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The map label for this gene is ddc [H]

Identifier: 116626964

GI number: 116626964

Start: 9951836

End: 9953272

Strand: Direct

Name: ddc [H]

Synonym: Acid_7941

Alternate gene names: 116626964

Gene position: 9951836-9953272 (Clockwise)

Preceding gene: 116626960

Following gene: 116626965

Centisome position: 99.86

GC content: 65.0

Gene sequence:

>1437_bases
ATGCCCGACAACCTGGCAATTCCCGCGGACGAGATCCGCGAAATGGGCCGCGCAGCCCTCGACCTGATCGCCAGTTACTA
CGACACCCTGGCGGATCGCGACATCCTGCACCCCACCACGTCCGCCGATCTGCGCGCGCTGCTGGACGAGCCGGCTCCGA
CAGGTGCGACGCCCTTTCCCGAGCTGCTCGGGACGTTTCGCGGAGTGGTGGAGGAGTACAGCCGCCACAACGCGCACGCG
CGATTCTTCGGCTACGTTTCCTCACCCGGGAATCCCGTGAACACGGTGGGCAGCATGATCGCCGCCGCGCTCAATATCAA
CGTCACGTGTTGGCGCTCCGGGCCCGCGGCCGCTGAAATGGAGCTGCTCACCATCCGCTGGCTCAAGGAGCTGCTCGGAT
TTCCGCACACGGGCGCCGGACTGCTGGTGAGCGGCGGCTCGATGGCGAACTTCGCCGGAATTGCCGCGGCACGCAGCGCC
AAAGCCCCGCACGACGTAATGCGCGAAGGCATGCACGGCGCCGCTGGCCGCATGCGCCTTTACGCCTCCTCGGAGGCGCA
TTTTTCCATCCGCAAGGCTGCCTCGCTGCTCGGCATTGGCGCCGCGAACGTGCGCGTAGTGCGGACGGATCCCAGCCTCC
GCATGGATCTGCAGCACCTCGACGACCTCGTGCGCGAAGATCGCGCTGCCGGCCATCTGCCCTTCTGCGTGGTGGCCAGC
GCCGGCACCGCTGGTACTGGCGCCATCGATCCGATCGGCCCGATCGCCGATTTCGCCCGCGCCCACGATCTTTGGCTCCA
CGTGGACGGAGCCTATGGTGGATTCGCAGCGCTGGCGGGTTCCGCGCGCGAGGCGCTATCCCGCATCGGCGATGCCGATT
CGCTCTCGCTCGACCCCCACAAGTGGCTCTATCTGCCGGTCGGCTGCGGCTGCGTGCTCTATCGCGATCCGGCCGCCGCC
CGCGCCGCCTTCAGCGAGAACGCCGAGTACACGCGCGTCATCGGCCTGCAAGACGATGAGAGCTTCGCCTTCTGGGACTA
TGGTCCCGAGCTCTCCCGCCCCTTCCGCGCGCTCGATCTCTGGCTGCTGATGAAATCGGTGGGAACAACGGCGCTCGCCG
CCGCCATCGAGGAGAACATCGCCTGCGCACGCTATTTCGCGGAACTCGTGAACGCCAGCGACGATTTCGAAATGCTGGCC
CCGGTGGACCTCTCCATCTTCTGCTTCCGTTATCGCCCAAAGAATTTCGCGGGCGACCTCGACAAGCTGAATGAGAACCT
GATGATCGCCCTTCAACGCGGCGGCAGCAGCTACGTTTCCAACGCCAAGATCGATGGAAAATTCGCCCTCCGCGGCTGCG
TCCTCAATTACCGCACCACAAGGCGCGACATGGAAAGGCTCCTGGAAGATTTGAGAGCGCTTGTAATACTGATGTAA

Upstream 100 bases:

>100_bases
CGCCAGTGCCAGAGTCTGCATCCTTTCAACAGGTAAAACTCCGCGAGGCGGCAAAACGTGTAGACGATTTTCCTGTTACC
CTGAGCACTGTTCGTCACCA

Downstream 100 bases:

>100_bases
CCAGTGTTTGTGTTTTTTTGCTTATGGAGTGAACCCCAAAAGTGAGACAGGAGGAATAGACGCACTTTGCATCGAATGGA
GGCAAAATGGCCAAGATGAA

Product: pyridoxal-dependent decarboxylase

Products: NA

Alternate protein names: DABA decarboxylase; DABA-DC [H]

Number of amino acids: Translated: 478; Mature: 477

Protein sequence:

>478_residues
MPDNLAIPADEIREMGRAALDLIASYYDTLADRDILHPTTSADLRALLDEPAPTGATPFPELLGTFRGVVEEYSRHNAHA
RFFGYVSSPGNPVNTVGSMIAAALNINVTCWRSGPAAAEMELLTIRWLKELLGFPHTGAGLLVSGGSMANFAGIAAARSA
KAPHDVMREGMHGAAGRMRLYASSEAHFSIRKAASLLGIGAANVRVVRTDPSLRMDLQHLDDLVREDRAAGHLPFCVVAS
AGTAGTGAIDPIGPIADFARAHDLWLHVDGAYGGFAALAGSAREALSRIGDADSLSLDPHKWLYLPVGCGCVLYRDPAAA
RAAFSENAEYTRVIGLQDDESFAFWDYGPELSRPFRALDLWLLMKSVGTTALAAAIEENIACARYFAELVNASDDFEMLA
PVDLSIFCFRYRPKNFAGDLDKLNENLMIALQRGGSSYVSNAKIDGKFALRGCVLNYRTTRRDMERLLEDLRALVILM

Sequences:

>Translated_478_residues
MPDNLAIPADEIREMGRAALDLIASYYDTLADRDILHPTTSADLRALLDEPAPTGATPFPELLGTFRGVVEEYSRHNAHA
RFFGYVSSPGNPVNTVGSMIAAALNINVTCWRSGPAAAEMELLTIRWLKELLGFPHTGAGLLVSGGSMANFAGIAAARSA
KAPHDVMREGMHGAAGRMRLYASSEAHFSIRKAASLLGIGAANVRVVRTDPSLRMDLQHLDDLVREDRAAGHLPFCVVAS
AGTAGTGAIDPIGPIADFARAHDLWLHVDGAYGGFAALAGSAREALSRIGDADSLSLDPHKWLYLPVGCGCVLYRDPAAA
RAAFSENAEYTRVIGLQDDESFAFWDYGPELSRPFRALDLWLLMKSVGTTALAAAIEENIACARYFAELVNASDDFEMLA
PVDLSIFCFRYRPKNFAGDLDKLNENLMIALQRGGSSYVSNAKIDGKFALRGCVLNYRTTRRDMERLLEDLRALVILM
>Mature_477_residues
PDNLAIPADEIREMGRAALDLIASYYDTLADRDILHPTTSADLRALLDEPAPTGATPFPELLGTFRGVVEEYSRHNAHAR
FFGYVSSPGNPVNTVGSMIAAALNINVTCWRSGPAAAEMELLTIRWLKELLGFPHTGAGLLVSGGSMANFAGIAAARSAK
APHDVMREGMHGAAGRMRLYASSEAHFSIRKAASLLGIGAANVRVVRTDPSLRMDLQHLDDLVREDRAAGHLPFCVVASA
GTAGTGAIDPIGPIADFARAHDLWLHVDGAYGGFAALAGSAREALSRIGDADSLSLDPHKWLYLPVGCGCVLYRDPAAAR
AAFSENAEYTRVIGLQDDESFAFWDYGPELSRPFRALDLWLLMKSVGTTALAAAIEENIACARYFAELVNASDDFEMLAP
VDLSIFCFRYRPKNFAGDLDKLNENLMIALQRGGSSYVSNAKIDGKFALRGCVLNYRTTRRDMERLLEDLRALVILM

Specific function: Unknown

COG id: COG0076

COG function: function code E; Glutamate decarboxylase and related PLP-dependent proteins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the group II decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI197383062, Length=443, Percent_Identity=30.0225733634311, Blast_Score=192, Evalue=4e-49,
Organism=Homo sapiens, GI92110055, Length=487, Percent_Identity=29.5687885010267, Blast_Score=189, Evalue=7e-48,
Organism=Homo sapiens, GI194294551, Length=444, Percent_Identity=30.1801801801802, Blast_Score=179, Evalue=5e-45,
Organism=Homo sapiens, GI58331246, Length=417, Percent_Identity=27.0983213429257, Blast_Score=175, Evalue=9e-44,
Organism=Homo sapiens, GI4503281, Length=478, Percent_Identity=24.8953974895398, Blast_Score=173, Evalue=3e-43,
Organism=Homo sapiens, GI132814448, Length=478, Percent_Identity=24.8953974895398, Blast_Score=173, Evalue=3e-43,
Organism=Homo sapiens, GI197276620, Length=417, Percent_Identity=26.1390887290168, Blast_Score=172, Evalue=7e-43,
Organism=Homo sapiens, GI4503875, Length=417, Percent_Identity=26.1390887290168, Blast_Score=172, Evalue=7e-43,
Organism=Homo sapiens, GI190341074, Length=203, Percent_Identity=28.0788177339901, Blast_Score=78, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17534819, Length=470, Percent_Identity=27.6595744680851, Blast_Score=205, Evalue=5e-53,
Organism=Caenorhabditis elegans, GI17534817, Length=470, Percent_Identity=27.6595744680851, Blast_Score=205, Evalue=5e-53,
Organism=Caenorhabditis elegans, GI17555682, Length=467, Percent_Identity=26.338329764454, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI71993062, Length=408, Percent_Identity=27.2058823529412, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI71993058, Length=383, Percent_Identity=27.154046997389, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI71981211, Length=507, Percent_Identity=22.0907297830375, Blast_Score=137, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI71981217, Length=516, Percent_Identity=21.7054263565891, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI133931025, Length=434, Percent_Identity=23.963133640553, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17551992, Length=505, Percent_Identity=22.1782178217822, Blast_Score=129, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI17543922, Length=210, Percent_Identity=29.5238095238095, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI28573972, Length=468, Percent_Identity=29.7008547008547, Blast_Score=200, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24652373, Length=481, Percent_Identity=29.1060291060291, Blast_Score=193, Evalue=2e-49,
Organism=Drosophila melanogaster, GI24586044, Length=472, Percent_Identity=26.9067796610169, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24585139, Length=481, Percent_Identity=25.5717255717256, Blast_Score=177, Evalue=2e-44,
Organism=Drosophila melanogaster, GI221476190, Length=478, Percent_Identity=25.7322175732218, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24585143, Length=478, Percent_Identity=25.7322175732218, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI17136190, Length=488, Percent_Identity=28.2786885245902, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI24657193, Length=415, Percent_Identity=26.5060240963855, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24657185, Length=415, Percent_Identity=26.5060240963855, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24657188, Length=415, Percent_Identity=26.5060240963855, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI17136594, Length=412, Percent_Identity=28.6407766990291, Blast_Score=158, Evalue=7e-39,
Organism=Drosophila melanogaster, GI21356415, Length=350, Percent_Identity=31.1428571428571, Blast_Score=152, Evalue=5e-37,
Organism=Drosophila melanogaster, GI24585135, Length=487, Percent_Identity=26.8993839835729, Blast_Score=150, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002129
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR021115 [H]

Pfam domain/function: PF00282 Pyridoxal_deC [H]

EC number: =4.1.1.86 [H]

Molecular weight: Translated: 51736; Mature: 51605

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: PS00392 DDC_GAD_HDC_YDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDNLAIPADEIREMGRAALDLIASYYDTLADRDILHPTTSADLRALLDEPAPTGATPFP
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCCCCHH
ELLGTFRGVVEEYSRHNAHARFFGYVSSPGNPVNTVGSMIAAALNINVTCWRSGPAAAEM
HHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCEEEEECCCCCCHHH
ELLTIRWLKELLGFPHTGAGLLVSGGSMANFAGIAAARSAKAPHDVMREGMHGAAGRMRL
HHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCEEE
YASSEAHFSIRKAASLLGIGAANVRVVRTDPSLRMDLQHLDDLVREDRAAGHLPFCVVAS
EECCCCHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEC
AGTAGTGAIDPIGPIADFARAHDLWLHVDGAYGGFAALAGSAREALSRIGDADSLSLDPH
CCCCCCCCCCCCHHHHHHHHHCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC
KWLYLPVGCGCVLYRDPAAARAAFSENAEYTRVIGLQDDESFAFWDYGPELSRPFRALDL
CEEEEEECCCEEEECCCHHHHHHHCCCCCEEEEEEECCCCCEEEECCCCCCCCHHHHHHH
WLLMKSVGTTALAAAIEENIACARYFAELVNASDDFEMLAPVDLSIFCFRYRPKNFAGDL
HHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCEEEEEEEECCCCCCCCH
DKLNENLMIALQRGGSSYVSNAKIDGKFALRGCVLNYRTTRRDMERLLEDLRALVILM
HHCCCCEEEEEECCCCCHHCCCCCCCEEEEEEEEECHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PDNLAIPADEIREMGRAALDLIASYYDTLADRDILHPTTSADLRALLDEPAPTGATPFP
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCCCCHH
ELLGTFRGVVEEYSRHNAHARFFGYVSSPGNPVNTVGSMIAAALNINVTCWRSGPAAAEM
HHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCEEEEECCCCCCHHH
ELLTIRWLKELLGFPHTGAGLLVSGGSMANFAGIAAARSAKAPHDVMREGMHGAAGRMRL
HHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCEEE
YASSEAHFSIRKAASLLGIGAANVRVVRTDPSLRMDLQHLDDLVREDRAAGHLPFCVVAS
EECCCCHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEC
AGTAGTGAIDPIGPIADFARAHDLWLHVDGAYGGFAALAGSAREALSRIGDADSLSLDPH
CCCCCCCCCCCCHHHHHHHHHCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC
KWLYLPVGCGCVLYRDPAAARAAFSENAEYTRVIGLQDDESFAFWDYGPELSRPFRALDL
CEEEEEECCCEEEECCCHHHHHHHCCCCCEEEEEEECCCCCEEEECCCCCCCCHHHHHHH
WLLMKSVGTTALAAAIEENIACARYFAELVNASDDFEMLAPVDLSIFCFRYRPKNFAGDL
HHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCEEEEEEEECCCCCCCCH
DKLNENLMIALQRGGSSYVSNAKIDGKFALRGCVLNYRTTRRDMERLLEDLRALVILM
HHCCCCEEEEEECCCCCHHCCCCCCCEEEEEEEEECHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800; 9514614 [H]