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The map label for this gene is srpA [H]

Identifier: 116688034

GI number: 116688034

Start: 16187

End: 17272

Strand: Reverse

Name: srpA [H]

Synonym: Bcen2424_0010

Alternate gene names: 116688034

Gene position: 17272-16187 (Counterclockwise)

Preceding gene: 116688038

Following gene: 116688033

Centisome position: 0.5

GC content: 70.26

Gene sequence:

>1086_bases
ATGAAGCAATCTTCTTCTTCGCCGCAGCGCGAGCCCGGGCGCGGGTGGTGGCGCTGGGCCGTGATCGGCGGCGCGGTGGC
CGGCGTGGCTGCGGCGTTCGGGTATGCCGGCGGGTGGCTCGCGCCGGCGCGTCTGACCCCGCACCGGCTCGTCGACGCGC
TGCAGACCAACAGCGGTATCCATCCCGGCTACCGGCGCAATCACGCGAAGGGCGTGTGCGTGACCGGCTACTTCGAAGGC
AACGGCGCCGCGAGCGCGTATTCGGTCGCGCCGTTCTTCAAGGCGGTGCGCACGCCGGTGGTCGGGCGCTTCGCGTTGCC
GGGCGGGAATCCTTATGCGCCCGACAGCAGCGTGCCGATCCGCAGCCTCGCGCTGAAGCTGACCGCACCGGACGGCCAGC
AATGGCGGACGGGGATGAACGCGATGCCGGTGTTTCCCGTCGCGACGCCACAGGCGTTCTACGAGCAGACGCTCGCGACC
CGGCCCGATCCGAAGACGGGCAAGCCGGACCCGGCAAAGGTGAAGGCGTTCTTCGGCGCGCATCCGGAAGCGGGCGCGTT
CCTGCAATGGGTGAAGGGTGCGAAGCCGAGCGCGAGCTACGTCACCGAAAGCTATTACGGGCTGAACGCGTTCTACTTCG
TCGACGTGGCCGGCAAGCGCCAGGCAGTGCGGTGGCGCGTCGTGCCGGAGCAGACGGCGGGCGCCGGTGACGTCGCGACG
GCCGCGGACCCGAACGTACTGCAACAGGACGTGACGCAGCGCATCGCGGCCGGCCCGCAGAAGTGGAAGCTGCTGGTCAC
GCTGGCGGAGCCCGGCGACCCGGTGGACGACGCGACGAAGATCTGGCCCGCGCAGCGCACGACGATCGATGCGGGCACGC
TCGTGCTCGACCGCGTGGAGGCGCAGGACAGCGGCCCGTGCCGCGACGTGAACTACGACCCGACGGTGCTGCCGCAGGGA
ATTCAGGTATCGGGCGATCCGTTGCTGGCGGCGCGCTCGGCCGCGTATGCGGATTCGTATTTGCGGCGCACGAGTGAAGA
GGCCGGCGTGGCAGGCGTGGCGCGAGTAAGTGGGGAGGGACGGTGA

Upstream 100 bases:

>100_bases
TTATTCCCTCCAGCATACGAAAAAACTGTTCGTGGAATAAAGCGGCGTGGGCGGCGTCCTACACGCGTTCGACAATGATC
TGACGATCGGGAGTGCATTC

Downstream 100 bases:

>100_bases
TGAAGGCTTCGACGACGTTTAGTTTGCCGGCGCGGGTGCTGCACTGGGTGATGGCCGCGATGATCCTCGCGATGCTGTTC
ATCGGGGTGGGGATGGTGGC

Product: catalase domain-containing protein

Products: O2; H2O

Alternate protein names: NA

Number of amino acids: Translated: 361; Mature: 361

Protein sequence:

>361_residues
MKQSSSSPQREPGRGWWRWAVIGGAVAGVAAAFGYAGGWLAPARLTPHRLVDALQTNSGIHPGYRRNHAKGVCVTGYFEG
NGAASAYSVAPFFKAVRTPVVGRFALPGGNPYAPDSSVPIRSLALKLTAPDGQQWRTGMNAMPVFPVATPQAFYEQTLAT
RPDPKTGKPDPAKVKAFFGAHPEAGAFLQWVKGAKPSASYVTESYYGLNAFYFVDVAGKRQAVRWRVVPEQTAGAGDVAT
AADPNVLQQDVTQRIAAGPQKWKLLVTLAEPGDPVDDATKIWPAQRTTIDAGTLVLDRVEAQDSGPCRDVNYDPTVLPQG
IQVSGDPLLAARSAAYADSYLRRTSEEAGVAGVARVSGEGR

Sequences:

>Translated_361_residues
MKQSSSSPQREPGRGWWRWAVIGGAVAGVAAAFGYAGGWLAPARLTPHRLVDALQTNSGIHPGYRRNHAKGVCVTGYFEG
NGAASAYSVAPFFKAVRTPVVGRFALPGGNPYAPDSSVPIRSLALKLTAPDGQQWRTGMNAMPVFPVATPQAFYEQTLAT
RPDPKTGKPDPAKVKAFFGAHPEAGAFLQWVKGAKPSASYVTESYYGLNAFYFVDVAGKRQAVRWRVVPEQTAGAGDVAT
AADPNVLQQDVTQRIAAGPQKWKLLVTLAEPGDPVDDATKIWPAQRTTIDAGTLVLDRVEAQDSGPCRDVNYDPTVLPQG
IQVSGDPLLAARSAAYADSYLRRTSEEAGVAGVARVSGEGR
>Mature_361_residues
MKQSSSSPQREPGRGWWRWAVIGGAVAGVAAAFGYAGGWLAPARLTPHRLVDALQTNSGIHPGYRRNHAKGVCVTGYFEG
NGAASAYSVAPFFKAVRTPVVGRFALPGGNPYAPDSSVPIRSLALKLTAPDGQQWRTGMNAMPVFPVATPQAFYEQTLAT
RPDPKTGKPDPAKVKAFFGAHPEAGAFLQWVKGAKPSASYVTESYYGLNAFYFVDVAGKRQAVRWRVVPEQTAGAGDVAT
AADPNVLQQDVTQRIAAGPQKWKLLVTLAEPGDPVDDATKIWPAQRTTIDAGTLVLDRVEAQDSGPCRDVNYDPTVLPQG
IQVSGDPLLAARSAAYADSYLRRTSEEAGVAGVARVSGEGR

Specific function: Decomposes Hydrogen Peroxide Into Water And Oxygen; Serves To Protect Cells From The Toxic Effects Of Hydrogen Peroxide. [C]

COG id: COG0753

COG function: function code P; Catalase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the catalase family [H]

Homologues:

Organism=Homo sapiens, GI4557014, Length=295, Percent_Identity=27.7966101694915, Blast_Score=94, Evalue=3e-19,
Organism=Escherichia coli, GI48994891, Length=296, Percent_Identity=24.6621621621622, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71998444, Length=301, Percent_Identity=27.5747508305648, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI25147792, Length=296, Percent_Identity=25.3378378378378, Blast_Score=78, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI25151141, Length=296, Percent_Identity=25.3378378378378, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI19920968, Length=358, Percent_Identity=26.8156424581006, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17981717, Length=293, Percent_Identity=25.938566552901, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020835
- InterPro:   IPR018028
- InterPro:   IPR011614 [H]

Pfam domain/function: PF00199 Catalase [H]

EC number: 1.11.1.6

Molecular weight: Translated: 38375; Mature: 38375

Theoretical pI: Translated: 9.75; Mature: 9.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQSSSSPQREPGRGWWRWAVIGGAVAGVAAAFGYAGGWLAPARLTPHRLVDALQTNSGI
CCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCC
HPGYRRNHAKGVCVTGYFEGNGAASAYSVAPFFKAVRTPVVGRFALPGGNPYAPDSSVPI
CCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCH
RSLALKLTAPDGQQWRTGMNAMPVFPVATPQAFYEQTLATRPDPKTGKPDPAKVKAFFGA
HHEEEEEECCCCHHHHCCCCCCCEECCCCHHHHHHHHHCCCCCCCCCCCCHHHEEEEECC
HPEAGAFLQWVKGAKPSASYVTESYYGLNAFYFVDVAGKRQAVRWRVVPEQTAGAGDVAT
CCCHHHHHHHHCCCCCCHHHHHHHHCCCEEEEEEEECCCCEEEEEEECCCCCCCCCCCCC
AADPNVLQQDVTQRIAAGPQKWKLLVTLAEPGDPVDDATKIWPAQRTTIDAGTLVLDRVE
CCCCHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCHHHHCCCCCCCEECCCCEEEEECC
AQDSGPCRDVNYDPTVLPQGIQVSGDPLLAARSAAYADSYLRRTSEEAGVAGVARVSGEG
CCCCCCCCCCCCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHCCHHCCCEEEEECCCCC
R
C
>Mature Secondary Structure
MKQSSSSPQREPGRGWWRWAVIGGAVAGVAAAFGYAGGWLAPARLTPHRLVDALQTNSGI
CCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCC
HPGYRRNHAKGVCVTGYFEGNGAASAYSVAPFFKAVRTPVVGRFALPGGNPYAPDSSVPI
CCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCH
RSLALKLTAPDGQQWRTGMNAMPVFPVATPQAFYEQTLATRPDPKTGKPDPAKVKAFFGA
HHEEEEEECCCCHHHHCCCCCCCEECCCCHHHHHHHHHCCCCCCCCCCCCHHHEEEEECC
HPEAGAFLQWVKGAKPSASYVTESYYGLNAFYFVDVAGKRQAVRWRVVPEQTAGAGDVAT
CCCHHHHHHHHCCCCCCHHHHHHHHCCCEEEEEEEECCCCEEEEEEECCCCCCCCCCCCC
AADPNVLQQDVTQRIAAGPQKWKLLVTLAEPGDPVDDATKIWPAQRTTIDAGTLVLDRVE
CCCCHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCHHHHCCCCCCCEECCCCEEEEECC
AQDSGPCRDVNYDPTVLPQGIQVSGDPLLAARSAAYADSYLRRTSEEAGVAGVARVSGEG
CCCCCCCCCCCCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHCCHHCCCEEEEECCCCC
R
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Heme Group. [C]

Metal ions: NA

Kcat value (1/min): 980000 [C]

Specific activity: NA

Km value (mM): 18.2 {H2O2}} 10 {H2O2}} 3.7 {H2O2}} [C]

Substrates: H2O2

Specific reaction: 2 H2O2 = O2 + 2 H2O

General reaction: Redox reaction [C]

Inhibitor: 3-Amino-1-H-1, 2, 4-triazolecoli, Rhodopseudomonascapsulata; Dianisidine; H2O2 [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7536734 [H]