECCEEECCCCCHHHHHHH
ADELNGELDNA
HHHHCCCCCCC
>Mature Secondary Structure
MLLIPAIDLKDGQCVRLKQGDMDQATIFSEDPAAMARKWVDLGARRLHLVDLNGAFAGKP
CEEEEEEECCCCCEEEECCCCCCCEEEECCCHHHHHHHHHHCCCCEEEEEEECCCCCCCC
KNLEAIEAILDEVGDEIPVQLGGGIRSLETIEKYLDAGLSYVIIGTAAVKNPGFLQDACT
CCHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHCCCEEEEEEEECCCCCCCHHHHHH
AFSGSIIVGLDAKDGKVATDGWSKLTGHEVIDLAKKFEDYGVESIVYTDIGRDGMLQGIN
HHCCCEEEEEECCCCEEECCCCHHCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCEECCC
IDATVKLAQAVGIPVIASGGLSNLPDIESLCEVEEHGVEGVICGRAIYSGDLDFAAAQKR
CCHHHHHHHHCCCCEEECCCCCCCCCHHHHHHHHHCCCCEEEECCEEECCCCCHHHHHHH
ADELNGELDNA
HHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA