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The map label for this gene is mutS2 [H]

Identifier: 116626746

GI number: 116626746

Start: 9691539

End: 9693929

Strand: Direct

Name: mutS2 [H]

Synonym: Acid_7718

Alternate gene names: 116626746

Gene position: 9691539-9693929 (Clockwise)

Preceding gene: 116626745

Following gene: 116626750

Centisome position: 97.25

GC content: 64.37

Gene sequence:

>2391_bases
GTGAAAACCAGCGCTGAAGTACTCGAATACGAAGCCCTGCGGCAACTGTTGGGTCGCTACATTGCCAGCGCCCCCGGCAA
GCGCGAACTCGACAAGGTGAGCCCGCACGCCGATCGCGCGCGTCTGGAAGCCGACCTGGCCGAAGCCGGCGAAGCCACCC
AGTATCTCCAGGTGGCTGCCTCGCGAGGCGGCGCCGTCCGCATCGAATTCGGCGGCATCCCCGACGTGGAGTCACCGATT
CAGAAGCTGCACATCGAAGGCGCCGGACTGGAACCCAAAGAAATCTTCCAGATCTTCTCGCTGCTCGATATCGCGGCCGA
TGCCAAGAGCAACCTGACAGCCGCCGCAGAGCGTTTCCCCATCCTGGCGCGCCGCGCCGCCACCATCGGCGAATTCCGCA
CGCTGCTGCGCGAGCTCGATGGCAAGATCCTTCCCGATGGCAGCGTGGCCGATAATGCCAGCGTGGCGCTCGCCCGCCTG
CGCCGCGATATCGAGCGCCAGAAAAAATCGATCCAGAGTTCGCTCGAACGTTTCCTGCGCTCGCACCGCGAAGATGGAGT
GCTGCAGGAGGAATTCGTCACCATCCGCAACGAACGCTTCGTGGTCCCGGTGATCGCCGGGCAGCGCCGCAAGCTGGATG
GCGTGATCCACGGCACCAGCGCGAGCGGCCACACGCTCTTCGTGGAGCCGCTCGAAACCATCGACCTCAACAACGAACTG
GTGCGGCTCACCGAAGAAGAAATGCGCGAGGTGCACCGCGTTCTGGTGGAAATGACCGACCGTCTCCGCCAGTACGGCGA
TTCCATCCGGCAGACGCTGACCACTATGGCCGAGCTCGAGCTGGTCTTCGGCAAAGCGCGCTTCGCCAGCGATTTCGATT
GCGTGATCCCACGCTTCGGCGAGCGTCTCTACCTGAAGGAGGCGCGTCACCCGCTGCTTGCCGACGTGCTGCGCCGGCGC
CGCAAAGTCGCCGTGCCGATCAGCATGGAACTCACGCAGGACCGCCGGACGCTGCTGATCAGCGGACCGAATACCGGCGG
CAAAACGGTCACGTTGAAGACCGTCGGACTGCTCAGCCTCATGGCGCAATCGGCGCTGCCGGTGCCCGCGCTCGAAGCCG
AGCTCCCGCTGTTCGAACAGGTGCTGGCCGATATCGGCGACTATCAATCCATCCAGGAAAACCTCAGTACGTTTTCCGCG
CACGTCTCCAACATCCGCGAAATGGCGCTCGATGTGACGCCGGATTCCCTGGTGCTGCTGGACGAGCTCGGCGCCGCCAC
CGATCCGGAAGAAGGCGGAGCGCTCGGCGTCGCGCTGGTGGAGCATTTCCGCTCCGCGGGCGCGTTCACGCTGGTCTCCA
CGCACTTGATGGCGCTCAAGATTTATGGCGCCGCCACGGAAGGCGTGGTCAATGGGTCCATGGGTTTCGACGAGCAGACC
TTCGAGCCGACGTATCACCTGCAACTCGGCCTGCCCGGAAAATCCGCCGGCCTCGAGATCGCGACGCGCCTCGGCATGCC
CGACGACATCATGCGCCGCGCGCGCCTTTCAATGAGCGACCGCGAGCGCGATGTCACGCGCTTCCTCAGCGAGCTTCATC
ACCGCATCGAAGAGACTCAGGCGCTCGAGGTCACGCTGCGCGAAAAGATCGCCGAGTTGAGCCGTCGGGAAAAGGAGATC
GCCGCCGAGTGGGAGAAGCGCGAGACGGCGAAGATCAAGGAACTGGAGCGCCGCACCGATCAGGCCTTGGCCAAATTCGA
AGAACAGGCGCAGGATGCGATCGGCAGGATCGCGCAGGGCGGTGACCGCCGCAAGGCCGATCAGGATGCGCTGCGCCGCG
TCGCCAAGACCAAGCGCGAACTCCGTGAGGACTTTCAGACCACGGTGCTCTCCACGCAGGACGATTCACGCCAGGATCGC
ATTGTGCCGCTGCGCATCGAAGAAGGCTCGCGCGTGCGATTGAAGGATGTCCGCGAACCGGCGCGCGTGCGACGCCTGCT
CGGAAATGGCCGCGTCGAAGTGGAGGCCGGCTTCATGAAGATGCAGGTCTCCATCGACGACGTCCTCGAAGTACTGCCCG
AAGGCGCGTCCGCGGGCAAGCTACCGAAGAACGTGAGCTATAAGCCCGCGCCGGAACTCGCTCCCGTTCATCAGGAGATC
AACGTGATCGGCCAGCACGTGGAAGAAGCGCGCGACGCGATCGATGAATTCCTGGACCGCGCCGTGATGGCGACGGCCAG
CCGCATCCGCATCGTCCACGGCCACGGCATGGGGATCTTGAAAAAGATGGTGGCGGAGATGCTCACCAAGCACCCCCACG
TCGCCCGCTTCTACCCGGCTCCCCAGCAGGAGGGCGGCTCGGGCGCCACAATCGTCGAGTTGCGGGAGTAG

Upstream 100 bases:

>100_bases
CCGGCCTGAAAGACCTGCAAATTACCGAAGGCACCCTGCGCGTGATTGAAAAAGCCTTCCGCAAACGTCGAAGATATAAG
TAGAAGATATAAGTAGCCCC

Downstream 100 bases:

>100_bases
TTAGGTGAGGTCTTCCAGCACTGCGGCGGCGTGGCCCTGAGCCTTCACCTTGTCGTAGATCTTTTCGATCTTCCCATCGG
CGCCGATGACGAAGGTAGTG

Product: Smr protein/MutS2

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 796; Mature: 796

Protein sequence:

>796_residues
MKTSAEVLEYEALRQLLGRYIASAPGKRELDKVSPHADRARLEADLAEAGEATQYLQVAASRGGAVRIEFGGIPDVESPI
QKLHIEGAGLEPKEIFQIFSLLDIAADAKSNLTAAAERFPILARRAATIGEFRTLLRELDGKILPDGSVADNASVALARL
RRDIERQKKSIQSSLERFLRSHREDGVLQEEFVTIRNERFVVPVIAGQRRKLDGVIHGTSASGHTLFVEPLETIDLNNEL
VRLTEEEMREVHRVLVEMTDRLRQYGDSIRQTLTTMAELELVFGKARFASDFDCVIPRFGERLYLKEARHPLLADVLRRR
RKVAVPISMELTQDRRTLLISGPNTGGKTVTLKTVGLLSLMAQSALPVPALEAELPLFEQVLADIGDYQSIQENLSTFSA
HVSNIREMALDVTPDSLVLLDELGAATDPEEGGALGVALVEHFRSAGAFTLVSTHLMALKIYGAATEGVVNGSMGFDEQT
FEPTYHLQLGLPGKSAGLEIATRLGMPDDIMRRARLSMSDRERDVTRFLSELHHRIEETQALEVTLREKIAELSRREKEI
AAEWEKRETAKIKELERRTDQALAKFEEQAQDAIGRIAQGGDRRKADQDALRRVAKTKRELREDFQTTVLSTQDDSRQDR
IVPLRIEEGSRVRLKDVREPARVRRLLGNGRVEVEAGFMKMQVSIDDVLEVLPEGASAGKLPKNVSYKPAPELAPVHQEI
NVIGQHVEEARDAIDEFLDRAVMATASRIRIVHGHGMGILKKMVAEMLTKHPHVARFYPAPQQEGGSGATIVELRE

Sequences:

>Translated_796_residues
MKTSAEVLEYEALRQLLGRYIASAPGKRELDKVSPHADRARLEADLAEAGEATQYLQVAASRGGAVRIEFGGIPDVESPI
QKLHIEGAGLEPKEIFQIFSLLDIAADAKSNLTAAAERFPILARRAATIGEFRTLLRELDGKILPDGSVADNASVALARL
RRDIERQKKSIQSSLERFLRSHREDGVLQEEFVTIRNERFVVPVIAGQRRKLDGVIHGTSASGHTLFVEPLETIDLNNEL
VRLTEEEMREVHRVLVEMTDRLRQYGDSIRQTLTTMAELELVFGKARFASDFDCVIPRFGERLYLKEARHPLLADVLRRR
RKVAVPISMELTQDRRTLLISGPNTGGKTVTLKTVGLLSLMAQSALPVPALEAELPLFEQVLADIGDYQSIQENLSTFSA
HVSNIREMALDVTPDSLVLLDELGAATDPEEGGALGVALVEHFRSAGAFTLVSTHLMALKIYGAATEGVVNGSMGFDEQT
FEPTYHLQLGLPGKSAGLEIATRLGMPDDIMRRARLSMSDRERDVTRFLSELHHRIEETQALEVTLREKIAELSRREKEI
AAEWEKRETAKIKELERRTDQALAKFEEQAQDAIGRIAQGGDRRKADQDALRRVAKTKRELREDFQTTVLSTQDDSRQDR
IVPLRIEEGSRVRLKDVREPARVRRLLGNGRVEVEAGFMKMQVSIDDVLEVLPEGASAGKLPKNVSYKPAPELAPVHQEI
NVIGQHVEEARDAIDEFLDRAVMATASRIRIVHGHGMGILKKMVAEMLTKHPHVARFYPAPQQEGGSGATIVELRE
>Mature_796_residues
MKTSAEVLEYEALRQLLGRYIASAPGKRELDKVSPHADRARLEADLAEAGEATQYLQVAASRGGAVRIEFGGIPDVESPI
QKLHIEGAGLEPKEIFQIFSLLDIAADAKSNLTAAAERFPILARRAATIGEFRTLLRELDGKILPDGSVADNASVALARL
RRDIERQKKSIQSSLERFLRSHREDGVLQEEFVTIRNERFVVPVIAGQRRKLDGVIHGTSASGHTLFVEPLETIDLNNEL
VRLTEEEMREVHRVLVEMTDRLRQYGDSIRQTLTTMAELELVFGKARFASDFDCVIPRFGERLYLKEARHPLLADVLRRR
RKVAVPISMELTQDRRTLLISGPNTGGKTVTLKTVGLLSLMAQSALPVPALEAELPLFEQVLADIGDYQSIQENLSTFSA
HVSNIREMALDVTPDSLVLLDELGAATDPEEGGALGVALVEHFRSAGAFTLVSTHLMALKIYGAATEGVVNGSMGFDEQT
FEPTYHLQLGLPGKSAGLEIATRLGMPDDIMRRARLSMSDRERDVTRFLSELHHRIEETQALEVTLREKIAELSRREKEI
AAEWEKRETAKIKELERRTDQALAKFEEQAQDAIGRIAQGGDRRKADQDALRRVAKTKRELREDFQTTVLSTQDDSRQDR
IVPLRIEEGSRVRLKDVREPARVRRLLGNGRVEVEAGFMKMQVSIDDVLEVLPEGASAGKLPKNVSYKPAPELAPVHQEI
NVIGQHVEEARDAIDEFLDRAVMATASRIRIVHGHGMGILKKMVAEMLTKHPHVARFYPAPQQEGGSGATIVELRE

Specific function: This Protein Is Involved In The Repair Of Mismatches In DNA. It Is Possible That It Carries Out The Mismatch Recognition Step. This Protein Has A Weak Atpase Activity. [C]

COG id: COG1193

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Smr domain [H]

Homologues:

Organism=Homo sapiens, GI284813531, Length=434, Percent_Identity=24.8847926267281, Blast_Score=122, Evalue=1e-27,
Organism=Homo sapiens, GI36949366, Length=297, Percent_Identity=27.9461279461279, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI26638666, Length=258, Percent_Identity=27.906976744186, Blast_Score=91, Evalue=6e-18,
Organism=Homo sapiens, GI4505253, Length=258, Percent_Identity=27.906976744186, Blast_Score=91, Evalue=6e-18,
Organism=Homo sapiens, GI4557761, Length=218, Percent_Identity=28.4403669724771, Blast_Score=89, Evalue=2e-17,
Organism=Homo sapiens, GI26638664, Length=259, Percent_Identity=27.7992277992278, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI262231786, Length=199, Percent_Identity=31.1557788944724, Blast_Score=83, Evalue=9e-16,
Organism=Homo sapiens, GI4504191, Length=228, Percent_Identity=27.1929824561404, Blast_Score=78, Evalue=4e-14,
Organism=Escherichia coli, GI1789089, Length=271, Percent_Identity=29.520295202952, Blast_Score=114, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17534743, Length=412, Percent_Identity=24.5145631067961, Blast_Score=112, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI17508445, Length=333, Percent_Identity=22.8228228228228, Blast_Score=79, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17508447, Length=406, Percent_Identity=23.6453201970443, Blast_Score=72, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17539736, Length=224, Percent_Identity=24.1071428571429, Blast_Score=67, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6319935, Length=410, Percent_Identity=26.5853658536585, Blast_Score=102, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6324482, Length=278, Percent_Identity=27.3381294964029, Blast_Score=98, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6321109, Length=288, Percent_Identity=26.3888888888889, Blast_Score=96, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6321912, Length=320, Percent_Identity=23.75, Blast_Score=79, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6320302, Length=319, Percent_Identity=23.1974921630094, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24584320, Length=216, Percent_Identity=27.7777777777778, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24664545, Length=285, Percent_Identity=28.0701754385965, Blast_Score=92, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005747
- InterPro:   IPR000432
- InterPro:   IPR007696
- InterPro:   IPR002625 [H]

Pfam domain/function: PF05192 MutS_III; PF00488 MutS_V; PF01713 Smr [H]

EC number: NA

Molecular weight: Translated: 88658; Mature: 88658

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS50828 SMR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTSAEVLEYEALRQLLGRYIASAPGKRELDKVSPHADRARLEADLAEAGEATQYLQVAA
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCHHHHHHHHHHHHHCHHHHHHHHHH
SRGGAVRIEFGGIPDVESPIQKLHIEGAGLEPKEIFQIFSLLDIAADAKSNLTAAAERFP
CCCCEEEEEECCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
ILARRAATIGEFRTLLRELDGKILPDGSVADNASVALARLRRDIERQKKSIQSSLERFLR
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SHREDGVLQEEFVTIRNERFVVPVIAGQRRKLDGVIHGTSASGHTLFVEPLETIDLNNEL
HHCCCCCHHHHHHHHCCCEEEEEEECCCCCCCCCEEECCCCCCCEEEECCHHHCCCCHHH
VRLTEEEMREVHRVLVEMTDRLRQYGDSIRQTLTTMAELELVFGKARFASDFDCVIPRFG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHC
ERLYLKEARHPLLADVLRRRRKVAVPISMELTQDRRTLLISGPNTGGKTVTLKTVGLLSL
CHHHHHHHCCHHHHHHHHHHCCEECCEEEEECCCCCEEEEECCCCCCCEEEEHHHHHHHH
MAQSALPVPALEAELPLFEQVLADIGDYQSIQENLSTFSAHVSNIREMALDVTPDSLVLL
HHHHCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHH
DELGAATDPEEGGALGVALVEHFRSAGAFTLVSTHLMALKIYGAATEGVVNGSMGFDEQT
HHCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCC
FEPTYHLQLGLPGKSAGLEIATRLGMPDDIMRRARLSMSDRERDVTRFLSELHHRIEETQ
CCCEEEEEEECCCCCCCHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
ALEVTLREKIAELSRREKEIAAEWEKRETAKIKELERRTDQALAKFEEQAQDAIGRIAQG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GDRRKADQDALRRVAKTKRELREDFQTTVLSTQDDSRQDRIVPLRIEEGSRVRLKDVREP
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCEEHHHHHCCH
ARVRRLLGNGRVEVEAGFMKMQVSIDDVLEVLPEGASAGKLPKNVSYKPAPELAPVHQEI
HHHHHHHCCCCEEEEECEEEEEECHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
NVIGQHVEEARDAIDEFLDRAVMATASRIRIVHGHGMGILKKMVAEMLTKHPHVARFYPA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHCCCCCEEECCC
PQQEGGSGATIVELRE
CCCCCCCCCEEEEECC
>Mature Secondary Structure
MKTSAEVLEYEALRQLLGRYIASAPGKRELDKVSPHADRARLEADLAEAGEATQYLQVAA
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCHHHHHHHHHHHHHCHHHHHHHHHH
SRGGAVRIEFGGIPDVESPIQKLHIEGAGLEPKEIFQIFSLLDIAADAKSNLTAAAERFP
CCCCEEEEEECCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
ILARRAATIGEFRTLLRELDGKILPDGSVADNASVALARLRRDIERQKKSIQSSLERFLR
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SHREDGVLQEEFVTIRNERFVVPVIAGQRRKLDGVIHGTSASGHTLFVEPLETIDLNNEL
HHCCCCCHHHHHHHHCCCEEEEEEECCCCCCCCCEEECCCCCCCEEEECCHHHCCCCHHH
VRLTEEEMREVHRVLVEMTDRLRQYGDSIRQTLTTMAELELVFGKARFASDFDCVIPRFG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHC
ERLYLKEARHPLLADVLRRRRKVAVPISMELTQDRRTLLISGPNTGGKTVTLKTVGLLSL
CHHHHHHHCCHHHHHHHHHHCCEECCEEEEECCCCCEEEEECCCCCCCEEEEHHHHHHHH
MAQSALPVPALEAELPLFEQVLADIGDYQSIQENLSTFSAHVSNIREMALDVTPDSLVLL
HHHHCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHH
DELGAATDPEEGGALGVALVEHFRSAGAFTLVSTHLMALKIYGAATEGVVNGSMGFDEQT
HHCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCC
FEPTYHLQLGLPGKSAGLEIATRLGMPDDIMRRARLSMSDRERDVTRFLSELHHRIEETQ
CCCEEEEEEECCCCCCCHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
ALEVTLREKIAELSRREKEIAAEWEKRETAKIKELERRTDQALAKFEEQAQDAIGRIAQG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GDRRKADQDALRRVAKTKRELREDFQTTVLSTQDDSRQDRIVPLRIEEGSRVRLKDVREP
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCEEHHHHHCCH
ARVRRLLGNGRVEVEAGFMKMQVSIDDVLEVLPEGASAGKLPKNVSYKPAPELAPVHQEI
HHHHHHHCCCCEEEEECEEEEEECHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
NVIGQHVEEARDAIDEFLDRAVMATASRIRIVHGHGMGILKKMVAEMLTKHPHVARFYPA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHCCCCCEEECCC
PQQEGGSGATIVELRE
CCCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA