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The map label for this gene is emrA [C]

Identifier: 116625734

GI number: 116625734

Start: 8385667

End: 8386992

Strand: Direct

Name: emrA [C]

Synonym: Acid_6683

Alternate gene names: 116625734

Gene position: 8385667-8386992 (Clockwise)

Preceding gene: 116625733

Following gene: 116625735

Centisome position: 84.15

GC content: 64.71

Gene sequence:

>1326_bases
ATGGCATTTCCCAGCTCTCATCGGACGCCGCCGGCCGCGACCAAAATCGTCGCCGTCGAACCCGTGAAACTGCAGGAAGG
GCCGCCTCGATGGCCCATCTACATCTTCCTCGCAGCCCTGCTCGCCGGCTCGGCCTGGTATTTGCGTCCGCGTCCCCAAC
AGCGAGCCACGCCCGCGCCCGCCATCCCGACAGCACGCGTCTACCGCGGTGTGATCGACCCCACGCGCCGCGTCGCCGGG
TCCATCAGCGCCGGTCGCTTCGCCAACGTCGCCGCCCCCGTCCTCCAGGCGCCCGACACCGGCCGCGGACTTACCCTGAC
CTTCCTTGCCGAATCCGGCACCCGCGTGAAAAGAGGCCAGCGCATCGCCGAAATCGACGCGCAAGATATCAAAGACCATC
TCGACGATGTGGAAGCCGGCATTGTGCAGTCGCGCTTGGATATCAAGCGGCGCCAGGCGCAGTTGCTCGCCCAGATGGAA
AACCTGAAGCAGGGCCTTCGCGTTCTCAAGGCCACGCTCGATAAGGCCAAACAGAACGCCCGCGCTATCCCCGTCTCTAA
CTCCATCAGCCAGGAAAATCTGCGGCTCGCCGTCGAAGAATATCAAGCGGCCTACGATGAAGCCGTGAAGCAGATGCCGC
TCACCGAAGAGCGCCAGCTCGCCGACCTCAAGCTCTACCAGCTCAGCTACGAACATGACATCCGGCACCGCGACCGCCAC
ATGACCGACTTTCGCCGCTGCACCATCGAAGCCCCGATGGATGGCATGGTCGTCATGCAGACCACCTACCGCGGCGGCGA
GATGAACCAGATCAAAGTCGGCGACCGCTTGTCACCCGGCCAGCCCTTCATGGCCGTGGTGGACCCGAACAGCATGCAGT
TGGATGCCATGATGAGCCAGGCGGAAAGTGAACTCGTCCGCCTCGGCCAACCGGCCACAGTGCGCTTCGATGCCTTCCCC
GATATCGTGGTCAAAGGTCGCGTGAAGGCCGTGGGAGCCTTCGCGATGGGCGGTCGCCGCGTGAACTATTACGTGCGCCG
CATCCCCGTCCGCGTCGAACTCGAAAACCCCGACGAGCGCGTGATCCCCGACCTCTCGGCCAGCGCCGACGTCCTAACCG
GCCGTCCGGCCGCCGGCCTGATCATCCCCCGCGAAGCTCTCGCCGAAGCCGAAGGGAAACCCGTAGTCTACGTGAAGCAA
GGTGACACCTTCCTCGCCCACGCCGTCGAGATCGCGACCGCCACCAACACTCAGGTGGCCGTCGCCTCCGGTATTGAAGA
AGGCCAGGAAGTCGCCCTCCAACCCCCGCCCTCCACCATCCGCTGA

Upstream 100 bases:

>100_bases
CCGGAAAGCTGCGCTAACCCTCGCCCGTTTACACAACCTTACACATTGCCTTTTAGGTTCTGTAACTCCTTTTGAGCTAC
ATTAGTAGTTCGGGCAGCTC

Downstream 100 bases:

