Click here to switch to the map view.

The map label for this gene is hemE [H]

Identifier: 116688135

GI number: 116688135

Start: 113625

End: 114803

Strand: Direct

Name: hemE [H]

Synonym: Bcen2424_0111

Alternate gene names: 116688135

Gene position: 113625-114803 (Clockwise)

Preceding gene: 116688132

Following gene: 116688136

Centisome position: 3.26

GC content: 69.21

Gene sequence:

>1179_bases
ATGGCCGCCATCGCATCGGCATGCGCAGCCCGATCGCGGCTGTCCGGTAAAATGCCGCTTTGCCTTCGCATCGTCGCTCC
TACCGTGGCCCATAACCTGCTCAACGACACCTTCCTGCGTGCGCTTCTGCGCGAGCCGACCGACTACACGCCGATCTGGC
TGATGCGCCAGGCCGGCCGCTACCTGCCCGAATACAACGCGACGCGCGCGCGCGCCGGCAGCTTCCTCGGCCTCGCGAAG
AATCCCGACTACGCGACCGAAGTGACGTTGCAGCCGCTCGAGCGCTTTCCGCTCGACGCGGCGATTCTGTTCTCGGACAT
CCTGACGATTCCCGACGCGATGGGGCTCGGCCTCGACTTCCAGGTCGGCGAAGGGCCGAAGTTCGCGCATCCGGTGCGCA
CCGAGGCCGACGTCGCGAAGCTCGCGGTGCCGGACATCGAGGAGACGCTCGGCTACGTGACGGGCGCCGTGCGCGAGATC
CGCCGCGCGCTCACCGACGGCCAGGGCCGGCAGCGCGTGCCGCTGATCGGCTTCTCGGGCAGCCCGTGGACGCTCGCGTG
CTACATGGTCGAAGGCGGCGGCTCGGACGATTTCCGCACGGTGAAGTCGATGGCGTATTCGCGCCCCGACCTGATGCACC
GAATTCTCGACGTGAACGCGCAGGCGGTGGCCGCGTACCTGAACGCGCAGATCGAAGCGGGCGCGCAGGCCGTGATGATC
TTCGATACGTGGGGCGGCGCGCTGGCCGACGGCGCGTATCAGCGCTTCTCGCTCGACTACATCCGCCGCGTGGTGTCGCA
GCTCAAGCGCGAGCACGACGGCGAACGCGTGCCGGTGATCACGTTCACGAAGGGCGGCGGGCTGTGGCTCGAGGAGATCG
CGGCGACCGGCGTCGACGCGGTCGGGCTCGACTGGACGGTCAACCTCGGCGCCGCGCGCGAGCGCGTCGCGGGGCGCGTG
GCGCTGCAGGGCAACCTCGACCCGACGATCCTGTTTGCGCCGCCGGCCGCGGTGCGCGAACAGGTGCGCGCGGTGCTCGA
CAGCTACGGCAACCATCCGGGCCACGTGTTCAACCTCGGGCACGGCATCTCGCAATTCACGTCGCCCGACCACGTCGCCG
AACTCGTCGACGAAGTACATACCCACAGCCGCGCGATCCGTAGCGGAGCGGCGGGCTGA

Upstream 100 bases:

>100_bases
GCAGCGAGCGTGGCAAGCGTGGCGAATGTCTTCATCGGTCTCCTCCTTCGTTCGGTTGGATATGAGCGTCCGATCATAAC
GGAGCCATCGCGCGCGTCAT

Downstream 100 bases:

>100_bases
ACGCAAGTGCCGTCATGCTGCGCTGCGGCATGACGATGTTTCGTTTCTGAAACTAAACAGGACGCAACCCCGCTCCCGTT
GCCGATTCGGTGCTTGTCAA

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 392; Mature: 391

Protein sequence:

>392_residues
MAAIASACAARSRLSGKMPLCLRIVAPTVAHNLLNDTFLRALLREPTDYTPIWLMRQAGRYLPEYNATRARAGSFLGLAK
NPDYATEVTLQPLERFPLDAAILFSDILTIPDAMGLGLDFQVGEGPKFAHPVRTEADVAKLAVPDIEETLGYVTGAVREI
RRALTDGQGRQRVPLIGFSGSPWTLACYMVEGGGSDDFRTVKSMAYSRPDLMHRILDVNAQAVAAYLNAQIEAGAQAVMI
FDTWGGALADGAYQRFSLDYIRRVVSQLKREHDGERVPVITFTKGGGLWLEEIAATGVDAVGLDWTVNLGAARERVAGRV
ALQGNLDPTILFAPPAAVREQVRAVLDSYGNHPGHVFNLGHGISQFTSPDHVAELVDEVHTHSRAIRSGAAG

Sequences:

>Translated_392_residues
MAAIASACAARSRLSGKMPLCLRIVAPTVAHNLLNDTFLRALLREPTDYTPIWLMRQAGRYLPEYNATRARAGSFLGLAK
NPDYATEVTLQPLERFPLDAAILFSDILTIPDAMGLGLDFQVGEGPKFAHPVRTEADVAKLAVPDIEETLGYVTGAVREI
RRALTDGQGRQRVPLIGFSGSPWTLACYMVEGGGSDDFRTVKSMAYSRPDLMHRILDVNAQAVAAYLNAQIEAGAQAVMI
FDTWGGALADGAYQRFSLDYIRRVVSQLKREHDGERVPVITFTKGGGLWLEEIAATGVDAVGLDWTVNLGAARERVAGRV
ALQGNLDPTILFAPPAAVREQVRAVLDSYGNHPGHVFNLGHGISQFTSPDHVAELVDEVHTHSRAIRSGAAG
>Mature_391_residues
AAIASACAARSRLSGKMPLCLRIVAPTVAHNLLNDTFLRALLREPTDYTPIWLMRQAGRYLPEYNATRARAGSFLGLAKN
PDYATEVTLQPLERFPLDAAILFSDILTIPDAMGLGLDFQVGEGPKFAHPVRTEADVAKLAVPDIEETLGYVTGAVREIR
RALTDGQGRQRVPLIGFSGSPWTLACYMVEGGGSDDFRTVKSMAYSRPDLMHRILDVNAQAVAAYLNAQIEAGAQAVMIF
DTWGGALADGAYQRFSLDYIRRVVSQLKREHDGERVPVITFTKGGGLWLEEIAATGVDAVGLDWTVNLGAARERVAGRVA
LQGNLDPTILFAPPAAVREQVRAVLDSYGNHPGHVFNLGHGISQFTSPDHVAELVDEVHTHSRAIRSGAAG

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=361, Percent_Identity=47.3684210526316, Blast_Score=318, Evalue=4e-87,
Organism=Escherichia coli, GI2367337, Length=352, Percent_Identity=61.6477272727273, Blast_Score=448, Evalue=1e-127,
Organism=Saccharomyces cerevisiae, GI6320252, Length=355, Percent_Identity=36.9014084507042, Blast_Score=243, Evalue=3e-65,
Organism=Drosophila melanogaster, GI221330099, Length=351, Percent_Identity=37.8917378917379, Blast_Score=242, Evalue=3e-64,
Organism=Drosophila melanogaster, GI19921920, Length=351, Percent_Identity=37.8917378917379, Blast_Score=242, Evalue=3e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 42427; Mature: 42296

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAIASACAARSRLSGKMPLCLRIVAPTVAHNLLNDTFLRALLREPTDYTPIWLMRQAGR
CCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCC
YLPEYNATRARAGSFLGLAKNPDYATEVTLQPLERFPLDAAILFSDILTIPDAMGLGLDF
CCCCCCCHHHHCCCEEECCCCCCCCCEEEHHHHHHCCCHHHHHHHHHHHCCHHHCCCCEE
QVGEGPKFAHPVRTEADVAKLAVPDIEETLGYVTGAVREIRRALTDGQGRQRVPLIGFSG
EECCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECC
SPWTLACYMVEGGGSDDFRTVKSMAYSRPDLMHRILDVNAQAVAAYLNAQIEAGAQAVMI
CCCEEEEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEE
FDTWGGALADGAYQRFSLDYIRRVVSQLKREHDGERVPVITFTKGGGLWLEEIAATGVDA
EECCCCHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHCCCCE
VGLDWTVNLGAARERVAGRVALQGNLDPTILFAPPAAVREQVRAVLDSYGNHPGHVFNLG
ECCCEEEECCHHHHHHHCEEEEECCCCCEEEECCCHHHHHHHHHHHHHHCCCCCEEEECC
HGISQFTSPDHVAELVDEVHTHSRAIRSGAAG
CCHHHCCCHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
AAIASACAARSRLSGKMPLCLRIVAPTVAHNLLNDTFLRALLREPTDYTPIWLMRQAGR
CHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCC
YLPEYNATRARAGSFLGLAKNPDYATEVTLQPLERFPLDAAILFSDILTIPDAMGLGLDF
CCCCCCCHHHHCCCEEECCCCCCCCCEEEHHHHHHCCCHHHHHHHHHHHCCHHHCCCCEE
QVGEGPKFAHPVRTEADVAKLAVPDIEETLGYVTGAVREIRRALTDGQGRQRVPLIGFSG
EECCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECC
SPWTLACYMVEGGGSDDFRTVKSMAYSRPDLMHRILDVNAQAVAAYLNAQIEAGAQAVMI
CCCEEEEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEE
FDTWGGALADGAYQRFSLDYIRRVVSQLKREHDGERVPVITFTKGGGLWLEEIAATGVDA
EECCCCHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHCCCCE
VGLDWTVNLGAARERVAGRVALQGNLDPTILFAPPAAVREQVRAVLDSYGNHPGHVFNLG
ECCCEEEECCHHHHHHHCEEEEECCCCCEEEECCCHHHHHHHHHHHHHHCCCCCEEEECC
HGISQFTSPDHVAELVDEVHTHSRAIRSGAAG
CCHHHCCCHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA