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The map label for this gene is cpxA [H]

Identifier: 116626086

GI number: 116626086

Start: 8857736

End: 8859040

Strand: Direct

Name: cpxA [H]

Synonym: Acid_7044

Alternate gene names: 116626086

Gene position: 8857736-8859040 (Clockwise)

Preceding gene: 116626085

Following gene: 116626087

Centisome position: 88.88

GC content: 64.98

Gene sequence:

>1305_bases
ATGAATTCCCTTTTCGCCAAGATCCTGCTGTGGTTCTGGTTCGCACTGGCGATCACGGTGGTGGGGTCGGCCTTCATCTC
CGCGTTAAACGTCAATGAAAACGATAGGGACGAACGCGCCCCGGTAGCGCGCCTGGTGCGATTCCAACTGGAAGAGGCGC
GTACCGCCTATGAAAGCGGCGGTCGTCCGGCACTGCAGGCCTTTCTAGATACGCTGCATCGCGTATACGACGCGCGCGGC
GTGCTCACCGACGAGAGCGGCCGCGACCTGCTGACCAACGAAGACCGCAGCGACCTGATCACGCACGCCAAACGCCGCGT
GCTGTACCAGGTCTTTCGCACCGGTGATTCCACCGTGGCGCGTACCGCCGACGACGGGCGCTACTGGTTCTTCTTCATCG
TGCCGCCGACCCATGTGGGCTCCTGGTTTCTGCAGCCGGAGCACATTTTCGTAATGGCGGCGGCAGTGGTGCTGTGCTAC
TGGCTGGCATTTCACCTGACGCGCCCAGTGCGGAAACTGCAAAAGGCGGTGGAGCGATTCGGCAAGGGCGATCTTTCGGC
GCGCGCCGAAAGCGTGCGCCGCGACGAACTCGGCCAGTTGGCGCGCACCTTCGACCGCATGGCGGACCGGCTGGAGACGC
TGCTGGCCGCGGAACGCCGGTTGCTGCTCGATATTTCGCATGAATTGCGGTCGCCGCTGGCGCGGTTGGGCGTCGCGATC
GAACTGGCGCGGTCGGGCGACGATACGGAAGCGGCGCTCAATCGCATCCAGAAGGAATCGGACCGGCTCAATGCGCTGGT
GGGGCAACTGCTGCAAGTAACGCGCGCGGAGGGCGACCCGAACTCGCTGCGGCGAGACCCGATCCGGCTGGATCAACTGG
TGCAGGAACTGGTGGACGATTCGGCGATCGAGGCGGAGGCACACGGCTGCGAGCTGCAATACGCATCGGGCGAGCCGGTC
ACGGTCGCCGGGGACCAGGAACTGCTGCGGCGCGCGGTGGAGAATGTAATTCGCAACGCCATCCGCTATTCGCCGCGCGA
TACCGCGGTCGAGGTGACGCTGGCGCGCGATAACGGCCGCGCGGTGGTGGCGGTTCGCGATCACGGGCCGGGCGTTCCCG
ATGACGCGCTGCCGCGCTTGTTCGATCCGTTTTACCGGGTGGAGTCAGACCGCAACCGGACCAGCGGCGGCATTGGACTC
GGGCTTTCCATCGCGCGCCGGGCGATCGAACTCTACCAGGGGACGATTCGGGCTCGGAATGCGCACCCGGGGTTGGAAGT
AGAGTTGGAACTTCCAGCGGCATGA

Upstream 100 bases:

>100_bases
GCCACCTGCGCAAGAAGCTGGAGAATGGCGACGATCTGATTAAGACCATCCGCGGCGTGGGCTATCAGTTTTGCCGCACG
CCGGAGGACGCCGCGGCGGA

Downstream 100 bases:

>100_bases
AGAACTGCGGGACAAATTGCCGCCGCGATGTAGGGAAAGAACTTCGAAACCCACTTAAAATAGATACGTCTGGAGATTTA
TGTCGTTTTTCACCGCACGC

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MNSLFAKILLWFWFALAITVVGSAFISALNVNENDRDERAPVARLVRFQLEEARTAYESGGRPALQAFLDTLHRVYDARG
VLTDESGRDLLTNEDRSDLITHAKRRVLYQVFRTGDSTVARTADDGRYWFFFIVPPTHVGSWFLQPEHIFVMAAAVVLCY
WLAFHLTRPVRKLQKAVERFGKGDLSARAESVRRDELGQLARTFDRMADRLETLLAAERRLLLDISHELRSPLARLGVAI
ELARSGDDTEAALNRIQKESDRLNALVGQLLQVTRAEGDPNSLRRDPIRLDQLVQELVDDSAIEAEAHGCELQYASGEPV
TVAGDQELLRRAVENVIRNAIRYSPRDTAVEVTLARDNGRAVVAVRDHGPGVPDDALPRLFDPFYRVESDRNRTSGGIGL
GLSIARRAIELYQGTIRARNAHPGLEVELELPAA

Sequences:

>Translated_434_residues
MNSLFAKILLWFWFALAITVVGSAFISALNVNENDRDERAPVARLVRFQLEEARTAYESGGRPALQAFLDTLHRVYDARG
VLTDESGRDLLTNEDRSDLITHAKRRVLYQVFRTGDSTVARTADDGRYWFFFIVPPTHVGSWFLQPEHIFVMAAAVVLCY
WLAFHLTRPVRKLQKAVERFGKGDLSARAESVRRDELGQLARTFDRMADRLETLLAAERRLLLDISHELRSPLARLGVAI
ELARSGDDTEAALNRIQKESDRLNALVGQLLQVTRAEGDPNSLRRDPIRLDQLVQELVDDSAIEAEAHGCELQYASGEPV
TVAGDQELLRRAVENVIRNAIRYSPRDTAVEVTLARDNGRAVVAVRDHGPGVPDDALPRLFDPFYRVESDRNRTSGGIGL
GLSIARRAIELYQGTIRARNAHPGLEVELELPAA
>Mature_434_residues
MNSLFAKILLWFWFALAITVVGSAFISALNVNENDRDERAPVARLVRFQLEEARTAYESGGRPALQAFLDTLHRVYDARG
VLTDESGRDLLTNEDRSDLITHAKRRVLYQVFRTGDSTVARTADDGRYWFFFIVPPTHVGSWFLQPEHIFVMAAAVVLCY
WLAFHLTRPVRKLQKAVERFGKGDLSARAESVRRDELGQLARTFDRMADRLETLLAAERRLLLDISHELRSPLARLGVAI
ELARSGDDTEAALNRIQKESDRLNALVGQLLQVTRAEGDPNSLRRDPIRLDQLVQELVDDSAIEAEAHGCELQYASGEPV
TVAGDQELLRRAVENVIRNAIRYSPRDTAVEVTLARDNGRAVVAVRDHGPGVPDDALPRLFDPFYRVESDRNRTSGGIGL
GLSIARRAIELYQGTIRARNAHPGLEVELELPAA

Specific function: This protein is involved in several diverse cellular processes, such as the functioning of acetohydroxyacid synthetase I, in the biosynthesis of isoleucine and valine, the TraJ protein activation activity for tra gene expression in F plasmid, and the synt

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790346, Length=358, Percent_Identity=34.0782122905028, Blast_Score=162, Evalue=5e-41,
Organism=Escherichia coli, GI1788393, Length=270, Percent_Identity=31.8518518518519, Blast_Score=141, Evalue=1e-34,
Organism=Escherichia coli, GI1786783, Length=289, Percent_Identity=29.757785467128, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1787894, Length=320, Percent_Identity=30, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1790551, Length=274, Percent_Identity=31.021897810219, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1786600, Length=212, Percent_Identity=29.7169811320755, Blast_Score=111, Evalue=9e-26,
Organism=Escherichia coli, GI1789403, Length=234, Percent_Identity=35.4700854700855, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1789808, Length=281, Percent_Identity=27.7580071174377, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1789149, Length=331, Percent_Identity=26.8882175226586, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1790861, Length=233, Percent_Identity=28.3261802575107, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1788279, Length=292, Percent_Identity=27.3972602739726, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI87082128, Length=315, Percent_Identity=24.7619047619048, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1788549, Length=241, Percent_Identity=27.8008298755187, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI145693157, Length=233, Percent_Identity=24.0343347639485, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1790436, Length=224, Percent_Identity=25.8928571428571, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1786912, Length=223, Percent_Identity=27.3542600896861, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1787374, Length=291, Percent_Identity=25.4295532646048, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI48994928, Length=221, Percent_Identity=26.6968325791855, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788713, Length=220, Percent_Identity=25.4545454545455, Blast_Score=65, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 48623; Mature: 48623

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSLFAKILLWFWFALAITVVGSAFISALNVNENDRDERAPVARLVRFQLEEARTAYESG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
GRPALQAFLDTLHRVYDARGVLTDESGRDLLTNEDRSDLITHAKRRVLYQVFRTGDSTVA
CCHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEE
RTADDGRYWFFFIVPPTHVGSWFLQPEHIFVMAAAVVLCYWLAFHLTRPVRKLQKAVERF
ECCCCCCEEEEEEECCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GKGDLSARAESVRRDELGQLARTFDRMADRLETLLAAERRLLLDISHELRSPLARLGVAI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELARSGDDTEAALNRIQKESDRLNALVGQLLQVTRAEGDPNSLRRDPIRLDQLVQELVDD
EECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHHHCC
SAIEAEAHGCELQYASGEPVTVAGDQELLRRAVENVIRNAIRYSPRDTAVEVTLARDNGR
CHHHHHCCCCEEEECCCCCEEECCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCC
AVVAVRDHGPGVPDDALPRLFDPFYRVESDRNRTSGGIGLGLSIARRAIELYQGTIRARN
EEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
AHPGLEVELELPAA
CCCCCEEEEECCCC
>Mature Secondary Structure
MNSLFAKILLWFWFALAITVVGSAFISALNVNENDRDERAPVARLVRFQLEEARTAYESG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
GRPALQAFLDTLHRVYDARGVLTDESGRDLLTNEDRSDLITHAKRRVLYQVFRTGDSTVA
CCHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEE
RTADDGRYWFFFIVPPTHVGSWFLQPEHIFVMAAAVVLCYWLAFHLTRPVRKLQKAVERF
ECCCCCCEEEEEEECCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GKGDLSARAESVRRDELGQLARTFDRMADRLETLLAAERRLLLDISHELRSPLARLGVAI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELARSGDDTEAALNRIQKESDRLNALVGQLLQVTRAEGDPNSLRRDPIRLDQLVQELVDD
EECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHHHCC
SAIEAEAHGCELQYASGEPVTVAGDQELLRRAVENVIRNAIRYSPRDTAVEVTLARDNGR
CHHHHHCCCCEEEECCCCCEEECCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCC
AVVAVRDHGPGVPDDALPRLFDPFYRVESDRNRTSGGIGLGLSIARRAIELYQGTIRARN
EEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
AHPGLEVELELPAA
CCCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]