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The map label for this gene is ubiE [H]

Identifier: 116626385

GI number: 116626385

Start: 9224281

End: 9225009

Strand: Direct

Name: ubiE [H]

Synonym: Acid_7345

Alternate gene names: 116626385

Gene position: 9224281-9225009 (Clockwise)

Preceding gene: 116626384

Following gene: 116626386

Centisome position: 92.56

GC content: 66.12

Gene sequence:

>729_bases
ATGAGCGGCGCCAAACCGCTGGGCGCGCGCGATGAGCAGGAGGCGGCACGCTGGGTGCGCGGGATGTTCGGCCGCGTCGC
CCACCGCTACGACCTCGCCAACCACCTGCTCTCCTTAAACATCGATCGCTACTGGCGGGCGCACACGGTCAACAAGGTCC
GCGACGTCCTGGAACGCCCCGGCGCGCGCGTGCTCGATATCTGCTGCGGCACCGGGGACCTTGTTCTCGCGCTCGCCAAA
ACCGGCCACCCCGTGCTCGGCAGTGATTTCTGCCATCCCATGCTGATCGCCGCCCACCAGAAGATCGCGAATCGCCGCGC
GCCAGCCGTGCTCTTCGAATCCGACGCCCTGCGCCTTCCGCTGCGCGATGCCTCGCTTGACCTCCTCACGGTCGCGTTCG
GCTTTCGCAATCTCGCCAACTACGAAGCCGGACTTGCCGAAGTACGCCGCGTGCTGCGTCCCGGTGGGTTAGCGGCGATC
CTGGAATTTTCGCGCCCGCCGAACCCCGCCTTCGGCGCGCTGTACAATTTTTACTCGCGCCGTATTCTGCCCATCATCGG
CGGCGCCATCTCGGGATCGCGCGACGCCTACACATACCTTCCGGACTCGGTGAGCAAGTTCCCCGACGCACCGCAGCTCG
CCGCCAAAATGACCGCTGCCGGATTCAGCGGCGTGGATTTCGAGTACCTGACCGGCGGCATCGTCGCCTTACACCTGGGG
AGGACCTGA

Upstream 100 bases:

>100_bases
GTAAAGTCCACTTCGTGCTGCCCGTGCGCATCGGCGAAGTGACGGTGGTCTCCGGAATCGAGGAACCGCTGGTGTTCGAG
GCCATGCGGTCCGCCCTCGC

Downstream 100 bases:

>100_bases
TTCATGGACCAGCTTTTGGAGAGGCTCAAGTTGTGCAGGAGTCAGTACCTCGAGGGGCTCGCCGCCTTTCCGGAGGAGAA
GGCAAGCGTGAAGCCCGCCG

Product: demethylmenaquinone methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 242; Mature: 241

Protein sequence:

>242_residues
MSGAKPLGARDEQEAARWVRGMFGRVAHRYDLANHLLSLNIDRYWRAHTVNKVRDVLERPGARVLDICCGTGDLVLALAK
TGHPVLGSDFCHPMLIAAHQKIANRRAPAVLFESDALRLPLRDASLDLLTVAFGFRNLANYEAGLAEVRRVLRPGGLAAI
LEFSRPPNPAFGALYNFYSRRILPIIGGAISGSRDAYTYLPDSVSKFPDAPQLAAKMTAAGFSGVDFEYLTGGIVALHLG
RT

Sequences:

>Translated_242_residues
MSGAKPLGARDEQEAARWVRGMFGRVAHRYDLANHLLSLNIDRYWRAHTVNKVRDVLERPGARVLDICCGTGDLVLALAK
TGHPVLGSDFCHPMLIAAHQKIANRRAPAVLFESDALRLPLRDASLDLLTVAFGFRNLANYEAGLAEVRRVLRPGGLAAI
LEFSRPPNPAFGALYNFYSRRILPIIGGAISGSRDAYTYLPDSVSKFPDAPQLAAKMTAAGFSGVDFEYLTGGIVALHLG
RT
>Mature_241_residues
SGAKPLGARDEQEAARWVRGMFGRVAHRYDLANHLLSLNIDRYWRAHTVNKVRDVLERPGARVLDICCGTGDLVLALAKT
GHPVLGSDFCHPMLIAAHQKIANRRAPAVLFESDALRLPLRDASLDLLTVAFGFRNLANYEAGLAEVRRVLRPGGLAAIL
EFSRPPNPAFGALYNFYSRRILPIIGGAISGSRDAYTYLPDSVSKFPDAPQLAAKMTAAGFSGVDFEYLTGGIVALHLGR
T

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) [H]

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family [H]

Homologues:

Organism=Homo sapiens, GI116063536, Length=267, Percent_Identity=32.5842696629214, Blast_Score=140, Evalue=1e-33,
Organism=Escherichia coli, GI48994983, Length=235, Percent_Identity=36.1702127659575, Blast_Score=142, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17557039, Length=237, Percent_Identity=34.1772151898734, Blast_Score=137, Evalue=5e-33,
Organism=Saccharomyces cerevisiae, GI6323526, Length=242, Percent_Identity=33.4710743801653, Blast_Score=134, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24641702, Length=252, Percent_Identity=33.3333333333333, Blast_Score=129, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004033 [H]

Pfam domain/function: PF01209 Ubie_methyltran [H]

EC number: 2.1.1.-

Molecular weight: Translated: 26353; Mature: 26222

Theoretical pI: Translated: 9.79; Mature: 9.79

Prosite motif: PS01183 UBIE_1 ; PS01184 UBIE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGAKPLGARDEQEAARWVRGMFGRVAHRYDLANHLLSLNIDRYWRAHTVNKVRDVLERP
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCC
GARVLDICCGTGDLVLALAKTGHPVLGSDFCHPMLIAAHQKIANRRAPAVLFESDALRLP
CCEEEEEECCCCHHEEEEHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCEECC
LRDASLDLLTVAFGFRNLANYEAGLAEVRRVLRPGGLAAILEFSRPPNPAFGALYNFYSR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHH
RILPIIGGAISGSRDAYTYLPDSVSKFPDAPQLAAKMTAAGFSGVDFEYLTGGIVALHLG
HHHHHHCCCCCCCCCCEEECCCHHHHCCCCHHHHHHHHHCCCCCCCHHHHCCCEEEEEEC
RT
CC
>Mature Secondary Structure 
SGAKPLGARDEQEAARWVRGMFGRVAHRYDLANHLLSLNIDRYWRAHTVNKVRDVLERP
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCC
GARVLDICCGTGDLVLALAKTGHPVLGSDFCHPMLIAAHQKIANRRAPAVLFESDALRLP
CCEEEEEECCCCHHEEEEHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCEECC
LRDASLDLLTVAFGFRNLANYEAGLAEVRRVLRPGGLAAILEFSRPPNPAFGALYNFYSR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHH
RILPIIGGAISGSRDAYTYLPDSVSKFPDAPQLAAKMTAAGFSGVDFEYLTGGIVALHLG
HHHHHHCCCCCCCCCCEEECCCHHHHCCCCHHHHHHHHHCCCCCCCHHHHCCCEEEEEEC
RT
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA