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The map label for this gene is phr [H]

Identifier: 116625724

GI number: 116625724

Start: 8376956

End: 8378326

Strand: Reverse

Name: phr [H]

Synonym: Acid_6673

Alternate gene names: 116625724

Gene position: 8378326-8376956 (Counterclockwise)

Preceding gene: 116625727

Following gene: 116625723

Centisome position: 84.07

GC content: 63.75

Gene sequence:

>1371_bases
GTGGACGAACGCGTGCGGCTGCTCAACGATCGACCTGTCCGGCAGGGCGGGAAGTACGTGTTGTACTGGTGCCGCTGGAA
TCGGCGGGTAGAGGCCAATCACGCGCTACTGCATGCGGCGGAGACGGCAAATCGCATGGACCTGCCGCTGGTGGTGTACG
AGCGGCTGTCGTGCGCATACCCGACTGCGTGCGACCGGTTTCACACGTTTGTGCTCGAGGGCGTACCGCATTTTCAGGCG
CAGCTGCGCAAACTCGGGATTCCCTACATTTTCCAACTGCCGCGACGGAAGACGGTGCGCGATGAGCGGCGCGACGCCGT
GTTGCGGGATGCGGCGGTAGTGGTTACGGACGATTGTCTGCGCGCGGCGCCCCGGCTGGACGTGCGGCTCGAGGCGGTGG
ACGGGAGCTGCATCGTGCCGGTGGGCGCGATTCCAGGGCGGAGTTACGCGGCGTACTCGATCCGGCCAAGGATTCACCGG
CTGCTGCCCAAGTATTTGAAGGCTGCACCGGCGCTCGAGATCCGGCGGCGGTCACGCGAGCGGTTCGAAGATTTGCATAC
GGAGGTCTCGGCGCCGAATATCGCGAGCCTGGTGGCGGAGTGCGAGATCGATCACGGCGTGCGGGCTTCGACTACGTTTC
CGGGAGGACGGATGGCGGCCGAAGCAGGCCTGCAACGCTTTTTGGAGGAGCGGCTGCGGCGGTATGCGCGGGATAAGAAC
GAACCGTCGCTACATGCCACGAGCGAGCTGAGTCCGTACCTGCATTACGGGCATATCGGGGCGCTGGAAGTGGCGCTGGC
GGTGAGGGAGCATGCGGCGGCGCACAAGCTGATTGCCGACGAGTTTCTGGAGGAGCTGATTGTGAGGCGCGAACTGGCAC
ACAATTTCGCGCGTTATGCGCCGCGGCTGGATTCGCTCGACGTGCTGCCGGATTGGGCGCGGAAGACGATCGAGGATCAC
CGCCGCGATACGCGGGATCCGGTGTACGGGCGCGCGGAATTCGAAGGGGCGGCCACGCACGACGATTTGTGGAACGCGAC
GCAGAAGGAACTGGTGCTGCGCGGGAAGATTCACGGGTATTACCGGATGTATTGGGGGAAGAGGATCATCGAATGGTCGC
CCAGCGCGGAGGAGGCGCATGCCACGATGCTGTGGCTGCACGACCGGTACGCGCTGGATGGGGACGACCCGAATACGTAC
ACGAACATCCTTTGGTGCTTCGGTCTGCACGACCGGCCCTGGCCCGAGCGGCCGATTTATGGGACCATCCGCAGCATGGT
GCGGTCGGGGATGGAACGAAAGACCGATGTGCATGCGTACATTCGGGAGATTCAATATCTCGAAAGCACGGGAAGGGAGC
TGACCTCGTGA

Upstream 100 bases:

>100_bases
TGGCCCGCCGCGTGAGATAGCCCCACAGCAATTTCGCGCGGTTCCAGGCCCTCATTCATTTTTATTGTACCTGCCGAGTG
CGCGCGGCAATCGAATCGTC

Downstream 100 bases:

>100_bases
ATATCACGCTCACCGGCGCGTCCGGGCTGATCGGGCGCCGCCTGCTGAAGAACTTCGCGACGGCGGGGCATGGGCTGCGC
GTGCTCAGCCGCCATGCAGG

Product: deoxyribodipyrimidine photo-lyase type II

Products: NA

Alternate protein names: DNA photolyase; Photoreactivating enzyme [H]

Number of amino acids: Translated: 456; Mature: 456

Protein sequence:

>456_residues
MDERVRLLNDRPVRQGGKYVLYWCRWNRRVEANHALLHAAETANRMDLPLVVYERLSCAYPTACDRFHTFVLEGVPHFQA
QLRKLGIPYIFQLPRRKTVRDERRDAVLRDAAVVVTDDCLRAAPRLDVRLEAVDGSCIVPVGAIPGRSYAAYSIRPRIHR
LLPKYLKAAPALEIRRRSRERFEDLHTEVSAPNIASLVAECEIDHGVRASTTFPGGRMAAEAGLQRFLEERLRRYARDKN
EPSLHATSELSPYLHYGHIGALEVALAVREHAAAHKLIADEFLEELIVRRELAHNFARYAPRLDSLDVLPDWARKTIEDH
RRDTRDPVYGRAEFEGAATHDDLWNATQKELVLRGKIHGYYRMYWGKRIIEWSPSAEEAHATMLWLHDRYALDGDDPNTY
TNILWCFGLHDRPWPERPIYGTIRSMVRSGMERKTDVHAYIREIQYLESTGRELTS

Sequences:

>Translated_456_residues
MDERVRLLNDRPVRQGGKYVLYWCRWNRRVEANHALLHAAETANRMDLPLVVYERLSCAYPTACDRFHTFVLEGVPHFQA
QLRKLGIPYIFQLPRRKTVRDERRDAVLRDAAVVVTDDCLRAAPRLDVRLEAVDGSCIVPVGAIPGRSYAAYSIRPRIHR
LLPKYLKAAPALEIRRRSRERFEDLHTEVSAPNIASLVAECEIDHGVRASTTFPGGRMAAEAGLQRFLEERLRRYARDKN
EPSLHATSELSPYLHYGHIGALEVALAVREHAAAHKLIADEFLEELIVRRELAHNFARYAPRLDSLDVLPDWARKTIEDH
RRDTRDPVYGRAEFEGAATHDDLWNATQKELVLRGKIHGYYRMYWGKRIIEWSPSAEEAHATMLWLHDRYALDGDDPNTY
TNILWCFGLHDRPWPERPIYGTIRSMVRSGMERKTDVHAYIREIQYLESTGRELTS
>Mature_456_residues
MDERVRLLNDRPVRQGGKYVLYWCRWNRRVEANHALLHAAETANRMDLPLVVYERLSCAYPTACDRFHTFVLEGVPHFQA
QLRKLGIPYIFQLPRRKTVRDERRDAVLRDAAVVVTDDCLRAAPRLDVRLEAVDGSCIVPVGAIPGRSYAAYSIRPRIHR
LLPKYLKAAPALEIRRRSRERFEDLHTEVSAPNIASLVAECEIDHGVRASTTFPGGRMAAEAGLQRFLEERLRRYARDKN
EPSLHATSELSPYLHYGHIGALEVALAVREHAAAHKLIADEFLEELIVRRELAHNFARYAPRLDSLDVLPDWARKTIEDH
RRDTRDPVYGRAEFEGAATHDDLWNATQKELVLRGKIHGYYRMYWGKRIIEWSPSAEEAHATMLWLHDRYALDGDDPNTY
TNILWCFGLHDRPWPERPIYGTIRSMVRSGMERKTDVHAYIREIQYLESTGRELTS

Specific function: Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ul

COG id: COG0415

COG function: function code L; Deoxyribodipyrimidine photolyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DNA photolyase domain [H]

Homologues:

Organism=Drosophila melanogaster, GI24586396, Length=457, Percent_Identity=37.855579868709, Blast_Score=272, Evalue=4e-73,
Organism=Drosophila melanogaster, GI24586398, Length=457, Percent_Identity=37.855579868709, Blast_Score=271, Evalue=6e-73,
Organism=Drosophila melanogaster, GI24586404, Length=150, Percent_Identity=46.6666666666667, Blast_Score=153, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008148
- InterPro:   IPR006050
- InterPro:   IPR005101
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00875 DNA_photolyase; PF03441 FAD_binding_7 [H]

EC number: =4.1.99.3 [H]

Molecular weight: Translated: 52774; Mature: 52774

Theoretical pI: Translated: 8.45; Mature: 8.45

Prosite motif: PS01083 DNA_PHOTOLYASES_2_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDERVRLLNDRPVRQGGKYVLYWCRWNRRVEANHALLHAAETANRMDLPLVVYERLSCAY
CCCCHHHCCCCCCCCCCCEEEEEEECCCEECCCHHHHHHHHHCCCCCCHHHHHHHHHCCC
PTACDRFHTFVLEGVPHFQAQLRKLGIPYIFQLPRRKTVRDERRDAVLRDAAVVVTDDCL
CHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHCCEEEEECHHH
RAAPRLDVRLEAVDGSCIVPVGAIPGRSYAAYSIRPRIHRLLPKYLKAAPALEIRRRSRE
HCCCCCCEEEEEECCCEEEEECCCCCCCCEEEECCHHHHHHHHHHHHHCCHHHHHHHHHH
RFEDLHTEVSAPNIASLVAECEIDHGVRASTTFPGGRMAAEAGLQRFLEERLRRYARDKN
HHHHHHHHCCCCHHHHHHHHHHCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
EPSLHATSELSPYLHYGHIGALEVALAVREHAAAHKLIADEFLEELIVRRELAHNFARYA
CCCCCCHHCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PRLDSLDVLPDWARKTIEDHRRDTRDPVYGRAEFEGAATHDDLWNATQKELVLRGKIHGY
CCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHCHH
YRMYWGKRIIEWSPSAEEAHATMLWLHDRYALDGDDPNTYTNILWCFGLHDRPWPERPIY
HHHHHCCEEEECCCCHHHHHEEEEEEECCEEECCCCCCHHEEEEEEEECCCCCCCCCCHH
GTIRSMVRSGMERKTDVHAYIREIQYLESTGRELTS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCC
>Mature Secondary Structure
MDERVRLLNDRPVRQGGKYVLYWCRWNRRVEANHALLHAAETANRMDLPLVVYERLSCAY
CCCCHHHCCCCCCCCCCCEEEEEEECCCEECCCHHHHHHHHHCCCCCCHHHHHHHHHCCC
PTACDRFHTFVLEGVPHFQAQLRKLGIPYIFQLPRRKTVRDERRDAVLRDAAVVVTDDCL
CHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHCCEEEEECHHH
RAAPRLDVRLEAVDGSCIVPVGAIPGRSYAAYSIRPRIHRLLPKYLKAAPALEIRRRSRE
HCCCCCCEEEEEECCCEEEEECCCCCCCCEEEECCHHHHHHHHHHHHHCCHHHHHHHHHH
RFEDLHTEVSAPNIASLVAECEIDHGVRASTTFPGGRMAAEAGLQRFLEERLRRYARDKN
HHHHHHHHCCCCHHHHHHHHHHCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
EPSLHATSELSPYLHYGHIGALEVALAVREHAAAHKLIADEFLEELIVRRELAHNFARYA
CCCCCCHHCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PRLDSLDVLPDWARKTIEDHRRDTRDPVYGRAEFEGAATHDDLWNATQKELVLRGKIHGY
CCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHCHH
YRMYWGKRIIEWSPSAEEAHATMLWLHDRYALDGDDPNTYTNILWCFGLHDRPWPERPIY
HHHHHCCEEEECCCCHHHHHEEEEEEECCEEECCCCCCHHEEEEEEEECCCCCCCCCCHH
GTIRSMVRSGMERKTDVHAYIREIQYLESTGRELTS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2668276 [H]