>100_bases
GTGAAGAAAACCCTCCCATCCGATGAGCCAGAATGCCATAACGATTCAGATCGACCATCCCGATCTACCTCCCGGGCCCA
TTCAGGGCTTCCGTTTTTTC

Product: multidrug resistance efflux pump-like protein

Products: NA

Alternate protein names: Secretion Protein HlyD; RND Family Efflux Transporter MFP Subunit; Membrane-Fusion Protein; Secretion Protein HlyD Family Protein; Multidrug Resistance Efflux Pump-Like Protein; Membrane Fusion Protein; Efflux Transporter Rnd Family Mfp Subunit; RND Divalent Metal Cation Efflux Membrane Fusion Protein; Heavy Metal Efflux Pump Czcb Family; Periplasmic Component Of Efflux System; RND Family Efflux Pump Membrane Fusion Protein; CzcB Family Heavy Metal Efflux Protein; Efflux Transporter; Multidrug Resistance Protein A; PAS/PAC Sensor Protein; Nickel-Cobalt Resistance Protein; RND Family Efflux Transporter; Membrane-Fusion Protein-Like Protein

Number of amino acids: Translated: 441; Mature: 440

Protein sequence:

>441_residues
MAFPSSHRTPPAATKIVAVEPVKLQEGPPRWPIYIFLAALLAGSAWYLRPRPQQRATPAPAIPTARVYRGVIDPTRRVAG
SISAGRFANVAAPVLQAPDTGRGLTLTFLAESGTRVKRGQRIAEIDAQDIKDHLDDVEAGIVQSRLDIKRRQAQLLAQME
NLKQGLRVLKATLDKAKQNARAIPVSNSISQENLRLAVEEYQAAYDEAVKQMPLTEERQLADLKLYQLSYEHDIRHRDRH
MTDFRRCTIEAPMDGMVVMQTTYRGGEMNQIKVGDRLSPGQPFMAVVDPNSMQLDAMMSQAESELVRLGQPATVRFDAFP
DIVVKGRVKAVGAFAMGGRRVNYYVRRIPVRVELENPDERVIPDLSASADVLTGRPAAGLIIPREALAEAEGKPVVYVKQ
GDTFLAHAVEIATATNTQVAVASGIEEGQEVALQPPPSTIR

Sequences:

>Translated_441_residues
MAFPSSHRTPPAATKIVAVEPVKLQEGPPRWPIYIFLAALLAGSAWYLRPRPQQRATPAPAIPTARVYRGVIDPTRRVAG
SISAGRFANVAAPVLQAPDTGRGLTLTFLAESGTRVKRGQRIAEIDAQDIKDHLDDVEAGIVQSRLDIKRRQAQLLAQME
NLKQGLRVLKATLDKAKQNARAIPVSNSISQENLRLAVEEYQAAYDEAVKQMPLTEERQLADLKLYQLSYEHDIRHRDRH
MTDFRRCTIEAPMDGMVVMQTTYRGGEMNQIKVGDRLSPGQPFMAVVDPNSMQLDAMMSQAESELVRLGQPATVRFDAFP
DIVVKGRVKAVGAFAMGGRRVNYYVRRIPVRVELENPDERVIPDLSASADVLTGRPAAGLIIPREALAEAEGKPVVYVKQ
GDTFLAHAVEIATATNTQVAVASGIEEGQEVALQPPPSTIR
>Mature_440_residues
AFPSSHRTPPAATKIVAVEPVKLQEGPPRWPIYIFLAALLAGSAWYLRPRPQQRATPAPAIPTARVYRGVIDPTRRVAGS
ISAGRFANVAAPVLQAPDTGRGLTLTFLAESGTRVKRGQRIAEIDAQDIKDHLDDVEAGIVQSRLDIKRRQAQLLAQMEN
LKQGLRVLKATLDKAKQNARAIPVSNSISQENLRLAVEEYQAAYDEAVKQMPLTEERQLADLKLYQLSYEHDIRHRDRHM
TDFRRCTIEAPMDGMVVMQTTYRGGEMNQIKVGDRLSPGQPFMAVVDPNSMQLDAMMSQAESELVRLGQPATVRFDAFPD
IVVKGRVKAVGAFAMGGRRVNYYVRRIPVRVELENPDERVIPDLSASADVLTGRPAAGLIIPREALAEAEGKPVVYVKQG
DTFLAHAVEIATATNTQVAVASGIEEGQEVALQPPPSTIR

