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The map label for this gene is accD [C]

Identifier: 116626002

GI number: 116626002

Start: 8748737

End: 8750290

Strand: Reverse

Name: accD [C]

Synonym: Acid_6960

Alternate gene names: 116626002

Gene position: 8750290-8748737 (Counterclockwise)

Preceding gene: 116626003

Following gene: 116626001

Centisome position: 87.8

GC content: 61.45

Gene sequence:

>1554_bases
ATGGCCATTCATACAATGCAGGAAAAGGTTGCCGAGCTCCATGAGCGCACCAGCAAAGCCATGCTGGGAGGCGGCGCGGA
GCGGTTGGAAAAGCAGCGCCAGGGCGGTAAGCTCACGGCACGCGAAAGAGTCGAAGCGCTCGTCGATCCGGATAGTTTCG
AGGAGTCCGGGCTGTTCGCCGAGCATCGCGCCACGCTGTTCGGCATGGCTGGAAAGGACTTCCCCGCCGATGGCGTGGTC
ACTGGCGCGGCGTCGGTAAACGGCCGGCTGGTCCATCTTGCGAGCCAGGATTTCACCGTATCCGGCGGCTCGGCCGGAGA
GGTGCATTCCATCAAAGTCGCGGAAATCATGGAGATGTCGCTGAAGACCGGCTCGCCCTTTGTCTTCATCAATGATTCCG
GGGGCGCCCGCGTCCAGGAAGGCATCGATTCGCTTTCCGGCTATGGCAAGGTCTTCTACACCAACGTCATGCTCTCCGGC
GCCGTCCCGCAAATCTCCCTGATCTGCGGCCCGTGCGCAGGGGGCGCGGCCTACAGCCCCGCGCTCACGGATTTCATCAT
TCAAACCCGACAGGCGCAGATGTTCATCACCGGCCCGCAAGTTATCAAGGGCGTCACCGGGGAGACCGTCACTGCCGAGC
AGTTGGGCGGTGCCGAAGCGCATATGGCGAACTCCGGCGTCATCCACTTTATTGCTGAAGACGACCGCCACGCCATCATG
CTCGCGCAGAAGCTGCTCAGCTTTTTGCCCAGCAACAACCTGGAAGATCCGCCGCGCGTCGATGGCAACCCTAATGTGGA
CCCCGACCCGTCGCTCGACGACATCGTTCCAGCCGATAATAAAAAGGGCTATGACGTTCGCGAAGTCATCGCCAAAGTAG
TGGACTTCGCCGACTTTCTGGAGGTCCAGTCCGGCTACGCGATGAACATCGTGGTCGGCTTCGCGCGCATTGCCGGCCGG
ACCATCGGCATCATCGCCAATCAACCCTCGGTGCAGGCCGGGGTGCTCGATATCAACGCCGCCAACAAGGCATCACGCTT
CATCCGCTTCTGCAACGCGTTCAACATCTCGCTCTTGACCTTCGTTGATGTCCCCGGCTTCCTTCCAGGGGTGCAGCAGG
AGCACGGCGGCATTATCCGTCACGGCGCGAAGATGCTCTTCGCATATTCCGCCGCCACCGTCCCGAAAGTCACCGTGATT
CTCCGCAAGAGTTACGGCGGTGCTTATCTGGCGATGTGCGGCAAAGATCTCGGCGCCGACCGCGTGTTCGCGTGGCCCAC
GGCAGAGGTCGCGGTGATGGGCGCGGAGGGTGCTGCCGACATCGTTTTCCGCAAAGAAATACAGGAGGCCGCCGACAAGA
CCGCGAAACGCGCGGAACTGATCGAGCAATATCGCGAGGCCTTCTCGAATCCGTACGTCGCTGCCGGACGCCGTCTGGTG
GACGCGGTAATCGAACCATCCAAGACTCGCCGCCACGTGGCCCAGGTACTCGAGTACCTGCACACCAAGCGCGAATTGCG
TCCGCCCAAGAAGCACGGCTTGATGCCGCTGTAA

Upstream 100 bases:

>100_bases
CACCATCACCTACGACGTGAAATATAACGGCAAAACGCACAAGGTAACCGTGGCGGCCTGTAAGTAACTATCGAAGTAAG
TACTCATAAAAGGAACCCAT

Downstream 100 bases:

>100_bases
ACGCGAAAGGGGAAAACCATGGTGAAAGTAGAAGATCTCGCCGTTACGCTGGAGCAGCTTCAGGCAAAAATCGCGGAGAT
GTCGCGCCACATCGAGTTCC

Product: carboxyl transferase

Products: NA

Alternate protein names: Transcarboxylase 12S subunit [H]

Number of amino acids: Translated: 517; Mature: 516

Protein sequence:

