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The map label for this gene is uvrA [H]

Identifier: 116625960

GI number: 116625960

Start: 8687247

End: 8689811

Strand: Reverse

Name: uvrA [H]

Synonym: Acid_6918

Alternate gene names: 116625960

Gene position: 8689811-8687247 (Counterclockwise)

Preceding gene: 116625961

Following gene: 116625959

Centisome position: 87.2

GC content: 60.66

Gene sequence:

>2565_bases
ATGAGCACGCACAAAGAGTTCACCGGATTCGTTACCGTCAAGGGCGCGCGGCAGCACAACCTGAAGGATATCGACGTCCG
CATACCACGCAATGCCCTGGTGGTTTTCACCGGCGTCTCAGGATCGGGAAAATCCTCACTGGCTTTCGGGACTCTTTATG
CCGAGGCGCAACGCCGGTACCTTGATTCGGTGGCGCCCTATGCCAGGCGTCTGTTCGAGCAAATCGGCATTCCGGAAGTG
GACAGCATCGAGGGTCTGCCGCCCGCGGTGGCGCTTCAGCAACAGCGCGGATCTCCCACCACTCGATCTTCTGTTGGGAG
CGTAACGACGGTGTCCAACCTGCTTCGGATGATCTATTCGCGCGCGGGCACATATCCCCCGGGTCAACCGGAACTCCACG
GAGAGGCATTCTCGACGAACAGCCCGGAAGGCGCTTGCCCGCGCTGTCACGGGATTGGCCGCGTTTACGAGGCGACCGAA
AAGACGATGGTTCCCGATGACTCGCTGACAATTCGCGAGCGAGCGATCGCCGCTTGGCCCACCGCATGGGGCGGACAGAA
CCAGCGCGACATTCTGGTCACGCTTGGTTACGATGTCGATCGTCCCTGGCGCGAGCTCCCCAGGAGCGATCGCGATTGGA
TCCTTTTCACCGAAGATCAACCCACGGTACCGGTGTATGCCGGATTCACTCCGGAGGAAACCCGCCGAGCTCTCAAGCGA
AAAGAGGAGCCGAGCTATCAGGGGACGTTCACAGGCGTTCGCCGGTATCTGCTCCATACCCTGGCTCACACGGAAAGCGC
GCTAACCCGGAAGCGGGTGCTGCAATTTCTCATCGCTGCGCCGTGCCCGGCTTGTAAGGGAAAACGTCTGCGGCCCGAGT
CTCTCTCTGTCAAATTCGCCGGGCTGGATATCGCGCAGATCTCTGCGTTGCCGCTCACCCGTCTGCTGGAACTGCTTCGC
TCGGCGGCCCGCAGTGCGTTGACGAAGCCGAATGCTTCCCATCCCGAACGTGGGATTGTCGCACAACGGATTACCCAAGA
TCTCGTCCGGCGCCTCGCAGTGATGCTCGATCTGGGGCTCGGCTACCTCTCACTCGAAAGAAGCACGCCCACGCTGTCGC
CGGGCGAGCTGCAGCGGCTGCGCCTGGCCACACAAGTCTGCTCGAACCTTTTTGGGGTTGTTTACGTGCTCGACGAACCG
TCCGCCGGACTACATCCGGCAGACACCGAGGCGCTGCTGGTGGCGCTCGACCGGCTCAAGGCGTCTGGCAACTCGTTGTT
TATCGTCGAACACGAACTGGACGTAATCCGCCACGCGGACTGGATCGTGGATGTTGGGCCGGCCGCCGGCGAACAGGGCG
GCCGCATACTCTACAGCGGCCCGCCAAAGGGGTTGAATGAGGTTGAGGAATCGAAAACGCGCCTGTATTTATTCGGTGAG
GAGGGGCCGGTGCAGCGGACGCCTCGAAGCGCCGGCGGATGGCTTCGCCTGGATAACGTGACCCGCAACAACCTTCACAA
ACTGTCGGTGGCGTTTCCACTGGAGACCCTCACGGCGGTCACCGGTGTATCAGGCTCCGGAAAATCGACGCTGGTGAGTC
AGGTCCTGGTCGAACTGATAGGTGAACGCCTCGGACAGCAGCGATCATCCGATCCCGACGACACGGAATCCCCCGGTGAC
GACGGCCCGATCACTTTGGAGGGCCGGATTACGGAGGGCGCGACCGCGATCAAGCGATTGGTCCAGGTGGATCAAAAACC
GATTGGACGCACGCCCCGCTCCAATCTCGCAACCTACACGGGCCTGTTCGATCACGTGCGCAGAACATTCGCTACGACGA
AAACGGCCAAGGCACGGCGCTACACTGCCAGCCGCTTCTCCTTCAATGTCTCCGAGGGACGCTGCGAAACCTGTGAAGGT
GAGGGCTTCGTCTGCGTCGAATTGCTGTTCATGCCCAGTGTCTACGCGCCTTGCTCCTCATGCCACGGAGCACGCTACAA
CTCGAAAACCCTGGAAATCGAATATCGTGGGAAAAACATTGCCGAAGTTCTCGCGATGACGGTGGATGCAGCCAGCAATT
TCTTTGATGAGCAACCGCAGGTGAGCCATGCGCTCGCAGTTCTTCAGCAGGTGGGCCTTGGATATCTGCGGCTCGGCCAG
GCGGCCACTGAATTGTCTGGCGGGGAGGCGCAGCGTATCAAACTTGCTACAGAACTGCAGCGCAACCAGCGCGGAAACAC
CTTGTATGTTCTCGATGAACCAACGACGGGGCTGCACCCTTCAGACGTTCGACGATTGGTGACTCAGCTTGATGGGCTGG
TCGGACTGGGCAACACTGTGATCGTGGTGGAGCACGACCTCGACGTAATCGCAGCGAGTGACTACGTAATCGACATGGGT
CCCGGCGCGGGAGAAGAGGGAGGCCGCGTAGTCGCTGTCGGTACGCCGGTAGAGGTGTCGAATGCTGTGGGGAGCCGGAC
GGGTTCATATCTCAAGCGGCGCCTTGGGTTGGCGATGGAAGGAACCCATGCGCGCGAGAACAATCGCCGGCAACAGGCGC
ATTGA

Upstream 100 bases:

>100_bases
GATTGATCAGGCGCGGAGGGCCGGCCTGGAGCCGGCTTCTGTCCTCAATTGCTTGCCGTGGGCGTCTCTTCAGCCATTGT
TCCGCCGATGATGAAGGATT

Downstream 100 bases:

>100_bases
CAGGAGTCGCTATGAGACGGATTCGAACAATTCACTTCGATAAAGCCGCGGACGTTCCGAACAGCAATCTGCCGGTACTG
CTCTATCGGTCTGTGCTCGA

Product: excinuclease ABC subunit A

Products: NA

Alternate protein names: UvrA protein; Excinuclease ABC subunit A [H]

Number of amino acids: Translated: 854; Mature: 853

Protein sequence:

>854_residues
MSTHKEFTGFVTVKGARQHNLKDIDVRIPRNALVVFTGVSGSGKSSLAFGTLYAEAQRRYLDSVAPYARRLFEQIGIPEV
DSIEGLPPAVALQQQRGSPTTRSSVGSVTTVSNLLRMIYSRAGTYPPGQPELHGEAFSTNSPEGACPRCHGIGRVYEATE
KTMVPDDSLTIRERAIAAWPTAWGGQNQRDILVTLGYDVDRPWRELPRSDRDWILFTEDQPTVPVYAGFTPEETRRALKR
KEEPSYQGTFTGVRRYLLHTLAHTESALTRKRVLQFLIAAPCPACKGKRLRPESLSVKFAGLDIAQISALPLTRLLELLR
SAARSALTKPNASHPERGIVAQRITQDLVRRLAVMLDLGLGYLSLERSTPTLSPGELQRLRLATQVCSNLFGVVYVLDEP
SAGLHPADTEALLVALDRLKASGNSLFIVEHELDVIRHADWIVDVGPAAGEQGGRILYSGPPKGLNEVEESKTRLYLFGE
EGPVQRTPRSAGGWLRLDNVTRNNLHKLSVAFPLETLTAVTGVSGSGKSTLVSQVLVELIGERLGQQRSSDPDDTESPGD
DGPITLEGRITEGATAIKRLVQVDQKPIGRTPRSNLATYTGLFDHVRRTFATTKTAKARRYTASRFSFNVSEGRCETCEG
EGFVCVELLFMPSVYAPCSSCHGARYNSKTLEIEYRGKNIAEVLAMTVDAASNFFDEQPQVSHALAVLQQVGLGYLRLGQ
AATELSGGEAQRIKLATELQRNQRGNTLYVLDEPTTGLHPSDVRRLVTQLDGLVGLGNTVIVVEHDLDVIAASDYVIDMG
PGAGEEGGRVVAVGTPVEVSNAVGSRTGSYLKRRLGLAMEGTHARENNRRQQAH

Sequences:

>Translated_854_residues
MSTHKEFTGFVTVKGARQHNLKDIDVRIPRNALVVFTGVSGSGKSSLAFGTLYAEAQRRYLDSVAPYARRLFEQIGIPEV
DSIEGLPPAVALQQQRGSPTTRSSVGSVTTVSNLLRMIYSRAGTYPPGQPELHGEAFSTNSPEGACPRCHGIGRVYEATE
KTMVPDDSLTIRERAIAAWPTAWGGQNQRDILVTLGYDVDRPWRELPRSDRDWILFTEDQPTVPVYAGFTPEETRRALKR
KEEPSYQGTFTGVRRYLLHTLAHTESALTRKRVLQFLIAAPCPACKGKRLRPESLSVKFAGLDIAQISALPLTRLLELLR
SAARSALTKPNASHPERGIVAQRITQDLVRRLAVMLDLGLGYLSLERSTPTLSPGELQRLRLATQVCSNLFGVVYVLDEP
SAGLHPADTEALLVALDRLKASGNSLFIVEHELDVIRHADWIVDVGPAAGEQGGRILYSGPPKGLNEVEESKTRLYLFGE
EGPVQRTPRSAGGWLRLDNVTRNNLHKLSVAFPLETLTAVTGVSGSGKSTLVSQVLVELIGERLGQQRSSDPDDTESPGD
DGPITLEGRITEGATAIKRLVQVDQKPIGRTPRSNLATYTGLFDHVRRTFATTKTAKARRYTASRFSFNVSEGRCETCEG
EGFVCVELLFMPSVYAPCSSCHGARYNSKTLEIEYRGKNIAEVLAMTVDAASNFFDEQPQVSHALAVLQQVGLGYLRLGQ
AATELSGGEAQRIKLATELQRNQRGNTLYVLDEPTTGLHPSDVRRLVTQLDGLVGLGNTVIVVEHDLDVIAASDYVIDMG
PGAGEEGGRVVAVGTPVEVSNAVGSRTGSYLKRRLGLAMEGTHARENNRRQQAH
>Mature_853_residues
STHKEFTGFVTVKGARQHNLKDIDVRIPRNALVVFTGVSGSGKSSLAFGTLYAEAQRRYLDSVAPYARRLFEQIGIPEVD
SIEGLPPAVALQQQRGSPTTRSSVGSVTTVSNLLRMIYSRAGTYPPGQPELHGEAFSTNSPEGACPRCHGIGRVYEATEK
TMVPDDSLTIRERAIAAWPTAWGGQNQRDILVTLGYDVDRPWRELPRSDRDWILFTEDQPTVPVYAGFTPEETRRALKRK
EEPSYQGTFTGVRRYLLHTLAHTESALTRKRVLQFLIAAPCPACKGKRLRPESLSVKFAGLDIAQISALPLTRLLELLRS
AARSALTKPNASHPERGIVAQRITQDLVRRLAVMLDLGLGYLSLERSTPTLSPGELQRLRLATQVCSNLFGVVYVLDEPS
AGLHPADTEALLVALDRLKASGNSLFIVEHELDVIRHADWIVDVGPAAGEQGGRILYSGPPKGLNEVEESKTRLYLFGEE
GPVQRTPRSAGGWLRLDNVTRNNLHKLSVAFPLETLTAVTGVSGSGKSTLVSQVLVELIGERLGQQRSSDPDDTESPGDD
GPITLEGRITEGATAIKRLVQVDQKPIGRTPRSNLATYTGLFDHVRRTFATTKTAKARRYTASRFSFNVSEGRCETCEGE
GFVCVELLFMPSVYAPCSSCHGARYNSKTLEIEYRGKNIAEVLAMTVDAASNFFDEQPQVSHALAVLQQVGLGYLRLGQA
ATELSGGEAQRIKLATELQRNQRGNTLYVLDEPTTGLHPSDVRRLVTQLDGLVGLGNTVIVVEHDLDVIAASDYVIDMGP
GAGEEGGRVVAVGTPVEVSNAVGSRTGSYLKRRLGLAMEGTHARENNRRQQAH

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion h

COG id: COG0178

COG function: function code L; Excinuclease ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Escherichia coli, GI2367343, Length=707, Percent_Identity=39.038189533239, Blast_Score=491, Evalue=1e-140,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017871 [H]

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 93226; Mature: 93095

Theoretical pI: Translated: 8.11; Mature: 8.11

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTHKEFTGFVTVKGARQHNLKDIDVRIPRNALVVFTGVSGSGKSSLAFGTLYAEAQRRY
CCCCCCEEEEEEEECCCCCCCCEEEEEECCCEEEEEECCCCCCCCCEEHHHHHHHHHHHH
LDSVAPYARRLFEQIGIPEVDSIEGLPPAVALQQQRGSPTTRSSVGSVTTVSNLLRMIYS
HHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCHHHCCCHHHHHHHHHHHHH
RAGTYPPGQPELHGEAFSTNSPEGACPRCHGIGRVYEATEKTMVPDDSLTIRERAIAAWP
HCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCHHHHHHCCCCCCCCCCHHHHHHHEECC
TAWGGQNQRDILVTLGYDVDRPWRELPRSDRDWILFTEDQPTVPVYAGFTPEETRRALKR
CCCCCCCCCEEEEEECCCCCCHHHHCCCCCCCEEEEECCCCCCEEEECCCHHHHHHHHHH
KEEPSYQGTFTGVRRYLLHTLAHTESALTRKRVLQFLIAAPCPACKGKRLRPESLSVKFA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEE
GLDIAQISALPLTRLLELLRSAARSALTKPNASHPERGIVAQRITQDLVRRLAVMLDLGL
CCCHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
GYLSLERSTPTLSPGELQRLRLATQVCSNLFGVVYVLDEPSAGLHPADTEALLVALDRLK
CEEEEECCCCCCCHHHHHHHHHHHHHHHHHCEEEEEEECCCCCCCCCCHHHHHHHHHHHH
ASGNSLFIVEHELDVIRHADWIVDVGPAAGEQGGRILYSGPPKGLNEVEESKTRLYLFGE
CCCCEEEEEECCHHHHHCCCCEEECCCCCCCCCCEEEECCCCCCHHHHHHCCCEEEEECC
EGPVQRTPRSAGGWLRLDNVTRNNLHKLSVAFPLETLTAVTGVSGSGKSTLVSQVLVELI
CCCCCCCCCCCCCEEEECCCCCCCCEEEEEECCHHHHHHHHCCCCCCHHHHHHHHHHHHH
GERLGQQRSSDPDDTESPGDDGPITLEGRITEGATAIKRLVQVDQKPIGRTPRSNLATYT
HHHHHHCCCCCCCCCCCCCCCCCEEEEEEECHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
GLFDHVRRTFATTKTAKARRYTASRFSFNVSEGRCETCEGEGFVCVELLFMPSVYAPCSS
HHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCEEEEHHHHHCCHHCCHHH
CHGARYNSKTLEIEYRGKNIAEVLAMTVDAASNFFDEQPQVSHALAVLQQVGLGYLRLGQ
CCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHCH
AATELSGGEAQRIKLATELQRNQRGNTLYVLDEPTTGLHPSDVRRLVTQLDGLVGLGNTV
HHHHCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHEECCCEE
IVVEHDLDVIAASDYVIDMGPGAGEEGGRVVAVGTPVEVSNAVGSRTGSYLKRRLGLAME
EEEECCCCEEEECCEEEECCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCC
GTHARENNRRQQAH
CCCCCCCCCCCCCC
>Mature Secondary Structure 
STHKEFTGFVTVKGARQHNLKDIDVRIPRNALVVFTGVSGSGKSSLAFGTLYAEAQRRY
CCCCCEEEEEEEECCCCCCCCEEEEEECCCEEEEEECCCCCCCCCEEHHHHHHHHHHHH
LDSVAPYARRLFEQIGIPEVDSIEGLPPAVALQQQRGSPTTRSSVGSVTTVSNLLRMIYS
HHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCHHHCCCHHHHHHHHHHHHH
RAGTYPPGQPELHGEAFSTNSPEGACPRCHGIGRVYEATEKTMVPDDSLTIRERAIAAWP
HCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCHHHHHHCCCCCCCCCCHHHHHHHEECC
TAWGGQNQRDILVTLGYDVDRPWRELPRSDRDWILFTEDQPTVPVYAGFTPEETRRALKR
CCCCCCCCCEEEEEECCCCCCHHHHCCCCCCCEEEEECCCCCCEEEECCCHHHHHHHHHH
KEEPSYQGTFTGVRRYLLHTLAHTESALTRKRVLQFLIAAPCPACKGKRLRPESLSVKFA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEE
GLDIAQISALPLTRLLELLRSAARSALTKPNASHPERGIVAQRITQDLVRRLAVMLDLGL
CCCHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
GYLSLERSTPTLSPGELQRLRLATQVCSNLFGVVYVLDEPSAGLHPADTEALLVALDRLK
CEEEEECCCCCCCHHHHHHHHHHHHHHHHHCEEEEEEECCCCCCCCCCHHHHHHHHHHHH
ASGNSLFIVEHELDVIRHADWIVDVGPAAGEQGGRILYSGPPKGLNEVEESKTRLYLFGE
CCCCEEEEEECCHHHHHCCCCEEECCCCCCCCCCEEEECCCCCCHHHHHHCCCEEEEECC
EGPVQRTPRSAGGWLRLDNVTRNNLHKLSVAFPLETLTAVTGVSGSGKSTLVSQVLVELI
CCCCCCCCCCCCCEEEECCCCCCCCEEEEEECCHHHHHHHHCCCCCCHHHHHHHHHHHHH
GERLGQQRSSDPDDTESPGDDGPITLEGRITEGATAIKRLVQVDQKPIGRTPRSNLATYT
HHHHHHCCCCCCCCCCCCCCCCCEEEEEEECHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
GLFDHVRRTFATTKTAKARRYTASRFSFNVSEGRCETCEGEGFVCVELLFMPSVYAPCSS
HHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCEEEEHHHHHCCHHCCHHH
CHGARYNSKTLEIEYRGKNIAEVLAMTVDAASNFFDEQPQVSHALAVLQQVGLGYLRLGQ
CCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHCH
AATELSGGEAQRIKLATELQRNQRGNTLYVLDEPTTGLHPSDVRRLVTQLDGLVGLGNTV
HHHHCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHEECCCEE
IVVEHDLDVIAASDYVIDMGPGAGEEGGRVVAVGTPVEVSNAVGSRTGSYLKRRLGLAME
EEEECCCCEEEECCEEEECCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCC
GTHARENNRRQQAH
CCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8269961 [H]