Specific function: The Emr Locus Confers Resistance To Substances Of High Hydrophobicity. Emra Probably Participate In A Transport System To Extrude Toxins And Drugs From The Cell. [C]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Inner Membrane-Bound [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789041, Length=287, Percent_Identity=26.4808362369338, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 48486; Mature: 48355

Theoretical pI: Translated: 9.53; Mature: 9.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFPSSHRTPPAATKIVAVEPVKLQEGPPRWPIYIFLAALLAGSAWYLRPRPQQRATPAP
CCCCCCCCCCCCCEEEEEECCEEECCCCCCCHHHHHHHHHHCCCEEEECCCCCCCCCCCC
AIPTARVYRGVIDPTRRVAGSISAGRFANVAAPVLQAPDTGRGLTLTFLAESGTRVKRGQ
CCCHHHHHHHHCCHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCEEEEEEECCCCHHHHCC
RIAEIDAQDIKDHLDDVEAGIVQSRLDIKRRQAQLLAQMENLKQGLRVLKATLDKAKQNA
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
RAIPVSNSISQENLRLAVEEYQAAYDEAVKQMPLTEERQLADLKLYQLSYEHDIRHRDRH
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHEEEEEECCHHHHHHHHHH
MTDFRRCTIEAPMDGMVVMQTTYRGGEMNQIKVGDRLSPGQPFMAVVDPNSMQLDAMMSQ
HHHHHHEEEECCCCCEEEEEEECCCCCCCEEEECCCCCCCCCEEEEECCCCCHHHHHHHH
AESELVRLGQPATVRFDAFPDIVVKGRVKAVGAFAMGGRRVNYYVRRIPVRVELENPDER
HHHHHHHCCCCCEEEECCCCCEEEECCHHEEEEHHCCCCEEEEEEEEEEEEEEECCCCHH
VIPDLSASADVLTGRPAAGLIIPREALAEAEGKPVVYVKQGDTFLAHAVEIATATNTQVA
CCCCCCCCCCEECCCCCCCEEECHHHHHHCCCCCEEEEECCCEEEEHHEEEEECCCCEEE
VASGIEEGQEVALQPPPSTIR
EECCCCCCCEEEECCCCCCCC
>Mature Secondary Structure 
AFPSSHRTPPAATKIVAVEPVKLQEGPPRWPIYIFLAALLAGSAWYLRPRPQQRATPAP
CCCCCCCCCCCCEEEEEECCEEECCCCCCCHHHHHHHHHHCCCEEEECCCCCCCCCCCC
AIPTARVYRGVIDPTRRVAGSISAGRFANVAAPVLQAPDTGRGLTLTFLAESGTRVKRGQ
CCCHHHHHHHHCCHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCEEEEEEECCCCHHHHCC
RIAEIDAQDIKDHLDDVEAGIVQSRLDIKRRQAQLLAQMENLKQGLRVLKATLDKAKQNA
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
RAIPVSNSISQENLRLAVEEYQAAYDEAVKQMPLTEERQLADLKLYQLSYEHDIRHRDRH
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHEEEEEECCHHHHHHHHHH
MTDFRRCTIEAPMDGMVVMQTTYRGGEMNQIKVGDRLSPGQPFMAVVDPNSMQLDAMMSQ
HHHHHHEEEECCCCCEEEEEEECCCCCCCEEEECCCCCCCCCEEEEECCCCCHHHHHHHH
AESELVRLGQPATVRFDAFPDIVVKGRVKAVGAFAMGGRRVNYYVRRIPVRVELENPDER
HHHHHHHCCCCCEEEECCCCCEEEECCHHEEEEHHCCCCEEEEEEEEEEEEEEECCCCHH
VIPDLSASADVLTGRPAAGLIIPREALAEAEGKPVVYVKQGDTFLAHAVEIATATNTQVA
CCCCCCCCCCEECCCCCCCEEECHHHHHHCCCCCEEEEECCCEEEEHHEEEEECCCCEEE
VASGIEEGQEVALQPPPSTIR
EECCCCCCCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA