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The map label for this gene is cpxR [H]

Identifier: 116626085

GI number: 116626085

Start: 8857047

End: 8857739

Strand: Direct

Name: cpxR [H]

Synonym: Acid_7043

Alternate gene names: 116626085

Gene position: 8857047-8857739 (Clockwise)

Preceding gene: 116626084

Following gene: 116626086

Centisome position: 88.88

GC content: 62.48

Gene sequence:

>693_bases
GTGCACATCCTGCTGGTTGATGACGATGCGGAGCTGGCCTCTCTGTTGAGCGAATTCCTGCGCCGGGAAGGCTTTACGGT
AGAAGCGGCCCACGAAGGCAACCGGGGACTGGAGAAGGCGCTGCAGCCGGGAATCGACCTGGTGGTGCTGGATGTCATGC
TGCCCGGCATCGACGGATTCGAGATTCTCAAGCGGCTCCGCCAGAGGAGCAAGGTGCCGGTGCTGATGCTGACCGCGCGC
GGGGAAGACGTGGATCGCATCGTGGGGTTGGAGCTGGGCGCGGACGATTACCTGGCGAAGCCCTTCAATCCGCGTGAACT
GGCGGCGCGCATCCGCGCGATTCTGCGGCGCTATGAACGGGACACGCCGGCAACGGGCCATCGCATCGAGACCAACGGCA
TCGTGCTCGACCCGGGGACGCGCGAGGTGACGGCCGGCGGTAAGAAGATCGAACTCACCACCTTTGAGTTCGACATTCTG
GAAATGCTGATGCGCTCGGCGGGGCGGGTACTTTCGCGCGACGCGCTGATGGAGAATTTTTATAATCGCAAGGCGACGCC
CTTCGATCGATCCATCGACATGCACATCAGCCACCTGCGCAAGAAGCTGGAGAATGGCGACGATCTGATTAAGACCATCC
GCGGCGTGGGCTATCAGTTTTGCCGCACGCCGGAGGACGCCGCGGCGGAATGA

Upstream 100 bases:

>100_bases
GTGCTCTGATGGTTTGCGAAAACAATCGACGGATGTGCGAAACAATGGATCCCGTGTCGTGCTGCCTCACGGGTGCGGTT
ACACGTGGTAAATTTTAGCC

Downstream 100 bases:

>100_bases
ATTCCCTTTTCGCCAAGATCCTGCTGTGGTTCTGGTTCGCACTGGCGATCACGGTGGTGGGGTCGGCCTTCATCTCCGCG
TTAAACGTCAATGAAAACGA

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 230; Mature: 230

Protein sequence:

>230_residues
MHILLVDDDAELASLLSEFLRREGFTVEAAHEGNRGLEKALQPGIDLVVLDVMLPGIDGFEILKRLRQRSKVPVLMLTAR
GEDVDRIVGLELGADDYLAKPFNPRELAARIRAILRRYERDTPATGHRIETNGIVLDPGTREVTAGGKKIELTTFEFDIL
EMLMRSAGRVLSRDALMENFYNRKATPFDRSIDMHISHLRKKLENGDDLIKTIRGVGYQFCRTPEDAAAE

Sequences:

>Translated_230_residues
MHILLVDDDAELASLLSEFLRREGFTVEAAHEGNRGLEKALQPGIDLVVLDVMLPGIDGFEILKRLRQRSKVPVLMLTAR
GEDVDRIVGLELGADDYLAKPFNPRELAARIRAILRRYERDTPATGHRIETNGIVLDPGTREVTAGGKKIELTTFEFDIL
EMLMRSAGRVLSRDALMENFYNRKATPFDRSIDMHISHLRKKLENGDDLIKTIRGVGYQFCRTPEDAAAE
>Mature_230_residues
MHILLVDDDAELASLLSEFLRREGFTVEAAHEGNRGLEKALQPGIDLVVLDVMLPGIDGFEILKRLRQRSKVPVLMLTAR
GEDVDRIVGLELGADDYLAKPFNPRELAARIRAILRRYERDTPATGHRIETNGIVLDPGTREVTAGGKKIELTTFEFDIL
EMLMRSAGRVLSRDALMENFYNRKATPFDRSIDMHISHLRKKLENGDDLIKTIRGVGYQFCRTPEDAAAE

Specific function: Member of the two-component regulatory system CpxA/CpxR. This system combats a variety of extracytoplasmic protein-mediated toxicities. It performs this function by increasing the synthesis of the periplasmic protease, DegP as well as that of CpxP protein

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI2367329, Length=224, Percent_Identity=50.4464285714286, Blast_Score=194, Evalue=6e-51,
Organism=Escherichia coli, GI1786599, Length=225, Percent_Identity=40.8888888888889, Blast_Score=170, Evalue=6e-44,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=43.1718061674009, Blast_Score=166, Evalue=9e-43,
Organism=Escherichia coli, GI1788394, Length=227, Percent_Identity=37.8854625550661, Blast_Score=165, Evalue=2e-42,
Organism=Escherichia coli, GI1790860, Length=223, Percent_Identity=42.152466367713, Blast_Score=160, Evalue=8e-41,
Organism=Escherichia coli, GI1789402, Length=221, Percent_Identity=40.2714932126697, Blast_Score=159, Evalue=1e-40,
Organism=Escherichia coli, GI87082012, Length=223, Percent_Identity=36.322869955157, Blast_Score=145, Evalue=3e-36,
Organism=Escherichia coli, GI1786784, Length=223, Percent_Identity=37.6681614349776, Blast_Score=144, Evalue=4e-36,
Organism=Escherichia coli, GI1790552, Length=228, Percent_Identity=39.0350877192982, Blast_Score=140, Evalue=7e-35,
Organism=Escherichia coli, GI1790863, Length=234, Percent_Identity=35.4700854700855, Blast_Score=137, Evalue=6e-34,
Organism=Escherichia coli, GI1786911, Length=223, Percent_Identity=35.8744394618834, Blast_Score=134, Evalue=5e-33,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=36.3636363636364, Blast_Score=130, Evalue=9e-32,
Organism=Escherichia coli, GI1787229, Length=223, Percent_Identity=34.5291479820628, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1787375, Length=224, Percent_Identity=33.4821428571429, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1790437, Length=127, Percent_Identity=33.8582677165354, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1790299, Length=137, Percent_Identity=31.3868613138686, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788191, Length=121, Percent_Identity=32.2314049586777, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1788550, Length=106, Percent_Identity=33.9622641509434, Blast_Score=64, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322000, Length=122, Percent_Identity=34.4262295081967, Blast_Score=72, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25913; Mature: 25913

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHILLVDDDAELASLLSEFLRREGFTVEAAHEGNRGLEKALQPGIDLVVLDVMLPGIDGF
CEEEEECCCHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHCCCCCEEEEEHHHCCCCHH
EILKRLRQRSKVPVLMLTARGEDVDRIVGLELGADDYLAKPFNPRELAARIRAILRRYER
HHHHHHHHHCCCCEEEEEECCCCHHHHEEEEECCCCHHCCCCCHHHHHHHHHHHHHHHHC
DTPATGHRIETNGIVLDPGTREVTAGGKKIELTTFEFDILEMLMRSAGRVLSRDALMENF
CCCCCCCEEECCCEEECCCCCEEECCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
YNRKATPFDRSIDMHISHLRKKLENGDDLIKTIRGVGYQFCRTPEDAAAE
HCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHCCCCCCCCC
>Mature Secondary Structure
MHILLVDDDAELASLLSEFLRREGFTVEAAHEGNRGLEKALQPGIDLVVLDVMLPGIDGF
CEEEEECCCHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHCCCCCEEEEEHHHCCCCHH
EILKRLRQRSKVPVLMLTARGEDVDRIVGLELGADDYLAKPFNPRELAARIRAILRRYER
HHHHHHHHHCCCCEEEEEECCCCHHHHEEEEECCCCHHCCCCCHHHHHHHHHHHHHHHHC
DTPATGHRIETNGIVLDPGTREVTAGGKKIELTTFEFDILEMLMRSAGRVLSRDALMENF
CCCCCCCEEECCCEEECCCCCEEECCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
YNRKATPFDRSIDMHISHLRKKLENGDDLIKTIRGVGYQFCRTPEDAAAE
HCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]