>517_residues
MAIHTMQEKVAELHERTSKAMLGGGAERLEKQRQGGKLTARERVEALVDPDSFEESGLFAEHRATLFGMAGKDFPADGVV
TGAASVNGRLVHLASQDFTVSGGSAGEVHSIKVAEIMEMSLKTGSPFVFINDSGGARVQEGIDSLSGYGKVFYTNVMLSG
AVPQISLICGPCAGGAAYSPALTDFIIQTRQAQMFITGPQVIKGVTGETVTAEQLGGAEAHMANSGVIHFIAEDDRHAIM
LAQKLLSFLPSNNLEDPPRVDGNPNVDPDPSLDDIVPADNKKGYDVREVIAKVVDFADFLEVQSGYAMNIVVGFARIAGR
TIGIIANQPSVQAGVLDINAANKASRFIRFCNAFNISLLTFVDVPGFLPGVQQEHGGIIRHGAKMLFAYSAATVPKVTVI
LRKSYGGAYLAMCGKDLGADRVFAWPTAEVAVMGAEGAADIVFRKEIQEAADKTAKRAELIEQYREAFSNPYVAAGRRLV
DAVIEPSKTRRHVAQVLEYLHTKRELRPPKKHGLMPL

Sequences:

>Translated_517_residues
MAIHTMQEKVAELHERTSKAMLGGGAERLEKQRQGGKLTARERVEALVDPDSFEESGLFAEHRATLFGMAGKDFPADGVV
TGAASVNGRLVHLASQDFTVSGGSAGEVHSIKVAEIMEMSLKTGSPFVFINDSGGARVQEGIDSLSGYGKVFYTNVMLSG
AVPQISLICGPCAGGAAYSPALTDFIIQTRQAQMFITGPQVIKGVTGETVTAEQLGGAEAHMANSGVIHFIAEDDRHAIM
LAQKLLSFLPSNNLEDPPRVDGNPNVDPDPSLDDIVPADNKKGYDVREVIAKVVDFADFLEVQSGYAMNIVVGFARIAGR
TIGIIANQPSVQAGVLDINAANKASRFIRFCNAFNISLLTFVDVPGFLPGVQQEHGGIIRHGAKMLFAYSAATVPKVTVI
LRKSYGGAYLAMCGKDLGADRVFAWPTAEVAVMGAEGAADIVFRKEIQEAADKTAKRAELIEQYREAFSNPYVAAGRRLV
DAVIEPSKTRRHVAQVLEYLHTKRELRPPKKHGLMPL
>Mature_516_residues
AIHTMQEKVAELHERTSKAMLGGGAERLEKQRQGGKLTARERVEALVDPDSFEESGLFAEHRATLFGMAGKDFPADGVVT
GAASVNGRLVHLASQDFTVSGGSAGEVHSIKVAEIMEMSLKTGSPFVFINDSGGARVQEGIDSLSGYGKVFYTNVMLSGA
VPQISLICGPCAGGAAYSPALTDFIIQTRQAQMFITGPQVIKGVTGETVTAEQLGGAEAHMANSGVIHFIAEDDRHAIML
AQKLLSFLPSNNLEDPPRVDGNPNVDPDPSLDDIVPADNKKGYDVREVIAKVVDFADFLEVQSGYAMNIVVGFARIAGRT
IGIIANQPSVQAGVLDINAANKASRFIRFCNAFNISLLTFVDVPGFLPGVQQEHGGIIRHGAKMLFAYSAATVPKVTVIL
RKSYGGAYLAMCGKDLGADRVFAWPTAEVAVMGAEGAADIVFRKEIQEAADKTAKRAELIEQYREAFSNPYVAAGRRLVD
AVIEPSKTRRHVAQVLEYLHTKRELRPPKKHGLMPL

Specific function: The 12S subunit specifically catalyzes the transfer of the carboxyl group of methylmalonyl CoA to the biotin of the 1.3S subunit forming propanoyl-CoA and carboxylated 1.3S-biotin [H]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=525, Percent_Identity=50.8571428571429, Blast_Score=522, Evalue=1e-148,
Organism=Homo sapiens, GI295821216, Length=545, Percent_Identity=48.9908256880734, Blast_Score=510, Evalue=1e-144,
Organism=Homo sapiens, GI11545863, Length=503, Percent_Identity=35.5864811133201, Blast_Score=270, Evalue=2e-72,
Organism=Homo sapiens, GI38679971, Length=402, Percent_Identity=23.3830845771144, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI38679974, Length=402, Percent_Identity=23.3830845771144, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI38679960, Length=402, Percent_Identity=23.3830845771144, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI38679977, Length=402, Percent_Identity=23.3830845771144, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI38679967, Length=402, Percent_Identity=23.3830845771144, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI134142062, Length=397, Percent_Identity=22.6700251889169, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1788655, Length=239, Percent_Identity=28.4518828451883, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI25147362, Length=517, Percent_Identity=50.6769825918762, Blast_Score=527, Evalue=1e-150,
Organism=Caenorhabditis elegans, GI25147359, Length=517, Percent_Identity=50.6769825918762, Blast_Score=526, Evalue=1e-150,
Organism=Caenorhabditis elegans, GI17552936, Length=531, Percent_Identity=35.5932203389831, Blast_Score=291, Evalue=5e-79,
Organism=Caenorhabditis elegans, GI71997163, Length=398, Percent_Identity=24.6231155778894, Blast_Score=88, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6324343, Length=375, Percent_Identity=24.5333333333333, Blast_Score=67, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24586065, Length=519, Percent_Identity=34.4894026974952, Blast_Score=270, Evalue=1e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =2.1.3.1 [H]

Molecular weight: Translated: 55479; Mature: 55348

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIHTMQEKVAELHERTSKAMLGGGAERLEKQRQGGKLTARERVEALVDPDSFEESGLFA
CCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCH
EHRATLFGMAGKDFPADGVVTGAASVNGRLVHLASQDFTVSGGSAGEVHSIKVAEIMEMS
HHHHHEEECCCCCCCCCCEEEECCCCCCEEEEEECCCEEECCCCCCCEEEEHHHHHHHHH
LKTGSPFVFINDSGGARVQEGIDSLSGYGKVFYTNVMLSGAVPQISLICGPCAGGAAYSP
HCCCCCEEEEECCCCCHHHHHHHHHCCCCEEEEEEEEECCCCCEEEEEEECCCCCCCCCH
ALTDFIIQTRQAQMFITGPQVIKGVTGETVTAEQLGGAEAHMANSGVIHFIAEDDRHAIM
HHHHHHHHHCCCEEEEECHHHHHCCCCCEEEHHHCCCCHHEECCCCEEEEEECCCCHHHH
LAQKLLSFLPSNNLEDPPRVDGNPNVDPDPSLDDIVPADNKKGYDVREVIAKVVDFADFL
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
EVQSGYAMNIVVGFARIAGRTIGIIANQPSVQAGVLDINAANKASRFIRFCNAFNISLLT
HHHCCCEEHHHHHHHHHCCCEEEEEECCCCCEEEEEEECCCHHHHHHHHHHHHCCCEEEE
FVDVPGFLPGVQQEHGGIIRHGAKMLFAYSAATVPKVTVILRKSYGGAYLAMCGKDLGAD
EECCCCCCCCCCCCCCCHHHHCHHHHEEECCCCCCEEEEEEEECCCCEEEEECCCCCCCC
RVFAWPTAEVAVMGAEGAADIVFRKEIQEAADKTAKRAELIEQYREAFSNPYVAAGRRLV
CEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
DAVIEPSKTRRHVAQVLEYLHTKRELRPPKKHGLMPL
HHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHCCCCCC
>Mature Secondary Structure 
AIHTMQEKVAELHERTSKAMLGGGAERLEKQRQGGKLTARERVEALVDPDSFEESGLFA
CCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCH
EHRATLFGMAGKDFPADGVVTGAASVNGRLVHLASQDFTVSGGSAGEVHSIKVAEIMEMS
HHHHHEEECCCCCCCCCCEEEECCCCCCEEEEEECCCEEECCCCCCCEEEEHHHHHHHHH
LKTGSPFVFINDSGGARVQEGIDSLSGYGKVFYTNVMLSGAVPQISLICGPCAGGAAYSP
HCCCCCEEEEECCCCCHHHHHHHHHCCCCEEEEEEEEECCCCCEEEEEEECCCCCCCCCH
ALTDFIIQTRQAQMFITGPQVIKGVTGETVTAEQLGGAEAHMANSGVIHFIAEDDRHAIM
HHHHHHHHHCCCEEEEECHHHHHCCCCCEEEHHHCCCCHHEECCCCEEEEEECCCCHHHH
LAQKLLSFLPSNNLEDPPRVDGNPNVDPDPSLDDIVPADNKKGYDVREVIAKVVDFADFL
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
EVQSGYAMNIVVGFARIAGRTIGIIANQPSVQAGVLDINAANKASRFIRFCNAFNISLLT
HHHCCCEEHHHHHHHHHCCCEEEEEECCCCCEEEEEEECCCHHHHHHHHHHHHCCCEEEE
FVDVPGFLPGVQQEHGGIIRHGAKMLFAYSAATVPKVTVILRKSYGGAYLAMCGKDLGAD
EECCCCCCCCCCCCCCCHHHHCHHHHEEECCCCCCEEEEEEEECCCCEEEEECCCCCCCC
RVFAWPTAEVAVMGAEGAADIVFRKEIQEAADKTAKRAELIEQYREAFSNPYVAAGRRLV
CEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
DAVIEPSKTRRHVAQVLEYLHTKRELRPPKKHGLMPL
HHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8366018 [H]